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ATC Code: C02KX03

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2
Haemorrhage Haemorrhage 16.9% x
Haemoglobin Haemorrhage 16.9% x
Headache Headache very common, 15.4% 13.5% x x
Oedema peripheral Oedema peripheral 8.72% 3.23% x x
Nasal congestion Nasal congestion common, 8.72% 4.52% x x
International normalised ratio increased International normalised ratio increased 6.04% 2.58% x
Nausea Nausea common, 6.71% 3.87% x x
Diarrhoea Diarrhoea common x
Dizziness Dizziness common x
Oedema Oedema common x x
Epistaxis Epistaxis common, 3.36% - 7.99% 0% x x
Prothrombin level increased Prothrombin level increased 4.7% 0% x
Flushing Flushing common, 4.03% 0.645% x x
Constipation Constipation common, 3.36% 0% x x
Asthenia Fatigue common, 2.68% 1.94% x x
Fatigue Fatigue common, 2.68% 1.94% x x
Vomiting Vomiting common, 2.68% 1.29% x x
Dyspepsia Dyspepsia common, 2.01% 0.645% x x
Muscle spasms Cramp muscle common, 2.01% 0.645% x x
Abdominal pain upper Abdominal pain upper common, 2.01% 1.29% x x
Insomnia Insomnia common, 2.01% 0% x x
Gingival bleeding Gingival bleeding common, 1.37% x x
Haemoptysis Haemoptysis 2.05% x
Menorrhagia Menorrhagia 1.37% x
Haematuria Haematuria 0.913% x
Haematoma Haematoma 0.685% x
Vaginal haemorrhage Vaginal haemorrhage 0.685% x
Anaemia Anaemia uncommon x
Dermatitis Rash rare x
Rash Rash rare x
Hepatitis Hepatitis rare x x
Abortion spontaneous Abortion spontaneous x
Abscess Abscess x
Lactic acidosis Lactic acidosis x
Pancreatitis acute Pancreatitis acute x
Alopecia Alopecia x
Alveolitis allergic Alveolitis allergic x
Amenorrhoea Amenorrhoea x
Angina pectoris Angina pectoris x
Animal bite Animal bite x
Decreased appetite Anorexia x
Decreased appetite x
Appendicitis Appendicitis x
Arteriovenous fistula Arteriovenous fistula x
Arthritis Arthritis x
Arthritis infective Arthritis infective x
Ascites Ascites x
Asthma Asthma x
Ataxia Ataxia x
Atrial flutter Atrial flutter x
Mental disorder Mental disorder x
Bladder disorder Bladder disorder x
Breast disorder Breast disorder x
Candida infection Candida infection x
Oral candidiasis x
Oral candidiasis Oral candidiasis x
Basal cell carcinoma Basal cell carcinoma x
Cellulitis Cellulitis x
Pleuritic pain Pleuritic pain x
Musculoskeletal chest pain Chest wall pain x
Musculoskeletal chest pain x
Cholelithiasis Cholelithiasis x
Cholestasis Cholestasis x
Colitis Colitis x
Large intestine polyp Colonic polyp x
Infection Infection x
Confusional state Confusional state x
Feeling abnormal Confusional state x
Malaise x
Conjunctival haemorrhage Conjunctival haemorrhage x
Conjunctivitis Conjunctivitis x
Conjunctivitis allergic Conjunctivitis allergic x
Contusion Contusion x
Cyst Cyst x
Deafness Deafness x
Dehydration Dehydration x
Dermatitis atopic Dermatitis atopic x
Dermatitis contact Dermatitis contact x
Diverticulum Diverticulum x
Drug hypersensitivity Drug hypersensitivity x
Toxicity to various agents Drug toxicity x
Dysuria Dysuria x
Ear pain Ear pain x
Localised oedema Localised oedema x
Endocrine disorder Endocrine disorder x
Endophthalmitis Endophthalmitis x
Panophthalmitis Endophthalmitis x
Enteritis Enteritis x
Eosinophilia Eosinophilia x
Eructation Eructation x
Palmar erythema Palmar erythema x
Oesophageal spasm Oesophageal spasm x
Eye disorder Eye disorder x
Eye infection Eye infection x
Facial pain Facial pain x
VIIth nerve paralysis Facial paralysis x
Faecal incontinence Faecal incontinence x
Body temperature increased Body temperature increased x
Fibromyalgia Fibromyalgia x
Flank pain Flank pain x
Vitreous floaters Vitreous floaters x
Cardiac flutter Cardiac flutter x
Localised infection Localised infection x
Food poisoning Food poisoning x
Gallbladder disorder Gallbladder disorder x
Gastroenteritis Gastroenteritis x
Gastrointestinal disorder Gastrointestinal disorder x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage x
Gingivitis Gingivitis x
Glossodynia Glossodynia x
Goitre Goitre x
Gout Gout x
Head injury Head injury x
Cardiac disorder Cardiac disorder x
Cardiac failure Cardiac failure x
Cardiac failure congestive Cardiac failure congestive x
Cardiac murmur Cardiac murmur x
Haematochezia Haematochezia x
Haemorrhoids Haemorrhoids x
Hepatomegaly Hepatomegaly x
Herpes simplex Herpes simplex x
Herpes zoster Herpes zoster x
Hiccups Hiccups x
Dysphonia Hoarseness x
Dysphonia x
Hyperbilirubinaemia Hyperbilirubinaemia x
Hypercholesterolaemia Hypercholesterolaemia x
Hyperglycaemia Hyperglycaemia x
Hyperkalaemia Hyperkalaemia x
Hypernatraemia Hypernatraemia x
Hypersensitivity Hypersensitivity x
Hypocalcaemia Hypocalcaemia x
Hypoglycaemia Hypoglycaemia x
Hypotension Hypotension x
Orthostatic hypotension Orthostatic hypotension x
Immune system disorder Immune system disorder x
Cerumen impaction Cerumen impaction x
Intertrigo Intertrigo x
Eye pruritus Eye pruritus x
Jaundice Jaundice x
Dry eye Keratoconjunctivitis sicca x
Leukopenia Leukopenia x
Systemic lupus erythematosus Systemic lupus erythematosus x
Lymphoma Lymphoma x
Non-Hodgkin's lymphoma Lymphoma x
Breast pain Breast pain x
Mediastinal disorder Mediastinal disorder x x
Metrorrhagia Metrorrhagia x
Multi-organ failure Multi-organ failure x
Muscle atrophy Muscle atrophy x
Musculoskeletal pain Musculoskeletal pain x
Fungal infection Fungal infection x
Myeloproliferative disorder Myeloproliferative disorder x
Myocardial infarction Myocardial infarction x
Acute coronary syndrome Myocardial infarction x
Neoplasm Neoplasm x
Tubulointerstitial nephritis Nephritis interstitial x
Nervous system disorder Nervous system disorder x x
Nervousness Nervousness x
Tension Nervousness x
Night sweats Night sweats x
Mouth haemorrhage Mouth haemorrhage x
Osteoarthritis Osteoarthritis x
Osteochondrosis Osteochondrosis x
Otitis media Otitis media x
Ovarian cyst Ovarian cyst x
Pain Pain x
Pallor Pallor x
Pancreatic pseudocyst Pancreatic pseudocyst x
Pancytopenia Pancytopenia x
Paronychia Paronychia x
Peptic ulcer Peptic ulcer x
Pericardial effusion Pericardial effusion x
Petechiae Petechiae x
Pleural effusion Pleural effusion x
Pleurisy Pleurisy x
Pneumonia aspiration Pneumonia aspiration x
Lobar pneumonia Lobar pneumonia x
Pneumothorax Pneumothorax x
Polyp Polyp x
Pregnancy Pregnancy x
Supraventricular extrasystoles Supraventricular extrasystoles x
Proteinuria Proteinuria x
Protein urine present Proteinuria x
Anal pruritus Anal pruritus x
Pruritus genital Anal pruritus x
Genital itching female x
Anorectal discomfort Anal pruritus x
Psoriasis Psoriasis x
Pulmonary embolism Pulmonary embolism x
Proctalgia Proctalgia x
Respiratory tract infection Respiratory tract infection x
Restless legs syndrome Restless legs syndrome x
Retinal tear Retinal tear x
Rhinitis Rhinitis x
Rib fracture Rib fracture x
Rosacea Rosacea x
Sciatica Sciatica x
Sinus headache Sinus headache x
Sinus pain x
Sinusitis Sinusitis x
Skin disorder Skin disorder x
Unspecified disorder of skin and subcutaneous tissue x
Skin lesion Skin lesion x
Skin ulcer Skin ulcer x
Sneezing Sneezing x
Soft tissue injury Soft tissue injury x
Stomatitis Stomatitis x
Sunburn Sunburn x
Photosensitivity reaction Sunburn x
Tachycardia Tachycardia x
Supraventricular tachycardia Supraventricular tachycardia x
Tendonitis Tendonitis x
Testicular pain Testicular pain x
Thrombocytopenia Thrombocytopenia x
Onychomycosis Onychomycosis x
Tinnitus Tinnitus x
Tongue disorder Tongue disorder x
Tremor Tremor x
Pollakiuria Pollakiuria x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria x
Uterine leiomyoma Uterine leiomyoma x
Angiopathy Angiopathy x x
Venous thrombosis Venous thrombosis x
Ventricular tachycardia Ventricular tachycardia x
Vertigo Vertigo x
Viral infection Viral infection x
Weight decreased Weight decreased x
Wheezing Wheezing x
Laceration Laceration x
Skin laceration x
Dry mouth Dry mouth x
Polydipsia Polydipsia x
Hepatic failure Hepatic failure x x
Sinus bradycardia Sinus bradycardia x
Atrioventricular block first degree Atrioventricular block first degree x
Orthopnoea Orthopnoea x
Agitation Agitation x
Photophobia Photophobia x
Rash pustular Rash pustular x
Cholecystitis chronic Cholecystitis chronic x
Acute sinusitis Acute sinusitis x
Bronchitis Acute bronchitis x
Tracheobronchitis Acute bronchitis x
Lower respiratory tract infection Lower respiratory tract infection x
Urosepsis Urosepsis x
Migraine Migraine x
Coagulation time prolonged Coagulation time prolonged x
Crystalluria Crystalluria x
Tongue discolouration Tongue discolouration x
Ventricular extrasystoles Ventricular extrasystoles x
Ventricular bigeminy x
Muscle haemorrhage Muscle haemorrhage x
Muscular weakness Muscular weakness x
Skin necrosis Skin necrosis x
Skin exfoliation Skin necrosis x
Skin exfoliation x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged x
Aspartate aminotransferase increased Aspartate aminotransferase increased x
Alanine aminotransferase increased Alanine aminotransferase increased x
Dry skin Dry skin x
Sinus congestion Sinus congestion x
Skin irritation Skin irritation x
Lacrimation increased Lacrimation increased x
Viral diarrhoea Viral diarrhoea x
Haemoglobin decreased Haemoglobin decreased x x
Joint stiffness Joint stiffness x
Polyarthritis Polyarthritis x
Malnutrition Malnutrition x
Skin hyperpigmentation Skin hyperpigmentation x
Abdominal hernia Abdominal hernia x
Vaginal prolapse Vaginal prolapse x
Rash macular Rash macular x
Gouty tophus Gouty tophus x
Malaise Malaise x
Discomfort Malaise x
Ill-defined disorder Malaise x
Muscle twitching Muscle twitching x
Dyspnoea exertional Dyspnoea exertional x
Tachypnoea Tachypnoea x
Increased appetite Increased appetite x
Abdominal tenderness Abdominal tenderness x
Retching Retching x
Disturbance in attention Disturbance in attention x
Thinking abnormal Thinking abnormal x
Mental disability Thinking abnormal x
Memory impairment Memory impairment x
Dizziness postural Dizziness postural x
Head discomfort Head discomfort x
Dry throat Dry throat x
Eye irritation Eye irritation x
Tongue ulceration Tongue ulceration x
Blood uric acid increased Blood uric acid increased x
Blood creatinine increased Blood creatinine increased x
Chest pain Chest discomfort x
Chest discomfort Chest discomfort x
Hepatic enzyme increased Hepatic enzyme increased x
Pain in jaw Pain in jaw x
Menopausal symptoms Menopausal symptoms x
Heart rate irregular Heart rate irregular x
Gingival pain Gingival pain x
Groin pain Groin pain x
Haematocrit increased Haematocrit increased x
Frequent bowel movements Frequent bowel movements x
Sinus operation Nasal sinus drainage x
Hyperaesthesia Nipple pain x
Nipple pain Nipple pain x
Activated partial thromboplastin time prolonged Activated partial thromboplastin time prolonged x
Pregnancy test positive Pregnancy test positive x
Sputum purulent Sputum purulent x
Subcutaneous abscess Subcutaneous abscess x
Weight fluctuation Weight fluctuation x
Hypoxia Hypoxia x
Furuncle Furuncle x
Muscle fatigue Muscle fatigue x
Breast tenderness Breast tenderness x
Extrasystoles Ventricular bigeminy x
Nail hypertrophy Nail hypertrophy x
Dilatation atrial Dilatation atrial x
Hepatobiliary disease Hepatobiliary disease x x
Fluid retention Fluid retention x
Venous insufficiency Post thrombotic syndrome x
Post thrombotic syndrome Post thrombotic syndrome x
Blood bilirubin increased Blood bilirubin increased x
Nocturnal dyspnoea Nocturnal dyspnoea x
Anal skin tags Anal skin tags x
Skin papilloma Skin papilloma x
Dysaesthesia Dysaesthesia x
Vaginal infection Vaginal infection x
Joint injury Joint injury x
Sensation of foreign body Sensation of foreign body x
Red blood cell count decreased Red blood cell count decreased x
Bradycardia Bradycardia x
Ligament sprain Joint sprain x
Ligament injury Ligament injury x
Pruritus generalised Pruritus generalised x
Blood pressure increased Blood pressure increased x
Tooth abscess Tooth abscess x
Breast calcifications Breast microcalcification x
Venous pressure jugular increased Venous pressure jugular increased x
Injection site dermatitis Injection site dermatitis x
Paraesthesia oral Paraesthesia oral x
Ear discomfort Ear feels clogged x
Inflammation Inflammation localised x
Visual impairment Visual disturbance x
Vulvovaginal mycotic infection Vaginal mycosis x
Haemoglobin increased Haemoglobin increased x
Gastroenteritis bacterial Gastroenteritis bacterial x
Gastritis viral Gastritis viral x
Blood glucose increased Blood glucose increased x
Throat irritation Throat irritation x
Thermal burn Thermal burn x
Gastrointestinal fungal infection Gastrointestinal fungal infection x
Eye oedema Eye oedema x
Haematocrit decreased Haematocrit decreased x
Oxygen saturation decreased Oxygen saturation decreased x
White blood cell count decreased White blood cell count decreased x
Partial seizures Partial seizures x
Ear congestion Ear congestion x
Infestation Infestation NOS x
Sleep disorder Sleep disorder x
Blood bicarbonate decreased Blood bicarbonate decreased x
Arthropod sting Arthropod sting x
Blood creatine phosphokinase increased Blood creatine phosphokinase increased x
Blood lactate dehydrogenase increased Blood lactate dehydrogenase increased x
Arthropod bite Arthropod bite x
Blood potassium increased Blood potassium increased x
Blood potassium decreased Blood potassium decreased x
Tongue blistering Tongue blistering x
Blood creatine phosphokinase MB increased Blood creatine phosphokinase MB increased x
Limb discomfort Limb discomfort x
Sputum discoloured Sputum discoloured x
Nasal discomfort Nasal discomfort x
Lung infection Lung infection x
Application site haematoma Application site haematoma x
Liver function test abnormal Raised liver function tests x
Blood phosphorus increased Blood phosphorus increased x
Post procedural haemorrhage Post procedural haemorrhage x
Puncture site haemorrhage Puncture site haemorrhage x
Catheter site haemorrhage Catheter site haemorrhage x
Ischaemic stroke Ischaemic stroke x
Oral pruritus Oral pruritus x
Musculoskeletal stiffness Musculoskeletal stiffness x
Abdominal strangulated hernia Abdominal strangulated hernia x
Abdominal discomfort Gastrointestinal discomfort x
Vessel puncture site inflammation Vessel puncture site inflammation x
Connective tissue inflammation Connective tissue inflammation x
Paranasal sinus hypersecretion Paranasal sinus hypersecretion x
Peripheral artery aneurysm Peripheral artery aneurysm x
Respiratory failure Respiratory failure x
Gastrointestinal infection Gastrointestinal infection x
Thrombophlebitis superficial Thrombophlebitis superficial x
Rash papular Rash papular x
Renal failure Renal impairment x
Renal impairment Renal impairment x
Arthritis bacterial Arthritis bacterial x
Conjunctival hyperaemia Conjunctival hyperaemia x
Dyspnoea paroxysmal nocturnal Dyspnoea paroxysmal nocturnal x
Somnolence Somnolence x
Feeling hot Feeling hot x
Right ventricular failure Right ventricular failure x


Information about indications was extracted from the indications and usage sections of the labels.

sitaxentan sodium / sitaxentan sodium

Side effects:28


Side effects:376
Source:Health Canada

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label