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Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Show MedDRA Preferred Terms,   display all 37 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased 83% x x x
Bone pain 20-30% - 77% x x x
Mucosal dryness 77%
Shivering 63% x x x
Dyspnoea 60% x x x
Vomiting 51% - 57% x x x
Dermatitis postmarketing — 3.8% - 55% x x x
Oedema peripheral common, 52% x
Nasal congestion 24-65% x x
Serum creatinine increased 20-56% x
Gastrointestinal haemorrhage 34%
Chest discomfort 32% x
Abdominal pain 31% x x x
Disseminated intravascular coagulation 26% x
Gastrointestinal disorder 26%
Respiratory insufficiency 26% x x
Mucosal inflammation 26%
Arrhythmia 23% x x
Diarrhoea postmarketing, 23% x x
Weight increased 23% - 32% x
Ototoxicity 19-25% x
Pleural effusion 20% x x
Sweating increased 20% x
Anorexia 17% x
Anxiety postmarketing, 17% x x
Constipation 17% x x
Injection site reaction 17%
Blood bilirubin increased 16% x
Excoriation very common x
Skin irritation very common, 3.8% - 6.4% x x x x x x
Tenderness very common
Skin exfoliation common — 1.44% - 50% x x x x x
Skin tenderness very common x x
Redness very common x x x
Application site erythema very common x x
Application site pruritus very common x x
Application site stinging very common x x
Dyspepsia 14%
Hypotension 14% x x
Pneumonia 14% x
Rales 14% x x
Wheezing expiratory 14%
Retinoic acid syndrome postmarketing, 25% x x x
Abdominal distension 11% x
Confusional state 11% x x
Hypertension 11% x
Phlebitis uncommon, 11%
Eye irritation postmarketing, 11%
Renal impairment 11% x
Dysuria 9% x
Flank pain 9% x
Hepatosplenomegaly 9%
Agitation 9% x
Intracranial pressure increased postmarketing, 9% x x x x
Cerebral haemorrhage 9%
Cellulitis uncommon, 8%
Embolism 8% x
Skin burning sensation very common, 1.64% - 7.86% x x x
Erythema very common, 0.205% - 41% x x x x x x x x x x x
Alopecia postmarketing, 13% - 14% x x x x x
Hallucination 6%
Cardiac failure 6% x
Pallor 6% x
Pericarditis 6% x
Lung infiltration 6% x x
Face oedema 6%
Fluid imbalance 6%
Inflammation common x
Skin ulcer common
Skin discolouration common
Stinging common x x x x x x
Tingling sensation common x
Pain postmarketing — 0% - 37% x x x x x
Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x
Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x
Rash postmarketing — 1% - 54% x x x x x x x x
Acidosis 3% x
Ascites 3%
Dermatitis exfoliative common, 0% - 9% x x
Oedema postmarketing — 0% - 29% x x x x x x x x x x x
Body temperature decreased 3% x
Renal failure acute 3%
Laryngeal oedema 3%
Liver disorder 3%
Lung disorder 3%
Osteitis 3%
Paraesthesia postmarketing — 0% - 22% x x x x x x x
Pulmonary oedema 3%
Scotoma 3% x
Telangiectasia 3% x
Ulcer 3% x
Pollakiuria 3% x
Prostatomegaly 3%
Renal tubular necrosis 3%
Swelling postmarketing, common x x
Hyperaesthesia 2% x
Pain of skin very common, 0% - 1.04% x x x
Rosacea 1% x
Skin disorder very common, 0% - 8% x x
Papule 1% x
Acne postmarketing, 1% - 5% x
Bacterial infection uncommon
Angiopathy uncommon
Vesiculobullous rash uncommon
Rash maculo-papular uncommon
Aggression postmarketing x
Agranulocytosis postmarketing x x
Anaphylactic shock postmarketing
Anaemia postmarketing x x x
Arthralgia postmarketing, 20-30% x x x x
Arthritis postmarketing x x
Asthenia postmarketing x x x
Asthma postmarketing, 3% x
Back pain postmarketing x x x
Behavior disorder postmarketing x
Mental disorder postmarketing x x
Blepharitis postmarketing x x
Bronchospasm postmarketing x x x
Cardiovascular disorder postmarketing
Central nervous system disorder postmarketing x
Cheilitis postmarketing, 24-65% - 96% x x x x x
Colitis postmarketing x x x
Infection postmarketing — 58% x x x
Conjunctivitis postmarketing, 19% x x x x x
Contusion postmarketing x x
Corneal opacity postmarketing x x x
Deafness postmarketing
Diabetes mellitus postmarketing
Dizziness postmarketing, 20% x x x x
Drowsiness postmarketing x x
Eczema postmarketing x x
Toxic epidermal necrolysis postmarketing
Epistaxis postmarketing x x x x
Erythema multiforme postmarketing
Erythema nodosum postmarketing x x
Oesophagitis postmarketing x
Fatigue postmarketing x x x x
Flushing postmarketing, 23% x x x x
Gingivitis postmarketing x x
Glomerulonephritis postmarketing x x
Headache postmarketing, 29-90% - 86% x x x x x x
Partial hearing loss postmarketing x
Haematuria postmarketing x
Haemorrhage postmarketing — 60% x x x x x
Hepatitis postmarketing, 3% x x x
Herpes simplex postmarketing x x
Hirsutism postmarketing x x x
Hoarseness postmarketing x
Hyperostosis postmarketing x x x
Hypersensitivity postmarketing, uncommon x x x x x x
Hypertriglyceridaemia postmarketing x x x
Hypervitaminosis A postmarketing x x x
Ileitis postmarketing x x x
Inflammatory bowel disease postmarketing x x x
Keratitis postmarketing x x x
Lethargy postmarketing x x x
Menstrual disorder postmarketing x x
Myositis postmarketing x x x
Nasopharyngitis postmarketing
Nausea postmarketing x x x x x x
Nervousness postmarketing x x
Neutropenia postmarketing x x x
Optic neuritis postmarketing x x
Palpitations postmarketing x x
Pancreatitis postmarketing x x x x x
Papilloedema postmarketing x
Paronychia postmarketing x x x
Pregnancy postmarketing x
Proteinuria postmarketing x x
Benign intracranial hypertension postmarketing x x x x x x
Psychotic disorder postmarketing x x
Renal failure postmarketing x x
Respiratory tract infection postmarketing x x
Rhabdomyolysis postmarketing x
Seborrhoeic dermatitis postmarketing x x
Convulsion postmarketing x x x
Stevens-Johnson syndrome postmarketing
Cerebrovascular accident postmarketing x x x x
Suicide postmarketing x x
Suicide attempt postmarketing x x
Sunburn postmarketing, 0.616% - 1.04% x x x
Sweating postmarketing x x x x
Syncope postmarketing x x
Tachycardia postmarketing x x x x
Tendonitis postmarketing x x
Thrombocytopenia postmarketing x x
Tinnitus postmarketing x x
Urticaria postmarketing x x x x
Vasculitis postmarketing x x x x
Disorder sight postmarketing x x
Wegener's granulomatosis postmarketing x x
Weight decreased postmarketing, 17% x x
Dry mouth postmarketing, 1% x x x x
Acute febrile neutrophilic dermatosis postmarketing x x x
Mood swings postmarketing x x
Photophobia postmarketing x x x x x
Pyogenic granuloma postmarketing x x x
Cataract postmarketing x x x
Allergic cutaneous angiitis postmarketing x
Skin atrophy postmarketing x x
Epiphyses premature fusion postmarketing x x x
Impaired healing postmarketing x x
Phosphatase alkaline increased postmarketing x x
Oesophageal ulcer postmarketing x
Sensory disturbance postmarketing
Abnormalities of the hair postmarketing x x
Photosensitivity reaction postmarketing x x x x x x
Skin hyperpigmentation postmarketing, common x x x
Leukoderma postmarketing x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x
Scab postmarketing, very common x x x
Eruptive xanthoma postmarketing x x
Nail dystrophy postmarketing x x x
Contact lens intolerance postmarketing
Malaise postmarketing, 66% x x x x
Myalgia postmarketing, 14% x
Nasal dryness postmarketing, 51% x x x x
Application site oedema postmarketing x
Dry throat postmarketing
Hepatotoxicity postmarketing x x
Depression aggravated postmarketing
Erythema facial postmarketing x x
Creatine phosphokinase serum increased postmarketing
Violent postmarketing x
Sepsis postmarketing x
Acne fulminans postmarketing x x x
Excessive granulation tissue postmarketing x x
Dry eye postmarketing x x
Vision blurred postmarketing x
Photosensitivity postmarketing x
Suicidal ideation postmarketing x x
Violent behavior postmarketing
Gastrointestinal symptom NOS postmarketing x x
Frank hematuria postmarketing x x
Lymphadenopathy postmarketing — 10% x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x
Application site rash postmarketing x
Visual disturbance postmarketing, 17% x x x x x
Skin fragility postmarketing x x
Lip dry postmarketing x x
Blood glucose increased postmarketing
Basophilia postmarketing x x x
Hyperuricaemia postmarketing x x x
Thrombocytosis postmarketing x x
Alopecia reversible postmarketing x
Decreased night vision postmarketing x x x
Insomnia postmarketing, 14% x x x x
Hearing impaired postmarketing x x
Exostosis postmarketing
Visual impairment postmarketing
Acquired immunodeficiency syndrome x x
Pancreatitis acute
Agnosia
Anger
Aphasia
Asthenopia
Blister x x x
Clotting x
Neoplasm malignant x
Candida infection x
Cerebellar syndrome
Neck pain
Chest pain x x x
Coma
Cough x x
Cyanosis x
Cystitis x
Dysphagia x
Dehydration x
Depression
Dermatitis contact
Dry eye syndrome x
Duodenal ulcer x
Dysarthria
Ear disorder
Ear pain x
Eye disorder
Facial paralysis
Fasciitis x
Flatulence x
Folliculitis x
Gastritis x
Gout x
Hair disorder
Cardiac arrest
Cardiomegaly x
Cardiac failure congestive x
Cardiac murmur
Hemiplegia
Hordeolum
Hypercalcaemia x x x
Hypercholesterolaemia x
Hyperlipidaemia x
Pulmonary hypertension
Irritability
Ischaemia
Leukocytosis
Miliaria x
Multi-organ failure x
Musculoskeletal pain x
Myocardial infarction x x
Myocarditis
Nail disorder x
Nervous system disorder
Numbness x
Ochronosis x
Ophthalmoplegia x
Pain in extremity
Pericardial effusion x
Neuropathy peripheral
Pharyngitis x
Renal infarct x x
Retinal haemorrhage x
Cardiomyopathy secondary NOS
Septicemia x
Shock x
Sinusitis x
Skin infection
Spinal cord disorder
Stomatitis x
Thrombosis x x x
Tremor
Loss of consciousness
Upper respiratory tract infection
Urinary tract infection x
Urinary tract disorder
Wheezing
Xeroderma x
Xerophthalmia x
Encephalopathy
Panic attack
Genital ulceration x
Application site reaction
CNS depression NOS
Creatine phosphokinase increased
Red blood cell sedimentation rate increased x
Lactic dehydrogenase activity increased
Hyporeflexia x
Decreased tolerance
Lacrimation increased
Skin striae x
Ocular hyperaemia
Malnutrition x
Allergic contact dermatitis x
Acneiform eruption x
Lightheadedness x
Distress
Tachypnoea x
Decreased appetite
Asterixis
Teratogenicity x x
Hallucination, auditory
Discomfort x
Visual acuity reduced
Neurologic reaction x
Euphoric mood
Ear buzzing x
Upset stomach x
Buccal mucosa ulceration x
Edema of lower extremities x
Groin pain x
Weight fluctuation
Auditory disorder NOS x
Dermatitis perioral x
Ileitis regional
Rectal haemorrhage
Scrotal ulcer x
Generalized aching x
Lividity x
Cushingoid x
Chapped lips
Secondary infection x
Respiratory distress x x
Dementia
Eschar x
Forgetfulness x
Fluid overload x
Gait disturbance x
Cutaneous hypersensitivity x
Blood cholesterol increased
Drug interaction
Hypoxemia
Febrile neutropenia x
White blood cell count decreased
Dry scalp x
Infestation NOS
Blood and lymphatic system disorders
Blood alkaline phosphatase increased
Blood triglycerides increased
Local reaction x x x
Headache occurring x
Musculoskeletal stiffness
Musculoskeletal discomfort
Cerebellar oedema
Sensitisation x
Post-traumatic pain x
Slow speech
Somnolence
Unspecified visual loss x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

tretinoin / Retin-A

Side effects:3
Source:FDA

TRETINOIN / VITAMIN A ACID 0.01% GEL

Side effects:5
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

TRETINOIN

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:9
Source:FDA Structured Product Label

Isotretinoin

Side effects:13
Source:medicines.org.au

ALITRETINOIN / PANRETIN

Side effects:20
Source:FDA

/ TRI-LUMA

Side effects:24
Source:FDA

Tretinoin

Side effects:65
Source:BC Cancer

isotretinoin / Accutane

Side effects:102
Source:FDA

isotretinoin

Side effects:112
Source:FDA Structured Product Label

TRETINOIN / VESANOID - CAP 10MG

Side effects:120
Source:Health Canada

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label