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Cladribine

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L01BB04

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6
Body temperature increased Body temperature increased very common, 33% - 69% x x x x
Asthenia Fatigue very common, 11% - 45% x x x x x x
Asthenia very common, 6% - 9% x x x x x x
Fatigue Fatigue very common, 11% - 45% x x x x x x
Neurotoxicity Neurotoxicity 35-45% x x x x x
Renal failure Renal impairment 19-45% x x x
Renal failure rare x x x
Renal impairment Renal impairment 19-45% x x x
Nausea Nausea very common, 5-28% - 28% x x x x x x
Dermatitis Rash very common, 10% - 27% x x x x x x
Rash Rash very common, 10% - 27% x x x x x x
Bacterial infection Bacterial infection 21.8% x
Infection Infection very common, 28% x x x x x x
Viral skin infection Viral skin infection 20.8% x
Injection site reaction Injection site reaction very common, 9% - 19% x x x x
Headache Headache very common, 7% - 22% x x x x x x
Decreased appetite Decreased appetite very common, 8% - 17% x x x x x
Anorexia x
Lymphopenia Lymphopenia very common x x x x x x
Neutropenia Neutropenia very common x x x x x x
Pancytopenia Pancytopenia very common x x x x x
Myelosuppression very common x x x x x x
Hyperhidrosis Sweating increased very common x x x x
Hyperhidrosis 3% x x
Vomiting Vomiting very common, 1-13% - 13% x x x x x x
Upper respiratory tract infection Upper respiratory tract infection 12.9% x
Thrombocytopenia Thrombocytopenia very common, 6% - 12% x x x x x x
Candida infection Oral candidiasis 11.9% x
Oral candidiasis Oral candidiasis 11.9% x
Urinary tract infection Urinary tract infection 11.9% x
Breath sounds abnormal Breath sounds abnormal very common, 4% - 11% x x x x x x
Abnormal chest sounds NOS very common, 9% x x x
Administration site reaction Administration site reaction 11% x x
Inflammation Inflammation 8.9% - 12.9% x
Purpura Purpura very common, 10% x x x x x x
Vascular purpura Purpura very common, 10% x x x x x x
Constipation Constipation very common, 4% - 9% x x x x x x
Dizziness Dizziness very common, 6% - 9% x x x x x x
Chills Chills very common, 2% - 9% x x x x x x
Skin infection Skin infection 5.7% - 11.9% x
Petechiae Petechiae common, 2% - 8% x x x x x x
Febrile neutropenia Febrile neutropenia 8% - 47% x x x
Diarrhoea Diarrhoea very common, 7% - 3-12% x x x x x x
Pneumonia Pneumonia 6% - 28.7% x x x x x x
Cough Cough very common, 7% - 10% x x x x x x
Dyspnoea Dyspnoea common, 5% - 7% x x x x x x
Myalgia Myalgia common, 6% - 7% x x x x x x
Musculoskeletal discomfort Myalgia common, 6% - 7% x x x x x x
Arthralgia common, 3% - 5% x x x x x x
Insomnia Insomnia common, 3% - 7% x x x x x x
Abdominal pain Abdominal pain 4% - 6% x x x x x
Gastrointestinal pain Abdominal pain 4% - 6% x x x x x
Gastrointestinal pain common x
Oedema Oedema common, 6% x x x x x x
Pain Pain common, 6% x x x x x x
Pruritus Pruritus common, 2% - 6% x x x x x x
Tachycardia Tachycardia common, 2% - 6% x x x x x x
Erythema Erythema common, 6% x x x x x
Redness x x x
Haemorrhage Haemorrhage common, 6% x x x x
Haemoglobin Haemorrhage common, 6% x x x x
Arthralgia Arthralgia common, 3% - 5% x x x x x x
Arthritis Arthritis common x x x
Neoplasm malignant Neoplasm malignant common x
Epistaxis Epistaxis common, 5% x x x x
Cardiac murmur Cardiac murmur common x
Hypotension Hypotension common x
Urticaria Urticaria common x x x x x x
Myocardial ischaemia Myocardial ischaemia common x
Bone pain Bone pain common x x x
Malaise Malaise common, 5% - 7% x x x x x
Discomfort Malaise common, 5% - 7% x x x x x
Feeling abnormal Malaise common, 5% - 7% x x x x x
Confusional state uncommon x x x
Ill-defined disorder Malaise common, 5% - 7% x x x x x
Pain of skin Pain of skin common x
Mucosal inflammation Mucosal inflammation common x
Bacteraemia Bacteraemia 2% x x
Cellulitis Cellulitis 2% x x
Ecchymosis Ecchymosis 2% x x
Phlebitis Phlebitis uncommon, 2% - 5% x x x x x x
Thrombosis Thrombosis 2% x x x
Oedema peripheral Oedema peripheral 2% x x
Anaemia Anaemia very common, 1% x x x x x x
Anxiety Anxiety common, 1% x x x
Contusion Contusion 1% x x
Flatulence Flatulence common, 1% x x x
Localised infection Localised infection 1% x x
Rales Rales 1% x x
Muscular weakness Muscular weakness 1% x x
Haemolytic anaemia Haemolytic anaemia uncommon x x x x x x
Ataxia Ataxia uncommon x
Cachexia Cachexia uncommon x
Confusional state Confusional state uncommon x x x
Conjunctivitis Conjunctivitis uncommon x x x
Lethargy Lethargy uncommon x
Paraesthesia Paraesthesia uncommon x
Pharyngitis Pharyngitis uncommon x
Polyneuropathy Polyneuropathy uncommon x x x x
Somnolence Somnolence uncommon x
Toxic epidermal necrolysis Toxic epidermal necrolysis rare, 1% x x x x x
Tumour lysis syndrome Tumour lysis syndrome rare, 1% x x x x
Atrial fibrillation Atrial fibrillation rare x
Graft versus host disease Graft versus host disease rare x
Cardiac failure Cardiac failure rare x
Decompensation cardiac rare x
Erythema multiforme Stevens-Johnson syndrome rare x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome rare x x x
Cerebrovascular accident Cerebrovascular accident rare x
Hepatic failure Hepatic failure rare x
Eosinophilia Hypereosinophilia rare x x x x x x
Ileus Ileus rare x
Myelodysplastic syndrome Myelodysplastic syndrome 0.03% x x x x x
Amyloidosis Amyloidosis very rare x
Blepharitis Blepharitis very rare x
Cholecystitis Cholecystitis very rare x
Epilepsy Epilepsy very rare x
Pulmonary embolism Pulmonary embolism very rare x
Alopecia Alopecia x
Aplastic anaemia Aplastic anaemia x x x x x
Autoimmune haemolytic anaemia Autoimmune haemolytic anaemia x x x
Arrhythmia Arrhythmia x
Back pain Back pain x x
Mental disorder Mental disorder x x
Bone disorder Bone disorder x x
Chest pain Chest pain x x
Connective tissue disorder Connective tissue disorder x
Cyst Cyst x
Localised oedema Localised oedema x x
Extravasation Extravasation x
Eye disorder Eye disorder x x x
Gastrointestinal disorder Gastrointestinal disorder x x x
Cardiac disorder Cardiac disorder x x x
Blood disorder Blood disorder x x
Herpes virus infection Herpes NOS x
Herpes zoster Herpes zoster x x x
Hypersensitivity Hypersensitivity x x
Immune system disorder Immune system disorder x x x
Infarction Infarction x
Renal failure acute Renal failure acute x x x x
Mediastinal disorder Mediastinal disorder x x x
Musculoskeletal pain Musculoskeletal pain x
Fungal infection Fungal infection x x x x
Neoplasm Neoplasm x x
Nervous system disorder Nervous system disorder x x x
Opportunistic infection Opportunistic infection x x x x x x
Pain in extremity Pain in extremity x x
Polyp Polyp x
Pulmonary fibrosis Pulmonary fibrosis x x
Respiratory tract infection Respiratory tract infection x
Sepsis Septicemia x x x x x x
Sepsis x x x x
Septic shock Septic shock x x
Swelling Swelling x x x
Ureteric obstruction Ureteric obstruction x
Urethral disorder Urinary tract disorder x x x
Urinary tract disorder Urinary tract disorder x x x
Angiopathy Angiopathy x x
Wheezing Wheezing x x
Peripheral sensory neuropathy Peripheral sensory neuropathy x x
Malnutrition Malnutrition x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x x x
Interstitial lung disease Interstitial lung disease x x
Metabolic acidosis Metabolic acidosis x
Paraparesis Paraparesis x x x
Rash macular Rash macular x
Dyspnoea exertional Dyspnoea exertional x x
Abdominal discomfort Abdominal discomfort x x
Disorientation Disorientation x x
Rash erythematous Rash erythematous x
Neuritis Peripheral motor neuropathy x
Peripheral motor neuropathy Peripheral motor neuropathy x
Lung infiltration Lung infiltration x x
Hepatobiliary disease Hepatobiliary disease x x x
Quadriparesis Quadriparesis x
Blood bilirubin increased Blood bilirubin increased x
Paralysis Paralysis x x
Altered state of consciousness Depressed level of consciousness x x
Depressed level of consciousness Depressed level of consciousness x x
Blood uric acid increased Hyperuricaemia x x
Hyperuricaemia Hyperuricaemia x x
Infestation Infestation NOS x x x
Culture negative Culture negative x
Catheter site cellulitis Catheter site cellulitis x
Infusion site reaction Infusion site reaction x x
Urine output Urine output x
Death Death x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

CLADRIBINE

Side effects:55
Source:FDA Structured Product Label

CLADRIBINE

Side effects:55
Source:FDA Structured Product Label

Cladribine

Side effects:63
Source:BC Cancer

cladribine / cladribine

Side effects:108
Source:EMA

CLADRIBINE

Side effects:106
Source:FDA Structured Product Label

LEUSTATIN / Leustatin, Solution for infusion

Side effects:117
Source:Medsafe

Color scheme:

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    100%
    75%
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    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label