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Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 37 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased Body temperature increased 83% x x
Bone pain Bone pain 20-30% - 77% x x
Mucosal dryness Mucosal dryness 77%
Chills Shivering 63% x x
Dyspnoea Dyspnoea 60% x x
Vomiting Vomiting 51% - 57% x x x
Dermatitis Dermatitis postmarketing — 3.8% - 55% x x x x x
Rash postmarketing — 1% - 54% x x x x x x x x x x
Dermatitis perioral x
Oedema peripheral Oedema peripheral common, 52% x
Edema of lower extremities x
Nasal congestion Nasal congestion 24-65% x
Blood creatinine increased Serum creatinine increased 20-56% x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage 34%
Chest pain Chest discomfort 32%
Chest pain x x
Chest discomfort Chest discomfort 32%
Abdominal pain Abdominal pain 31% x x x
Gastrointestinal pain Abdominal pain 31% x x x
Disseminated intravascular coagulation Disseminated intravascular coagulation 26%
Gastrointestinal disorder Gastrointestinal disorder 26%
Gastrointestinal symptom NOS postmarketing x x x x
Respiratory failure Respiratory insufficiency 26% x
Mucosal inflammation Mucosal inflammation 26%
Arrhythmia Arrhythmia 23% x
Diarrhoea Diarrhoea postmarketing, 23% x x
Weight increased Weight increased 23% - 32% x
Ototoxicity Ototoxicity 19-25% x
Pleural effusion Pleural effusion 20% x
Hyperhidrosis Sweating increased 20%
Sweating postmarketing x x x x x x
Decreased appetite Anorexia 17%
Decreased appetite x
Anxiety Anxiety postmarketing, 17% x x
Constipation Constipation 17% x x
Injection site reaction Injection site reaction 17%
Blood bilirubin increased Blood bilirubin increased 16% x x
Excoriation Excoriation very common x x
Skin irritation Skin irritation very common, 3.8% - 6.4% x x x x
Tenderness Tenderness very common x
Skin exfoliation Skin exfoliation common — 1.44% - 50% x x x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x x x
Pain of skin Skin tenderness very common x x
Pain of skin very common, 0% - 1.04% x x x
Erythema Redness very common x x
Erythema very common, 0.205% - 41% x x x x x x x x x x x x
Erythema facial postmarketing x x x x
Application site erythema Application site erythema very common x x
Application site pruritus Application site pruritus very common x x
Application site pain Application site stinging very common x x
Dyspepsia Dyspepsia 14%
Hypotension Hypotension 14% x
Pneumonia Pneumonia 14%
Rales Rales 14% x
Wheezing Wheezing expiratory 14%
Wheezing
Retinoic acid syndrome Retinoic acid syndrome postmarketing, 25% x x
Abdominal distension Abdominal distension 11%
Confusional state Confusional state 11% x
Feeling abnormal Confusional state 11% x
Malaise postmarketing, 66% x x x x x
Hypertension Hypertension 11%
Phlebitis Phlebitis uncommon, 11% x
Eye irritation Eye irritation postmarketing, 11% x
Renal failure Renal impairment 11%
Renal failure postmarketing x
Renal impairment Renal impairment 11%
Dysuria Dysuria 9%
Flank pain Flank pain 9%
Hepatosplenomegaly Hepatosplenomegaly 9%
Agitation Agitation 9%
Intracranial pressure increased Intracranial pressure increased postmarketing, 9% x x x
Cerebral haemorrhage Cerebral haemorrhage 9%
Cellulitis Cellulitis uncommon, 8% x
Embolism Embolism 8% x
Skin burning sensation Skin burning sensation very common, 1.64% - 7.86% x x x
Alopecia Alopecia postmarketing, 13% - 14% x x x x x x
Alopecia reversible postmarketing x
Hallucination Hallucination 6%
Cardiac failure Cardiac failure 6%
Pallor Pallor 6%
Pericarditis Pericarditis 6% x
Lung infiltration Lung infiltration 6% x
Face oedema Face oedema 6%
Fluid imbalance Fluid imbalance 6%
Inflammation Inflammation common x x
Skin ulcer Skin ulcer common x
Skin discolouration Skin discolouration common x
Pain Stinging common x x x x x x
Pain postmarketing — 0% - 37% x x x x x x x x
Generalized aching
Paraesthesia Tingling sensation common x x
Paraesthesia postmarketing — 0% - 22% x x x x x x x x x
Pruritus Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x x
Dry skin Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x x
Dry scalp
Rash Rash postmarketing — 1% - 54% x x x x x x x x x x
Acidosis Acidosis 3%
Ascites Ascites 3%
Dermatitis exfoliative Dermatitis exfoliative common, 0% - 9% x x x
Oedema Oedema postmarketing — 0% - 29% x x x x x x x x x x x x x
Body temperature decreased Body temperature decreased 3%
Hypothermia Body temperature decreased 3%
Renal failure acute Renal failure acute 3%
Laryngeal oedema Laryngeal oedema 3%
Liver disorder Liver disorder 3%
Hepatocellular injury Liver disorder 3%
Foetor hepaticus Liver disorder 3%
Lung disorder Lung disorder 3%
Osteitis Osteitis 3%
Pulmonary oedema Pulmonary oedema 3%
Scotoma Scotoma 3%
Telangiectasia Telangiectasia 3% x
Ulcer Ulcer 3%
Pollakiuria Pollakiuria 3%
Prostatomegaly Prostatomegaly 3%
Renal tubular necrosis Renal tubular necrosis 3%
Swelling Swelling postmarketing, common x x x
Hyperaesthesia Hyperaesthesia 2% x
Rosacea Rosacea 1% x
Skin disorder Skin disorder very common, 0% - 8% x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x x
Papule Papule 1% x
Acne Acne postmarketing, 1% - 5% x
Bacterial infection Bacterial infection uncommon x
Angiopathy Angiopathy uncommon x
Rash pustular Vesiculobullous rash uncommon x
Dermatitis bullous Vesiculobullous rash uncommon x
Blister x x x
Rash maculo-papular Rash maculo-papular uncommon x
Aggression Aggression postmarketing x x x
Violent postmarketing x x x
Violent behavior postmarketing
Agranulocytosis Agranulocytosis postmarketing x x x x
Anaphylactic shock Anaphylactic shock postmarketing
Anaemia Anaemia postmarketing x x x x x
Arthralgia Arthralgia postmarketing, 20-30% x x x x x
Musculoskeletal discomfort Arthralgia postmarketing, 20-30% x x x x x
Myalgia postmarketing, 14% x x
Musculoskeletal discomfort x
Arthritis Arthritis postmarketing x x x x
Asthenia Asthenia postmarketing x x x x
Fatigue postmarketing x x x x x
Asthma Asthma postmarketing, 3% x
Back pain Back pain postmarketing x x x x
Abnormal behaviour Behavior disorder postmarketing x
Mental disorder Mental disorder postmarketing x x x x
Blepharitis Blepharitis postmarketing x x x x
Bronchospasm Bronchospasm postmarketing x x x x x
Cardiovascular disorder Cardiovascular disorder postmarketing
Nervous system disorder Central nervous system disorder postmarketing x
Cerebellar syndrome
Nervous system disorder x
Cheilitis Cheilitis postmarketing, 24-65% - 96% x x x x x x
Colitis Colitis postmarketing x x x x x
Infection Infection postmarketing — 58% x x x x x
Secondary infection x
Conjunctivitis Conjunctivitis postmarketing, 19% x x x x x x
Contusion Contusion postmarketing x x x x
Corneal opacity Corneal opacity postmarketing x x x x x
Deafness Deafness postmarketing
Hearing impaired postmarketing x x x x
Diabetes mellitus Diabetes mellitus postmarketing
Dizziness Dizziness postmarketing, 20% x x x x x
Syncope postmarketing x x x x
Lightheadedness
Somnolence Drowsiness postmarketing x x x x
Somnolence
Eczema Eczema postmarketing x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing x
Epistaxis Epistaxis postmarketing x x x x x
Erythema multiforme Erythema multiforme postmarketing x
Stevens-Johnson syndrome postmarketing x
Erythema nodosum Erythema nodosum postmarketing x
Oesophagitis Oesophagitis postmarketing x x x
Fatigue Fatigue postmarketing x x x x x
Flushing Flushing postmarketing, 23% x x x x x
Gingivitis Gingivitis postmarketing x x x x
Glomerulonephritis Glomerulonephritis postmarketing x x x x
Headache Headache postmarketing, 29-90% - 86% x x x x x x x
Headache occurring x
Hearing impaired Partial hearing loss postmarketing x
Hearing impaired postmarketing x x x x
Auditory disorder NOS x
Haematuria Haematuria postmarketing x
Frank hematuria postmarketing x x x x
Haemorrhage Haemorrhage postmarketing — 60% x x x x x x x
Haemoglobin Haemorrhage postmarketing — 60% x x x x x x x
Hepatitis Hepatitis postmarketing, 3% x x x x x
Herpes simplex Herpes simplex postmarketing x x x x
Hirsutism Hirsutism postmarketing x x x x x
Dysphonia Hoarseness postmarketing x
Exostosis Hyperostosis postmarketing x x x x x
Exostosis postmarketing
Hypersensitivity Hypersensitivity postmarketing, uncommon x x x x x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia postmarketing x x x x x
Blood triglycerides increased Hypertriglyceridaemia postmarketing x x x x x
Blood triglycerides increased x
Hypervitaminosis A Hypervitaminosis A postmarketing x x
Ileitis Ileitis postmarketing x x x x x
Inflammatory bowel disease Inflammatory bowel disease postmarketing x x x x x
Keratitis Keratitis postmarketing x x x x x
Lethargy Lethargy postmarketing x x x x
Menstrual disorder Menstrual disorder postmarketing x x x x
Myositis Myositis postmarketing x x
Nasopharyngitis Nasopharyngitis postmarketing x
Nausea Nausea postmarketing x x x x x x x
Nervousness Nervousness postmarketing x x x x
Tension Nervousness postmarketing x x x x
Neutropenia Neutropenia postmarketing x x x x x
Optic neuritis Optic neuritis postmarketing x x x x
Papilloedema postmarketing x
Palpitations Palpitations postmarketing x x x x
Pancreatitis Pancreatitis postmarketing x x x x x x
Papilloedema Papilloedema postmarketing x
Paronychia Paronychia postmarketing x x x x x
Pregnancy Pregnancy postmarketing x
Proteinuria Proteinuria postmarketing x x x x
Protein urine present Proteinuria postmarketing x x x x
Benign intracranial hypertension Benign intracranial hypertension postmarketing x x x x x x x
Psychotic disorder Psychotic disorder postmarketing x x x x
Respiratory tract infection Respiratory tract infection postmarketing x x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x
Seborrhoeic dermatitis Seborrhoeic dermatitis postmarketing x x x x
Convulsion Convulsion postmarketing x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x
Cerebrovascular accident Cerebrovascular accident postmarketing x x x x x
Completed suicide Suicide postmarketing x x x x
Suicide attempt Suicide attempt postmarketing x x x x
Sunburn Sunburn postmarketing, 0.616% - 1.04% x x x x x
Photosensitivity reaction Sunburn postmarketing, 0.616% - 1.04% x x x x x
Photosensitivity reaction postmarketing x x x x x x x
Photosensitivity postmarketing x
Shock Syncope postmarketing x x x x
Shock x
Syncope Syncope postmarketing x x x x
Loss of consciousness Syncope postmarketing x x x x
Loss of consciousness
Tachycardia Tachycardia postmarketing x x x x x
Tendonitis Tendonitis postmarketing x x x x
Thrombocytopenia Thrombocytopenia postmarketing x x x x
Tinnitus Tinnitus postmarketing x x x x
Ear buzzing
Urticaria Urticaria postmarketing x x x x x x x
Vasculitis Vasculitis postmarketing x x x x x
Visual impairment Disorder sight postmarketing x x x x
Visual disturbance postmarketing, 17% x x x x x x
Visual impairment postmarketing
Granulomatosis with polyangiitis Wegener's granulomatosis postmarketing x x x x
Weight decreased Weight decreased postmarketing, 17% x x x x
Dry mouth Dry mouth postmarketing, 1% x x x x
Acute febrile neutrophilic dermatosis Acute febrile neutrophilic dermatosis postmarketing x x
Mood swings Mood swings postmarketing x x x x
Affect lability Mood swings postmarketing x x x x
Photophobia Photophobia postmarketing x x x x x
Pyogenic granuloma Pyogenic granuloma postmarketing x x x x x
Cataract Cataract postmarketing x x x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis postmarketing x
Skin atrophy Skin atrophy postmarketing x x
Epiphyses premature fusion Epiphyses premature fusion postmarketing x x x x x
Impaired healing Impaired healing postmarketing x x x x
Blood alkaline phosphatase increased Phosphatase alkaline increased postmarketing x x x
Blood alkaline phosphatase increased x
Oesophageal ulcer Oesophageal ulcer postmarketing x x x
Sensory disturbance Sensory disturbance postmarketing
Hair disorder Abnormalities of the hair postmarketing x x x x
Hair disorder
Skin hyperpigmentation Skin hyperpigmentation postmarketing, common x x x x
Leukoderma Leukoderma postmarketing x x x x x x x x x x x
Scab Scab postmarketing, very common x x x x x x
Xanthoma Eruptive xanthoma postmarketing x x x x
Nail dystrophy Nail dystrophy postmarketing x x x x x
Contact lens intolerance Contact lens intolerance postmarketing
Malaise Malaise postmarketing, 66% x x x x x
Discomfort Malaise postmarketing, 66% x x x x x
Discomfort x
Ill-defined disorder Malaise postmarketing, 66% x x x x x
Myalgia Myalgia postmarketing, 14% x x
Nasal dryness Nasal dryness postmarketing, 51% x x x x x
Application site oedema Application site oedema postmarketing x
Dry throat Dry throat postmarketing
Hepatotoxicity Hepatotoxicity postmarketing x x x x
Depression Depression aggravated postmarketing
Depression
Blood creatine phosphokinase increased Creatine phosphokinase serum increased postmarketing
Creatine phosphokinase increased
Sepsis Sepsis postmarketing x x
Septicemia
Acne fulminans Acne fulminans postmarketing x x x x x
Excessive granulation tissue Excessive granulation tissue postmarketing x x x x
Dry eye Dry eye postmarketing x x x x
Dry eye syndrome x
Vision blurred Vision blurred postmarketing x
Suicidal ideation Suicidal ideation postmarketing x x x x
Lymphadenopathy Lymphadenopathy postmarketing — 10% x x x x x x x
Application site rash Application site rash postmarketing x
Skin fragility Skin fragility postmarketing x x x x
Lip dry Lip dry postmarketing x x x x
Blood glucose increased Blood glucose increased postmarketing x
Basophilia Basophilia postmarketing x x
Blood uric acid increased Hyperuricaemia postmarketing x x x x x
Hyperuricaemia Hyperuricaemia postmarketing x x x x x
Thrombocytosis Thrombocytosis postmarketing x
Night blindness Decreased night vision postmarketing x x x x x
Insomnia Insomnia postmarketing, 14% x x x x x
Acquired immunodeficiency syndrome Acquired immunodeficiency syndrome x x x
Autoimmune disorder Acquired immunodeficiency syndrome x x x
Pancreatitis acute Pancreatitis acute
Agnosia Agnosia
Anger Anger x
Aphasia Aphasia
Asthenopia Asthenopia x
Blister Blister x x x
Coagulopathy Clotting
Neoplasm malignant Neoplasm malignant x
Candida infection Candida infection
Cerebellar syndrome Cerebellar syndrome
Neck pain Neck pain x
Coma Coma
Cough Cough x
Cyanosis Cyanosis
Cystitis Cystitis
Bladder pain Cystitis
Cystitis noninfective Cystitis
Dysphagia Dysphagia
Dehydration Dehydration
Dermatitis contact Dermatitis contact x
Allergic contact dermatitis x
Lacrimation decreased Dry eye syndrome x
Duodenal ulcer Duodenal ulcer x
Dysarthria Dysarthria
Osteoarthritis Dysarthria
Ear disorder Ear disorder
Ear pain Ear pain
Eye disorder Eye disorder
VIIth nerve paralysis Facial paralysis
Fasciitis Fasciitis x
Flatulence Flatulence
Folliculitis Folliculitis x
Gastritis Gastritis x
Gout Gout
Cardiac arrest Cardiac arrest
Cardiomegaly Cardiomegaly
Cardiac failure congestive Cardiac failure congestive x
Cardiac murmur Cardiac murmur
Hemiplegia Hemiplegia
Hordeolum Hordeolum x
Hypercalcaemia Hypercalcaemia x x
Hypercholesterolaemia Hypercholesterolaemia x
Hyperlipidaemia Hyperlipidaemia x x
Pulmonary hypertension Pulmonary hypertension
Irritability Irritability x
Ischaemia Ischaemia
Leukocytosis Leukocytosis
Miliaria Miliaria x
Multi-organ failure Multi-organ failure x
Musculoskeletal pain Musculoskeletal pain x
Myocardial infarction Myocardial infarction x
Acute coronary syndrome Myocardial infarction x
Myocarditis Myocarditis
Nail disorder Nail disorder
Hypoaesthesia Numbness
Sensory loss Numbness
Ochronosis Ochronosis x
IIIrd nerve paralysis Ophthalmoplegia x
Ophthalmoplegia Ophthalmoplegia x
Pain in extremity Pain in extremity x
Pericardial effusion Pericardial effusion x
Neuropathy peripheral Neuropathy peripheral
Pharyngitis Pharyngitis
Renal infarct Renal infarct x
Retinal haemorrhage Retinal haemorrhage x
Cardiomyopathy Cardiomyopathy secondary NOS
Sinusitis Sinusitis
Skin infection Skin infection
Spinal cord disorder Spinal cord disorder
Stomatitis Stomatitis
Thrombosis Thrombosis x x
Tremor Tremor
Upper respiratory tract infection Upper respiratory tract infection x
Urinary tract infection Urinary tract infection
Urethral disorder Urinary tract disorder
Urinary tract disorder Urinary tract disorder
Xeroderma Xeroderma
Xerophthalmia Xerophthalmia
Encephalopathy Encephalopathy
Panic attack Panic attack x
Genital ulceration Genital ulceration x
Application site reaction Application site reaction x
Depressed level of consciousness CNS depression NOS
Red blood cell sedimentation rate increased Red blood cell sedimentation rate increased x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased x
Hyporeflexia Hyporeflexia
Drug tolerance decreased Decreased tolerance
Lacrimation increased Lacrimation increased x
Skin striae Skin striae x
Endophthalmitis Ocular hyperaemia x
Ocular hyperaemia Ocular hyperaemia x
Malnutrition Malnutrition
Dermatitis acneiform Acneiform eruption x
Emotional distress Distress
Tachypnoea Tachypnoea
Asterixis Asterixis
Teratogenicity Teratogenicity x x
Hallucination, auditory Hallucination, auditory x
Visual acuity reduced Visual acuity reduced x
Neurological symptom Neurologic reaction
Euphoric mood Euphoric mood x
Abdominal discomfort Upset stomach
Mouth ulceration Buccal mucosa ulceration
Groin pain Groin pain
Weight fluctuation Weight fluctuation x
Crohn's disease Ileitis regional
Rectal haemorrhage Rectal haemorrhage
Scrotal ulcer Scrotal ulcer x
Lividity Lividity x
Cushingoid Cushingoid
Chapped lips Chapped lips x
Respiratory distress Respiratory distress x
Dementia Dementia
Eschar Eschar x
Memory impairment Forgetfulness
Fluid overload Fluid overload
Gait disturbance Gait disturbance
Dermatitis atopic Cutaneous hypersensitivity x
Blood cholesterol increased Blood cholesterol increased x
Drug interaction Drug interaction
Hypoxia Hypoxemia
Febrile neutropenia Febrile neutropenia x
White blood cell count decreased White blood cell count decreased x
Infestation Infestation NOS x
Local reaction Local reaction x
Musculoskeletal stiffness Musculoskeletal stiffness x
Brain oedema Cerebellar oedema
Sensitisation Sensitisation x
Post-traumatic pain Post-traumatic pain
Slow speech Slow speech
Blindness Unspecified visual loss x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

TRETINOIN / VITAMIN A ACID 0.01% GEL

Side effects:5
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:9
Source:FDA Structured Product Label

tretinoin gel / Retin-A MICRO

Side effects:9
Source:FDA

Isotretinoin

Side effects:13
Source:medicines.org.au

ALITRETINOIN / PANRETIN

Side effects:20
Source:FDA

/ TRI-LUMA

Side effects:24
Source:FDA

alitretinoin / alitretinoin

Side effects:40
Source:EMA

Tretinoin

Side effects:65
Source:BC Cancer

isotretinoin / Accutane

Side effects:102
Source:FDA

isotretinoin / Accutane

Side effects:109
Source:FDA

isotretinoin

Side effects:112
Source:FDA Structured Product Label

ISOTRETINOIN

Side effects:148
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label