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Retinoic acid

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: D10AD01, D10AD04, D10BA01, D11AX19, L01XX14, L01XX22

Side effects

Options: Show MedDRA Preferred Terms,   display all 37 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Body temperature increased 83% x x x x
Bone pain 20-30% - 77% x x x x
Mucosal dryness 77% x
Shivering 63% x x x x
Dyspnoea 60% x x x x
Vomiting 51% - 57% x x x x
Dermatitis postmarketing — 3.8% - 55% x x x x x x
Oedema peripheral common, 52% x x
Nasal congestion 24-65% x x
Serum creatinine increased 20-56% x
Gastrointestinal haemorrhage 34% x x x
Chest discomfort 32% x x
Abdominal pain 31% x x x x x
Disseminated intravascular coagulation 26% x x
Gastrointestinal disorder 26% x
Respiratory insufficiency 26% x x x
Mucosal inflammation 26% x
Arrhythmia 23% x x x
Diarrhoea postmarketing, 23% x x x x x
Weight increased 23% - 32% x x
Ototoxicity 19-25% x
Pleural effusion 20% x x x
Sweating increased 20% x x
Anorexia 17% x x
Anxiety postmarketing, 17% x x x x
Constipation 17% x x x
Injection site reaction 17% x
Blood bilirubin increased 16% x
Excoriation very common x
Skin irritation very common, 3.8% - 6.4% x x x x
Tenderness very common
Skin exfoliation common — 1.44% - 50% x x x x x x
Skin tenderness very common x
Redness very common x x
Application site erythema very common x
Application site pruritus very common x
Application site stinging very common x
Dyspepsia 14% x
Hypotension 14% x x x
Pneumonia 14% x x
Rales 14% x x x
Wheezing expiratory 14% x
Retinoic acid syndrome postmarketing, 25% x x x
Abdominal distension 11% x x
Confusional state 11% x x x
Hypertension 11% x x
Phlebitis uncommon, 11% x
Eye irritation postmarketing, 11% x x x
Renal impairment 11% x x
Dysuria 9% x x
Flank pain 9% x x
Hepatosplenomegaly 9% x
Agitation 9% x x
Intracranial pressure increased postmarketing, 9% x x x x x x
Cerebral haemorrhage 9% x
Cellulitis uncommon, 8% x
Embolism 8% x
Skin burning sensation very common, 1.64% - 7.86% x x
Erythema very common, 0.205% - 41% x x x x x x x x x
Alopecia postmarketing, 13% - 14% x x x x x x x x x
Hallucination 6% x
Cardiac failure 6% x x
Pallor 6% x x
Pericarditis 6% x x
Lung infiltration 6% x x x
Face oedema 6% x
Fluid imbalance 6% x
Inflammation common x
Skin ulcer common
Skin discolouration common
Stinging common x x x x x
Tingling sensation common x
Pain postmarketing — 0% - 37% x x x x x x x x x
Pruritus postmarketing — 0.616% - 30% x x x x x x x x x x x x x x x x x x
Dry skin postmarketing — 1.64% - 24-65% x x x x x x x x x x
Rash postmarketing — 1% - 54% x x x x x x x x x x x x
Acidosis 3% x x
Ascites 3% x
Dermatitis exfoliative common, 0% - 9% x x
Oedema postmarketing — 0% - 29% x x x x x x x x x x x x x
Body temperature decreased 3% x x
Renal failure acute 3% x
Laryngeal oedema 3% x
Liver disorder 3% x
Lung disorder 3% x
Osteitis 3% x
Paraesthesia postmarketing — 0% - 22% x x x x x x x x x x x
Pulmonary oedema 3% x
Scotoma 3% x x
Telangiectasia 3% x
Ulcer 3% x x
Pollakiuria 3% x x
Prostatomegaly 3% x
Renal tubular necrosis 3% x
Swelling postmarketing, common x
Hyperaesthesia 2% x
Pain of skin very common, 0% - 1.04% x x
Rosacea 1% x
Skin disorder very common, 0% - 8% x x
Papule 1% x
Acne postmarketing, 1% - 5% x x
Bacterial infection uncommon
Angiopathy uncommon
Vesiculobullous rash uncommon
Rash maculo-papular uncommon
Aggression postmarketing x
Agranulocytosis postmarketing x x x
Anaphylactic shock postmarketing x
Anaemia postmarketing x x x x x x
Arthralgia postmarketing, 20-30% x x x x x x x
Arthritis postmarketing x x x x x
Asthenia postmarketing x x x x x x x
Asthma postmarketing, 3% x x x
Back pain postmarketing x x x x x
Behavior disorder postmarketing x x
Mental disorder postmarketing x x x x
Blepharitis postmarketing x x x x x
Bronchospasm postmarketing x x x x x x
Cardiovascular disorder postmarketing x
Central nervous system disorder postmarketing x x
Cheilitis postmarketing, 24-65% - 96% x x x x x x x x
Colitis postmarketing x x x x x x
Infection postmarketing — 58% x x x x x
Conjunctivitis postmarketing, 19% x x x x x x x x
Contusion postmarketing x x x x x
Corneal opacity postmarketing x x x x x x
Deafness postmarketing x
Diabetes mellitus postmarketing x
Dizziness postmarketing, 20% x x x x x x x x
Drowsiness postmarketing x x x x x
Eczema postmarketing x x x
Toxic epidermal necrolysis postmarketing x
Epistaxis postmarketing x x x x x x x
Erythema multiforme postmarketing x
Erythema nodosum postmarketing x x x x x
Oesophagitis postmarketing x x
Fatigue postmarketing x x x x x x x x
Flushing postmarketing, 23% x x x x x x x x
Gingivitis postmarketing x x x x x
Glomerulonephritis postmarketing x x x x x
Headache postmarketing, 29-90% - 86% x x x x x x x x x x
Partial hearing loss postmarketing x x x x
Haematuria postmarketing x x x
Haemorrhage postmarketing — 60% x x x x x x x x x
Hepatitis postmarketing, 3% x x x x x x
Herpes simplex postmarketing x x x x x
Hirsutism postmarketing x x x x x x
Hoarseness postmarketing x x x x
Hyperostosis postmarketing x x x x x x
Hypersensitivity postmarketing, uncommon x x x x x x x
Hypertriglyceridaemia postmarketing x x x x x
Hypervitaminosis A postmarketing x x x x
Ileitis postmarketing x x x x
Inflammatory bowel disease postmarketing x x x x x x
Keratitis postmarketing x x x x x x
Lethargy postmarketing x x x x x x
Menstrual disorder postmarketing x x x x x
Myositis postmarketing x x x x
Nasopharyngitis postmarketing x
Nausea postmarketing x x x x x x x x x x
Nervousness postmarketing x x x x x
Neutropenia postmarketing x x x x
Optic neuritis postmarketing x x x x x
Palpitations postmarketing x x x x x
Pancreatitis postmarketing x x x x x x x x x
Papilloedema postmarketing x x x
Paronychia postmarketing x x x x x x
Pregnancy postmarketing x
Proteinuria postmarketing x x x x x
Benign intracranial hypertension postmarketing x x x x x x x x x
Psychotic disorder postmarketing x x x x x
Renal failure postmarketing x x x
Respiratory tract infection postmarketing x x x x x
Rhabdomyolysis postmarketing x x x
Seborrhoeic dermatitis postmarketing x x x
Convulsion postmarketing x x x x x x x
Stevens-Johnson syndrome postmarketing x
Cerebrovascular accident postmarketing x x x x x x x
Suicide postmarketing x x x x
Suicide attempt postmarketing x x x x x
Sunburn postmarketing, 0.616% - 1.04% x x x x x x
Sweating postmarketing x x x x x x x
Syncope postmarketing x x x
Tachycardia postmarketing x x x x x x x
Tendonitis postmarketing x x x x x
Thrombocytopenia postmarketing x x x x
Tinnitus postmarketing x x x x
Urticaria postmarketing x x x x x x x
Vasculitis postmarketing x x x x x x x x
Disorder sight postmarketing x x
Wegener's granulomatosis postmarketing x x x x x
Weight decreased postmarketing, 17% x x x x x x
Dry mouth postmarketing, 1% x x x x x
Acute febrile neutrophilic dermatosis postmarketing x x x x
Mood swings postmarketing x x x x x
Photophobia postmarketing x x x x x x x x
Pyogenic granuloma postmarketing x x x x x x
Cataract postmarketing x x x x x x
Allergic cutaneous angiitis postmarketing x x x x
Skin atrophy postmarketing x
Epiphyses premature fusion postmarketing x x x
Impaired healing postmarketing x x x
Phosphatase alkaline increased postmarketing x x x
Oesophageal ulcer postmarketing x x
Sensory disturbance postmarketing x
Abnormalities of the hair postmarketing x x
Photosensitivity reaction postmarketing x x x x x x x
Skin hyperpigmentation postmarketing, common x x x
Leukoderma postmarketing x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x
Scab postmarketing, very common x x x x
Eruptive xanthoma postmarketing x x x
Nail dystrophy postmarketing x x x x x x
Contact lens intolerance postmarketing x
Malaise postmarketing, 66% x x x x x x x x
Myalgia postmarketing, 14% x x x x x
Nasal dryness postmarketing, 51% x x x x x x
Application site oedema postmarketing
Dry throat postmarketing x
Hepatotoxicity postmarketing x x x
Depression aggravated postmarketing x
Erythema facial postmarketing x x x x x
Creatine phosphokinase serum increased postmarketing x
Violent postmarketing x x x
Sepsis postmarketing x x
Acne fulminans postmarketing x x x x x x
Excessive granulation tissue postmarketing x x
Dry eye postmarketing x x x x x
Vision blurred postmarketing x x x
Photosensitivity postmarketing x x
Suicidal ideation postmarketing x x x
Violent behavior postmarketing x
Gastrointestinal symptom NOS postmarketing x x x x
Frank hematuria postmarketing x x
Lymphadenopathy postmarketing — 10% x x x x x x
Localized exfoliation postmarketing — 1.44% - 11.6% x x x x x x x x x x x
Application site rash postmarketing
Visual disturbance postmarketing, 17% x x x x x x x x x
Skin fragility postmarketing x x x x x
Lip dry postmarketing x x
Blood glucose increased postmarketing x x
Basophilia postmarketing x x x x
Hyperuricaemia postmarketing x x x x x x
Thrombocytosis postmarketing x x x x
Alopecia reversible postmarketing x x
Decreased night vision postmarketing x x x x x
Insomnia postmarketing, 14% x x x x x x x x
Hearing impaired postmarketing x x x
Exostosis postmarketing x
Visual impairment postmarketing x x x
Acquired immunodeficiency syndrome x x
Pancreatitis acute x
Agnosia x
Anger
Aphasia x
Asthenopia
Blister x x x
Clotting x
Neoplasm malignant x
Candida infection x
Cerebellar syndrome x
Neck pain
Chest pain x x x
Coma x
Cough x x
Cyanosis x
Cystitis x
Dysphagia x
Dehydration x
Depression x x
Dermatitis contact
Dry eye syndrome x
Duodenal ulcer x
Dysarthria x
Ear disorder x
Ear pain x x
Eye disorder x
Facial paralysis x
Fasciitis x
Flatulence x
Folliculitis x
Gastritis x
Gout x
Hair disorder x x
Cardiac arrest x
Cardiomegaly x x
Cardiac failure congestive x
Cardiac murmur x
Hemiplegia x
Hordeolum
Hypercalcaemia x x x x
Hypercholesterolaemia x
Hyperlipidaemia x
Pulmonary hypertension x
Irritability
Ischaemia x
Leukocytosis x
Miliaria x
Multi-organ failure x x
Musculoskeletal pain x
Myocardial infarction x x x
Myocarditis x
Nail disorder x
Nervous system disorder
Numbness x
Ochronosis x
Ophthalmoplegia x
Pain in extremity
Pericardial effusion x x
Neuropathy peripheral x
Pharyngitis x
Renal infarct x x x
Retinal haemorrhage x
Cardiomyopathy secondary NOS x
Septicemia x x
Shock x
Sinusitis x
Skin infection x x
Spinal cord disorder x
Stomatitis x
Thrombosis x x x x
Tremor x
Loss of consciousness x
Upper respiratory tract infection
Urinary tract infection x
Urinary tract disorder x
Wheezing
Xeroderma x
Xerophthalmia x
Encephalopathy x
Panic attack
Genital ulceration x x
Application site reaction
CNS depression NOS x
Creatine phosphokinase increased x x
Red blood cell sedimentation rate increased x x x
Lactic dehydrogenase activity increased
Hyporeflexia x x
Decreased tolerance x x
Lacrimation increased
Skin striae x
Ocular hyperaemia
Malnutrition x
Allergic contact dermatitis x
Acneiform eruption x
Lightheadedness x
Distress
Tachypnoea x
Decreased appetite
Asterixis x
Teratogenicity x
Hallucination, auditory
Discomfort
Visual acuity reduced
Neurologic reaction x x
Euphoric mood
Ear buzzing x
Upset stomach x
Buccal mucosa ulceration x
Edema of lower extremities x
Groin pain x
Weight fluctuation
Auditory disorder NOS x x
Dermatitis perioral x
Ileitis regional x x
Rectal haemorrhage x x
Scrotal ulcer x
Generalized aching x
Lividity x
Cushingoid x
Chapped lips
Secondary infection x
Respiratory distress x x x
Dementia x
Eschar x
Forgetfulness x x
Fluid overload x
Gait disturbance x x
Cutaneous hypersensitivity x
Blood cholesterol increased
Drug interaction x
Hypoxemia x
Febrile neutropenia x
White blood cell count decreased
Dry scalp x
Infestation NOS
Blood and lymphatic system disorders
Blood alkaline phosphatase increased
Blood triglycerides increased
Local reaction x x
Headache occurring x
Musculoskeletal stiffness
Musculoskeletal discomfort
Cerebellar oedema x
Sensitisation x
Post-traumatic pain x
Slow speech x
Somnolence x
Unspecified visual loss x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRETINOIN / RETIN-A MICRO

Side effects:3
Source:Health Canada

Tretinoin

Side effects:7
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

TRETINOIN

Side effects:8
Source:FDA Structured Product Label

alitretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:8
Source:FDA Structured Product Label

Tretinoin

Side effects:9
Source:FDA Structured Product Label

Isotretinoin

Side effects:13
Source:medicines.org.au

ALITRETINOIN / PANRETIN

Side effects:20
Source:FDA

/ TRI-LUMA

Side effects:24
Source:FDA

Tretinoin

Side effects:65
Source:BC Cancer

ISOTRETINOIN / CLARUS

Side effects:101
Source:Health Canada

isotretinoin / Accutane

Side effects:102
Source:FDA

ISOTRETINOIN / ACCUTANE ROCHE

Side effects:106
Source:Health Canada

isotretinoin

Side effects:112
Source:FDA Structured Product Label

TRETINOIN / VESANOID - CAP 10MG

Side effects:120
Source:Health Canada

Isotretinoin / ISOTRETINOIN CAPSULES

Side effects:133
Source:medicines.org.au

TRETINOIN / VESANOID

Side effects:135
Source:FDA

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label