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Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 37 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased Body temperature increased 83% x x
Bone pain Bone pain 20-30% - 77% x x
Mucosal dryness Mucosal dryness 77%
Chills Shivering 63% x x
Dyspnoea Dyspnoea 60% x x
Vomiting Vomiting 51% - 57% x x
Dermatitis Dermatitis postmarketing — 3.8% - 55% x x x x x
Rash postmarketing — 1% - 54% x x x x x x x x x
Dermatitis perioral x
Oedema peripheral Oedema peripheral common, 52% x
Edema of lower extremities x
Nasal congestion Nasal congestion 24-65% x
Blood creatinine increased Serum creatinine increased 20-56% x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage 34% x
Chest pain Chest discomfort 32%
Chest pain x x
Chest discomfort Chest discomfort 32%
Abdominal pain Abdominal pain 31% x x
Gastrointestinal pain Abdominal pain 31% x x
Disseminated intravascular coagulation Disseminated intravascular coagulation 26%
Gastrointestinal disorder Gastrointestinal disorder 26%
Gastrointestinal symptom NOS postmarketing x x x
Respiratory failure Respiratory insufficiency 26% x
Mucosal inflammation Mucosal inflammation 26%
Arrhythmia Arrhythmia 23% x
Diarrhoea Diarrhoea postmarketing, 23% x
Weight increased Weight increased 23% - 32% x
Ototoxicity Ototoxicity 19-25% x
Pleural effusion Pleural effusion 20% x
Hyperhidrosis Sweating increased 20%
Sweating postmarketing x x x x x
Decreased appetite Anorexia 17%
Decreased appetite
Anxiety Anxiety postmarketing, 17% x
Constipation Constipation 17% x
Injection site reaction Injection site reaction 17%
Blood bilirubin increased Blood bilirubin increased 16% x
Excoriation Excoriation very common x x
Skin irritation Skin irritation very common, 3.8% - 6.4% x x x x
Tenderness Tenderness very common x
Skin exfoliation Skin exfoliation common — 1.44% - 50% x x x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x x x
Pain of skin Skin tenderness very common x
Pain of skin very common, 0% - 1.04% x x
Erythema Redness very common x x x
Erythema very common, 0.205% - 41% x x x x x x x x x x x x
Erythema facial postmarketing x x x
Application site erythema Application site erythema very common x
Application site pruritus Application site pruritus very common x
Application site pain Application site stinging very common x
Dyspepsia Dyspepsia 14%
Hypotension Hypotension 14% x
Pneumonia Pneumonia 14%
Rales Rales 14% x
Wheezing Wheezing expiratory 14%
Wheezing
Retinoic acid syndrome Retinoic acid syndrome postmarketing, 25% x x
Abdominal distension Abdominal distension 11%
Confusional state Confusional state 11% x
Feeling abnormal Confusional state 11% x
Malaise postmarketing, 66% x x x x
Hypertension Hypertension 11%
Phlebitis Phlebitis uncommon, 11% x
Eye irritation Eye irritation postmarketing, 11% x
Renal failure Renal impairment 11%
Renal failure postmarketing x
Renal impairment Renal impairment 11%
Dysuria Dysuria 9%
Flank pain Flank pain 9%
Hepatosplenomegaly Hepatosplenomegaly 9%
Agitation Agitation 9%
Intracranial pressure increased Intracranial pressure increased postmarketing, 9% x x x
Cerebral haemorrhage Cerebral haemorrhage 9%
Cellulitis Cellulitis uncommon, 8% x
Embolism Embolism 8% x
Skin burning sensation Skin burning sensation very common, 1.64% - 7.86% x x
Alopecia Alopecia postmarketing, 13% - 14% x x x x x
Alopecia reversible postmarketing x
Hallucination Hallucination 6%
Cardiac failure Cardiac failure 6%
Pallor Pallor 6%
Pericarditis Pericarditis 6% x
Lung infiltration Lung infiltration 6% x
Face oedema Face oedema 6%
Fluid imbalance Fluid imbalance 6%
Inflammation Inflammation common x x
Skin ulcer Skin ulcer common x
Skin discolouration Skin discolouration common x
Pain Stinging common x x x x x x x
Pain postmarketing — 0% - 37% x x x x x x x
Generalized aching
Paraesthesia Tingling sensation common x x
Paraesthesia postmarketing — 0% - 22% x x x x x x x x
Pruritus Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x x
Dry skin Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x
Dry scalp
Rash Rash postmarketing — 1% - 54% x x x x x x x x x
Acidosis Acidosis 3%
Ascites Ascites 3%
Dermatitis exfoliative Dermatitis exfoliative common, 0% - 9% x x x
Oedema Oedema postmarketing — 0% - 29% x x x x x x x x x x x x x
Body temperature decreased Body temperature decreased 3%
Hypothermia Body temperature decreased 3%
Renal failure acute Renal failure acute 3%
Laryngeal oedema Laryngeal oedema 3%
Liver disorder Liver disorder 3%
Hepatocellular injury Liver disorder 3%
Foetor hepaticus Liver disorder 3%
Lung disorder Lung disorder 3%
Osteitis Osteitis 3%
Pulmonary oedema Pulmonary oedema 3%
Scotoma Scotoma 3%
Telangiectasia Telangiectasia 3% x
Ulcer Ulcer 3%
Pollakiuria Pollakiuria 3%
Prostatomegaly Prostatomegaly 3%
Renal tubular necrosis Renal tubular necrosis 3%
Swelling Swelling postmarketing, common x x
Hyperaesthesia Hyperaesthesia 2% x
Rosacea Rosacea 1% x
Skin disorder Skin disorder very common, 0% - 8% x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x
Papule Papule 1% x
Acne Acne postmarketing, 1% - 5% x
Bacterial infection Bacterial infection uncommon x
Angiopathy Angiopathy uncommon x
Rash pustular Vesiculobullous rash uncommon x
Dermatitis bullous Vesiculobullous rash uncommon x
Blister x x x
Rash maculo-papular Rash maculo-papular uncommon x
Aggression Aggression postmarketing x
Violent postmarketing x x
Violent behavior postmarketing
Agranulocytosis Agranulocytosis postmarketing x x
Anaphylactic shock Anaphylactic shock postmarketing
Anaemia Anaemia postmarketing x x x x
Arthralgia Arthralgia postmarketing, 20-30% x x x x x
Musculoskeletal discomfort Arthralgia postmarketing, 20-30% x x x x x
Myalgia postmarketing, 14% x x
Musculoskeletal discomfort
Arthritis Arthritis postmarketing x x x
Asthenia Asthenia postmarketing x x x
Fatigue postmarketing x x x x
Asthma Asthma postmarketing, 3% x
Back pain Back pain postmarketing x x
Abnormal behaviour Behavior disorder postmarketing x
Mental disorder Mental disorder postmarketing x x x
Blepharitis Blepharitis postmarketing x x x
Bronchospasm Bronchospasm postmarketing x x x x
Cardiovascular disorder Cardiovascular disorder postmarketing
Nervous system disorder Central nervous system disorder postmarketing x
Cerebellar syndrome
Nervous system disorder x
Cheilitis Cheilitis postmarketing, 24-65% - 96% x x x x x
Colitis Colitis postmarketing x x x x
Infection Infection postmarketing — 58% x x x
Secondary infection x
Conjunctivitis Conjunctivitis postmarketing, 19% x x x x x
Contusion Contusion postmarketing x x x
Corneal opacity Corneal opacity postmarketing x x x x
Deafness Deafness postmarketing
Hearing impaired postmarketing x x
Diabetes mellitus Diabetes mellitus postmarketing
Dizziness Dizziness postmarketing, 20% x x x x
Syncope postmarketing x x
Lightheadedness
Somnolence Drowsiness postmarketing x x x
Somnolence
Eczema Eczema postmarketing x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing
Epistaxis Epistaxis postmarketing x x x x
Erythema multiforme Erythema multiforme postmarketing
Stevens-Johnson syndrome postmarketing
Erythema nodosum Erythema nodosum postmarketing x x
Oesophagitis Oesophagitis postmarketing x
Fatigue Fatigue postmarketing x x x x
Flushing Flushing postmarketing, 23% x x x x
Gingivitis Gingivitis postmarketing x x x
Glomerulonephritis Glomerulonephritis postmarketing x x x
Headache Headache postmarketing, 29-90% - 86% x x x x x x
Headache occurring x
Hearing impaired Partial hearing loss postmarketing x x
Hearing impaired postmarketing x x
Auditory disorder NOS x
Haematuria Haematuria postmarketing x x
Frank hematuria postmarketing x x
Haemorrhage Haemorrhage postmarketing — 60% x x x x x x
Haemoglobin Haemorrhage postmarketing — 60% x x x x x x
Hepatitis Hepatitis postmarketing, 3% x x x
Herpes simplex Herpes simplex postmarketing x x x
Hirsutism Hirsutism postmarketing x x x x
Dysphonia Hoarseness postmarketing x x
Exostosis Hyperostosis postmarketing x x x x
Exostosis postmarketing
Hypersensitivity Hypersensitivity postmarketing, uncommon x x x x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia postmarketing x x x x
Blood triglycerides increased Hypertriglyceridaemia postmarketing x x x x
Blood triglycerides increased
Hypervitaminosis A Hypervitaminosis A postmarketing x x
Ileitis Ileitis postmarketing x x x
Inflammatory bowel disease Inflammatory bowel disease postmarketing x x x x
Keratitis Keratitis postmarketing x x x x
Lethargy Lethargy postmarketing x x x
Menstrual disorder Menstrual disorder postmarketing x x x
Myositis Myositis postmarketing x x
Nasopharyngitis Nasopharyngitis postmarketing
Nausea Nausea postmarketing x x x x x x
Nervousness Nervousness postmarketing x x x
Tension Nervousness postmarketing x x x
Neutropenia Neutropenia postmarketing x x x
Optic neuritis Optic neuritis postmarketing x x x
Papilloedema postmarketing x
Palpitations Palpitations postmarketing x x x
Pancreatitis Pancreatitis postmarketing x x x x x
Papilloedema Papilloedema postmarketing x
Paronychia Paronychia postmarketing x x x x
Pregnancy Pregnancy postmarketing x
Proteinuria Proteinuria postmarketing x x x
Protein urine present Proteinuria postmarketing x x x
Benign intracranial hypertension Benign intracranial hypertension postmarketing x x x x x x
Psychotic disorder Psychotic disorder postmarketing x x x
Respiratory tract infection Respiratory tract infection postmarketing x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x
Seborrhoeic dermatitis Seborrhoeic dermatitis postmarketing x x
Convulsion Convulsion postmarketing x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing
Cerebrovascular accident Cerebrovascular accident postmarketing x x x
Completed suicide Suicide postmarketing x x
Suicide attempt Suicide attempt postmarketing x x x
Sunburn Sunburn postmarketing, 0.616% - 1.04% x x x x
Photosensitivity reaction Sunburn postmarketing, 0.616% - 1.04% x x x x
Photosensitivity reaction postmarketing x x x x x
Photosensitivity postmarketing x
Shock Syncope postmarketing x x
Shock x
Syncope Syncope postmarketing x x
Loss of consciousness Syncope postmarketing x x
Loss of consciousness
Tachycardia Tachycardia postmarketing x x x x
Tendonitis Tendonitis postmarketing x x x
Thrombocytopenia Thrombocytopenia postmarketing x x
Tinnitus Tinnitus postmarketing x x
Ear buzzing
Urticaria Urticaria postmarketing x x x x x x
Vasculitis Vasculitis postmarketing x x x x
Visual impairment Disorder sight postmarketing x x
Visual disturbance postmarketing, 17% x x x x x
Visual impairment postmarketing x
Granulomatosis with polyangiitis Wegener's granulomatosis postmarketing x x x
Weight decreased Weight decreased postmarketing, 17% x x x
Dry mouth Dry mouth postmarketing, 1% x x x
Acute febrile neutrophilic dermatosis Acute febrile neutrophilic dermatosis postmarketing x x
Mood swings Mood swings postmarketing x x x
Affect lability Mood swings postmarketing x x x
Photophobia Photophobia postmarketing x x x x x
Pyogenic granuloma Pyogenic granuloma postmarketing x x x x
Cataract Cataract postmarketing x x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis postmarketing x x
Skin atrophy Skin atrophy postmarketing x
Epiphyses premature fusion Epiphyses premature fusion postmarketing x x x
Impaired healing Impaired healing postmarketing x x
Blood alkaline phosphatase increased Phosphatase alkaline increased postmarketing x x
Blood alkaline phosphatase increased
Oesophageal ulcer Oesophageal ulcer postmarketing x
Sensory disturbance Sensory disturbance postmarketing
Hair disorder Abnormalities of the hair postmarketing x x
Hair disorder x
Skin hyperpigmentation Skin hyperpigmentation postmarketing, common x x x
Leukoderma Leukoderma postmarketing x x x x x x x x x
Scab Scab postmarketing, very common x x x x
Xanthoma Eruptive xanthoma postmarketing x x
Nail dystrophy Nail dystrophy postmarketing x x x x
Contact lens intolerance Contact lens intolerance postmarketing
Malaise Malaise postmarketing, 66% x x x x
Discomfort Malaise postmarketing, 66% x x x x
Discomfort x
Ill-defined disorder Malaise postmarketing, 66% x x x x
Myalgia Myalgia postmarketing, 14% x x
Nasal dryness Nasal dryness postmarketing, 51% x x x x
Application site oedema Application site oedema postmarketing
Dry throat Dry throat postmarketing
Hepatotoxicity Hepatotoxicity postmarketing x x x
Depression Depression aggravated postmarketing
Depression x
Blood creatine phosphokinase increased Creatine phosphokinase serum increased postmarketing
Creatine phosphokinase increased x
Sepsis Sepsis postmarketing x x
Septicemia
Acne fulminans Acne fulminans postmarketing x x x x
Excessive granulation tissue Excessive granulation tissue postmarketing x x
Dry eye Dry eye postmarketing x x x
Dry eye syndrome x
Vision blurred Vision blurred postmarketing
Suicidal ideation Suicidal ideation postmarketing x x
Lymphadenopathy Lymphadenopathy postmarketing — 10% x x x x x x
Application site rash Application site rash postmarketing
Skin fragility Skin fragility postmarketing x x x
Lip dry Lip dry postmarketing x x
Blood glucose increased Blood glucose increased postmarketing x
Basophilia Basophilia postmarketing x x
Blood uric acid increased Hyperuricaemia postmarketing x x x x
Hyperuricaemia Hyperuricaemia postmarketing x x x x
Thrombocytosis Thrombocytosis postmarketing x
Night blindness Decreased night vision postmarketing x x x x
Insomnia Insomnia postmarketing, 14% x x x x
Acquired immunodeficiency syndrome Acquired immunodeficiency syndrome x x x
Autoimmune disorder Acquired immunodeficiency syndrome x x x
Pancreatitis acute Pancreatitis acute x
Agnosia Agnosia
Anger Anger
Aphasia Aphasia
Asthenopia Asthenopia
Blister Blister x x x
Coagulopathy Clotting
Neoplasm malignant Neoplasm malignant x
Candida infection Candida infection
Cerebellar syndrome Cerebellar syndrome
Neck pain Neck pain
Coma Coma
Cough Cough x
Cyanosis Cyanosis
Cystitis Cystitis
Bladder pain Cystitis
Cystitis noninfective Cystitis
Dysphagia Dysphagia
Dehydration Dehydration
Dermatitis contact Dermatitis contact
Allergic contact dermatitis x
Lacrimation decreased Dry eye syndrome x
Duodenal ulcer Duodenal ulcer x
Dysarthria Dysarthria
Osteoarthritis Dysarthria
Ear disorder Ear disorder
Ear pain Ear pain
Eye disorder Eye disorder x
VIIth nerve paralysis Facial paralysis
Fasciitis Fasciitis x
Flatulence Flatulence
Folliculitis Folliculitis x
Gastritis Gastritis x
Gout Gout
Cardiac arrest Cardiac arrest
Cardiomegaly Cardiomegaly
Cardiac failure congestive Cardiac failure congestive x
Cardiac murmur Cardiac murmur
Hemiplegia Hemiplegia
Hordeolum Hordeolum
Hypercalcaemia Hypercalcaemia x x
Hypercholesterolaemia Hypercholesterolaemia x
Hyperlipidaemia Hyperlipidaemia x
Pulmonary hypertension Pulmonary hypertension
Irritability Irritability
Ischaemia Ischaemia
Leukocytosis Leukocytosis
Miliaria Miliaria x
Multi-organ failure Multi-organ failure x
Musculoskeletal pain Musculoskeletal pain
Myocardial infarction Myocardial infarction x
Acute coronary syndrome Myocardial infarction x
Myocarditis Myocarditis
Nail disorder Nail disorder
Hypoaesthesia Numbness
Sensory loss Numbness
Ochronosis Ochronosis x
IIIrd nerve paralysis Ophthalmoplegia x
Ophthalmoplegia Ophthalmoplegia x
Pain in extremity Pain in extremity
Pericardial effusion Pericardial effusion x
Neuropathy peripheral Neuropathy peripheral
Pharyngitis Pharyngitis
Renal infarct Renal infarct x
Retinal haemorrhage Retinal haemorrhage x
Cardiomyopathy Cardiomyopathy secondary NOS
Sinusitis Sinusitis
Skin infection Skin infection x
Spinal cord disorder Spinal cord disorder
Stomatitis Stomatitis
Thrombosis Thrombosis x x
Tremor Tremor
Upper respiratory tract infection Upper respiratory tract infection
Urinary tract infection Urinary tract infection
Urethral disorder Urinary tract disorder
Urinary tract disorder Urinary tract disorder
Xeroderma Xeroderma
Xerophthalmia Xerophthalmia
Encephalopathy Encephalopathy
Panic attack Panic attack
Genital ulceration Genital ulceration x
Application site reaction Application site reaction x
Depressed level of consciousness CNS depression NOS
Red blood cell sedimentation rate increased Red blood cell sedimentation rate increased x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased
Hyporeflexia Hyporeflexia
Drug tolerance decreased Decreased tolerance x
Lacrimation increased Lacrimation increased
Skin striae Skin striae x
Endophthalmitis Ocular hyperaemia
Ocular hyperaemia Ocular hyperaemia
Malnutrition Malnutrition
Dermatitis acneiform Acneiform eruption x
Emotional distress Distress
Tachypnoea Tachypnoea
Asterixis Asterixis
Teratogenicity Teratogenicity x x
Hallucination, auditory Hallucination, auditory
Visual acuity reduced Visual acuity reduced
Neurological symptom Neurologic reaction
Euphoric mood Euphoric mood
Abdominal discomfort Upset stomach
Mouth ulceration Buccal mucosa ulceration
Groin pain Groin pain
Weight fluctuation Weight fluctuation
Crohn's disease Ileitis regional x
Rectal haemorrhage Rectal haemorrhage x
Scrotal ulcer Scrotal ulcer x
Lividity Lividity x
Cushingoid Cushingoid
Chapped lips Chapped lips
Respiratory distress Respiratory distress x
Dementia Dementia
Eschar Eschar x
Memory impairment Forgetfulness
Fluid overload Fluid overload
Gait disturbance Gait disturbance
Dermatitis atopic Cutaneous hypersensitivity x
Blood cholesterol increased Blood cholesterol increased
Drug interaction Drug interaction x
Hypoxia Hypoxemia
Febrile neutropenia Febrile neutropenia x
White blood cell count decreased White blood cell count decreased
Infestation Infestation NOS
Local reaction Local reaction x x
Musculoskeletal stiffness Musculoskeletal stiffness
Brain oedema Cerebellar oedema
Sensitisation Sensitisation x
Post-traumatic pain Post-traumatic pain
Slow speech Slow speech
Blindness Unspecified visual loss x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

tretinoin / Retin-A

Side effects:3
Source:FDA

TRETINOIN / VITAMIN A ACID 0.01% GEL

Side effects:5
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:9
Source:FDA Structured Product Label

tretinoin gel / Retin-A MICRO

Side effects:9
Source:FDA

Isotretinoin

Side effects:13
Source:medicines.org.au

ALITRETINOIN / PANRETIN

Side effects:20
Source:FDA

/ TRI-LUMA

Side effects:24
Source:FDA

alitretinoin / alitretinoin

Side effects:40
Source:EMA

Tretinoin

Side effects:65
Source:BC Cancer

ISOTRETINOIN / CLARUS

Side effects:101
Source:Health Canada

isotretinoin / Accutane

Side effects:102
Source:FDA

isotretinoin

Side effects:112
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label