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Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 37 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased Body temperature increased 83% x x x
Bone pain Bone pain 20-30% - 77% x x x
Mucosal dryness Mucosal dryness 77% x
Chills Shivering 63% x x x
Dyspnoea Dyspnoea 60% x x x
Vomiting Vomiting 51% - 57% x x x
Dermatitis Dermatitis postmarketing — 3.8% - 55% x x x
Rash postmarketing — 1% - 54% x x x x x x x x x
Dermatitis perioral x
Oedema peripheral Oedema peripheral common, 52% x x
Edema of lower extremities
Nasal congestion Nasal congestion 24-65% x
Blood creatinine increased Serum creatinine increased 20-56%
Gastrointestinal haemorrhage Gastrointestinal haemorrhage 34% x x
Chest pain Chest discomfort 32% x x
Chest pain x x
Chest discomfort Chest discomfort 32% x x
Abdominal pain Abdominal pain 31% x x x
Gastrointestinal pain Abdominal pain 31% x x x
Disseminated intravascular coagulation Disseminated intravascular coagulation 26% x x
Gastrointestinal disorder Gastrointestinal disorder 26% x
Gastrointestinal symptom NOS postmarketing x x x x
Respiratory failure Respiratory insufficiency 26% x x x
Mucosal inflammation Mucosal inflammation 26% x
Arrhythmia Arrhythmia 23% x x x
Diarrhoea Diarrhoea postmarketing, 23% x x x
Weight increased Weight increased 23% - 32% x
Ototoxicity Ototoxicity 19-25%
Pleural effusion Pleural effusion 20% x x x
Hyperhidrosis Sweating increased 20% x x
Sweating postmarketing x x x x x x
Decreased appetite Anorexia 17% x x
Decreased appetite
Anxiety Anxiety postmarketing, 17% x x x
Constipation Constipation 17% x x x
Injection site reaction Injection site reaction 17% x
Blood bilirubin increased Blood bilirubin increased 16%
Excoriation Excoriation very common
Skin irritation Skin irritation very common, 3.8% - 6.4% x x x x x
Tenderness Tenderness very common
Skin exfoliation Skin exfoliation common — 1.44% - 50% x x x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x x
Pain of skin Skin tenderness very common x x
Pain of skin very common, 0% - 1.04% x x x x
Erythema Redness very common x
Erythema very common, 0.205% - 41% x x x x x x x x x x
Erythema facial postmarketing x x x x
Application site erythema Application site erythema very common x x
Application site pruritus Application site pruritus very common x x
Application site pain Application site stinging very common x x
Dyspepsia Dyspepsia 14% x
Hypotension Hypotension 14% x x
Pneumonia Pneumonia 14% x x
Rales Rales 14% x x
Wheezing Wheezing expiratory 14% x
Wheezing
Retinoic acid syndrome Retinoic acid syndrome postmarketing, 25% x x
Abdominal distension Abdominal distension 11% x x
Confusional state Confusional state 11% x x x
Feeling abnormal Confusional state 11% x x x
Malaise postmarketing, 66% x x x x x x x
Hypertension Hypertension 11% x x
Phlebitis Phlebitis uncommon, 11% x
Eye irritation Eye irritation postmarketing, 11% x
Renal failure Renal impairment 11% x x
Renal failure postmarketing x
Renal impairment Renal impairment 11% x x
Dysuria Dysuria 9% x x
Flank pain Flank pain 9% x x
Hepatosplenomegaly Hepatosplenomegaly 9% x
Agitation Agitation 9% x x
Intracranial pressure increased Intracranial pressure increased postmarketing, 9% x x x x
Cerebral haemorrhage Cerebral haemorrhage 9% x
Cellulitis Cellulitis uncommon, 8% x
Embolism Embolism 8%
Skin burning sensation Skin burning sensation very common, 1.64% - 7.86% x x x x
Alopecia Alopecia postmarketing, 13% - 14% x x x x x x x x
Alopecia reversible postmarketing x
Hallucination Hallucination 6% x
Cardiac failure Cardiac failure 6% x x
Pallor Pallor 6% x x
Pericarditis Pericarditis 6% x
Lung infiltration Lung infiltration 6% x x
Face oedema Face oedema 6% x
Fluid imbalance Fluid imbalance 6% x
Inflammation Inflammation common
Skin ulcer Skin ulcer common
Skin discolouration Skin discolouration common
Pain Stinging common x x x x
Pain postmarketing — 0% - 37% x x x x x x
Generalized aching x
Paraesthesia Tingling sensation common
Paraesthesia postmarketing — 0% - 22% x x x x x x x x x
Pruritus Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x x
Dry skin Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x x
Dry scalp x
Rash Rash postmarketing — 1% - 54% x x x x x x x x x
Acidosis Acidosis 3% x x
Ascites Ascites 3% x
Dermatitis exfoliative Dermatitis exfoliative common, 0% - 9% x
Oedema Oedema postmarketing — 0% - 29% x x x x x x x x x x x
Body temperature decreased Body temperature decreased 3% x x
Hypothermia Body temperature decreased 3% x x
Renal failure acute Renal failure acute 3% x
Laryngeal oedema Laryngeal oedema 3% x
Liver disorder Liver disorder 3% x
Hepatocellular injury Liver disorder 3% x
Foetor hepaticus Liver disorder 3% x
Lung disorder Lung disorder 3% x
Osteitis Osteitis 3% x
Pulmonary oedema Pulmonary oedema 3% x
Scotoma Scotoma 3% x x
Telangiectasia Telangiectasia 3% x
Ulcer Ulcer 3% x x
Pollakiuria Pollakiuria 3% x x
Prostatomegaly Prostatomegaly 3% x
Renal tubular necrosis Renal tubular necrosis 3% x
Swelling Swelling postmarketing, common x
Hyperaesthesia Hyperaesthesia 2% x
Rosacea Rosacea 1% x
Skin disorder Skin disorder very common, 0% - 8% x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x
Papule Papule 1% x
Acne Acne postmarketing, 1% - 5% x
Bacterial infection Bacterial infection uncommon
Angiopathy Angiopathy uncommon
Rash pustular Vesiculobullous rash uncommon
Dermatitis bullous Vesiculobullous rash uncommon
Blister x x x
Rash maculo-papular Rash maculo-papular uncommon
Aggression Aggression postmarketing x
Violent postmarketing x x
Violent behavior postmarketing
Agranulocytosis Agranulocytosis postmarketing x x x
Anaphylactic shock Anaphylactic shock postmarketing
Anaemia Anaemia postmarketing x x x x x
Arthralgia Arthralgia postmarketing, 20-30% x x x x x
Musculoskeletal discomfort Arthralgia postmarketing, 20-30% x x x x x
Myalgia postmarketing, 14% x x x
Musculoskeletal discomfort
Arthritis Arthritis postmarketing x x x x
Asthenia Asthenia postmarketing x x x x x x
Fatigue postmarketing x x x x x x
Asthma Asthma postmarketing, 3% x x
Back pain Back pain postmarketing x x
Abnormal behaviour Behavior disorder postmarketing x
Mental disorder Mental disorder postmarketing x x x x
Blepharitis Blepharitis postmarketing x x x x
Bronchospasm Bronchospasm postmarketing x x x x x
Cardiovascular disorder Cardiovascular disorder postmarketing
Nervous system disorder Central nervous system disorder postmarketing x
Cerebellar syndrome x
Nervous system disorder
Cheilitis Cheilitis postmarketing, 24-65% - 96% x x x x x x
Colitis Colitis postmarketing x x x x x
Infection Infection postmarketing — 58% x x x x x
Secondary infection x
Conjunctivitis Conjunctivitis postmarketing, 19% x x x x x x
Contusion Contusion postmarketing x x x x
Corneal opacity Corneal opacity postmarketing x x x x x
Deafness Deafness postmarketing
Hearing impaired postmarketing x x x x
Diabetes mellitus Diabetes mellitus postmarketing
Dizziness Dizziness postmarketing, 20% x x x x x x x
Syncope postmarketing x x x
Lightheadedness x
Somnolence Drowsiness postmarketing x x x x
Somnolence x
Eczema Eczema postmarketing x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing
Epistaxis Epistaxis postmarketing x x x x x x
Erythema multiforme Erythema multiforme postmarketing
Stevens-Johnson syndrome postmarketing
Erythema nodosum Erythema nodosum postmarketing x x x x
Oesophagitis Oesophagitis postmarketing x x
Fatigue Fatigue postmarketing x x x x x x
Flushing Flushing postmarketing, 23% x x x x x x x
Gingivitis Gingivitis postmarketing x x x x
Glomerulonephritis Glomerulonephritis postmarketing x x x x
Headache Headache postmarketing, 29-90% - 86% x x x x x x x x
Headache occurring
Hearing impaired Partial hearing loss postmarketing x x
Hearing impaired postmarketing x x x x
Auditory disorder NOS x
Haematuria Haematuria postmarketing x x
Frank hematuria postmarketing x x x
Haemorrhage Haemorrhage postmarketing — 60% x x x x x x x
Haemoglobin Haemorrhage postmarketing — 60% x x x x x x x
Hepatitis Hepatitis postmarketing, 3% x x x x x
Herpes simplex Herpes simplex postmarketing x x x x
Hirsutism Hirsutism postmarketing x x x x x
Dysphonia Hoarseness postmarketing x x
Exostosis Hyperostosis postmarketing x x x x x
Exostosis postmarketing
Hypersensitivity Hypersensitivity postmarketing, uncommon x x x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia postmarketing x x x x
Blood triglycerides increased Hypertriglyceridaemia postmarketing x x x x
Blood triglycerides increased
Hypervitaminosis A Hypervitaminosis A postmarketing x x x
Ileitis Ileitis postmarketing x x x x
Inflammatory bowel disease Inflammatory bowel disease postmarketing x x x x x
Keratitis Keratitis postmarketing x x x x x
Lethargy Lethargy postmarketing x x x x x
Menstrual disorder Menstrual disorder postmarketing x x x x
Myositis Myositis postmarketing x x x
Nasopharyngitis Nasopharyngitis postmarketing
Nausea Nausea postmarketing x x x x x x x x
Nervousness Nervousness postmarketing x x x x
Tension Nervousness postmarketing x x x x
Neutropenia Neutropenia postmarketing x x x x
Optic neuritis Optic neuritis postmarketing x x x x
Papilloedema postmarketing
Palpitations Palpitations postmarketing x x x x
Pancreatitis Pancreatitis postmarketing x x x x x x x x
Papilloedema Papilloedema postmarketing
Paronychia Paronychia postmarketing x x x x x
Pregnancy Pregnancy postmarketing x
Proteinuria Proteinuria postmarketing x x x x
Protein urine present Proteinuria postmarketing x x x x
Benign intracranial hypertension Benign intracranial hypertension postmarketing x x x x x x x
Psychotic disorder Psychotic disorder postmarketing x x x x
Respiratory tract infection Respiratory tract infection postmarketing x x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x
Seborrhoeic dermatitis Seborrhoeic dermatitis postmarketing x x x
Convulsion Convulsion postmarketing x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing
Cerebrovascular accident Cerebrovascular accident postmarketing x x x x x x
Completed suicide Suicide postmarketing x x x
Suicide attempt Suicide attempt postmarketing x x x x
Sunburn Sunburn postmarketing, 0.616% - 1.04% x x x x x x
Photosensitivity reaction Sunburn postmarketing, 0.616% - 1.04% x x x x x x
Photosensitivity reaction postmarketing x x x x x x x x
Photosensitivity postmarketing
Shock Syncope postmarketing x x x
Shock
Syncope Syncope postmarketing x x x
Loss of consciousness Syncope postmarketing x x x
Loss of consciousness x
Tachycardia Tachycardia postmarketing x x x x x
Tendonitis Tendonitis postmarketing x x x x
Thrombocytopenia Thrombocytopenia postmarketing x x x
Tinnitus Tinnitus postmarketing x x x
Ear buzzing x
Urticaria Urticaria postmarketing x x x x x x
Vasculitis Vasculitis postmarketing x x x x x x x
Visual impairment Disorder sight postmarketing x x x
Visual disturbance postmarketing, 17% x x x x x x x
Visual impairment postmarketing x
Granulomatosis with polyangiitis Wegener's granulomatosis postmarketing x x x
Weight decreased Weight decreased postmarketing, 17% x x x x x
Dry mouth Dry mouth postmarketing, 1% x x x x x
Acute febrile neutrophilic dermatosis Acute febrile neutrophilic dermatosis postmarketing x x x
Mood swings Mood swings postmarketing x x x x
Affect lability Mood swings postmarketing x x x x
Photophobia Photophobia postmarketing x x x x x x
Pyogenic granuloma Pyogenic granuloma postmarketing x x x x x
Cataract Cataract postmarketing x x x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis postmarketing x x
Skin atrophy Skin atrophy postmarketing x x
Epiphyses premature fusion Epiphyses premature fusion postmarketing x x x x
Impaired healing Impaired healing postmarketing x x x
Blood alkaline phosphatase increased Phosphatase alkaline increased postmarketing x x x
Blood alkaline phosphatase increased
Oesophageal ulcer Oesophageal ulcer postmarketing x x
Sensory disturbance Sensory disturbance postmarketing
Hair disorder Abnormalities of the hair postmarketing x x x
Hair disorder x
Skin hyperpigmentation Skin hyperpigmentation postmarketing, common x x x
Leukoderma Leukoderma postmarketing x x x x x x x x x x
Scab Scab postmarketing, very common x x x
Xanthoma Eruptive xanthoma postmarketing x x x
Nail dystrophy Nail dystrophy postmarketing x x x x x
Contact lens intolerance Contact lens intolerance postmarketing
Malaise Malaise postmarketing, 66% x x x x x x x
Discomfort Malaise postmarketing, 66% x x x x x x x
Discomfort x
Ill-defined disorder Malaise postmarketing, 66% x x x x x x x
Myalgia Myalgia postmarketing, 14% x x x
Nasal dryness Nasal dryness postmarketing, 51% x x x x x x
Application site oedema Application site oedema postmarketing x
Dry throat Dry throat postmarketing
Hepatotoxicity Hepatotoxicity postmarketing x x x x
Depression Depression aggravated postmarketing
Depression x
Blood creatine phosphokinase increased Creatine phosphokinase serum increased postmarketing
Creatine phosphokinase increased x
Sepsis Sepsis postmarketing x
Septicemia x x
Acne fulminans Acne fulminans postmarketing x x x x x
Excessive granulation tissue Excessive granulation tissue postmarketing x x x
Dry eye Dry eye postmarketing x x x x
Dry eye syndrome x
Vision blurred Vision blurred postmarketing x
Suicidal ideation Suicidal ideation postmarketing x x x
Lymphadenopathy Lymphadenopathy postmarketing — 10% x x x x x
Application site rash Application site rash postmarketing x
Skin fragility Skin fragility postmarketing x x x x
Lip dry Lip dry postmarketing x x x
Blood glucose increased Blood glucose increased postmarketing x
Basophilia Basophilia postmarketing x x x
Blood uric acid increased Hyperuricaemia postmarketing x x x x x
Hyperuricaemia Hyperuricaemia postmarketing x x x x x
Thrombocytosis Thrombocytosis postmarketing x x x
Night blindness Decreased night vision postmarketing x x x x x
Insomnia Insomnia postmarketing, 14% x x x x x x x
Acquired immunodeficiency syndrome Acquired immunodeficiency syndrome x
Autoimmune disorder Acquired immunodeficiency syndrome x
Pancreatitis acute Pancreatitis acute x
Agnosia Agnosia x
Anger Anger
Aphasia Aphasia x
Asthenopia Asthenopia
Blister Blister x x x
Coagulopathy Clotting x
Neoplasm malignant Neoplasm malignant
Candida infection Candida infection x
Cerebellar syndrome Cerebellar syndrome x
Neck pain Neck pain
Coma Coma x
Cough Cough x
Cyanosis Cyanosis x
Cystitis Cystitis x
Bladder pain Cystitis x
Cystitis noninfective Cystitis x
Dysphagia Dysphagia x
Dehydration Dehydration x
Dermatitis contact Dermatitis contact
Allergic contact dermatitis x
Lacrimation decreased Dry eye syndrome x
Duodenal ulcer Duodenal ulcer
Dysarthria Dysarthria x
Osteoarthritis Dysarthria x
Ear disorder Ear disorder x
Ear pain Ear pain x x
Eye disorder Eye disorder x
VIIth nerve paralysis Facial paralysis x
Fasciitis Fasciitis
Flatulence Flatulence x
Folliculitis Folliculitis x
Gastritis Gastritis
Gout Gout x
Cardiac arrest Cardiac arrest x
Cardiomegaly Cardiomegaly x x
Cardiac failure congestive Cardiac failure congestive
Cardiac murmur Cardiac murmur x
Hemiplegia Hemiplegia x
Hordeolum Hordeolum
Hypercalcaemia Hypercalcaemia x x x
Hypercholesterolaemia Hypercholesterolaemia
Hyperlipidaemia Hyperlipidaemia
Pulmonary hypertension Pulmonary hypertension x
Irritability Irritability
Ischaemia Ischaemia x
Leukocytosis Leukocytosis x
Miliaria Miliaria x
Multi-organ failure Multi-organ failure x
Musculoskeletal pain Musculoskeletal pain x
Myocardial infarction Myocardial infarction x x x
Acute coronary syndrome Myocardial infarction x x x
Myocarditis Myocarditis x
Nail disorder Nail disorder x
Hypoaesthesia Numbness x
Sensory loss Numbness x
Ochronosis Ochronosis x
IIIrd nerve paralysis Ophthalmoplegia
Ophthalmoplegia Ophthalmoplegia
Pain in extremity Pain in extremity
Pericardial effusion Pericardial effusion x
Neuropathy peripheral Neuropathy peripheral x
Pharyngitis Pharyngitis x
Renal infarct Renal infarct x x x
Retinal haemorrhage Retinal haemorrhage
Cardiomyopathy Cardiomyopathy secondary NOS x
Sinusitis Sinusitis x
Skin infection Skin infection x
Spinal cord disorder Spinal cord disorder x
Stomatitis Stomatitis x
Thrombosis Thrombosis x x x
Tremor Tremor x
Upper respiratory tract infection Upper respiratory tract infection
Urinary tract infection Urinary tract infection x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Xeroderma Xeroderma x
Xerophthalmia Xerophthalmia x
Encephalopathy Encephalopathy x
Panic attack Panic attack
Genital ulceration Genital ulceration x x
Application site reaction Application site reaction
Depressed level of consciousness CNS depression NOS x
Red blood cell sedimentation rate increased Red blood cell sedimentation rate increased x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased
Hyporeflexia Hyporeflexia x x
Drug tolerance decreased Decreased tolerance x
Lacrimation increased Lacrimation increased
Skin striae Skin striae x
Endophthalmitis Ocular hyperaemia
Ocular hyperaemia Ocular hyperaemia
Malnutrition Malnutrition x
Dermatitis acneiform Acneiform eruption x
Emotional distress Distress
Tachypnoea Tachypnoea x
Asterixis Asterixis x
Teratogenicity Teratogenicity x x
Hallucination, auditory Hallucination, auditory
Visual acuity reduced Visual acuity reduced
Neurological symptom Neurologic reaction x x
Euphoric mood Euphoric mood
Abdominal discomfort Upset stomach x
Mouth ulceration Buccal mucosa ulceration x
Groin pain Groin pain x
Weight fluctuation Weight fluctuation
Crohn's disease Ileitis regional x
Rectal haemorrhage Rectal haemorrhage x
Scrotal ulcer Scrotal ulcer
Lividity Lividity x
Cushingoid Cushingoid x
Chapped lips Chapped lips
Respiratory distress Respiratory distress x x
Dementia Dementia x
Eschar Eschar
Memory impairment Forgetfulness x x
Fluid overload Fluid overload x
Gait disturbance Gait disturbance x x
Dermatitis atopic Cutaneous hypersensitivity x
Blood cholesterol increased Blood cholesterol increased
Drug interaction Drug interaction x
Hypoxia Hypoxemia x
Febrile neutropenia Febrile neutropenia
White blood cell count decreased White blood cell count decreased
Infestation Infestation NOS
Local reaction Local reaction x x
Musculoskeletal stiffness Musculoskeletal stiffness
Brain oedema Cerebellar oedema x
Sensitisation Sensitisation x
Post-traumatic pain Post-traumatic pain x
Slow speech Slow speech x
Blindness Unspecified visual loss

Indications

Information about indications was extracted from the indications and usage sections of the labels.