Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.)
Information about indications was extracted from the indications and usage sections of the labels.
|
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
(show all 47)
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
|
Dizziness def
|
Dizziness def
|
1.6% - 28%
|
1.6% - 7.5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Somnolence def
|
Somnolence def
|
4.5% - 21.4%
|
2.7% - 8.7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ataxia def
|
Ataxia def
|
3.3% - 12.5%
|
0% - 5.6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia def
|
Fatigue def
|
1.6% - 11%
|
1.6% - 5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia def
|
frequent, 5.7%
|
4.8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fatigue def
|
Fatigue def
|
1.6% - 11%
|
1.6% - 5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lassitude def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infection def
|
Infection def
|
postmarketing — 0.8% - 10.9%
|
0.5% - 3.5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection def
|
Viral infection def
|
postmarketing — 3.1% - 10.9%
|
3.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased def
|
Body temperature increased def
|
postmarketing — 3.1% - 10.1%
|
3.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fever chills
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nausea def
|
Nausea def
|
postmarketing, 3.9% - 8.4%
|
3.1% - 7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting def
|
Vomiting def
|
postmarketing, 3.3% - 8.4%
|
1.8% - 7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema def
|
Oedema def
|
rare — 0.5% - 8.3%
|
0.3% - 2.2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nystagmus def
|
Nystagmus def
|
infrequent, 4% - 8.3%
|
4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema peripheral def
|
Oedema peripheral def
|
postmarketing, 0.5% - 8.3%
|
0.3% - 2.2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hostility def
|
Hostility def
|
frequent, 2.3% - 7.6%
|
2.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tremor def
|
Tremor def
|
3.2% - 6.8%
|
3.2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diplopia def
|
Diplopia def
|
1.2% - 5.9%
|
0% - 1.9%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea def
|
Diarrhoea def
|
postmarketing, 3.3% - 5.7%
|
2.7% - 3.1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Decreased appetite
|
Anorexia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anxiety def
|
Anxiety def
|
postmarketing — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia def
|
Arthralgia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal discomfort
|
Arthralgia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia def
|
infrequent, 1.9% - 2%
|
1.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state def
|
Confusional state def
|
postmarketing, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Feeling abnormal
|
Confusional state def
|
postmarketing, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence def
|
Flatulence def
|
frequent, 2.1%
|
1% - 1.8%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingivitis def
|
Gingivitis def
|
rare, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertension def
|
Hypertension def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia def
|
Paraesthesia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia def
|
Pneumonia def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Purpura def
|
Purpura def
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vascular purpura
|
Purpura def
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo def
|
Vertigo def
|
infrequent — 1.4%
|
0% - 0.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual impairment def
|
Visual impairment def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual acuity reduced
|
Visual impairment def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blindness def
|
Visual impairment def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blindness def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperreflexia
|
Hyperreflexia
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
Malaise def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Discomfort def
|
Malaise def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ill-defined disorder
|
Malaise def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Areflexia
|
Areflexia
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation def
|
Hyperkinesia def
|
frequent, 0.8% - 2.5%
|
0.8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia def
|
Hyperkinesia def
|
frequent, 0.8% - 2.5%
|
0.8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Face oedema def
|
Face oedema def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth def
|
Dry mouth def
|
2.8% - 4.8%
|
1.3% - 2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amblyopia def
|
Amblyopia def
|
1.1% - 4.2%
|
0.9% - 1.1%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Headache def
|
Headache def
|
postmarketing, 3.3% - 4.2%
|
3.1% - 11%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mood swings
|
Mood swings
|
postmarketing — 1.6% - 4.2%
|
1.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Affect lability
|
Mood swings
|
postmarketing — 1.6% - 4.2%
|
1.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vision blurred def
|
Vision blurred def
|
2.7% - 4.2%
|
0.9% - 1.1%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rhinitis def
|
Rhinitis def
|
infrequent, 3.7% - 4.1%
|
3.7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation def
|
Constipation def
|
0.8% - 3.9%
|
0.3% - 1.8%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchitis def
|
Bronchitis def
|
infrequent, 0.8% - 3.4%
|
0.8%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight increased def
|
Weight increased def
|
0.8% - 3.4%
|
0% - 2%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pharyngitis def
|
Pharyngitis def
|
1.2% - 2.8%
|
0.4% - 1.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain def
|
Abdominal pain def
|
postmarketing, 2.7%
|
2.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal pain def
|
Abdominal pain def
|
postmarketing, 2.7%
|
2.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thinking abnormal
|
Thinking abnormal
|
1.3% - 2.7%
|
0% - 1.3%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental disability
|
Thinking abnormal
|
1.3% - 2.7%
|
0% - 1.3%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasopharyngitis def
|
Nasopharyngitis def
|
2.5%
|
2.2%
|
|
|
|
|
|
|
|
|
|
|
|
Respiratory tract infection def
|
Respiratory tract infection def
|
0.8% - 2.5%
|
0.8%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysarthria def
|
Dysarthria def
|
infrequent, 0.5% - 2.4%
|
0.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoarthritis def
|
Dysarthria def
|
infrequent, 0.5% - 2.4%
|
0.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervousness def
|
Nervousness def
|
infrequent, 1.9% - 2.4%
|
1.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tension def
|
Nervousness def
|
infrequent, 1.9% - 2.4%
|
1.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia def
|
Amnesia def
|
0% - 2.2%
|
0% - 0.9%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia def
|
Dyspepsia def
|
0.5% - 2.2%
|
0.5% - 0.8%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia def
|
Myalgia def
|
infrequent, 1.9% - 2%
|
1.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain in extremity def
|
Pain in extremity def
|
1.9%
|
0.5%
|
|
|
|
|
|
|
|
|
|
|
|
Back pain def
|
Back pain def
|
0.5% - 1.8%
|
0.5% - 1.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough def
|
Cough def
|
infrequent, 1.3% - 1.8%
|
1.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough increased
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary tract infection def
|
Urinary tract infection def
|
infrequent, 1.7%
|
0.5%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry throat
|
Dry throat
|
0.5% - 1.7%
|
0.5%
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Erectile dysfunction def
|
Erectile dysfunction def
|
infrequent, 1.1% - 1.5%
|
1.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
Coordination abnormal
|
0.3% - 1.5%
|
0% - 0.3%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gait disturbance def
|
Gait disturbance def
|
1.5%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus def
|
Pruritus def
|
rare — 0.5% - 1.3%
|
0.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle twitching def
|
Muscle twitching def
|
infrequent, 0.5% - 1.3%
|
0.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis def
|
Conjunctivitis def
|
infrequent, 1.2%
|
0%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
Rash def
|
postmarketing — 1.2%
|
0.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash def
|
Rash def
|
postmarketing — 1.2%
|
0.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia def
|
Hyperglycaemia def
|
1.2%
|
0.4%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia def
|
Hypoaesthesia def
|
infrequent, 1.2%
|
0.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear infection def
|
Otitis def
|
rare — 1.2%
|
0%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear infection def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis media def
|
Otitis media def
|
1.2%
|
0%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lethargy def
|
Lethargy def
|
1.1%
|
0.3%
|
|
|
|
|
|
|
|
|
|
|
|
Leukopenia def
|
Leukopenia def
|
0.5% - 1.1%
|
0.5%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vasodilation procedure
|
Vasodilation def
|
infrequent, 0.3% - 1.1%
|
0.3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Increased appetite
|
Increased appetite
|
infrequent, 0.8% - 1.1%
|
0.8% - 1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
White blood cell count decreased
|
White blood cell count decreased
|
0.5% - 1.1%
|
0.5%
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abscess def
|
Abscess def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ageusia def
|
Ageusia def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alopecia def
|
Alopecia def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amenorrhoea def
|
Amenorrhoea def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia def
|
Anaemia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angina pectoris def
|
Angina pectoris def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aphasia def
|
Aphasia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apnoea def
|
Apnoea def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthritis def
|
Arthritis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthma def
|
Asthma def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast cancer def
|
Breast cancer def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm malignant def
|
Neoplasm malignant def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Carcinoma def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Candidiasis def
|
Candidiasis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
Oral candidiasis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vulvovaginal candidiasis def
|
Vaginal moniliasis
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vulvovaginal mycotic infection
|
Vaginal moniliasis
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiovascular disorder def
|
Cardiovascular disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cellulitis def
|
Cellulitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebellar syndrome def
|
Cerebellar syndrome def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervous system disorder def
|
Cerebellar syndrome def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervous system disorder def
|
postmarketing, rare
|
|
|
|
|
|
|
|
|
|
|
|
|
Neck pain def
|
Neck pain def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chest pain def
|
Chest pain def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cystitis def
|
Cystitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bladder pain def
|
Cystitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cystitis noninfective def
|
Cystitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cyst def
|
Cyst def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deafness def
|
Deafness def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hearing impaired def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido decreased def
|
Libido decreased def
|
infrequent
|
1%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disturbance in sexual arousal
|
Libido decreased def
|
infrequent
|
1%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depersonalisation def
|
Depersonalisation def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fungal skin infection def
|
Fungal skin infection def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus def
|
Diabetes mellitus def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia def
|
Dysgeusia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysmenorrhoea def
|
Dysmenorrhoea def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspnoea def
|
Dyspnoea def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysuria def
|
Dysuria def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear pain def
|
Ear pain def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ecchymosis def
|
Ecchymosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eczema def
|
Eczema def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epistaxis def
|
Epistaxis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder def
|
Eye disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye haemorrhage def
|
Eye haemorrhage def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
VIIth nerve paralysis
|
Facial paralysis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Faecal incontinence def
|
Faecal incontinence def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Furuncle def
|
Furunculosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastritis def
|
Gastritis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastroenteritis def
|
Gastroenteritis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal disorder def
|
Gastrointestinal disorder def
|
postmarketing, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingival bleeding def
|
Gingival bleeding def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glossitis def
|
Glossitis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gout def
|
Gout def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hallucination def
|
Hallucination def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure def
|
Cardiac failure def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure congestive def
|
Cardiac failure congestive def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematochezia def
|
Haematochezia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematoma def
|
Haematoma def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Subdural haematoma def
|
Subdural haematoma def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria def
|
Haematuria def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hemiplegia def
|
Hemiplegia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage def
|
Haemorrhage def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoglobin def
|
Haemorrhage def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhoids def
|
Haemorrhoids def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatomegaly def
|
Hepatomegaly def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes virus infection def
|
Herpes NOS def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes simplex def
|
Herpes simplex def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes zoster def
|
Herpes zoster def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hirsutism def
|
Hirsutism def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hordeolum def
|
Hordeolum def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia def
|
Hyperaesthesia def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoglycaemia def
|
Hypoglycaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotension def
|
Hypotension def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Incontinence def
|
Incontinence def
|
postmarketing — infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infarction def
|
Infarction def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy def
|
Arthropathy def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms def
|
Cramps of lower extremities
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cramp muscle def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lung disorder def
|
Lung disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast pain def
|
Breast pain def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menorrhagia def
|
Menorrhagia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menstrual disorder def
|
Menstrual disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotonia def
|
Hypotonia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle relaxant therapy
|
Hypotonia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myocardial infarction def
|
Myocardial infarction def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute coronary syndrome def
|
Myocardial infarction def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm def
|
Neoplasm def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Palpitations def
|
Palpitations def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paresis def
|
Paresis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth abscess
|
Abscess periodontal def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Polyuria def
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine output increased
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eyelid ptosis def
|
Ptosis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Uterovaginal prolapse
|
Ptosis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psoriasis def
|
Psoriasis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psychotic disorder def
|
Psychotic disorder def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paranoia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extensor plantar response def
|
Extensor plantar response def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
Salivation def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Scotoma def
|
Scotoma def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Seborrhoeic dermatitis def
|
Seborrhoeic dermatitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis def
|
Sinusitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin disorder def
|
Skin disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin ulcer def
|
Skin ulcer def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leg ulcer def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Speech disorder def
|
Speech disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stomatitis def
|
Stomatitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebrovascular accident def
|
Cerebrovascular accident def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Completed suicide
|
Suicide def
|
rare, infrequent
|
|
|
x
|
|
x
|
|
|
x
|
|
x
|
x
|
|
Suicide attempt def
|
Suicide attempt def
|
infrequent
|
|
|
|
|
x
|
|
|
x
|
|
|
x
|
|
Hyperhidrosis def
|
Sweating def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sweating increased
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Swelling def
|
Swelling def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Shock def
|
Syncope def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope def
|
Syncope def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness def
|
Syncope def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tachycardia def
|
Tachycardia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tendonitis def
|
Tendonitis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thirst def
|
Thirst def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombocytopenia def
|
Thrombocytopenia def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tinnitus def
|
Tinnitus def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue disorder
|
Tongue disorder
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth disorder def
|
Tooth disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ulcer def
|
Ulcer def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria def
|
Pollakiuria def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Micturition urgency def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary incontinence def
|
Urinary incontinence def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria def
|
Urticaria def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angiopathy def
|
Angiopathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight decreased def
|
Weight decreased def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary retention def
|
Urinary retention def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral vascular disorder def
|
Peripheral vascular disorder def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Central nervous system neoplasm def
|
Central nervous system neoplasm def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills def
|
Chills def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stupor def
|
Stupor def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depressed level of consciousness def
|
Stupor def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apathy def
|
Apathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flat affect
|
Apathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photophobia def
|
Photophobia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokinesia def
|
Hypokinesia def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cataract def
|
Cataract def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Migraine def
|
Migraine def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Generalised oedema
|
Generalised oedema
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fluid retention
|
Generalised oedema
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage intracranial def
|
Haemorrhage intracranial def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver function test abnormal
|
Liver function test abnormal
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Raised liver function tests
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mucous membrane disorder
|
Mucous membrane disorder
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye pain def
|
Eye pain def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia oral
|
Circumoral paresthesia
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash pustular def
|
Vesiculobullous rash
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis bullous def
|
Vesiculobullous rash
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blister def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyporeflexia
|
Hyporeflexia
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry skin def
|
Dry skin def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Joint swelling
|
Joint swelling
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abnormal faeces
|
Abnormal faeces
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Joint stiffness def
|
Joint stiffness def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abnormal dreams
|
Abnormal dreams
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Euphoric mood def
|
Euphoric mood def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry eye
|
Dry eye
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysaesthesia def
|
Dysaesthesia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dystonia def
|
Dystonia def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal stiffness
|
Stiffness
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuropathy peripheral def
|
Neuropathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Inner ear disorder def
|
Inner ear disorder def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphadenopathy def
|
Lymphadenopathy def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paralysis def
|
Paralysis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nerve paralysis
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Insomnia def
|
Insomnia def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscular weakness def
|
Myasthenia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Labyrinthitis def
|
Inner ear infection
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Labyrinthitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hearing impaired def
|
Hearing impaired def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paranoia def
|
Paranoia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ejaculation disorder def
|
Abnormal ejaculation
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal haemorrhage def
|
Vaginal haemorrhage def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of libido
|
Loss of libido
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaphylactic shock def
|
Anaphylactic shock def
|
postmarketing
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Angioedema def
|
Angioedema def
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anuria def
|
Anuria def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apraxia def
|
Apraxia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation def
|
Atrial fibrillation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental disorder def
|
Mental disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Blister def
|
Blister def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchospasm def
|
Bronchospasm def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bursitis def
|
Bursitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Capillary fragility
|
Capillary fragility
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholecystitis def
|
Cholecystitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholelithiasis def
|
Cholelithiasis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chorioretinitis def
|
Chorioretinitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Colitis def
|
Colitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle contracture def
|
Muscle contracture def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Corneal disorder def
|
Corneal disorder def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphagia def
|
Dysphagia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetic ketoacidosis def
|
Diabetic ketoacidosis def
|
rare
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Diabetic retinopathy def
|
Diabetic retinopathy def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Duodenal ulcer def
|
Duodenal ulcer def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyskinesia def
|
Dyskinesia def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Movement disorder def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orofacial dyskinesia
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Effusion def
|
Effusion def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epididymitis def
|
Epididymitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eructation def
|
Eructation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema multiforme def
|
Erythema multiforme def
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophageal disorder def
|
Oesophageal disorder def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophageal spasm def
|
Oesophageal spasm def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophagitis def
|
Oesophagitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glaucoma def
|
Glaucoma def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glycosuria def
|
Glycosuria def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Goitre def
|
Goitre def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gynaecomastia def
|
Gynaecomastia def
|
rare, postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hair disorder def
|
Hair disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrioventricular block def
|
Block heart def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder def
|
Cardiac disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Haematemesis def
|
Haematemesis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoptysis def
|
Haemoptysis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis def
|
Hepatitis def
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hernia def
|
Hernia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diaphragmatic hernia def
|
Diaphragmatic hernia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hiccups def
|
Hiccups def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercholesterolaemia def
|
Hypercholesterolaemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaemia def
|
Hyperaemia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperlipidaemia def
|
Hyperlipidaemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertrophy def
|
Hypertrophy def
|
rare, postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast enlargement
|
Hypertrophy of breast
|
postmarketing
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Breast enlargement
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
Salivary gland enlargement
|
Salivary gland enlargement
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperventilation def
|
Hyperventilation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyponatraemia def
|
Hyponatraemia def
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypothyroidism def
|
Hypothyroidism def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conversion disorder def
|
Hysteria def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Immune system disorder def
|
Immune system disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Libido increased def
|
Libido increased def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal obstruction def
|
Intestinal obstruction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Iritis def
|
Iritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal functional disorder
|
Irritable bowel syndrome def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Irritable bowel syndrome def
|
Irritable bowel syndrome def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Irritability def
|
Irritability def
|
rare
|
1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye pruritus
|
Eye pruritus
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Jaundice def
|
Jaundice def
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nephrolithiasis def
|
Calculus of kidney def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal failure acute def
|
Renal failure acute def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Laryngitis def
|
Laryngitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Genital discharge
|
Leukorrhea def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphocytosis def
|
Lymphocytosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphoma def
|
Lymphoma def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mediastinal disorder def
|
Mediastinal disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Melanosis def
|
Melanosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Melaena def
|
Melaena def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Meningism def
|
Meningism def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Miosis def
|
Miosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Movement disorder def
|
Movement disorder def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertonia def
|
Hypertonia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myoclonus def
|
Myoclonus def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nail disorder def
|
Nail disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasal obstruction def
|
Nasal obstruction def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Necrosis def
|
Necrosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nephrotic syndrome def
|
Nephrosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neurosis def
|
Neurosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nodule def
|
Nodule def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nocturia def
|
Nocturia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Obstruction def
|
Obstruction def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoporosis def
|
Osteoporosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis externa def
|
Otitis externa def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis def
|
Pancreatitis def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pelvic pain def
|
Pelvic pain def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Penis disorder def
|
Penis disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peptic ulcer def
|
Peptic ulcer def
|
rare
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Pericardial effusion def
|
Pericardial effusion def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pericarditis def
|
Pericarditis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Personality disorder def
|
Personality disorder def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Phlebitis def
|
Phlebitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia aspiration def
|
Pneumonia aspiration def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Supraventricular extrasystoles def
|
Supraventricular extrasystoles def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Proctitis def
|
Proctitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus genital
|
Pruritus genital
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary oedema def
|
Pulmonary oedema def
|
rare, postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary embolism def
|
Pulmonary embolism def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyelonephritis def
|
Pyelonephritis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyuria def
|
Pyuria def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorectal disorder def
|
Rectal disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal failure def
|
Renal failure def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinal degeneration def
|
Retinal degeneration def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinal disorder def
|
Retinal disorder def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Snoring def
|
Snoring def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Strabismus def
|
Strabismus def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Testicular pain def
|
Testicular pain def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombophlebitis def
|
Thrombophlebitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombosis def
|
Thrombosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Costochondritis def
|
Costochondritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth discolouration def
|
Tooth discolouration def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema def
|
Erythema def
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urethral disorder def
|
Urinary tract disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Urinary tract disorder def
|
Urinary tract disorder def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Varicose vein def
|
Varicose vein def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Venous thrombosis def
|
Venous thrombosis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vestibular disorder def
|
Vestibular disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Choreoathetosis
|
Choreoathetosis
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Encephalopathy def
|
Encephalopathy def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin odour abnormal
|
Body odor def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic failure def
|
Hepatic failure def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Micturition urgency def
|
Micturition urgency def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic function abnormal
|
Hepatic function abnormal
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Neck mass
|
Neck mass
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
Mouth ulceration def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis cholestatic
|
Hepatitis cholestatic
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Alcohol intolerance def
|
Alcohol intolerance def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bleeding time prolonged
|
Bleeding time prolonged
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Capillary fragility increased
|
Capillary fragility increased
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular extrasystoles def
|
Ventricular extrasystoles def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gamma-glutamyltransferase increased def
|
Gamma-glutamyltransferase increased def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin hypertrophy
|
Skin hypertrophy
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood lactate dehydrogenase increased
|
Lactic dehydrogenase activity increased
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin necrosis
|
Skin necrosis
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin exfoliation
|
Skin necrosis
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin exfoliation
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Subcutaneous nodule
|
Subcutaneous nodule
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone pain def
|
Bone pain def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood alkaline phosphatase increased def
|
Phosphatase alkaline increased
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin discolouration def
|
Skin discolouration def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tendon disorder
|
Tendon disorder
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary thrombosis
|
Pulmonary thrombosis
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deep vein thrombosis def
|
Deep thrombophlebitis
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal ulcer
|
Intestinal ulcer
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lacrimation increased def
|
Lacrimation increased def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity reaction def
|
Photosensitivity reaction def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
Ketoacidosis
|
Ketoacidosis
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hangover
|
Hangover
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cheilitis def
|
Angular cheilitis
|
rare
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Dandruff
|
Dandruff
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pseudolymphoma def
|
Pseudolymphoma def
|
rare
|
|
|
|
|
|
|
|
|
|
|
|
|
Cardiac fibrillation
|
Cardiac fibrillation
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pericardial rub
|
Pericardial rub
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Antisocial personality disorder def
|
Antisocial behaviour def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Antisocial behaviour def
|
Antisocial behaviour def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asocial behaviour
|
Antisocial behaviour def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine abnormality
|
Urine abnormality
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine analysis abnormal
|
Urine abnormality
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vulvovaginal pain
|
Vaginal pain def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sepsis def
|
Sepsis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Interstitial lung disease def
|
Lymphoid interstitial pneumonia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rectal haemorrhage def
|
Rectal haemorrhage def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatobiliary disease def
|
Hepatobiliary disease def
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Scrotal disorder
|
Scrotal disorder
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eustachian tube disorder
|
Eustachian tube disorder
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Scrotal swelling
|
Scrotal swelling
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis fulminant
|
Hepatitis fulminant
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Papule def
|
Papule def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cushingoid
|
Cushingoid
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mucosal inflammation def
|
Mucosal inflammation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mania def
|
Mania def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extrasystoles def
|
Extrasystoles def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoxia def
|
Hypoventilation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoventilation def
|
Hypoventilation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory failure def
|
Hypoventilation def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash maculo-papular def
|
Rash maculo-papular def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradycardia def
|
Bradycardia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood urea abnormal
|
Blood urea abnormal
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Prothrombin level decreased
|
Prothrombin level decreased
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal pain
|
Renal pain
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mass def
|
Mass def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intentional self-injury
|
Parasuicide def
|
rare
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
Suicidal behaviour
|
Parasuicide def
|
rare
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
Skin cancer def
|
Skin carcinoma def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspiration
|
Aspiration
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acne def
|
Acne def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aortic dissection def
|
Dissecting aortic aneurysm, thoracic
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Ovarian failure
|
Ovarian failure
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lip haemorrhage
|
Lip haemorrhage
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infestation
|
Infestation NOS
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
Penile swelling
|
Penile swelling
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphonia def
|
Voice disturbance
|
rare
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Hoarseness def
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinal vein thrombosis
|
Retinal vein thrombosis
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Embolism def
|
Embolus def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctival hyperaemia
|
Conjunctival hyperaemia
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coagulopathy def
|
Coagulopathy def
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Occipital neuralgia
|
Occipital neuralgia
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Connective tissue disorder def
|
Connective tissue disorder def
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Convulsion def
|
Convulsion def
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|