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Pazopanib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE11

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Alanine aminotransferase increased Alanine aminotransferase increased 2% - 53% 0% - 22% x x x
Tumour pain Tumour pain 0% - 29% 2% - 21% x x
Asthenia Fatigue 0% - 65% 1% - 48% x x x
Asthenia 0% - 14% 0% - 8% x x x
Fatigue Fatigue 0% - 65% 1% - 48% x x x
Lymphopenia Lymphopenia 0% - 43% 0% - 36% x x
Aspartate aminotransferase increased Aspartate aminotransferase increased 1% - 53% 0% - 22% x x x
Decreased appetite Decreased appetite 0% - 40% 0% - 19% x x x
Anorexia common, 0% - 22% 0% - 10% x x x
Hypertension Hypertension 0% - 42% 0% - 10% x x x
Dyspnoea Dyspnoea 1% - 20% 1% - 17% x x x
Diarrhoea Diarrhoea 0% - 59% 0% - 15% x x x
Weight decreased Weight decreased 0% - 48% 0% - 15% x x x
Hyponatraemia Sodium decreased 0% - 31% 0% - 24% x x
Blood phosphorus decreased Phosphorus low 0% - 34% 0% - 11% x x
Blood alkaline phosphatase increased Phosphatase alkaline increased 0% - 32% 0% - 23% x
Gastrointestinal pain Gastrointestinal pain 0% - 23% 0% - 9% x x x
Abdominal pain 0% - 11% 0% - 1% x x x
Neutropenia Neutropenia 0% - 34% 0% - 7% x x x
Vomiting Vomiting 0% - 33% 0% - 11% x x x
Abdominal pain Abdominal pain 0% - 11% 0% - 1% x x x
Chest pain Chest pain 0% - 10% 0% - 6% x x x
Musculoskeletal pain Musculoskeletal pain 0% - 23% 0% - 20% x x x
Skin disorder Skin disorder 0% - 11% 0% - 1% x x x
Unspecified disorder of skin and subcutaneous tissue x
Thrombocytopenia Thrombocytopenia 1% - 36% 0% - 6% x x x
Oedema peripheral Oedema peripheral 0% - 14% 0% - 9% x x x
Myalgia Myalgia 0% - 23% 0% - 9% x x x
Musculoskeletal discomfort Myalgia 0% - 23% 0% - 9% x x x
Arthralgia x x x
Mucosal inflammation Mucosal inflammation 0% - 12% 0% - 2% x x
Blood bilirubin increased Bilirubin total increased 0% - 36% 0% - 10% x x
Blood bilirubin increased x
Nausea Nausea 0% - 56% 0% - 22% x x x
Dizziness Dizziness 0% - 11% 0% - 4% x x x
Syncope x
Blood magnesium decreased Mg reduced 1% - 26% 0% - 14% x x
Blood potassium increased Potassium increased 0% - 16% 0% - 11% x x
Blood albumin decreased Albumin low 0% - 34% 0% - 21% x
Cough Cough 0% - 17% 0% - 12% x x x
Headache Headache 0% - 23% 0% - 8% x x x
Leukopenia Leukopenia 0% - 44% 0% - 15% x x x
Stomatitis Stomatitis 0% - 11% 0% - 3% x x x
Mouth ulceration x
Blood glucose increased Glucose increased 0% - 45% 0% - 35% x x
Exfoliative rash Exfoliative rash 0% - 18% 0% - 9% x x x
Blood glucose decreased Glucose decreased 0% - 17% 0% - 3% x x
Blood glucose decreased x
Hair colour changes Hair colour changes 0% - 39% 0% - 3% x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x
Pancreatitis Pancreatitis postmarketing x x x
Abdominal distension Abdominal distension x
Alopecia Alopecia 0% - 12% 0% - 1% x x x
Anaemia Anaemia x
Arthralgia Arthralgia x x x
Mental disorder Mental disorder x
Breast disorder Breast disorder x
Neoplasm malignant Neoplasm malignant x
Restrictive cardiomyopathy Restrictive cardiomyopathy x
Cerebral infarction Cerebral infarction x
Transient ischaemic attack Transient ischaemic attack x
Infection Infection x x x
Connective tissue disorder Connective tissue disorder x x x
Cyst Cyst x
Dehydration Dehydration x
Dysgeusia Dysgeusia 0% - 28% 0% - 3% x x x
Taste altered x
Dyspepsia Dyspepsia x x x
Oedema Oedema x
Localised oedema Localised oedema x
Endocrine disorder Endocrine disorder x x
Epistaxis Epistaxis x x x
Dermatitis Rash x x x
Rash Rash x x x
Eye disorder Eye disorder x
Fistula Fistula x x
Flatulence Flatulence x x
Flushing Flushing x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage x x
Cardiac disorder Cardiac disorder x x
Cardiac failure Cardiac failure x
Cardiac failure congestive Cardiac failure congestive x
Haematemesis Haematemesis x
Haematochezia Haematochezia x
Haematuria Haematuria x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome x x
Haemoptysis Haemoptysis x
Haemorrhage Haemorrhage x
Haemoglobin Haemorrhage x
Hiccups Hiccups x
Hyperbilirubinaemia Hyperbilirubinaemia x x
Hyperhidrosis Hyperhidrosis x
Hypertensive crisis Hypertensive crisis x
Hypoaesthesia Hypoaesthesia x
Hypothyroidism Hypothyroidism x x x
Intestinal perforation Intestinal perforation x
Jaundice Jaundice x
Lethargy Lethargy x
Mediastinal disorder Mediastinal disorder x x
Melaena Melaena x
Menorrhagia Menorrhagia x
Metabolic disorder Metabolic disorder x
Metrorrhagia Metrorrhagia x
Myocardial infarction Myocardial infarction x x
Acute coronary syndrome Myocardial infarction x x
Nail disorder Nail disorder x x x
Nervous system disorder Nervous system disorder x x
Mouth haemorrhage Mouth haemorrhage x
Pain Pain x
Paraesthesia Paraesthesia x
Peritonitis Peritonitis x
Infectious peritonitis x
Pneumothorax Pneumothorax x x
Polyp Polyp x
Proteinuria Proteinuria x x x
Protein urine present Proteinuria x x x
Prurigo Prurigo x
Pruritus Pruritus x
Pulmonary embolism Pulmonary embolism x
Thrombotic thrombocytopenic purpura Thrombotic thrombocytopenic purpura x x
Skin ulcer Skin ulcer x
Muscle spasms Muscle spasms x x
Cerebrovascular accident Cerebrovascular accident x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Thrombosis Thrombosis x
Torsade de pointes Torsade de pointes x x
Erythema Erythema x
Upper gastrointestinal haemorrhage Upper gastrointestinal haemorrhage x
Urethral disorder Urinary tract disorder x x
Urinary tract disorder Urinary tract disorder x x
Angiopathy Angiopathy x x
Dry mouth Dry mouth x
Encephalopathy Encephalopathy x
Chills Chills x x x
Hepatic failure Hepatic failure x
Sinus bradycardia Sinus bradycardia x
Hypophosphataemia Hypophosphataemia x
Hepatic function abnormal Hepatic function abnormal x x
Mouth ulceration Mouth ulceration x
Deep vein thrombosis Deep vein thrombosis x
Peripheral sensory neuropathy Peripheral sensory neuropathy x
Amylase increased Amylase increased x
Blood urea increased Blood urea increased x
Blood creatinine increased Creatinine increased x
Blood creatinine increased x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x x
Gastrointestinal perforation Gastrointestinal perforation x x x
Pulmonary haemorrhage Pulmonary haemorrhage x x
Retroperitoneal haemorrhage Retroperitoneal haemorrhage x
Hypomagnesaemia Hypomagnesaemia x
Large intestine perforation Large intestine perforation x
Myocardial ischaemia Myocardial ischaemia x x
Liver function test abnormal Liver function test abnormal x
Mucous membrane disorder Mucous membrane disorder x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged x
Dry skin Dry skin x x x
Hypogeusia Hypogeusia x
Eyelid oedema Eyelid oedema x
Malnutrition Malnutrition x
Photosensitivity reaction Photosensitivity reaction x
Leukoderma Leukoderma 0% - 11% 0% x x x
Rash macular Rash macular x
Rash vesicular Rash vesicular x
Abdominal pain upper Abdominal pain upper x
Abdominal pain lower Abdominal pain lower x
Rash erythematous Rash erythematous x
Gastric haemorrhage Gastric haemorrhage x
Hepatotoxicity Hepatotoxicity x x
Haemorrhage urinary tract Haemorrhage urinary tract x
Hepatic enzyme increased Hepatic enzyme increased x
Skin exfoliation Skin exfoliation x
Oesophageal haemorrhage Oesophageal haemorrhage x
Frequent bowel movements Frequent bowel movements x
Plantar erythema Plantar erythema x
Left ventricular dysfunction Left ventricular dysfunction x x
Skin discolouration Skin depigmentation x x x
Skin depigmentation Skin depigmentation x x x
Haemorrhoidal haemorrhage Haemorrhoidal haemorrhage x
Rectal haemorrhage Rectal haemorrhage x
Hepatobiliary disease Hepatobiliary disease x x
Blood pressure systolic increased Blood pressure systolic increased x
Gastrointestinal fistula Gastrointestinal fistula x
Enterocutaneous fistula Enterocutaneous fistula x
Vision blurred Vision blurred x x x
Platelet count decreased Platelet count decreased x
Anal haemorrhage Anal haemorrhage x
Bradycardia Bradycardia x x x
Pruritus generalised Pruritus generalised x
Thyroid function test abnormal Thyroid function test abnormal x
Blood pressure increased Blood pressure increased x
Rash generalised Rash generalised x
Face oedema Face oedema x x
Lipase increased Lipase increased x
Ileal perforation Ileal perforation x
Menopausal symptoms Hot flush x
Hot flush Hot flush x
Blood albumin increased Albumin high x
Eye oedema Eye oedema x
Gingival infection Gingival infection x
White blood cell count decreased White blood cell count decreased x
Infestation Infestation NOS x x
Blood thyroid stimulating hormone increased Blood thyroid stimulating hormone increased x
Blood cholesterol abnormal Blood cholesterol abnormal x
Neutrophil count decreased Neutrophil count decreased x
Embolism Thromboembolic event x x x
Drug-induced liver injury Drug-induced liver injury x
Blood calcium decreased Calcium low x
Insomnia Insomnia x x
Ischaemic stroke Ischaemic stroke x x
Eyelash discolouration Eyelash discolouration x
Hyperalbuminaemia Hyperalbuminaemia x
Nasopharyngitis Rhinorrhoea x
Rhinorrhoea Rhinorrhoea x
Bronchial haemorrhage Bronchial haemorrhage x
Rash papular Rash papular x
Dysphonia Dysphonia x x x
Oropharyngeal pain Oropharyngeal pain x
Ageusia Ageusia x
Thrombotic microangiopathy Thrombotic microangiopathy x x x
Somnolence Somnolence x
Cerebral haemorrhage Cerebral haemorrhage x x
Vaginal haemorrhage Vaginal haemorrhage x
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

PAZOPANIB

Side effects:74
Source:FDA Structured Product Label

pazopanib / pazopanib

Side effects:185
Source:EMA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label