| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Leukopenia | Leukopenia | very common, 72% - 90% |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Neutropenia | Neutropenia | rare — 3% - 100% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Alopecia | Alopecia | very common, 87% - 94% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anaemia | Anaemia | uncommon — 4% - 97% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anemic |  |  | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Diarrhoea | Diarrhoea | rare, 5% - 90% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Loose stools |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Peripheral sensory neuropathy | Peripheral sensory neuropathy | 71% |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nausea | Nausea | postmarketing — 8% - 70% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Flushing | Flushing | common — 28% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Thrombocytopenia | Thrombocytopenia | very common, 2% - 70% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Infection | Infection | postmarketing — 0.249% - 38% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vomiting | Vomiting | 4% - 70% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Mucosal inflammation | Mucosal inflammation | 4% - 45% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Decreased appetite | Anorexia | very rare — 25% |  |  | x | x | x |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Decreased appetite | common |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Candida infection | Oral candidiasis | very common |  |  | x |  | x | x | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Candida infection | 7% - 9% |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Oral candidiasis | Oral candidiasis | very common |  |  | x |  | x | x | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pharyngitis | Pharyngitis | very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin ulcer | Skin ulcer | very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Swelling | Swelling | very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased | very common |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Blood alkaline phosphatase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Dry skin | Dry skin | very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Neurotoxicity | Neurotoxicity | very common |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  | x | 
| Pancytopenia | Myelosuppression | very rare, very common |  | x |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x |  | 
| Pancytopenia |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Haemorrhage | Haemorrhage | very common, 2% - 14% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Haemoglobin | Haemorrhage | very common, 2% - 14% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Herpes simplex | Herpes simplex | rare — 11% - 38% |  | x |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis | Rash | postmarketing — 9% - 14% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Rash | Rash | postmarketing — 9% - 14% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| B-cell type acute leukaemia | B-cell type acute leukaemia | 9% - 14% |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Oedema | Oedema | postmarketing — 10% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pain | Pain | common, very common |  | x |  | x |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Upper respiratory tract infection | Upper respiratory tract infection | common, very common |  | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypotension | Hypotension | very rare — 3% - 17% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypotensive |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Neuropathy peripheral | Neuropathy peripheral | very common, 1% - 15% |  | x |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Neuropathy | common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Chest pain | Chest pain | postmarketing, very common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Chest discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rhinitis | Rhinitis | rare, very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Chills | Chills | rare, very common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  | x | 
| Rigors |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Skin discolouration | Skin discolouration | rare, very common |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Pigmentation disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Tenderness | Tenderness | rare, very common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Cryptosporidiosis infection | Cryptosporidiosis infection | 7% |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Cough | Cough | very rare — 6% - 7% |  |  | x |  | x | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Asthenia | Fatigue | 4% - 8% |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Asthenia | postmarketing — 1% - 47% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fatigue | Fatigue | 4% - 8% |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pancreatitis acute | Pancreatitis acute | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Conjunctivitis | Conjunctivitis | postmarketing, common |  |  |  |  | x | x |  |  |  |  | x | x | x | x | x | x | x | x |  | x | x | 
| Dysgeusia | Dysgeusia | common |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dyspepsia | Dyspepsia | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Localised oedema | Localised oedema | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Deafness neurosensory | Deafness neurosensory | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypoaesthesia | Hypoaesthesia | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypokalaemia | Hypokalaemia | common |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Influenza | Influenza | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye pruritus | Eye pruritus | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Keratitis | Keratitis | common |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dry eye | Keratoconjunctivitis sicca | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dry eye | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Melaena | Melaena | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nervousness | Nervousness | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tension | Nervousness | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Palpitations | Palpitations | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dizziness | Syncope | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dizziness | very rare — common |  |  |  |  | x |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Lightheadedness |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Shock | Syncope | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Shock | very rare — uncommon |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Syncope | Syncope | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Loss of consciousness | Syncope | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urinary tract infection | Urinary tract infection | common |  | x |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dry mouth | Dry mouth | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypokinesia | Hypokinesia | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Stomatitis | Mouth ulceration | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Stomatitis |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Mouth ulceration | Mouth ulceration | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Skin necrosis | Skin necrosis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Skin exfoliation | Skin necrosis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Skin exfoliation | postmarketing |  |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Eye pain | Eye pain | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Lacrimation increased | Lacrimation increased | postmarketing, common |  |  |  |  | x | x |  |  |  |  | x | x | x | x | x | x | x | x |  | x | x | 
| Thinking abnormal | Thinking abnormal | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mental disability | Thinking abnormal | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Visual acuity reduced | Visual acuity reduced | postmarketing, common |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Eye irritation | Eye irritation | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Skin fibrosis | Skin fibrosis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Madarosis | Madarosis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blood bilirubin increased | Blood bilirubin increased | common |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Vision blurred | Vision blurred | common |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Necrotising colitis | Necrotizing enterocolitis | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Necrotising enterocolitis neonatal | Necrotizing enterocolitis | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Visual impairment | Visual disturbance | rare — 13% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Abnormal vision | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Disorder sight | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gait disturbance | Gait disturbance | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Febrile neutropenia | Febrile neutropenia | common, 1% - 55% |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Encephalopathy | Encephalopathy acute | common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Encephalopathy | very rare, postmarketing |  |  |  | x |  |  |  | x | x | x |  |  |  |  |  |  |  |  | x |  |  | 
| Gastrointestinal disorder | Gastrointestinal disorder | postmarketing, 3.48% - 47.8% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Connective tissue disorder | Connective tissue disorder | 0.746% - 5.97% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Gamma-glutamyltransferase increased | Gamma-glutamyltransferase increased | 3% |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bradycardia | Bradycardia | rare — 1% - 3% |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dehydration | Dehydration | postmarketing — 5% |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cardiomyopathy | Cardiomyopathy | uncommon, common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Epistaxis | Epistaxis | rare, common |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cystoid macular oedema | Cystoid macular oedema | postmarketing, common |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Myocardial infarction | Myocardial infarction | rare, common |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Acute coronary syndrome | Myocardial infarction | rare, common |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Neuritis | Peripheral motor neuropathy | rare, common |  |  |  | x | x | x | x | x | x | x |  |  |  |  |  |  |  |  | x | x | x | 
| Peripheral motor neuropathy | Peripheral motor neuropathy | rare, common |  |  |  | x | x | x | x | x | x | x |  |  |  |  |  |  |  |  | x | x | x | 
| Insomnia | Insomnia | rare, common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Ventricular tachycardia | Ventricular tachycardia | very rare, common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Ventricular extrasystoles | Ventricular bigeminy | very rare, common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Extrasystoles | Ventricular bigeminy | very rare, common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Extrasystoles | uncommon |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Pseudomembranous colitis | Pseudomembranous colitis | very rare, common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Meningitis cryptococcal | Meningitis cryptococcal | 2% - 3% |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Arthralgia | Arthralgia | rare — 1% - 2% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Musculoskeletal discomfort | Arthralgia | rare — 1% - 2% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Myalgia | 1% - 44% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dyspnoea | Dyspnoea | postmarketing — 1% - 12% |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tachycardia | Tachycardia | very rare — 2% |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Myalgia | Myalgia | 1% - 44% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Leukoencephalopathy | Leukoencephalopathy | 2% |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Malnutrition | Malnutrition | postmarketing, 1.99% - 25.9% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Hypersensitivity | Hypersensitivity | postmarketing — 1% - 14% |  | x | x |  |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Body temperature increased | Body temperature increased | postmarketing — 1% - 14% |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypertension | Hypertension | uncommon, 1% |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Injection site reaction | Injection site reaction | postmarketing — 1% - 13% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nail disorder | Nail changes | very common, 1% |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Nail disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nervous system disorder | Nervous system disorder | postmarketing, 0.746% - 12.7% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Angioedema | Angioedema | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Contusion | Contusion | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyperglycaemia | Hyperglycaemia | uncommon |  | x |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x |  | x | x | 
| Hypocalcaemia | Hypocalcaemia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypoglycaemia | Hypoglycaemia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyponatraemia | Hyponatraemia | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Septic shock | Septic shock | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Thrombophlebitis | Thrombophlebitis | uncommon |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Weight decreased | Weight decreased | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Polydipsia | Polydipsia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypophosphataemia | Hypophosphataemia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypoalbuminaemia | Hypoalbuminaemia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Fluid retention | Fluid retention | uncommon |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Tumour necrosis | Tumour necrosis | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Respiratory distress | Respiratory distress | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Urticaria | Generalized urticaria | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Urticaria | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Metastatic pain | Metastatic pain | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nail pigmentation | Nail pigmentation | uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pneumothorax | Pneumothorax | 1% |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Neutropenic sepsis | Neutropenic sepsis | 1% |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pneumonia | Pneumonia | postmarketing — 3% - 4% |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Thrombosis | Thrombosis | rare, uncommon |  |  | x |  | x | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Infestation | Infestation NOS | postmarketing, 0.249% - 4.98% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Anaphylactic shock | Anaphylactic shock | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Ascites | Ascites | very rare — common |  |  |  |  |  |  | x |  |  |  |  | x | x | x | x | x | x | x | x |  |  | 
| Atrial fibrillation | Atrial fibrillation | very rare — common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Atrioventricular block | Atrioventricular block | very rare — common |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Mental disorder | Mental disorder | postmarketing, 0% - 5.97% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cellulitis | Cellulitis | postmarketing — very common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Colitis | Colitis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Constipation | Constipation | very rare — 18% |  |  | x | x | x | x | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis exfoliative | Dermatitis exfoliative | very rare — very common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Scleroderma | Scleroderma | postmarketing |  |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x | x |  |  | 
| Erythema multiforme | Erythema multiforme | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Stevens-Johnson syndrome | very rare — uncommon |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Oesophagitis | Oesophagitis | very rare — common |  |  |  |  | x |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Extravasation | Extravasation | postmarketing — very common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Eye disorder | Eye disorder | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Fibrosis | Fibrosis | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Vitreous floaters | Vitreous floaters | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Headache | Headache | very rare — common |  |  |  |  |  | x | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Cardiac arrest | Cardiac arrest | rare |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Cardiac disorder | Cardiac disorder | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cardiac failure | Cardiac failure | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Cardiac failure congestive | Cardiac failure congestive | postmarketing — common |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blood disorder | Blood disorder | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Hepatic encephalopathy | Hepatic encephalopathy | postmarketing |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Hyperaesthesia | Hyperaesthesia | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Orthostatic hypotension | Orthostatic hypotension | very rare — common |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Immune system disorder | Immune system disorder | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Intestinal obstruction | Intestinal obstruction | postmarketing — 4% |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | x | 
| Intestinal perforation | Intestinal perforation | postmarketing — common |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Acute myeloid leukaemia | Acute myeloid leukaemia | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Acute leukaemia | Acute myeloid leukaemia | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Mediastinal disorder | Mediastinal disorder | postmarketing, 0% - 7.46% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Hypertonia | Hypertonia | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Myelodysplastic syndrome | Myelodysplastic syndrome | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Necrosis | Necrosis | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Pancreatitis | Pancreatitis | postmarketing, rare |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Ileus paralytic | Ileus paralytic | very rare — common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Paraesthesia | Paraesthesia | postmarketing |  |  |  | x |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Tingling sensation | postmarketing |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  |  | 
| Peritonitis | Peritonitis | rare |  | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Phlebitis | Phlebitis | postmarketing |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Pleural effusion | Pleural effusion | postmarketing, rare |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Pruritus | Pruritus | postmarketing — very common |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pulmonary embolism | Pulmonary embolism | postmarketing, rare |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Pulmonary thromboembolism |  |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pulmonary fibrosis | Pulmonary fibrosis | postmarketing, rare |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Scotoma | Scotoma | rare |  |  |  | x |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Convulsion | Convulsion | very rare — common |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Sinusitis | Sinusitis | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome | very rare — uncommon |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Erythema | Erythema | postmarketing — very common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Redness | postmarketing |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  |  | 
| Angiopathy | Angiopathy | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Photopsia | Photopsia | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Onycholysis | Onycholysis | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cranial nerve paralysis | Cranial nerve paralysis | postmarketing |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Injection site swelling | Injection site swelling | rare |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Toxic epidermal necrolysis | Necrolysis epidermal | very rare — uncommon |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Toxic epidermal necrolysis | very rare, postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Injury | Accidental injury | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Hepatic necrosis | Hepatic necrosis | postmarketing, rare |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Nerve injury | Nerve injury | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Colitis ischaemic | Colitis ischaemic | postmarketing — common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Photosensitivity reaction | Photosensitivity reaction | postmarketing |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Skin disorder | Unspecified disorder of skin and subcutaneous tissue | postmarketing, 0% - 5.22% |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Skin disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Interstitial lung disease | Interstitial pneumonia | postmarketing, rare |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Interstitial lung disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Radiation pneumonitis | Radiation pneumonitis | postmarketing, rare |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Malaise | Malaise | postmarketing — very common |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Discomfort | Malaise | postmarketing — very common |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Feeling abnormal | Malaise | postmarketing — very common |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Confusional state | very rare, postmarketing |  |  |  |  | x |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Ill-defined disorder | Malaise | postmarketing — very common |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blood creatinine increased | Blood creatinine increased | rare |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Oropharyngeal discomfort | Throat sore | postmarketing |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  |  | 
| Oropharyngeal pain | Throat sore | postmarketing |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  |  | 
| Left ventricular dysfunction | Left ventricular dysfunction | postmarketing, rare |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Sepsis | Sepsis | postmarketing, rare |  | x |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Autonomic neuropathy | Autonomic neuropathy | very rare — common |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Thrombosis mesenteric vessel | Thrombosis mesenteric vessel | very rare — common |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Caecitis | Caecitis | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Breast cancer stage IV | Breast cancer stage IV | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Induration | Induration | postmarketing |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Neutropenic colitis | Neutropenic enterocolitis | postmarketing |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Neutropenic colitis | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Rash maculo-papular | Rash maculo-papular | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Visual evoked potentials abnormal | Visual evoked potentials abnormal | postmarketing |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Vocal cord paresis | Vocal cord paresis | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Ventricular failure | Ventricular failure | postmarketing |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Respiratory failure | Respiratory failure | postmarketing, rare |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Recall phenomenon | Recall phenomenon | postmarketing, rare |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Radiation recall reaction (dermatologic) | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Ataxia | Ataxia | very rare, postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Confusional state | Confusional state | very rare, postmarketing |  |  |  |  | x |  | x |  |  |  | x | x | x | x | x | x | x | x | x |  |  | 
| Supraventricular tachycardia | Supraventricular tachycardia | very rare, postmarketing |  |  | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tinnitus | Tinnitus | very rare — common |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vertigo | Vertigo | very rare — common |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Grand mal convulsion | Tonic-clonic seizures | very rare, postmarketing |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Ototoxicity | Ototoxicity | very rare, postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Coronary artery stenosis | Coronary artery stenosis | very rare |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Drug interaction | Drug interaction | very rare |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Deafness | Hearing impaired | very rare, postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Hearing impaired | Hearing impaired | very rare, postmarketing |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Abdominal distension | Abdominal distension |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Abdominal pain | Abdominal pain |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Gastrointestinal pain | Abdominal pain |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Adenocarcinoma | Adenocarcinoma |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Amblyopia | Amblyopia |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anxiety | Anxiety |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Arrhythmia | Arrhythmia |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Back pain | Back pain |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Bone disorder | Bone disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Metabolic encephalopathy | Metabolic encephalopathy |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast disorder | Breast disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Bronchitis | Bronchitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Transient ischaemic attack | Transient ischaemic attack |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Neck pain | Neck pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Musculoskeletal chest pain | Chest wall pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Cholangitis | Cholangitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cyst | Cyst |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysphagia | Dysphagia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Depression | Depression |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dermatitis atopic | Dermatitis atopic |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Drug hypersensitivity | Drug hypersensitivity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Dyskinesia | Dyskinesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dysuria | Dysuria |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Ear pain | Ear pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Embolism | Embolism |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Flank pain | Flank pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Flatulence | Flatulence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Folliculitis | Folliculitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Gastrooesophageal reflux disease | Gastrooesophageal reflux disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Glossodynia | Glossodynia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Haematuria | Haematuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Haemolytic uraemic syndrome | Haemolytic uraemic syndrome |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Haemoptysis | Haemoptysis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hepatomegaly | Hepatomegaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Herpes zoster | Herpes zoster |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dysphonia | Hoarseness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyperbilirubinaemia | Hyperbilirubinaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hyperhidrosis | Hyperhidrosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Sweating increased |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  |  |  | 
| Pulmonary hypertension | Pulmonary hypertension |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypotrichosis | Hypotrichosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Infarction | Infarction |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Renal failure acute | Renal failure acute |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle spasms | Cramps of lower extremities |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cramp muscle |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Muscle spasms |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Lethargy | Lethargy |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Systemic lupus erythematosus | Systemic lupus erythematosus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Lymphoedema | Lymphoedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Lymphopenia | Lymphopenia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Breast pain | Breast pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Musculoskeletal pain | Musculoskeletal pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Fungal infection | Fungal infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nasal congestion | Nasal congestion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nasopharyngitis | Nasopharyngitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rhinorrhoea |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Neoplasm | Neoplasm |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Neuralgia | Neuralgia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Night sweats | Night sweats |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nocturia | Nocturia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Opportunistic infection | Opportunistic infection |  |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Pain in extremity | Pain in extremity |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Polyp | Polyp |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Polyuria | Polyuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Urine output increased | Polyuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Prurigo | Prurigo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Thrombotic thrombocytopenic purpura | Thrombotic thrombocytopenic purpura |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Respiratory tract infection | Respiratory tract infection |  |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Congenital skin disorder | Congenital skin disorder |  |  |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Skin lesion | Skin lesion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Cerebrovascular accident | Cerebrovascular accident |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sinus tachycardia | Sinus tachycardia |  |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Tremor | Tremor |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Tumour lysis syndrome | Tumour lysis syndrome |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Pollakiuria | Pollakiuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Urinary incontinence | Urinary incontinence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Urethral disorder | Urinary tract disorder |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Urinary tract disorder | Urinary tract disorder |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Venous thrombosis | Venous thrombosis |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Viral infection | Viral infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Vitiligo | Vitiligo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Weight increased | Weight increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Wheezing | Wheezing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Immunodeficiency | Immunocompromised |  |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Sinus bradycardia | Sinus bradycardia |  |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Agitation | Agitation |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x | x | 
| Oedema peripheral | Oedema peripheral |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Squamous cell carcinoma of lung | Squamous cell carcinoma of lung |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Atrioventricular block complete | Atrioventricular block complete |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Swelling face | Swelling face |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Electrolyte imbalance | Electrolyte abnormality |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood electrolytes abnormal | Electrolyte abnormality |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypomagnesaemia | Hypomagnesaemia |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Myocardial ischaemia | Myocardial ischaemia |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Muscular weakness | Muscular weakness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Myasthenia |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bone pain | Bone pain |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyporeflexia | Hyporeflexia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Aspartate aminotransferase increased | Aspartate aminotransferase increased |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Polyneuropathy | Polyneuropathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Sensory disturbance | Sensory disturbance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Sinus congestion | Sinus congestion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Skin hyperpigmentation | Skin hyperpigmentation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rash macular | Rash macular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nail discolouration | Nail discolouration |  |  |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Injection site infection | Injection site infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Oral pain | Oral pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dyspnoea exertional | Dyspnoea exertional |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nasal dryness | Nasal dryness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Abdominal pain upper | Abdominal pain upper |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Abdominal pain lower | Abdominal pain lower |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Areflexia | Areflexia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rash erythematous | Rash erythematous |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Dizziness postural | Dizziness postural |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Neurological symptom | Neurological symptom |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x |  |  | 
| Scintillating scotoma | Scintillating scotoma |  |  |  |  |  |  |  | x | x | x | x |  |  |  |  |  |  |  |  |  |  |  | 
| Dry throat | Dry throat |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Chest discomfort | Chest discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Breath sounds abnormal | Respiratory sounds decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Productive cough | Productive cough |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Gingival pain | Gingival pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Groin pain | Groin pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pain of skin | Pain of skin |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Onychomadesis | Onychomadesis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rectal haemorrhage | Rectal haemorrhage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hepatobiliary disease | Hepatobiliary disease |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Macular oedema | Macular oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Blood pressure systolic decreased | Blood pressure systolic decreased |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Peripheral coldness | Peripheral coldness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Sensory loss | Sensory loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pancreatic carcinoma | Malignant neoplasm of pancreas |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Influenza like illness | Influenza-like symptoms |  |  | x |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  |  |  | 
| Influenza like illness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyperpyrexia | Hyperpyrexia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Red blood cell count decreased | Red blood cell count decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pruritus generalised | Pruritus generalised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blood pressure increased | Blood pressure increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rash generalised | Rash generalised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypoaesthesia oral | Hypoaesthesia oral |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Electrocardiogram abnormal | Electrocardiogram abnormal |  |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x |  | 
| Nail discomfort | Nail discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Pigmentation disorder | Pigmentation disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blood glucose increased | Blood glucose increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nephropathy toxic | Nephropathy toxic |  |  | x |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Menopausal symptoms | Hot flush |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hot flush | Hot flush |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Haematocrit decreased | Haematocrit decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hyperlactacidaemia | Hyperlactacidaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blood potassium decreased | Blood potassium decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Limb discomfort | Limb discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Laryngeal pain | Pharyngolaryngeal pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Device related infection | Catheter related infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Nail bed tenderness | Nail bed tenderness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Liver function test abnormal | Raised liver function tests |  |  | x |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  |  |  | 
| VIIth nerve paralysis | VIIth nerve paralysis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ischaemic stroke | Ischaemic stroke |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Infusion site reaction | Infusion site reaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Infusion site inflammation | Infusion site inflammation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Skin toxicity | Skin toxicity |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Infusion site rash | Infusion site rash |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Ileus | Ileus |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rhinorrhoea | Rhinorrhoea |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rash papular | Rash papular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Renal failure | Renal impairment |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Renal impairment | Renal impairment |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x |  |  |  | 
| Infusion site extravasation | Infusion site extravasation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Rhinitis allergic | Rhinitis allergic |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Somnolence | Somnolence |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Mood swings | Mood alteration NOS |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |