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Retinoic acid

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Fever 83% x
Mucosal dryness 77%
Bone pain 20-30% - 77% x
Shivering 63% x
Dyspnea 60% x
Vomiting 51% - 57% x x
Dermatitis postmarketing — 55% x x x x
Peripheral edema common, 52%
Nasal congestion (finding) 24-65%
Serum creatinine increased 20-56%
Gastrointestinal Hemorrhage 34% x
Chest discomfort 32%
Abdominal Pain 31% x x x
Gastrointestinal Diseases 26%
Mucositis 26%
Disseminated Intravascular Coagulation 26%
Respiratory Insufficiency 26% x
Diarrhea postmarketing, 23% x x x
Cardiac Arrhythmia 23% x
Weight Gain 23% - 32%
Ototoxicity 19-25%
Increased sweating 20%
Pleural effusion disorder 20% x
Constipation 17% x x
Injection site reaction 17%
Anorexia 17%
Anxiety postmarketing, 17% x x
Increased bilirubin level (finding) 16% x
Peeling of skin common — 1.44% - 50% x x x
Application site stinging very common x
Application site pruritus very common x
Application site erythema very common x
Sore to touch very common
Redness very common
Excoriation very common
Skin irritation very common x x x
Skin tenderness very common x
Rales 14%
Wheezing expiratory 14%
Dyspepsia 14%
Hypotension 14%
Pneumonia 14%
Retinoic acid syndrome postmarketing, 25% x
Phlebitis uncommon, 11%
Abdomen distended 11%
Hypertensive disease 11%
Confusion 11% x
Renal Insufficiency 11%
Eye irritation postmarketing, 11% x x
Intracranial Hypertension postmarketing, 9% x x
Hepatosplenomegaly 9%
Agitation 9%
Flank Pain 9%
Dysuria 9%
Cerebral Hemorrhage 9%
Cellulitis uncommon, 8%
Embolism 8%
Burning sensation of skin very common, 1.64% - 7.86% x x
Erythema very common, 0.205% - 41% x x x x x x
Alopecia postmarketing, 13% - 14% x x x x
Hallucinations 6%
Pallor 6%
Pericarditis 6%
Lung infiltration 6%
Actual Impaired Fluid Volume 6%
Heart failure 6%
Facial edema 6%
Stinging Sensation common x x
Inflammation common
Has tingling sensation common
Skin Ulcer common
Discoloration of skin common
Pain postmarketing — 0% - 37% x x x
Pruritus postmarketing — 0.616% - 30% x x x x x x x x
Dry skin postmarketing — 1.64% - 24-65% x x x x x
Exanthema postmarketing — 1% - 54% x x x x
Hypothermia, natural 3%
Increased frequency of micturition 3%
Edema postmarketing — 0% - 29% x x x x x
Pulmonary Edema 3%
Laryngeal Edema 3%
Exfoliative dermatitis common, 0% - 9% x
Scotoma 3%
Renal Tubule Necrosis 3%
Acidosis 3%
Ascites 3%
Lung diseases 3%
Osteitis 3%
Paresthesia postmarketing — 0% - 22% x x x x
Telangiectasis 3%
Liver diseases 3%
Kidney Failure, Acute 3%
Prostatomegaly 3%
Ulcer 3%
Swelling postmarketing, common
Hyperesthesia 2%
Pain of skin very common, 0% - 1.04% x x
Papule 1%
Dermatologic disorders very common, 0% - 8% x
Rosacea 1%
Acne postmarketing, 1% - 5%
Vascular Diseases uncommon
Rash maculo-papular uncommon
Vesiculobullous rash uncommon
Bacterial Infections uncommon
Body Weight decreased postmarketing, 17% x x
Thrombocytosis postmarketing x
Pyogenic granuloma postmarketing x x x
Impaired healing postmarketing x
Dryness of eye postmarketing x x
Herpes Simplex Infections postmarketing x x
Hypersensitivity postmarketing, uncommon x x x
Esophagitis postmarketing x
Communicable Diseases postmarketing — 58% x
Lethargy postmarketing x x
Papilledema postmarketing x
Tinnitus postmarketing x x
Tendinitis postmarketing x x
Rhabdomyolysis postmarketing x x
Feeling suicidal (finding) postmarketing x
Violent postmarketing x x
Asthenia postmarketing x x
Hypertriglyceridemia postmarketing x x
Arthralgia postmarketing, 20-30% x x
Excessive granulation tissue postmarketing x
Pancreatitis postmarketing x x x x
Application site oedema postmarketing
Application site rash postmarketing
Respiratory Tract Infections postmarketing x x
Kidney Failure postmarketing
Hoarseness postmarketing x x
Vasculitis, Leukocytoclastic, Cutaneous postmarketing x x
Eczema postmarketing x
Epiphyses premature fusion postmarketing x x
Blood glucose increased postmarketing x
Stevens-Johnson Syndrome postmarketing x
Nervousness postmarketing x x
Dermatitis, Phototoxic postmarketing x x x x
Lymphadenopathy postmarketing — 10% x x x
Cardiovascular Diseases postmarketing
Eruptive xanthoma postmarketing x
Photosensitivity of skin postmarketing
Hypervitaminosis A postmarketing x x
Sweet Syndrome postmarketing x
hearing impairment postmarketing x
Myalgia postmarketing, 14% x x
Menstruation Disturbances postmarketing x x
Cataract postmarketing x x x
Diabetes Mellitus postmarketing
Atrophic condition of skin postmarketing
CNS disorder postmarketing x
Photophobia postmarketing x x
Suicide attempt postmarketing x x
Visual Impairment postmarketing x
Anemia postmarketing x x x
Back Pain postmarketing x x
Bronchial Spasm postmarketing x x x
On examination - dry lips postmarketing x
Palpitations postmarketing x x
Myositis postmarketing x
Frank hematuria postmarketing x
Acne fulminans postmarketing x x x
Hemorrhage postmarketing — 60% x x x
Pseudotumor Cerebri postmarketing x x x x
Proteinuria postmarketing x x
Psychotic Disorders postmarketing x x
Thrombocytopenia postmarketing x x
Suicide postmarketing x x
Mood swings postmarketing x x
Hyperostosis postmarketing x x x
Keratitis postmarketing x x x
Contusions postmarketing x x
Basophilia postmarketing x
Dizziness postmarketing, 20% x x x
Drowsiness postmarketing x x
Mental disorders postmarketing x x
Nasal dryness postmarketing, 51% x x x
Blepharitis postmarketing x x
Skin and subcutaneous tissue disorders postmarketing x
Erythema facial postmarketing x x
gastrointestinal symptom postmarketing x x
Sepsis postmarketing x
Cheilitis postmarketing, 24-65% - 96% x x x
Nausea postmarketing x x x x
Deafness postmarketing
Depression aggravated postmarketing
Hepatitis postmarketing, 3% x x x
Dry throat postmarketing
Colitis postmarketing x x x
Hyperuricemia postmarketing x x x
Syncope postmarketing x
Alkaline phosphatase raised postmarketing
anaphylaxis postmarketing
Hypopigmentation disorder postmarketing x x x
Creatine phosphokinase serum increased postmarketing
Urticaria postmarketing x x x
Flushing postmarketing, 23% x x x
Seborrheic dermatitis postmarketing x
Ileitis postmarketing x x
Asthma postmarketing, 3%
Vasculitis postmarketing x x x
Agranulocytosis postmarketing x
Pregnancy postmarketing x
Hyperpigmentation postmarketing, common x
Sweating postmarketing x x x x
Localized desquamation postmarketing — 1.44% - 11.6% x x x x x
Wegener Granulomatosis postmarketing x x x
Decreased night vision postmarketing x x
Ulcer of esophagus postmarketing x
Sleeplessness postmarketing, 14% x x x
Abnormalities of the hair postmarketing x
Glomerulonephritis postmarketing x x
Conjunctivitis postmarketing, 19% x x x
Hirsutism postmarketing x x x
Dystrophia unguium postmarketing x x x
Erythema Multiforme postmarketing x
Malaise postmarketing, 66% x x x
Fatigue postmarketing x x
Alopecia reversible postmarketing x
Hematuria postmarketing x
Hepatotoxicity postmarketing x
Neutropenia postmarketing x x
Sunburn postmarketing, 0.616% - 1.04% x x x
Toxic Epidermal Necrolysis postmarketing x
Gingivitis postmarketing x x
Aggressive behavior postmarketing x
Paronychia Inflammation postmarketing x x x
Contact lens intolerance postmarketing
Cerebrovascular accident postmarketing x x x
Arthritis postmarketing x x
Skin fragility postmarketing x x
Epistaxis postmarketing x x x
Tachycardia postmarketing x x
Erythema Nodosum postmarketing x x
Headache postmarketing, 29-90% - 86% x x x x
Corneal Opacity postmarketing x x x
Sensory Disorders postmarketing
Xerostomia postmarketing, 1%
Hearing Loss, Partial postmarketing x x
Blurred vision postmarketing x x
Seizures postmarketing x x x
Behavior Disorders postmarketing x
Vision Disorders postmarketing x
Scab postmarketing, very common x
Inflammatory Bowel Diseases postmarketing x x x
Visual disturbance postmarketing, 17% x x x
Exostoses postmarketing
Violent behavior postmarketing
Optic Neuritis postmarketing x x
Nasopharyngitis postmarketing x
Earache
Creatine phosphokinase increased x
Gastritis
Numbness
Gout
Ochronosis
Blood alkaline phosphatase increased x
Crohn's disease of the ileum x
Red blood cell sedimentation rate increased x x
Drug Interactions
Bulla x
Gait abnormality
Duodenal Ulcer
Deglutition Disorders
Rectal hemorrhage x
Stomatitis
Urologic Diseases
Hyperlipidemia x
Pericardial effusion
Hearing problem x x
Pancreatitis acute
Renal infarct x
Secondary Infections
Acneiform Eruptions
Encephalopathies
Cerebellar Diseases
Slow speech
Hordeolum x
Pharyngitis
Xerophthalmia
Thrombosis x
Visual acuity reduced x
Tachypnea
Cardiac Arrest
Coughing
Musculoskeletal discomfort x
Application site reaction
Urinary tract infection
Pain in limb x
Contact Dermatitis x
Dysarthria
Malignant Neoplasms
Hypoxemia
Multiple Organ Failure
Agnosia
Teratogenesis x
Myocarditis
Lactic dehydrogenase activity increased x
Comatose
nervous system disorder
Hallucinations, Auditory x
Asthenopia x
Cystitis
Unconscious State
Septicemia
Distress
Ophthalmoplegia
Mental Depression x
Panic Attacks x
Spinal Cord Diseases
Chest Pain x
Eschar
Ear buzzing
Blood and lymphatic system disorders
Infestation x
Hypercalcemia x
Upper Respiratory Infections x
Musculoskeletal stiffness x
Upset stomach
Hyporeflexia
Hair Diseases x
Local reaction x
Decrease in appetite x
Congestive heart failure
Aphasia
Xeroderma
Buccal mucosa ulceration
Ischemia
Excessive tearing x
Headache occurring
Dehydration
Euphoric mood x
Blood triglycerides increased x
Forgetfulness
Dementia
Cardiomegaly
Disorder of eye
Cerebellar oedema
Folliculitis
Ocular hyperemia x
Lividity
Peripheral Neuropathy
Malnutrition
Dry scalp
Febrile Neutropenia
Sensory Discomfort
Candidiasis
Skin Diseases, Infectious x
Weight fluctuation x
Tremor
Nail Diseases
Unspecified visual loss
Post-traumatic pain
Chapped lips x
Ear Diseases
Fluid overload
Somnolence
Leukocytosis
Fasciitis
Blood coagulation
Cutaneous hypersensitivity
Myocardial Diseases, Secondary
Flatulence
Genital ulceration x
Hemiplegia
Linear atrophy
Generalized aches and pains
Sinusitis
Asterixis
Cushingoid facies
Wheezing
Lightheadedness
Miliaria
Cyanosis
Pulmonary Hypertension
Facial paralysis
Blood cholesterol increased x
White blood cell count decreased x
Neurologic reaction
Shock
Groin pain
Heart murmur
Edema of lower extremities
TOLERANCE DECREASED x
Dry Eye Syndromes x
Anger x
Perioral Dermatitis
Irritable Mood x
Scrotal ulcer
Hypercholesterolemia
Retinal Hemorrhage
Dermatitis, Allergic Contact
Sensitisation
Myocardial Infarction x
Musculoskeletal Pain x
Acquired Immunodeficiency Syndrome x
Central nervous system depression (disorder)
Neck Pain x
Respiratory distress

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

Isotretinoin

Side effects:13
Source:medicines.org.au

ISOTRETINOIN / ACCUTANE ROCHE

Side effects:106
Source:Health Canada

ISOTRETINOIN

Side effects:148
Source:FDA Structured Product Label

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label