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ATC Code: C02KX03

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2
Haemorrhage 16.9% x
Headache very common, 15.4% 13.5% x x
Oedema peripheral 8.72% 3.23% x x
Nasal congestion common, 8.72% 4.52% x x
International normalised ratio increased 6.04% 2.58% x
Nausea common, 6.71% 3.87% x x
Diarrhoea common x
Dizziness common x
Oedema common x x
Epistaxis common, 3.36% - 7.99% 0% x x
Prothrombin level increased 4.7% 0% x
Flushing common, 4.03% 0.645% x x
Constipation common, 3.36% 0% x x
Fatigue common, 2.68% 1.94% x x
Vomiting common, 2.68% 1.29% x x
Dyspepsia common, 2.01% 0.645% x x
Cramp muscle common, 2.01% 0.645% x x
Abdominal pain upper common, 2.01% 1.29% x x
Insomnia common, 2.01% 0% x x
Gingival bleeding common, 1.37% x x
Haemoptysis 2.05% x
Menorrhagia 1.37% x
Haematuria 0.913% x
Haematoma 0.685% x
Vaginal haemorrhage 0.685% x
Anaemia uncommon x
Rash rare x
Hepatitis rare x x
Abortion spontaneous x
Abscess x
Lactic acidosis x
Pancreatitis acute x
Alopecia x
Alveolitis allergic x
Amenorrhoea x
Angina pectoris x
Animal bite x
Anorexia x
Appendicitis x
Arteriovenous fistula x
Arthritis x
Arthritis infective x
Ascites x
Asthma x
Ataxia x
Atrial flutter x
Mental disorder x
Bladder disorder x
Breast disorder x
Candida infection x
Oral candidiasis x
Basal cell carcinoma x
Cellulitis x
Pleuritic pain x
Chest wall pain x
Cholelithiasis x
Cholestasis x
Colitis x
Colonic polyp x
Infection x
Confusional state x
Conjunctival haemorrhage x
Conjunctivitis x
Conjunctivitis allergic x
Contusion x
Cyst x
Deafness x
Dehydration x
Dermatitis atopic x
Dermatitis contact x
Diverticulum x
Drug hypersensitivity x
Drug toxicity x
Dysuria x
Ear pain x
Localised oedema x
Endocrine disorder x
Endophthalmitis x
Enteritis x
Eosinophilia x
Eructation x
Palmar erythema x
Oesophageal spasm x
Eye disorder x
Eye infection x
Facial pain x
Facial paralysis x
Faecal incontinence x
Body temperature increased x
Fibromyalgia x
Flank pain x
Vitreous floaters x
Cardiac flutter x
Localised infection x
Food poisoning x
Gallbladder disorder x
Gastroenteritis x
Gastrointestinal disorder x x
Gastrointestinal haemorrhage x
Gingivitis x
Glossodynia x
Goitre x
Gout x
Head injury x
Cardiac disorder x
Cardiac failure x
Cardiac failure congestive x
Cardiac murmur x
Haematochezia x
Haemorrhoids x
Hepatomegaly x
Herpes simplex x
Herpes zoster x
Hiccups x
Hoarseness x
Hyperbilirubinaemia x
Hypercholesterolaemia x
Hyperglycaemia x
Hyperkalaemia x
Hypernatraemia x
Hypersensitivity x
Hypocalcaemia x
Hypoglycaemia x
Hypotension x
Orthostatic hypotension x
Immune system disorder x
Cerumen impaction x
Intertrigo x
Eye pruritus x
Jaundice x
Keratoconjunctivitis sicca x
Leukopenia x
Systemic lupus erythematosus x
Lymphoma x
Breast pain x
Mediastinal disorder x x
Metrorrhagia x
Multi-organ failure x
Muscle atrophy x
Musculoskeletal pain x
Fungal infection x
Myeloproliferative disorder x
Myocardial infarction x
Neoplasm x
Nephritis interstitial x
Nervous system disorder x x
Nervousness x
Night sweats x
Mouth haemorrhage x
Osteoarthritis x
Osteochondrosis x
Otitis media x
Ovarian cyst x
Pain x
Pallor x
Pancreatic pseudocyst x
Pancytopenia x
Paronychia x
Peptic ulcer x
Pericardial effusion x
Petechiae x
Pleural effusion x
Pleurisy x
Pneumonia aspiration x
Lobar pneumonia x
Pneumothorax x
Polyp x
Pregnancy x
Supraventricular extrasystoles x
Proteinuria x
Anal pruritus x
Psoriasis x
Pulmonary embolism x
Proctalgia x
Respiratory tract infection x
Restless legs syndrome x
Retinal tear x
Rhinitis x
Rib fracture x
Rosacea x
Sciatica x
Sinus headache x
Sinusitis x
Skin disorder x
Skin lesion x
Skin ulcer x
Sneezing x
Soft tissue injury x
Stomatitis x
Sunburn x
Tachycardia x
Supraventricular tachycardia x
Tendonitis x
Testicular pain x
Thrombocytopenia x
Onychomycosis x
Tinnitus x
Tongue disorder x
Tremor x
Pollakiuria x
Urinary tract disorder x
Urticaria x
Uterine leiomyoma x
Angiopathy x x
Venous thrombosis x
Ventricular tachycardia x
Vertigo x
Viral infection x
Weight decreased x
Wheezing x
Laceration x
Dry mouth x
Polydipsia x
Hepatic failure x x
Sinus bradycardia x
Atrioventricular block first degree x
Orthopnoea x
Agitation x
Photophobia x
Rash pustular x
Cholecystitis chronic x
Acute sinusitis x
Acute bronchitis x
Lower respiratory tract infection x
Urosepsis x
Migraine x
Coagulation time prolonged x
Crystalluria x
Tongue discolouration x
Ventricular extrasystoles x
Muscle haemorrhage x
Muscular weakness x
Skin necrosis x
Electrocardiogram QT prolonged x
Aspartate aminotransferase increased x
Alanine aminotransferase increased x
Dry skin x
Sinus congestion x
Skin irritation x
Lacrimation increased x
Viral diarrhoea x
Haemoglobin decreased x x
Joint stiffness x
Polyarthritis x
Malnutrition x
Skin hyperpigmentation x
Abdominal hernia x
Unspecified disorder of skin and subcutaneous tissue x
Vaginal prolapse x
Rash macular x
Gouty tophus x
Malaise x
Muscle twitching x
Dyspnoea exertional x
Tachypnoea x
Increased appetite x
Decreased appetite x
Abdominal tenderness x
Retching x
Disturbance in attention x
Thinking abnormal x
Memory impairment x
Dizziness postural x
Head discomfort x
Dry throat x
Eye irritation x
Tongue ulceration x
Blood uric acid increased x
Blood creatinine increased x
Chest discomfort x
Hepatic enzyme increased x
Pain in jaw x
Menopausal symptoms x
Heart rate irregular x
Skin exfoliation x
Gingival pain x
Groin pain x
Haematocrit increased x
Frequent bowel movements x
Nasal sinus drainage x
Nipple pain x
Activated partial thromboplastin time prolonged x
Pregnancy test positive x
Sputum purulent x
Subcutaneous abscess x
Weight fluctuation x
Hypoxia x
Furuncle x
Muscle fatigue x
Breast tenderness x
Ventricular bigeminy x
Nail hypertrophy x
Dilatation atrial x
Hepatobiliary disease x x
Fluid retention x
Post thrombotic syndrome x
Blood bilirubin increased x
Nocturnal dyspnoea x
Anal skin tags x
Skin papilloma x
Dysaesthesia x
Vaginal infection x
Joint injury x
Sensation of foreign body x
Red blood cell count decreased x
Bradycardia x
Joint sprain x
Ligament injury x
Pruritus generalised x
Musculoskeletal chest pain x
Blood pressure increased x
Tooth abscess x
Breast microcalcification x
Venous pressure jugular increased x
Injection site dermatitis x
Paraesthesia oral x
Genital itching female x
Sinus pain x
Ear feels clogged x
Inflammation localised x
Visual disturbance x
Vaginal mycosis x
Haemoglobin increased x
Gastroenteritis bacterial x
Skin laceration x
Gastritis viral x
Blood glucose increased x
Throat irritation x
Thermal burn x
Gastrointestinal fungal infection x
Eye oedema x
Haematocrit decreased x
Oxygen saturation decreased x
White blood cell count decreased x
Partial seizures x
Ear congestion x
Infestation NOS x
Blood and lymphatic system disorders x x
Ear and labyrinth disorders x
Sleep disorder x
Blood bicarbonate decreased x
Arthropod sting x
Blood creatine phosphokinase increased x
Blood lactate dehydrogenase increased x
Arthropod bite x
Blood potassium increased x
Blood potassium decreased x
Tongue blistering x
Blood creatine phosphokinase MB increased x
Limb discomfort x
Sputum discoloured x
Nasal discomfort x
Lung infection x
Application site haematoma x
Raised liver function tests x
Blood phosphorus increased x
Post procedural haemorrhage x
Puncture site haemorrhage x
Catheter site haemorrhage x
Ischaemic stroke x
Oral pruritus x
Musculoskeletal stiffness x
Abdominal strangulated hernia x
Gastrointestinal discomfort x
Vessel puncture site inflammation x
Connective tissue inflammation x
Paranasal sinus hypersecretion x
Peripheral artery aneurysm x
Respiratory failure x
Gastrointestinal infection x
Thrombophlebitis superficial x
Rash papular x
Dysphonia x
Renal impairment x
Arthritis bacterial x
Conjunctival hyperaemia x
Dyspnoea paroxysmal nocturnal x
Somnolence x
Feeling hot x
Right ventricular failure x


Information about indications was extracted from the indications and usage sections of the labels.

sitaxentan sodium / sitaxentan sodium

Side effects:28


Side effects:376
Source:Health Canada

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label