Clomipramine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5
Dry mouth def 63% - 84% 16% - 17% x x x x x
Dizziness def 41% - 54% 14% x x x x x
Tremor def 33% - 54% 2% x x x x x
Somnolence def 46% - 54% 11% - 16% x x x x x
Headache def 28% - 52% 34% - 41% x x x x x
Constipation def 22% - 47% 9% - 11% x x x x x
Ejaculation failure 6% - 42% 2% x x x x
Fatigue def 35% - 39% 9% - 18% x x x x x
Nausea def 9% - 33% 11% - 14% x x x x x
Sweating def 9% - 29% 3% x x x x x
Sweating increased 9% - 29% 3% x x x x x
Insomnia def 11% - 25% 7% - 15% x x x x x
Anorexia def 12% - 22% 2% x x x x x
Dyspepsia def 13% - 22% 2% - 10% x x x x x
Erectile dysfunction def 20% 3% x x x x x
Nervousness def 4% - 18% 2% x x x x x
Visual impairment def 7% - 18% 2% - 4% x x x x
Weight increased def 2% - 18% 1% x x x x x
Pharyngitis def 14% 5% - 9% x x x x
Micturition disorder def 4% - 14% 2% x x x x x
Abdominal pain def 11% - 13% 9% - 16% x x x x x
Diarrhoea def 7% - 13% 5% - 9% x x x x x
Myoclonus def 2% - 13% x x x x x
Pain def infrequent, 1% - 13% 2% - 16% x x x x x
Myalgia def 13% 9% x x x x x
Dysmenorrhoea def 10% - 12% 10% - 14% x x x x
Rhinitis def 7% - 12% 9% - 10% x x x x
Increased appetite 11% 2% x x x x x
Anxiety def 2% - 9% 4% x x x x x
Paraesthesia def 2% - 9% 2% - 3% x x x x x
Memory impairment def 7% - 9% 1% - 2% x x x x x
Sleep disorder def 4% - 9% 5% x x x x x
Dysgeusia def 4% - 8% x x x x
Rash def rare — 4% - 8% 1% - 2% x x x x x
Flushing def 2% - 8% x x x x x
Bronchospasm def 2% - 7% 2% x x x x
Chest pain def 4% - 7% 4% x x x x x
Hypersensitivity def 2% - 7% 3% - 5% x x x x x
Vomiting def 7% 2% x x x x x
Weight decreased def 7% x x x x
Urinary retention def 2% - 7% x x x x
Muscle twitching def 4% - 7% 1% - 5% x x x x x
Back pain def 6% 6% x x x x x
Cough def 4% - 6% 5% - 6% x x x x
Flatulence def 6% 2% - 3% x x x x x
Hypotension def 4% - 6% x x x x
Orthostatic hypotension def 4% - 6% x x x x
Infection def infrequent, 6% 1% x x x x x
Pruritus def infrequent, 2% - 6% 2% x x x x x
Sinusitis def 2% - 6% 4% - 5% x x x x
Tinnitus def 4% - 6% x x x x
Urinary tract infection def 6% 1% x x x x
Tooth disorder def 5% x x x x x
Pollakiuria def 5% 3% x x x x
Vertigo def frequent x x x x x
Thinking abnormal frequent x x x x x
Cerebration impaired def 5% 2% x x x x x
Hot flush def 2% - 5% x x x x x
Breast feeding def 4% x x x x
Body temperature increased def 2% - 4% 7% x x x x x
Menstrual disorder def 4% 2% x x x x
Hypertonia def 2% - 4% 1% x x x x x
Otitis def 4% 5% x x x x
Otitis media def 4% 5% x x x x
Palpitations def 4% 2% x x x x
Tachycardia def rare, 2% - 4% x x x x x
Arthralgia def 3% 5% x x x x x
Confusional state def 2% - 3% x x x x x
Psychosomatic disease def 3% x x x x x
Purpura def 3% x x x x x
Speech disorder def 3% x x x x x
Yawning def 3% x x x x x
Agitation def 3% x x x x x
Migraine def 3% x x x x x
Crocodile tears syndrome 3% 2% x x x x
Lacrimation def 3% 2% x x x x
Aggression def 2% x x x x x
Anaemia def 2% 2% x x x x x
Pupils unequal def 2% x x x x
Asthenia def 2% x x x x
Blepharospasm def 2% x x x x
Cystitis def 2% x x x x
Dysphagia def 2% x x x x x
Depersonalisation def 2% x x x x x
Dermatitis def 2% 2% x x x x x
Dyspnoea def 2% x x x x
Dysuria def 2% 2% x x x x
Oedema def rare — 2% 4% x x x x x
Epistaxis def 2% 2% x x x x
Eructation def 2% 2% x x x x x
Gastrointestinal disorder def 2% 2% x x x x x
Breath odour def 2% x x x x
Hypertrophy def rare, 2% x x x x x
Irritability def infrequent, 2% 2% x x x x x
Laryngitis def 2% 1% x x x x
Leukorrhea def 2% x x x x
Mydriasis def 2% x x x x
Panic reaction def 1% - 2% x x x x x
Paresis def 2% x x x x x
Stomatitis def 2% x x x x x
Ulcerative stomatitis 2% x x x x x
Syncope def 2% x x x x
Thirst def 2% 2% x x x x x
Ulcer def rare — 2% x x x x x
Vaginal inflammation def 2% x x x x
Vestibular disorder def 2% 2% x x x x
Chills def 2% 1% x x x x
Mood swings 2% 2% x x x x x
Muscular weakness def 1% - 2% x x x x x
Dry skin def 2% 5% x x x x x
Skin odour abnormal 2% x x x x x
Acne def 2% 2% - 5% x x x x x
Eye allergy 2% x x x x
Aggressive reaction 2% x x x x x
Weakness def 1% - 2% x x x x x
Breast enlargement 2% x x x x
Ageusia def infrequent x x x x
Alopecia def infrequent x x x x
Amenorrhoea def 1% x x x x
Arrhythmia def infrequent x x x x x
Ataxia def infrequent x x x x x
Bronchitis def infrequent x x x x
Cellulitis def infrequent x x x x
Colitis def infrequent x x x x x
Coma def infrequent x x x x x
Conjunctivitis def 1% x x x x
Convulsion def infrequent x x x x x
Cyst def rare, infrequent x x x x
Deafness def infrequent x x x x
Dehydration def infrequent x x x x x
Delirium def infrequent x x x x x
Delusion def infrequent x x x x x
Dental caries def infrequent x x x x x
Diabetes mellitus def infrequent x x x x x
Diplopia def infrequent x x x x
Duodenitis def infrequent x x x x x
Dyskinesia def infrequent x x x x x
Ear pain def infrequent x x x x
Eczema def infrequent x x x x
Endometriosis def infrequent x x x x
Epididymitis def infrequent x x x x
Oesophagitis def 1% x x x x x
Extrapyramidal disorder def infrequent x x x x
Gastritis def infrequent x x x x x
Gastrooesophageal reflux disease def infrequent x x x x x
Gingivitis def infrequent x x x x x
Glossitis def infrequent x x x x x
Gout def infrequent x x x x x
Hallucination def infrequent x x x x x
Cardiac arrest def infrequent x x x x x
Haematuria def infrequent x x x x
Haemorrhage def rare, infrequent x x x x x
Haemorrhoids def infrequent x x x x x
Hepatitis def infrequent x x x x x
Hostility def infrequent x x x x x
Hypercholesterolaemia def infrequent x x x x
Hyperglycaemia def infrequent x x x x x
Hyperventilation def infrequent x x x x x
Hypokalaemia def infrequent x x x x x
Hypothyroidism def infrequent x x x x x
Incontinence def infrequent x x x x
Irritable bowel syndrome def infrequent x x x x x
Arthropathy def infrequent x x x x x
Calculus of kidney def infrequent x x x x
Cramps of lower extremities infrequent x x x x x
Breast pain def 1% x x x x
Cramp muscle def infrequent x x x x x
Neuralgia def infrequent x x x x x
Nocturia def infrequent x x x x
Oliguria def infrequent x x x x
Ovarian cyst def infrequent x x x x
Pallor def infrequent x x x x x
Peptic ulcer def infrequent x x x x x
Pneumonia def infrequent x x x x
Polyuria def infrequent x x x x
Prostatic disorder def infrequent x x x x
Pruritus genital infrequent x x x x
Psoriasis def infrequent x x x x
Psychotic disorder def infrequent x x x x x
Hyperacusis def infrequent x x x x
Scleritis def infrequent x x x x
Salivary hypersecretion def infrequent x x x x x
Somnambulism def infrequent x x x x x
Gastric ulcer def infrequent x x x x x
Suicide def rare, infrequent x x x x x
Suicide attempt def infrequent x x x x x
Urethral disorder def infrequent x x x x
Urinary incontinence def infrequent x x x x
Urticaria def 1% x x x x x
Uterine haemorrhage def infrequent x x x x
Encephalopathy def infrequent x x x x x
Apathy def infrequent x x x x x
Photophobia def infrequent x x x x
Rash pustular def infrequent x x x x
Hypokinesia def infrequent x x x x x
Hepatic function abnormal infrequent x x x x x
Electroencephalogram abnormal infrequent x x x x x
Manic psychosis infrequent x x x x x
Eye pain def infrequent x x x x
Skin discolouration def infrequent x x x x
Sensory disturbance def infrequent x x x x x
Photosensitivity reaction def infrequent x x x x
Malaise def infrequent x x x x x
Hypnagogic hallucination infrequent x x x x x
Rash erythematous infrequent x x x x
Euphoric mood def infrequent x x x x x
Tongue ulceration infrequent x x x x x
Infection susceptibility increased infrequent x x x x x
Perineal pain def infrequent x x x x
Rectal haemorrhage def infrequent x x x x x
Mania def infrequent x x x x x
Extrasystoles def infrequent x x x x x
Phobia def infrequent x x x x x
Photosensitivity def infrequent x x x x
Sensation of foreign body def infrequent x x x x
Rash maculo-papular def infrequent x x x x
Suicidal ideation def infrequent x x x x
Hyperkinesia def infrequent x x x x x
Bradycardia def infrequent x x x x x
Lymphadenopathy def infrequent x x x x x
Coordination abnormal infrequent x x x x
Electrocardiogram abnormal infrequent x x x x x
Renal pain infrequent x x x x
Gait disturbance def infrequent x x x x x
Gas def infrequent x
Hyperuricaemia def infrequent x x x x x
Blood in stool infrequent x x x x x
Paranoia def infrequent x x x x x
Parosmia def infrequent x x x x
Dysphonia def infrequent x x x x x
Vaginal haemorrhage def infrequent x x x x
Albuminuria def rare x x x x
Aneurysm def rare x x x x x
Aphasia def rare x x x x x
Apraxia def rare x x x x x
Atrial flutter def rare x x x x x
Blepharitis def rare x x x x
Bundle branch block def rare x x x x x
Catalepsy def rare x x x x x
Cervical dysplasia def rare x x x x
Cheilitis def rare x x x x x
Conjunctival haemorrhage rare x x x x
Cyanosis def rare x x x x
Endometrial hyperplasia def rare x x x x
Enteritis def rare x x x x x
Exophthalmos def rare x x x x
Cardiac flutter rare x x x x x
Folliculitis def rare x x x x
Gingival bleeding def rare x x x x
Glaucoma def rare x x x x
Glycosuria def rare x x x x x
Goitre def rare x x x x x
Gynaecomastia def rare x x x x x
Block heart def rare x x x x x
Cardiac failure def rare x x x x x
Hemiparesis rare x x x x x
Haemoptysis def rare x x x x
Hiccups def rare x x x x x
Hyperaemia def rare x x x x
Hyperaesthesia def rare x x x x x
Hyperplasia def rare x x x x
Hyperthyroidism def rare x x x x x
Hypertrichosis def rare x x x x
Salivary gland enlargement rare x x x x x
Hypoaesthesia def rare x x x x x
Illusion def rare x x x x x
Infarction def rare x x x x x
Inflammation def rare x x x x
Intestinal obstruction def rare x x x x x
Ischaemia def rare x x x x x
Keratitis def rare x x x x
Renal cyst def rare x x x x
Labyrinthine disorder def rare x x x x
Laryngospasm def rare x x x x
Leukaemoid reaction def rare x x x x x
Lymphoma def rare x x x x x
Chloasma rare x x x x
Myopathy def rare x x x x
Mutism def rare x x x x x
Myocardial infarction def rare x x x x x
Myositis def rare x x x x x
Night blindness def rare x x x x
Nystagmus def rare x x x x x
Obstruction def rare x x x x x
IIIrd nerve paralysis def rare x x x x x
Ileus paralytic def rare x x x x x
Polyarteritis nodosa def rare x x x x x
Piloerection def rare x x x x
Premature ejaculation def rare x x x x
Pyelonephritis def rare x x x x
Pyuria def rare x x x x
Retinal disorder def rare x x x x
Scotoma def rare x x x x
Seborrhoeic dermatitis def rare x x x x
Skin ulcer def rare x x x x
Muscle spasms def rare x x x x x
Gastric dilatation def rare x x x x x
Strabismus def rare x x x x
Withdrawal syndrome def rare x x x x x
Thrombophlebitis def rare x x x x x
Torticollis def rare x x x x x
Ventricular tachycardia def rare x x x x x
Vulval disorder def rare x x x x
Choreoathetosis rare x x x x
Vasospasm def rare x x x x x
Stupor def rare x x x x x
Oculogyric crisis rare x x x x x
Breast engorgement def rare x x x x
Skin hypertrophy rare x x x x
Myocardial ischaemia def rare x x x x x
Bone marrow depression def rare x x x x
Hyperreflexia rare x x x x x
Schizophrenic reaction rare x x x x x
Spasm generalised rare x x x x x
Faeces discoloured rare x x x x x
Gravitational oedema rare x x x x x
Peripheral ischaemia def rare x x x x x
Uterine inflammation rare x x x x
Pharyngeal oedema rare x x x x x
Fat intolerance rare x x x x x
Nerve paralysis rare x x x x x
Dysplasia def rare x x x x
Dystonia def rare x x x x x
Hypoventilation def rare x x x x
Lupus erythematosus def rare x x x x x
Neuropathy def rare x x x x x
Blindness def rare x x x x
Chromatopsia rare x x x x
Paralysis def rare x x x x x
Leukemoid rare x x x x x
Ileus def rare x x x x x
Fibroadenosis of breast rare x x x x
Exostosis def rare x x x x x
Cerebral haemorrhage def rare x x x x x
Amyotrophic lateral sclerosis def x
Diuresis def x
Seizures def x
CNS depression NOS x
Death x
Indication Labels
Compulsions def x x x x x
Obsessive rumination x x x x x
Obsessive-compulsive disorder def x x x x x
Type 2 diabetes mellitus def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N06AA04

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. clomipramine hydrochloride capsules / Anafranil : 212 side effects (FDA MedWatch)
  2. clomipramine hydrochloride / Anafranil : 332 side effects (FDA MedWatch)
  3. CLOMIPRAMINE HYDROCHLORIDE / ANAFRANIL : 332 side effects (Drugs@FDA)
  4. CLOMIPRAMINE : 333 side effects (FDA XML label)
  5. Clomipramine : 333 side effects (FDA XML label)