Clomipramine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Dry mouth def Dry mouth def 63% - 84% 16% - 17% x x x x x
Dizziness def Dizziness def 41% - 54% 14% x x x x x
Syncope def 2% x x x x
Tremor def Tremor def 33% - 54% 2% x x x x x
Somnolence def Somnolence def 46% - 54% 11% - 16% x x x x x
Headache def Headache def 28% - 52% 34% - 41% x x x x x
Constipation def Constipation def 22% - 47% 9% - 11% x x x x x
Ejaculation failure Ejaculation failure 6% - 42% 2% x x x x
Asthenia def Fatigue def 35% - 39% 9% - 18% x x x x x
Asthenia def 2% x x x x
Weakness def 1% - 2% x x x x x
Fatigue def Fatigue def 35% - 39% 9% - 18% x x x x x
Nausea def Nausea def 9% - 33% 11% - 14% x x x x x
Hyperhidrosis def Sweating def 9% - 29% 3% x x x x x
Sweating increased 9% - 29% 3% x x x x x
Insomnia def Insomnia def 11% - 25% 7% - 15% x x x x x
Decreased appetite Anorexia def 12% - 22% 2% x x x x x
Dyspepsia def Dyspepsia def 13% - 22% 2% - 10% x x x x x
Erectile dysfunction def Erectile dysfunction def 20% 3% x x x x x
Nervousness def Nervousness def 4% - 18% 2% x x x x x
Tension def Nervousness def 4% - 18% 2% x x x x x
Visual impairment def Visual impairment def 7% - 18% 2% - 4% x x x x
Visual acuity reduced Visual impairment def 7% - 18% 2% - 4% x x x x
Blindness def Visual impairment def 7% - 18% 2% - 4% x x x x
Blindness def rare x x x x
Weight increased def Weight increased def 2% - 18% 1% x x x x x
Pharyngitis def Pharyngitis def 14% 5% - 9% x x x x
Micturition disorder def Micturition disorder def 4% - 14% 2% x x x x x
Abdominal pain def Abdominal pain def 11% - 13% 9% - 16% x x x x x
Gastrointestinal pain def Abdominal pain def 11% - 13% 9% - 16% x x x x x
Diarrhoea def Diarrhoea def 7% - 13% 5% - 9% x x x x x
Myoclonus def Myoclonus def 2% - 13% x x x x x
Pain def Pain def infrequent, 1% - 13% 2% - 16% x x x x x
Myalgia def Myalgia def 13% 9% x x x x x
Musculoskeletal discomfort Myalgia def 13% 9% x x x x x
Arthralgia def 3% 5% x x x x x
Dysmenorrhoea def Dysmenorrhoea def 10% - 12% 10% - 14% x x x x
Rhinitis def Rhinitis def 7% - 12% 9% - 10% x x x x
Increased appetite Increased appetite 11% 2% x x x x x
Anxiety def Anxiety def 2% - 9% 4% x x x x x
Phobia def infrequent x x x x x
Paraesthesia def Paraesthesia def 2% - 9% 2% - 3% x x x x x
Memory impairment def Memory impairment def 7% - 9% 1% - 2% x x x x x
Sleep disorder def Sleep disorder def 4% - 9% 5% x x x x x
Dysgeusia def Dysgeusia def 4% - 8% x x x x
Dermatitis def Rash def rare — 4% - 8% 1% - 2% x x x x x
Dermatitis def 2% 2% x x x x x
Rash def Rash def rare — 4% - 8% 1% - 2% x x x x x
Flushing def Flushing def 2% - 8% x x x x x
Bronchospasm def Bronchospasm def 2% - 7% 2% x x x x
Chest pain def Chest pain def 4% - 7% 4% x x x x x
Hypersensitivity def Hypersensitivity def 2% - 7% 3% - 5% x x x x x
Vomiting def Vomiting def 7% 2% x x x x x
Weight decreased def Weight decreased def 7% x x x x
Urinary retention def Urinary retention def 2% - 7% x x x x
Muscle twitching def Muscle twitching def 4% - 7% 1% - 5% x x x x x
Back pain def Back pain def 6% 6% x x x x x
Cough def Cough def 4% - 6% 5% - 6% x x x x
Flatulence def Flatulence def 6% 2% - 3% x x x x x
Gas def infrequent x
Hypotension def Hypotension def 4% - 6% x x x x
Orthostatic hypotension def Orthostatic hypotension def 4% - 6% x x x x
Infection def Infection def infrequent, 6% 1% x x x x x
Pruritus def Pruritus def infrequent, 2% - 6% 2% x x x x x
Sinusitis def Sinusitis def 2% - 6% 4% - 5% x x x x
Tinnitus def Tinnitus def 4% - 6% x x x x
Urinary tract infection def Urinary tract infection def 6% 1% x x x x
Tooth disorder def Tooth disorder def 5% x x x x x
Pollakiuria def Pollakiuria def 5% 3% x x x x
Vertigo def Vertigo def frequent x x x x x
Thinking abnormal Thinking abnormal frequent x x x x x
Mental disability Thinking abnormal frequent x x x x x
Cerebration impaired def 5% 2% x x x x x
Disturbance in attention Cerebration impaired def 5% 2% x x x x x
Menopausal symptoms def Hot flush def 2% - 5% x x x x x
Hot flush def Hot flush def 2% - 5% x x x x x
Breast feeding def Breast feeding def 4% x x x x
Body temperature increased def Body temperature increased def 2% - 4% 7% x x x x x
Menstrual disorder def Menstrual disorder def 4% 2% x x x x
Hypertonia def Hypertonia def 2% - 4% 1% x x x x x
Ear infection def Otitis def 4% 5% x x x x
Otitis media def Otitis media def 4% 5% x x x x
Palpitations def Palpitations def 4% 2% x x x x
Tachycardia def Tachycardia def rare, 2% - 4% x x x x x
Arthralgia def Arthralgia def 3% 5% x x x x x
Confusional state def Confusional state def 2% - 3% x x x x x
Feeling abnormal Confusional state def 2% - 3% x x x x x
Malaise def infrequent x x x x x
Psychosomatic disease def Psychosomatic disease def 3% x x x x x
Purpura def Purpura def 3% x x x x x
Vascular purpura Purpura def 3% x x x x x
Speech disorder def Speech disorder def 3% x x x x x
Yawning def Yawning def 3% x x x x x
Agitation def Agitation def 3% x x x x x
Hyperkinesia def infrequent x x x x x
Migraine def Migraine def 3% x x x x x
Crocodile tears syndrome Crocodile tears syndrome 3% 2% x x x x
Lacrimation increased def Lacrimation def 3% 2% x x x x
Aggression def Aggression def 2% x x x x x
Aggressive reaction 2% x x x x x
Anaemia def Anaemia def 2% 2% x x x x x
Pupils unequal def Pupils unequal def 2% x x x x
Blepharospasm def Blepharospasm def 2% x x x x
Cystitis def Cystitis def 2% x x x x
Bladder pain def Cystitis def 2% x x x x
Cystitis noninfective def Cystitis def 2% x x x x
Dysphagia def Dysphagia def 2% x x x x x
Depersonalisation def Depersonalisation def 2% x x x x x
Dyspnoea def Dyspnoea def 2% x x x x
Dysuria def Dysuria def 2% 2% x x x x
Oedema def Oedema def rare — 2% 4% x x x x x
Epistaxis def Epistaxis def 2% 2% x x x x
Eructation def Eructation def 2% 2% x x x x x
Gastrointestinal disorder def Gastrointestinal disorder def 2% 2% x x x x x
Breath odour def Breath odour def 2% x x x x
Hypertrophy def Hypertrophy def rare, 2% x x x x x
Irritability def Irritability def infrequent, 2% 2% x x x x x
Laryngitis def Laryngitis def 2% 1% x x x x
Genital discharge Leukorrhea def 2% x x x x
Mydriasis def Mydriasis def 2% x x x x
Panic reaction def Panic reaction def 1% - 2% x x x x x
Paresis def Paresis def 2% x x x x x
Stomatitis def Stomatitis def 2% x x x x x
Mouth ulceration def Ulcerative stomatitis 2% x x x x x
Shock def Syncope def 2% x x x x
Syncope def Syncope def 2% x x x x
Loss of consciousness def Syncope def 2% x x x x
Thirst def Thirst def 2% 2% x x x x x
Ulcer def Ulcer def rare — 2% x x x x x
Vaginal inflammation def Vaginal inflammation def 2% x x x x
Vaginal infection def Vaginal inflammation def 2% x x x x
Vestibular disorder def Vestibular disorder def 2% 2% x x x x
Chills def Chills def 2% 1% x x x x
Mood swings Mood swings 2% 2% x x x x x
Affect lability Mood swings 2% 2% x x x x x
Muscular weakness def Muscular weakness def 1% - 2% x x x x x
Dry skin def Dry skin def 2% 5% x x x x x
Skin odour abnormal Skin odour abnormal 2% x x x x x
Acne def Acne def 2% 2% - 5% x x x x x
Eye allergy Eye allergy 2% x x x x
Breast enlargement Breast enlargement 2% x x x x
Ageusia def Ageusia def infrequent x x x x
Alopecia def Alopecia def infrequent x x x x
Amenorrhoea def Amenorrhoea def 1% x x x x
Arrhythmia def Arrhythmia def infrequent x x x x x
Ataxia def Ataxia def infrequent x x x x x
Bronchitis def Bronchitis def infrequent x x x x
Cellulitis def Cellulitis def infrequent x x x x
Colitis def Colitis def infrequent x x x x x
Coma def Coma def infrequent x x x x x
Conjunctivitis def Conjunctivitis def 1% x x x x
Convulsion def Convulsion def infrequent x x x x x
Seizures def x
Cyst def Cyst def rare, infrequent x x x x
Deafness def Deafness def infrequent x x x x
Dehydration def Dehydration def infrequent x x x x x
Delirium def Delirium def infrequent x x x x x
Delusion def Delusion def infrequent x x x x x
Dental caries def Dental caries def infrequent x x x x x
Diabetes mellitus def Diabetes mellitus def infrequent x x x x x
Diplopia def Diplopia def infrequent x x x x
Duodenitis def Duodenitis def infrequent x x x x x
Dyskinesia def Dyskinesia def infrequent x x x x x
Ear pain def Ear pain def infrequent x x x x
Eczema def Eczema def infrequent x x x x
Endometriosis def Endometriosis def infrequent x x x x
Epididymitis def Epididymitis def infrequent x x x x
Oesophagitis def Oesophagitis def 1% x x x x x
Extrapyramidal disorder def Extrapyramidal disorder def infrequent x x x x
Gastritis def Gastritis def infrequent x x x x x
Gastrooesophageal reflux disease def Gastrooesophageal reflux disease def infrequent x x x x x
Gingivitis def Gingivitis def infrequent x x x x x
Glossitis def Glossitis def infrequent x x x x x
Gout def Gout def infrequent x x x x x
Hallucination def Hallucination def infrequent x x x x x
Cardiac arrest def Cardiac arrest def infrequent x x x x x
Haematuria def Haematuria def infrequent x x x x
Haemorrhage def Haemorrhage def rare, infrequent x x x x x
Haemoglobin def Haemorrhage def rare, infrequent x x x x x
Haemorrhoids def Haemorrhoids def infrequent x x x x x
Hepatitis def Hepatitis def infrequent x x x x x
Hostility def Hostility def infrequent x x x x x
Hypercholesterolaemia def Hypercholesterolaemia def infrequent x x x x
Hyperglycaemia def Hyperglycaemia def infrequent x x x x x
Hyperventilation def Hyperventilation def infrequent x x x x x
Hypokalaemia def Hypokalaemia def infrequent x x x x x
Hypothyroidism def Hypothyroidism def infrequent x x x x x
Incontinence def Incontinence def infrequent x x x x
Intestinal functional disorder Irritable bowel syndrome def infrequent x x x x x
Irritable bowel syndrome def Irritable bowel syndrome def infrequent x x x x x
Arthropathy def Arthropathy def infrequent x x x x x
Osteoarthritis def Arthropathy def infrequent x x x x x
Nephrolithiasis def Calculus of kidney def infrequent x x x x
Muscle spasms def Cramps of lower extremities infrequent x x x x x
Cramp muscle def infrequent x x x x x
Muscle spasms def rare x x x x x
Spasm generalised rare x x x x x
Breast pain def Breast pain def 1% x x x x
Neuralgia def Neuralgia def infrequent x x x x x
Nocturia def Nocturia def infrequent x x x x
Oliguria def Oliguria def infrequent x x x x
Ovarian cyst def Ovarian cyst def infrequent x x x x
Pallor def Pallor def infrequent x x x x x
Peptic ulcer def Peptic ulcer def infrequent x x x x x
Pneumonia def Pneumonia def infrequent x x x x
Polyuria def Polyuria def infrequent x x x x
Diuresis def x
Urine output increased Polyuria def infrequent x x x x
Prostatic disorder def Prostatic disorder def infrequent x x x x
Pruritus genital Pruritus genital infrequent x x x x
Psoriasis def Psoriasis def infrequent x x x x
Psychotic disorder def Psychotic disorder def infrequent x x x x x
Paranoia def infrequent x x x x x
Hyperacusis def Hyperacusis def infrequent x x x x
Scleritis def Scleritis def infrequent x x x x
Salivary hypersecretion def Salivary hypersecretion def infrequent x x x x x
Somnambulism def Somnambulism def infrequent x x x x x
Gastric ulcer def Gastric ulcer def infrequent x x x x x
Completed suicide Suicide def rare, infrequent x x x x x
Suicide attempt def Suicide attempt def infrequent x x x x x
Urethral disorder def Urethral disorder def infrequent x x x x
Urinary incontinence def Urinary incontinence def infrequent x x x x
Urticaria def Urticaria def 1% x x x x x
Uterine haemorrhage def Uterine haemorrhage def infrequent x x x x
Encephalopathy def Encephalopathy def infrequent x x x x x
Apathy def Apathy def infrequent x x x x x
Flat affect Apathy def infrequent x x x x x
Photophobia def Photophobia def infrequent x x x x
Rash pustular def Rash pustular def infrequent x x x x
Hypokinesia def Hypokinesia def infrequent x x x x x
Hepatic function abnormal Hepatic function abnormal infrequent x x x x x
Electroencephalogram abnormal Electroencephalogram abnormal infrequent x x x x x
Mania def Manic psychosis infrequent x x x x x
Mania def infrequent x x x x x
Eye pain def Eye pain def infrequent x x x x
Skin discolouration def Skin discolouration def infrequent x x x x
Sensory disturbance def Sensory disturbance def infrequent x x x x x
Photosensitivity reaction def Photosensitivity reaction def infrequent x x x x
Photosensitivity def infrequent x x x x
Malaise def Malaise def infrequent x x x x x
Discomfort def Malaise def infrequent x x x x x
Ill-defined disorder Malaise def infrequent x x x x x
Hypnagogic hallucination Hypnagogic hallucination infrequent x x x x x
Rash erythematous Rash erythematous infrequent x x x x
Euphoric mood def Euphoric mood def infrequent x x x x x
Tongue ulceration Tongue ulceration infrequent x x x x x
Infection susceptibility increased Infection susceptibility increased infrequent x x x x x
Perineal pain def Perineal pain def infrequent x x x x
Rectal haemorrhage def Rectal haemorrhage def infrequent x x x x x
Extrasystoles def Extrasystoles def infrequent x x x x x
Phobia def Phobia def infrequent x x x x x
Sensation of foreign body def Sensation of foreign body def infrequent x x x x
Rash maculo-papular def Rash maculo-papular def infrequent x x x x
Suicidal ideation def Suicidal ideation def infrequent x x x x
Hyperkinesia def Hyperkinesia def infrequent x x x x x
Bradycardia def Bradycardia def infrequent x x x x x
Lymphadenopathy def Lymphadenopathy def infrequent x x x x x
Coordination abnormal Coordination abnormal infrequent x x x x
Electrocardiogram abnormal Electrocardiogram abnormal infrequent x x x x x
Renal pain Renal pain infrequent x x x x
Gait disturbance def Gait disturbance def infrequent x x x x x
Blood uric acid increased Hyperuricaemia def infrequent x x x x x
Hyperuricaemia def Hyperuricaemia def infrequent x x x x x
Haematochezia def Blood in stool infrequent x x x x x
Paranoia def Paranoia def infrequent x x x x x
Parosmia def Parosmia def infrequent x x x x
Dysphonia def Dysphonia def infrequent x x x x x
Vaginal haemorrhage def Vaginal haemorrhage def infrequent x x x x
Albuminuria def Albuminuria def rare x x x x
Aneurysm def Aneurysm def rare x x x x x
Aphasia def Aphasia def rare x x x x x
Apraxia def Apraxia def rare x x x x x
Atrial flutter def Atrial flutter def rare x x x x x
Blepharitis def Blepharitis def rare x x x x
Bundle branch block def Bundle branch block def rare x x x x x
Waxy flexibility Catalepsy def rare x x x x x
Cervical dysplasia def Cervical dysplasia def rare x x x x
Cheilitis def Cheilitis def rare x x x x x
Conjunctival haemorrhage Conjunctival haemorrhage rare x x x x
Cyanosis def Cyanosis def rare x x x x
Endometrial hyperplasia def Endometrial hyperplasia def rare x x x x
Enteritis def Enteritis def rare x x x x x
Exophthalmos def Exophthalmos def rare x x x x
Cardiac flutter Cardiac flutter rare x x x x x
Folliculitis def Folliculitis def rare x x x x
Gingival bleeding def Gingival bleeding def rare x x x x
Glaucoma def Glaucoma def rare x x x x
Glycosuria def Glycosuria def rare x x x x x
Goitre def Goitre def rare x x x x x
Gynaecomastia def Gynaecomastia def rare x x x x x
Atrioventricular block def Block heart def rare x x x x x
Cardiac failure def Cardiac failure def rare x x x x x
Hemiparesis Hemiparesis rare x x x x x
Haemoptysis def Haemoptysis def rare x x x x
Hiccups def Hiccups def rare x x x x x
Hyperaemia def Hyperaemia def rare x x x x
Hyperaesthesia def Hyperaesthesia def rare x x x x x
Hyperplasia def Hyperplasia def rare x x x x
Hyperthyroidism def Hyperthyroidism def rare x x x x x
Hypertrichosis def Hypertrichosis def rare x x x x
Salivary gland enlargement Salivary gland enlargement rare x x x x x
Hypoaesthesia def Hypoaesthesia def rare x x x x x
Illusion def Illusion def rare x x x x x
Infarction def Infarction def rare x x x x x
Inflammation def Inflammation def rare x x x x
Intestinal obstruction def Intestinal obstruction def rare x x x x x
Ischaemia def Ischaemia def rare x x x x x
Keratitis def Keratitis def rare x x x x
Renal cyst def Renal cyst def rare x x x x
Inner ear disorder def Labyrinthine disorder def rare x x x x
Laryngospasm def Laryngospasm def rare x x x x
Leukaemoid reaction def Leukaemoid reaction def rare x x x x x
Leukemoid rare x x x x x
Lymphoma def Lymphoma def rare x x x x x
Chloasma Chloasma rare x x x x
Myopathy def Myopathy def rare x x x x
Mutism def Mutism def rare x x x x x
Myocardial infarction def Myocardial infarction def rare x x x x x
Acute coronary syndrome def Myocardial infarction def rare x x x x x
Myositis def Myositis def rare x x x x x
Night blindness def Night blindness def rare x x x x
Nystagmus def Nystagmus def rare x x x x x
Obstruction def Obstruction def rare x x x x x
IIIrd nerve paralysis def IIIrd nerve paralysis def rare x x x x x
Ileus paralytic def Ileus paralytic def rare x x x x x
Polyarteritis nodosa def Polyarteritis nodosa def rare x x x x x
Piloerection def Piloerection def rare x x x x
Premature ejaculation def Premature ejaculation def rare x x x x
Pyelonephritis def Pyelonephritis def rare x x x x
Pyuria def Pyuria def rare x x x x
Retinal disorder def Retinal disorder def rare x x x x
Scotoma def Scotoma def rare x x x x
Seborrhoeic dermatitis def Seborrhoeic dermatitis def rare x x x x
Skin ulcer def Skin ulcer def rare x x x x
Gastric dilatation def Gastric dilatation def rare x x x x x
Stomach dilation procedure Gastric dilatation def rare x x x x x
Strabismus def Strabismus def rare x x x x
Withdrawal syndrome def Withdrawal syndrome def rare x x x x x
Thrombophlebitis def Thrombophlebitis def rare x x x x x
Torticollis def Torticollis def rare x x x x x
Ventricular tachycardia def Ventricular tachycardia def rare x x x x x
Vulval disorder def Vulval disorder def rare x x x x
Choreoathetosis Choreoathetosis rare x x x x
Vasospasm def Vasospasm def rare x x x x x
Stupor def Stupor def rare x x x x x
Depressed level of consciousness def Stupor def rare x x x x x
CNS depression NOS x
Oculogyric crisis Oculogyric crisis rare x x x x x
Breast engorgement def Breast engorgement def rare x x x x
Skin hypertrophy Skin hypertrophy rare x x x x
Myocardial ischaemia def Myocardial ischaemia def rare x x x x x
Pancytopenia def Bone marrow depression def rare x x x x
Hyperreflexia Hyperreflexia rare x x x x x
Schizophreniform disorder def Schizophrenic reaction rare x x x x x
Faeces discoloured Faeces discoloured rare x x x x x
Gravitational oedema Gravitational oedema rare x x x x x
Peripheral ischaemia def Peripheral ischaemia def rare x x x x x
Uterine inflammation Uterine inflammation rare x x x x
Pharyngeal oedema Pharyngeal oedema rare x x x x x
Fat intolerance Fat intolerance rare x x x x x
Paralysis def Nerve paralysis rare x x x x x
Paralysis def rare x x x x x
Dysplasia def Dysplasia def rare x x x x
Dystonia def Dystonia def rare x x x x x
Hypoxia def Hypoventilation def rare x x x x
Hypoventilation def Hypoventilation def rare x x x x
Respiratory failure def Hypoventilation def rare x x x x
Systemic lupus erythematosus def Lupus erythematosus def rare x x x x x
Neuropathy peripheral def Neuropathy def rare x x x x x
Chromatopsia Chromatopsia rare x x x x
Ileus def Ileus def rare x x x x x
Fibroadenoma of breast def Fibroadenosis of breast rare x x x x
Exostosis def Exostosis def rare x x x x x
Cerebral haemorrhage def Cerebral haemorrhage def rare x x x x x
Amyotrophic lateral sclerosis def Amyotrophic lateral sclerosis def x
Death Death x
Indication Labels
Compulsions def x x x x x
Obsessive rumination x x x x x
Obsessive-compulsive disorder def x x x x x
Type 2 diabetes mellitus def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N06AA04

Legend

Color scheme: standard – alternative

100%    
75%    
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frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. clomipramine hydrochloride capsules / Anafranil : 212 side effects (FDA MedWatch)
  2. clomipramine hydrochloride / Anafranil : 332 side effects (FDA MedWatch)
  3. CLOMIPRAMINE HYDROCHLORIDE / ANAFRANIL : 332 side effects (Drugs@FDA)
  4. CLOMIPRAMINE : 333 side effects (FDA XML label)
  5. Clomipramine : 333 side effects (FDA XML label)