Tretinoin

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 21)
1 2 3 4 5 6 7 8 9 10
Dry skin def postmarketing, 16.2% 1.64% x x x x x x
Skin exfoliation 11.6% 1.44% x x x x
Localized exfoliation def postmarketing, 11.6% 1.44% x x x x x x x x
Burning sensation def 7.86% 1.64% x
Skin burning sensation def 7.86% 1.64% x
Erythema def postmarketing, 6.97% 0.205% x x x x x x x x
Pruritus def postmarketing, 1.63% 0.616% x x x x x x x x
Pain def postmarketing, 1.04% 0% x x x x
Pain of skin def 1.04% 0% x
Aggression def postmarketing x
Agranulocytosis def postmarketing
Alopecia def postmarketing x
Anaemia def postmarketing x
Arthralgia def postmarketing x x
Arthritis def postmarketing x
Asthma def postmarketing x
Back pain def postmarketing x
Mental disorder def postmarketing x
Blepharitis def postmarketing
Bronchospasm def postmarketing x
Cheilitis def postmarketing x x
Colitis def postmarketing x
Conjunctivitis def postmarketing x x
Corneal opacity def postmarketing x
Dizziness def postmarketing x
Drowsiness def postmarketing x
Eczema def postmarketing
Oedema def postmarketing x x x x
Toxic epidermal necrolysis def postmarketing
Epistaxis def postmarketing x
Erythema multiforme def postmarketing
Oesophageal disorder def postmarketing
Oesophagitis def postmarketing
Rash def postmarketing x x x x
Fasting def postmarketing x
Fatigue def postmarketing x x
Flushing def postmarketing x
Glomerulonephritis def postmarketing x
Granuloma def postmarketing x
Headache def postmarketing x x
Haematuria def postmarketing x
Haemorrhage def postmarketing x x
Hepatitis def postmarketing
Herpes NOS def postmarketing x
Herpes simplex def postmarketing x
Hirsutism def postmarketing x
Hypersensitivity def postmarketing x x x x
Hypertriglyceridaemia def postmarketing x x
Ileitis def postmarketing x
Infection def postmarketing x
Inflammation def postmarketing x x
Inflammatory bowel disease def postmarketing x
Unspecified disorder of intestine def postmarketing x
Keratitis def postmarketing x
Lethargy def postmarketing x
Menstrual disorder def postmarketing x
Nausea def postmarketing x x
Nervousness def postmarketing x
Neuritis def postmarketing x
Neutropenia def postmarketing x
Optic neuritis def postmarketing x
Palpitations def postmarketing x
Pancreatitis def postmarketing x
Paraesthesia def postmarketing x x
Paronychia def postmarketing x
Proteinuria def postmarketing x
Pseudotumor postmarketing x x
Benign intracranial hypertension def postmarketing x x
Psychotic disorder def postmarketing
Respiratory tract infection def postmarketing x
Rhabdomyolysis def postmarketing
Seborrhoeic dermatitis def postmarketing
Seizures def postmarketing x
Cerebrovascular accident def postmarketing
Suicide def postmarketing x
Suicide attempt def postmarketing x
Sweating def postmarketing x
Syncope def postmarketing
Tachycardia def postmarketing x x
Tendonitis def postmarketing x
Thrombocytopenia def postmarketing
Tinnitus def postmarketing
Ulcer def postmarketing x
Urticaria def postmarketing x x
Vasculitis def postmarketing x
Weight decreased def postmarketing x
Dry mouth def postmarketing
Mood swings postmarketing x
Photophobia def postmarketing x x
Pyogenic granuloma def postmarketing x
Cataract def postmarketing x
Necrolysis epidermal postmarketing
Impaired healing postmarketing
Phosphatase alkaline increased postmarketing
Oesophageal ulcer def postmarketing
Photosensitivity reaction def postmarketing x
Skin hyperpigmentation def postmarketing x x
Leukoderma def postmarketing x x
Scab postmarketing x x
Eruptive xanthoma postmarketing
Nail dystrophy postmarketing x
Malaise def postmarketing x
Myalgia def postmarketing x
Nasal dryness postmarketing x
Erythema facial postmarketing x
Violent postmarketing x
Acne fulminans postmarketing x
Excessive granulation tissue postmarketing
Xanthoma def postmarketing
Dry eye postmarketing x
Suicidal ideation def postmarketing
Gastrointestinal symptom NOS postmarketing x
Frank hematuria postmarketing
Lymphadenopathy def postmarketing x x
Visual disturbance postmarketing x x
Lip dry postmarketing
Hyperuricaemia def postmarketing x
Local reaction postmarketing x x
Insomnia def postmarketing x
Hearing impaired def postmarketing
Voice disturbance postmarketing
Deposit calcium def postmarketing x
Weakness def postmarketing x
Abdominal distension def
Abdominal pain def x
Acidosis def
Pancreatitis acute def x
Adhesion def x
Anorexia def
Anxiety def
Arrhythmia def
Asthenia def
Blister def x x
Candidiasis def
Chest pain def x
Confusional state def
Constipation def
Cough def x
Cyanosis def
Cystitis def
Dysphagia def
Dehydration def
Dermatitis def x x
Dermatitis exfoliative def x
Diabetes mellitus def x
Diarrhoea def
Disseminated intravascular coagulation def
Duodenal ulcer def x
Dyspnoea def x
Dysuria def
Ear pain def
Effusion def x
Embolism def x
Erythema nodosum def x
Eye disorder def x
Fasciitis def x
Body temperature increased def x
Flank pain def
Flatulence def
Gastritis def x
Gastrointestinal haemorrhage def x
Gout def
Hair disorder def x
Partial hearing loss x
Cardiomegaly def
Cardiac failure def x
Cardiac failure congestive def x
Hoarseness def x
Hypercalcaemia def x
Hypercholesterolaemia def x
Hyperlipidaemia def x
Hypertension def x x
Hypervitaminosis A def
Hypotension def x
Body temperature decreased def
Infarction def
Acute promyelocytic leukaemia def x
Musculoskeletal pain def
Myocardial infarction def
Myositis def x
Nail disorder def
Nasal congestion def x
Numbness def
Ophthalmoplegia def x
Pallor def
Papilloedema def x
Pericardial effusion def x
Pericarditis def x
Pharyngitis def
Pigmentation def x
Pleural disorder def x
Pleural effusion def
Pneumonia def
Rales x
Renal failure def x
Renal infarct
Respiratory insufficiency def
Retinal haemorrhage def x
Scotoma def
Septicemia def
Shivering def x
Shock def x
Sinusitis def
Skin disorder def x
Skin infection def x
Gastric disorder def
Stomatitis def
Swelling def x
Thrombosis def x
Pollakiuria def
Urinary tract infection def
Vasodilation def x
Visual impairment def x x
Vomiting def x
Weight increased def x
Xeroderma def
Xerophthalmia def
Agitation def
Oedema peripheral def x
Allergic cutaneous angiitis def x
Creatine phosphokinase increased def x
Red blood cell sedimentation rate increased x
Intracranial pressure increased def x x
Bone pain def x
Hyporeflexia
Skin irritation def x x x
Lightheadedness
Tachypnoea def
Teratogenicity def x
Discomfort def x
Neurologic reaction
Eye irritation x x
Ear buzzing
Upset stomach
Buccal mucosa ulceration
Chest discomfort
Lung infiltration x
Hepatic enzyme increased x
Edema of lower extremities x
Groin pain
Hypoxia def
Lymphoid interstitial pneumonia def
Ileitis regional x
Rectal haemorrhage def x
Scrotal ulcer x
Generalized aching
Blood bilirubin increased def x
Redness def x x
Hypervitaminosis
Vision blurred def
Photosensitivity def x
Hyperkinesia def x x x
Respiratory distress def x
Eschar x
Forgetfulness
Fluid overload def
Sensation of warmth
Skin fragility x
Gait disturbance def
Blood glucose increased x
Stinging x x x x x
Drug interaction def x
Serum creatinine increased x
Emotional distress def
Sweating increased
Basophilia x
Febrile neutropenia def x
Thrombocytosis def
Dry scalp
Headache occurring x
Retinoic acid syndrome def x
Organ failure x
Bleeding tendency
Insufficiency renal def
Post-traumatic pain
Tingling sensation def x
Indication Labels
Acne def x x x x
Acne vulgaris def x x x
Actinic keratosis def x x
Cutis laxa def x
Keratosis def x x
Lentigo def x x
Leukaemia def x
Lymphoedema def x
Myelodysplastic syndrome def x
Neoplasm def x x
Neoplasm malignant def x x
Neoplasm skin def x x
Sarcoma def x x
Skin cancer def x x
Skin hyperpigmentation def x x
Skin wrinkling x x
Telangiectasia def x x
Yellow skin x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Legend

Color scheme: standardalternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. TRETINOIN : 3 side effects (FDA XML label)
  2. TRETINOIN / VITAMIN A ACID 0.01% GEL : 7 side effects (Health Canada)
  3. TRETINOIN : 8 side effects (FDA XML label)
  4. Tretinoin : 8 side effects (FDA XML label)
  5. Tretinoin : 9 side effects (FDA XML label)
  6. Tretinoin : 10 side effects (FDA XML label)
  7. TRETINOIN / RETIN-A : 12 side effects (Health Canada)
  8. alitretinoin : 18 side effects (FDA XML label)
  9. Tretinoin : 74 side effects (BC Cancer)
  10. ISOTRETINOIN / CLARUS : 107 side effects (Health Canada)