Tizanidine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 17)
1 2 3 4 5 6 7 8 9 10
Somnolence def Somnolence def 48% - 92% 10% - 31% x x x x x x x x x x
Drowsiness def x x x x x x x x x x
Dry mouth def Dry mouth def 49% - 88% 10% - 35% x x x x x x x x x x
Asthenia def Asthenia def 41% - 78% 16% - 40% x x x x x x x x x x
Fatigue def 41% - 78% 16% - 40% x x x x x x x x x x
Weakness def 41% - 78% 16% - 40% x x x x x x x x x x
Fatigue def Fatigue def 41% - 78% 16% - 40% x x x x x x x x x x
Dizziness def Dizziness def 16% - 45% 4% x x x x x x x x x x
Syncope def infrequent x x x x x x x x x x
Hypotension def Hypotension def infrequent, 16% - 33% 0% x x x x x x x x x x
Bradycardia def Bradycardia def 2% - 10% 0% x x x x x x x x x x
Infection def Infection def 6% 5% x x x x x x x x x
Abdominal pain def Abdominal pain def frequent x x x x x x x x x x
Gastrointestinal pain def Abdominal pain def frequent x x x x x x x x x x
Anxiety def Anxiety def frequent x x x x x x x x x x
Back pain def Back pain def frequent x x x x x x x x x x
Diarrhoea def Diarrhoea def frequent x x x x x x x x x x
Dyspepsia def Dyspepsia def frequent x x x x x x x x x x
Dermatitis def Rash def frequent x x x x x x x x x x
Dermatitis def rare x x x x x x x x x x
Rash def Rash def frequent x x x x x x x x x x
Body temperature increased def Body temperature increased def frequent x x x x x x x x x x
Pain def Pain def infrequent, frequent x x x x x x x x x x
Paraesthesia def Paraesthesia def frequent x x x x x x x x x x
Skin ulcer def Skin ulcer def frequent x x x x x x x x x x
Hyperhidrosis def Sweating def frequent x x x x x x x x x x
Ulcer def Ulcer def frequent x x x x x x x x x x
Muscular weakness def Myasthenia def frequent x x x x x x x x x x
Constipation def Constipation def 4% 1% x x x x x x x x x
Amblyopia def Amblyopia def 3% 1% x x x x x x x x x
Dyskinesia def Dyskinesia def 3% 0% x x x x x x x x x
Influenza def Influenza def 3% 2% x x x x x x x x x
Flu symptoms 3% 2% x x x x x
Nervousness def Nervousness def 3% 1% x x x x x x x x x
Tension def Nervousness def 3% 1% x x x x x x x x x
Pharyngitis def Pharyngitis def 3% 1% x x x x x x x x x
Rhinitis def Rhinitis def 3% 2% x x x x x x x x x
Speech disorder def Speech disorder def 3% 0% x x x x x x x x x
Pollakiuria def Pollakiuria def 3% 2% x x x x x x x x x
Micturition urgency def infrequent x x x x x x x
Vomiting def Vomiting def 3% 0% x x x x x x x x x
Liver function test abnormal Liver function test abnormal 3% 1% x x x x x x x x
Alanine aminotransferase increased def Alanine aminotransferase increased def 3% 1% x x x x x x x x x
Vision blurred def Vision blurred def 3% 1% x x x x x x x x x
Abscess def Abscess def infrequent x x x x x x x x x x
Alopecia def Alopecia def infrequent x x x x x x x x x x
Anaemia def Anaemia def infrequent x x x x x x x x x x
Arrhythmia def Arrhythmia def infrequent x x x x x x x x x x
Arthralgia def Arthralgia def infrequent x x x x x x x x x x
Musculoskeletal discomfort Arthralgia def infrequent x x x x x x x x x x
Arthritis def Arthritis def infrequent x x x x x x x x x x
Bronchitis def Bronchitis def infrequent x x x x x x x x x x
Bursitis def Bursitis def infrequent x x x x x x x x x x
Candidiasis def Candidiasis def infrequent x x x x x x x x x x
Vulvovaginal candidiasis def Vaginal moniliasis infrequent x x x x x x x
Vulvovaginal mycotic infection Vaginal moniliasis infrequent x x x x x x x
Cellulitis def Cellulitis def infrequent x x x x x x x
Neck pain def Neck pain def infrequent x x x x x x x x x x
Cholelithiasis def Cholelithiasis def infrequent x x x x x x x x x x
Conjunctivitis def Conjunctivitis def infrequent x x x x x x x
Convulsion def Convulsion def infrequent x x x x x x x x x x
Cystitis def Cystitis def infrequent x x x x x x x
Bladder pain def Cystitis def infrequent x x x x x x x
Cystitis noninfective def Cystitis def infrequent x x x x x x x
Deafness def Deafness def infrequent x x x x x x x
Dysphagia def Dysphagia def infrequent x x x x x x x x x x
Depersonalisation def Depersonalisation def infrequent x x x x x x x x x x
Autonomic nervous system imbalance Dysautonomia def infrequent x x x x x x x x x x
Ear pain def Ear pain def infrequent x x x x x x x
Ecchymosis def Ecchymosis def infrequent x x x x x x x x x x
Oedema def Oedema def infrequent x x x x x x x x x x
Faecalith def Faecalith def infrequent x x x x x x x x x x
Faecaloma Faecalith def infrequent x x x x x x x x x x
Flatulence def Flatulence def infrequent x x x x x x x x x x
Pathological fracture def Pathological fracture def infrequent x x x x x x x x x x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def infrequent x x x x x x x
Glaucoma def Glaucoma def infrequent x x x x x x x
Haemorrhage def Haemorrhage def infrequent x x x x x x x x x x
Haemoglobin def Haemorrhage def infrequent x x x x x x x x x x
Hepatitis def Hepatitis def infrequent x x x x x x x x x x
Hypercholesterolaemia def Hypercholesterolaemia def infrequent x x x x x x x x x x
Hyperlipidaemia def Hyperlipidaemia def infrequent x x x x x x x x x x
Hypersensitivity def Hypersensitivity def infrequent x x x x x x x x x x
Orthostatic hypotension def Orthostatic hypotension def infrequent x x x x x x x x x x
Hypothyroidism def Hypothyroidism def infrequent x x x x x x x x x x
Nephrolithiasis def Calculus of kidney def infrequent x x x x x x x
Leiomyoma def Leiomyoma def infrequent x x x x x x x
Uterine leiomyoma def Leiomyoma def infrequent x x x x x x x
Uterine leiomyoma def infrequent x x x x x x x
Uterine fibroids enlarged infrequent x x x x x x x
Leukocytosis def Leukocytosis def infrequent x x x x x x x x x x
Leukopenia def Leukopenia def infrequent x x x x x x x x x x
Melaena def Melaena def infrequent x x x x x x x x x x
Menorrhagia def Menorrhagia def infrequent x x x x x x x
Neuralgia def Neuralgia def infrequent x x x x x x x x x x
Neuritis def Neuritis def infrequent x x x x x x x
Neuropathy peripheral def Neuritis def infrequent x x x x x x x
Neuropathy def rare x x x x x x x x x x
Optic neuritis def Optic neuritis def infrequent x x x x x x x
Ear infection def Otitis def infrequent x x x x x x x
Otitis media def Otitis media def infrequent x x x x x x x
Pneumonia def Pneumonia def infrequent x x x x x x x x x x
Pruritus def Pruritus def infrequent x x x x x x x x x x
Pyelonephritis def Pyelonephritis def infrequent x x x x x x x
Retinal haemorrhage def Retinal haemorrhage def infrequent x x x x x x x
Scotoma def Scotoma def infrequent x x x x x x x
Sinusitis def Sinusitis def infrequent x x x x x x x x x x
Shock def Syncope def infrequent x x x x x x x x x x
Shock def x
Syncope def Syncope def infrequent x x x x x x x x x x
Loss of consciousness def Syncope def infrequent x x x x x x x x x x
Loss of consciousness def x
Tinnitus def Tinnitus def infrequent x x x x x x x
Tooth impacted def Tooth impacted def infrequent x x x x x x x x x x
Tremor def Tremor def infrequent x x x x x x x x x x
Urticaria def Urticaria def infrequent x x x x x x x x x x
Vaginal inflammation def Vaginal inflammation def infrequent x x x x x x x
Vaginal infection def Vaginal inflammation def infrequent x x x x x x x
Vasodilation procedure Vasodilation def infrequent x x x x x x x x x x
Vertigo def Vertigo def infrequent x x x x x x x x x x
Weight decreased def Weight decreased def infrequent x x x x x x x x x x
Urinary retention def Urinary retention def infrequent x x x x x x x
Micturition urgency def Micturition urgency def infrequent x x x x x x x
Stupor def Stupor def infrequent x x x x x x x x x x
Depressed level of consciousness def Stupor def infrequent x x x x x x x x x x
Agitation def Agitation def infrequent x x x x x x x x x x
Mood swings Mood swings infrequent x x x x x x x x x x
Affect lability Mood swings infrequent x x x x x x x x x x
Migraine def Migraine def infrequent x x x x x x x x x x
Eye pain def Eye pain def infrequent x x x x x x x
Dry skin def Dry skin def infrequent x x x x x x x x x x
Malaise def Malaise def infrequent x x x x x x x x x x
Discomfort def Malaise def infrequent x x x x x x x x x x
Feeling abnormal Malaise def infrequent x x x x x x x x x x
Confusional state def x
Ill-defined disorder Malaise def infrequent x x x x x x x x x x
Thinking abnormal Thinking abnormal infrequent x x x x x x x x x x
Mental disability Thinking abnormal infrequent x x x x x x x x x x
Abnormal dreams Abnormal dreams infrequent x x x x x x x x x x
Euphoric mood def Euphoric mood def infrequent x x x x x x x x x x
Sepsis def Sepsis def infrequent x x x x x x x x x x
Paralysis def Paralysis def infrequent x x x x x x x x x x
Acne def Acne def infrequent x x x x x x x x x x
Death Death infrequent x x x x x x x x x x
Congenital anomaly def Congenital anomaly def rare x x x x x x x x x x
Developmental delay Congenital anomaly def rare x x x x x x x x x x
Acidosis def Acidosis def rare x x x x x x x x x x
Respiratory acidosis def Respiratory acidosis def rare x x x x x x x x x x
Albuminuria def Albuminuria def rare x x x x x x x
Angina pectoris def Angina pectoris def rare x x x x x x x x x x
Asthma def Asthma def rare x x x x x x x x x x
Neoplasm malignant def Carcinoma def rare x x x x x x x x x x
Dermatitis exfoliative def Dermatitis exfoliative def rare x x x x x x x x x x
Gastroenteritis def Gastroenteritis def rare x x x x x x x x x x
Glycosuria def Glycosuria def rare x x x x x x x
Cardiac failure def Cardiac failure def rare x x x x x x x x x
Haematemesis def Haematemesis def rare x x x x x x x x x x
Haematuria def Haematuria def rare x x x x x x x
Hemiplegia def Hemiplegia def rare x x x x x x x x x x
Herpes virus infection def Herpes NOS def rare x x x x x x x x x x
Herpes simplex def Herpes simplex def rare x x x x x x x x x x
Herpes zoster def Herpes zoster def rare x x x x x x x x x x
Hyperglycaemia def Hyperglycaemia def rare x x x x x x x x x x
Hypokalaemia def Hypokalaemia def rare x x x x x x x x x x
Hyponatraemia def Hyponatraemia def rare x x x x x x x x x x
Hypoproteinaemia def Hypoproteinaemia def rare x x x x x x x x x x
Infarction def Infarction def rare x x x x x x x x x x
Intestinal obstruction def Intestinal obstruction def rare x x x x x x x x x x
Iritis def Iritis def rare x x x x x x x
Keratitis def Keratitis def rare x x x x x x x
Metrorrhagia def Metrorrhagia def rare x x x x x x x
Myocardial infarction def Myocardial infarction def rare x x x x x x x x x
Acute coronary syndrome def Myocardial infarction def rare x x x x x x x x x
Nausea def Nausea def postmarketing x
Obstruction def Obstruction def rare x x x x x x x x x x
Optic atrophy def Optic atrophy def rare x x x x x x x
Petechiae def Petechiae def rare x x x x x x x x x x
Phlebitis def Phlebitis def rare x x x x x x x x x x
Pulmonary embolism def Pulmonary embolism def rare x x x x x x x x x x
Purpura def Purpura def rare x x x x x x x x x x
Vascular purpura Purpura def rare x x x x x x x x x x
Completed suicide Suicide def rare x x x x x x x x x x
Suicide attempt def Suicide attempt def rare x x x x x x x x x
Tachycardia def Tachycardia def rare x x x x x x x x x x
Thrombocytopenia def Thrombocytopenia def rare x x x x x x x x x x
Ventricular tachycardia def Ventricular tachycardia def rare x x x x x x x x x x
Ventricular extrasystoles def Ventricular extrasystoles def rare x x x x x x x x x x
Hepatocellular injury Hepatocellular injury rare x x x x x x x x x
Liver disorder def x
Liver injury Hepatocellular injury rare x x x x x x x x x
Cytolytic hepatitis Hepatocellular injury rare x x x x x x x x x
Atrophy def Atrophy def rare x x x x x x x
Extrasystoles def Extrasystoles def rare x x x x x x x x x x
Adrenal insufficiency def Adrenal cortical hypofunction rare x x x x x x x x
Dementia def Dementia def rare x x x x x x x x x x
Skin cancer def Skin carcinoma def rare x x x x x x x x x x
Thrombocytosis def Thrombocytosis def rare x x x x x x x x x x
Arterial disorder def Arterial disorder def rare x x x x x x x x x x
Embolism def Embolus def rare x x x x x x x x x x
Coronary artery disease def Coronary artery disease def rare x x x x x x x x x x
Hepatic neoplasm malignant Liver carcinoma def rare x x x x x x x x x x
Agranulocytosis def Agranulocytosis def x
Anaphylactic shock def Anaphylactic shock def x
Mental disorder def Mental disorder def x
Cerebral infarction def Cerebral infarction def x
Confusional state def Confusional state def x
Connective tissue disorder def Connective tissue disorder def x
Disseminated intravascular coagulation def Disseminated intravascular coagulation def x
Dyspnoea def Dyspnoea def x
Erythema multiforme def Erythema multiforme def x
Fibrosis def Fibrosis def x
Cardiac arrest def Cardiac arrest def x
Cardiac disorder def Cardiac disorder def x
Immune system disorder def Immune system disorder def x
Jaundice def Jaundice def x
Renal failure acute def Renal failure acute def x
Hepatic cirrhosis def Hepatic cirrhosis def x
Liver disorder def Liver disorder def x
Foetor hepaticus Liver disorder def x
Mediastinal disorder def Mediastinal disorder def x
Necrosis def Necrosis def x
Nervous system disorder def Nervous system disorder def x
Pulmonary oedema def Pulmonary oedema def x
Renal failure def Renal failure def x
Rhabdomyolysis def Rhabdomyolysis def x
Muscle spasms def Muscle spasms def x x x x x x x x x x
Cerebrovascular accident def Cerebrovascular accident def x
Torsade de pointes def Torsade de pointes def x
Erythema def Erythema def x
Urethral disorder def Urinary tract disorder def x
Urinary tract disorder def Urinary tract disorder def x
Angiopathy def Angiopathy def x
Ventricular fibrillation def Ventricular fibrillation def x
Hepatic failure def Hepatic failure def x
Hepatic function abnormal Hepatic function abnormal x
Hepatic necrosis def Hepatic necrosis def x
Electrocardiogram QT prolonged def Electrocardiogram QT prolonged def x
Respiratory arrest Respiratory arrest x
Cardiac fibrillation Cardiac fibrillation x
Hepatic fibrosis Hepatic fibrosis x
Hepatobiliary disease def Hepatobiliary disease def x
Hepatitis fulminant Hepatitis fulminant x
Sedation Sedation x x x x x x x x x x
Aortic dissection def Dissecting aortic aneurysm, thoracic x
Indication Labels
Elderly def x
Muscle spasticity def x x x x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: M03BX02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. TIZANIDINE HYDROCHLORIDE / ZANAFLEX : 135 side effects (Drugs@FDA)
  2. TIZANIDINE HYDROCHLORIDE / ZANAFLEX : 137 side effects (Drugs@FDA)
  3. TIZANIDINE (TIZANIDINE HYDROCHLORIDE) / GEN-TIZANIDINE : 138 side effects (Health Canada)
  4. TIZANIDINE : 154 side effects (FDA XML label)
  5. TIZANIDINE : 165 side effects (FDA XML label)
  6. TIZANIDINE : 169 side effects (FDA XML label)
  7. Tizanidine : 169 side effects (FDA XML label)
  8. tizanidine : 169 side effects (FDA XML label)
  9. Tizanidine : 170 side effects (FDA XML label)
  10. TIZANIDINE (TIZANIDINE HYDROCHLORIDE) / ZANAFLEX : 211 side effects (Health Canada)