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Lasofoxifene

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: None found

Side effects

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MedDRA Preferred Term Side effect Data for drug Placebo Labels
1
Muscle spasms Muscle spasms very common x
Constipation Constipation common x
Cystocele Cystocele common x
Hyperhidrosis Hyperhidrosis common x
Vaginal disorder Vaginal disorder common x
Endometrial disorder Endometrial disorder common x
Aspartate aminotransferase increased Aspartate aminotransferase increased common x
Uterine polyp Uterine polyp common x
Vaginal discharge Vaginal discharge common x
Menopausal symptoms Hot flush common x
Hot flush Hot flush common x
Therapeutic response unexpected Therapeutic response unexpected common x
Endometrial hypertrophy Endometrial hypertrophy common x
Abdominal pain Abdominal pain uncommon x
Gastrointestinal pain Abdominal pain uncommon x
Alopecia Alopecia uncommon x
Anaemia Anaemia uncommon x
Back pain Back pain uncommon x
Cerebral infarction Cerebral infarction uncommon x
Cervical polyp Cervical polyp uncommon x
Neck pain Neck pain uncommon x
Cervix disorder Cervix disorder uncommon x
Cervical dysplasia Cervical dysplasia uncommon x
Uterine cervical erosion Uterine cervical erosion uncommon x
Chest pain Chest pain uncommon x
Chest discomfort rare x
Cholelithiasis Cholelithiasis uncommon x
Cough Cough uncommon x
Diabetes mellitus Diabetes mellitus uncommon x
Endometrial hyperplasia Endometrial hyperplasia uncommon x
Asthenia Fatigue uncommon x
Fatigue Fatigue uncommon x
Fibroma Fibroma uncommon x
Flatulence Flatulence uncommon x
Flushing Flushing uncommon x
Gastritis Gastritis uncommon x
Headache Headache uncommon x
Irritable bowel syndrome Irritable bowel syndrome uncommon x
Functional gastrointestinal disorder Irritable bowel syndrome uncommon x
Breast pain Breast pain uncommon x
Metrorrhagia Metrorrhagia uncommon x
Night sweats Night sweats uncommon x
Nocturia Nocturia uncommon x
Pain in extremity Pain in extremity uncommon x
Palpitations Palpitations uncommon x
Phlebitis Phlebitis uncommon x
Pruritus Pruritus uncommon x
Pulmonary embolism Pulmonary embolism uncommon x
Restless legs syndrome Restless legs syndrome uncommon x
Tachycardia Tachycardia uncommon x
Thrombocytopenia Thrombocytopenia uncommon x
Thrombophlebitis Thrombophlebitis uncommon x
Erythema Erythema uncommon x
Urethral disorder Urethral disorder uncommon x
Urinary tract disorder rare x
Pollakiuria Pollakiuria uncommon x
Micturition urgency uncommon x
Urinary incontinence Urinary incontinence uncommon x
Uterine leiomyoma Uterine leiomyoma uncommon x
Leiomyoma rare x
Uterine prolapse Uterine prolapse uncommon x
Weight increased Weight increased uncommon x
Dry mouth Dry mouth uncommon x
Micturition urgency Micturition urgency uncommon x
Burning sensation Burning sensation uncommon x
Oedema peripheral Oedema peripheral uncommon x
Rectocele Rectocele uncommon x
Deep vein thrombosis Deep vein thrombosis uncommon x
Alanine aminotransferase increased Alanine aminotransferase increased uncommon x
Vaginal prolapse Vaginal prolapse uncommon x
Abdominal pain upper Abdominal pain upper uncommon x
Abdominal pain lower Abdominal pain lower uncommon x
Breast induration Breast induration uncommon x
Venous insufficiency Post thrombotic syndrome uncommon x
Post thrombotic syndrome Post thrombotic syndrome uncommon x
Dry eye Dry eye uncommon x
Keratoconjunctivitis sicca rare x
Transaminases increased Transaminases increased uncommon x
Smear cervix abnormal Smear cervix abnormal uncommon x
Blood glucose increased Blood glucose increased uncommon x
Breast disorder female Breast disorder female uncommon x
Genital haemorrhage Genital haemorrhage uncommon x
Hydrometra Hydrometra uncommon x
Vulvovaginal pruritus Vulvovaginal pruritus uncommon x
Genital discharge Genital discharge uncommon x
Colpocele Colpocele uncommon x
Thrombophlebitis superficial Thrombophlebitis superficial uncommon x
Rhinitis allergic Rhinitis allergic uncommon x
Hepatic steatosis Hepatic steatosis uncommon x
Feeling hot Feeling hot uncommon x
Vaginal haemorrhage Vaginal haemorrhage uncommon x
Dementia Alzheimer's type Dementia Alzheimer's type rare x
Amnesia Amnesia rare x
Anaemia megaloblastic Anaemia megaloblastic rare x
Angioedema Angioedema rare x
Pupils unequal Pupils unequal rare x
Decreased appetite Anorexia rare x
Decreased appetite rare x
Aortic aneurysm Aortic aneurysm rare x
Aphakia Aphakia rare x
Arterial occlusive disease Arterial occlusive disease rare x
Arthritis infective Arthritis infective rare x
Arthritis Rheumatoid arthritis rare x
Rheumatoid arthritis Rheumatoid arthritis rare x
Calculus bladder Calculus bladder rare x
Bronchitis Bronchitis rare x
Bursitis Bursitis rare x
Cellulitis Cellulitis rare x
Cervicitis Cervicitis rare x
Cheilitis Cheilitis rare x
Cholecystitis Cholecystitis rare x
Coccydynia Coccydynia rare x
Colitis ulcerative Colitis ulcerative rare x
Proctocolitis Colitis ulcerative rare x
Conjunctival haemorrhage Conjunctival haemorrhage rare x
Muscle contracture Muscle contracture rare x
Cyclothymic disorder Cyclothymic disorder rare x
Affective disorder Cyclothymic disorder rare x
Dysphagia Dysphagia rare x
Type 2 diabetes mellitus Type 2 diabetes mellitus rare x
Diverticulitis Diverticulitis rare x
Duodenal ulcer Duodenal ulcer rare x
Duodenitis Duodenitis rare x
Dysgeusia Dysgeusia rare x
Oedema Oedema rare x
Embolism Embolism rare x
Thromboembolic event x
Endometrial neoplasm Endometrial neoplasm rare x
Epilepsy Epilepsy rare x
Oesophagitis Oesophagitis rare x
Excoriation Excoriation rare x
Eye haemorrhage Eye haemorrhage rare x
Body temperature increased Body temperature increased rare x
Anal fissure Anal fissure rare x
Female reproductive neoplasm Female reproductive neoplasm rare x
Seasonal allergy Seasonal allergy rare x
Rhinitis seasonal Seasonal allergy rare x
Haemangioma Haemangioma rare x
Haemarthrosis Haemarthrosis rare x
Haematoma Haematoma rare x
Haemorrhage Haemorrhage rare x
Haemoglobin Haemorrhage rare x
Hepatitis Hepatitis rare x
Inguinal hernia Inguinal hernia rare x
Ophthalmic herpes simplex Ophthalmic herpes simplex rare x
Hydrocephalus Hydrocephalus rare x
Hypercalciuria Hypercalciuria rare x
Hyperparathyroidism Hyperparathyroidism rare x
Hypertriglyceridaemia Hypertriglyceridaemia rare x
Blood triglycerides increased Hypertriglyceridaemia rare x
Blood triglycerides increased rare x
Impetigo Impetigo rare x
Inflammation Inflammation rare x
Intermittent claudication Intermittent claudication rare x
Eye pruritus Eye pruritus rare x
Jaundice Jaundice rare x
Arthropathy Arthropathy rare x
Osteoarthritis Arthropathy rare x
Labyrinthitis Labyrinthitis rare x
Leiomyoma Leiomyoma rare x
Chronic lymphocytic leukaemia Chronic lymphocytic leukaemia rare x
Liver disorder Liver disorder rare x
Hepatocellular injury Liver disorder rare x
Foetor hepaticus Liver disorder rare x
Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease rare x
Bronchial hyperreactivity Chronic obstructive pulmonary disease rare x
Macular degeneration Macular degeneration rare x
Plasma cell myeloma Plasma cell myeloma rare x
Plasmacytoma Plasma cell myeloma rare x
Fungal infection Fungal infection rare x
Nail disorder Nail disorder rare x
Neoplasm Neoplasm rare x
Nephrosclerosis Nephrosclerosis rare x
Melanocytic naevus Melanocytic naevus rare x
Paresis Paresis rare x
Periarthritis Periarthritis rare x
Polyp Polyp rare x
Prurigo Prurigo rare x
Pyelonephritis Pyelonephritis rare x
Pyometra Pyometra rare x
Rectal polyp Rectal polyp rare x
Retinal detachment Retinal detachment rare x
Retinal disorder Retinal disorder rare x
Vasomotor rhinitis Vasomotor rhinitis rare x
Rosacea Rosacea rare x
Sciatica Sciatica rare x
Skin lesion Skin lesion rare x
Soft tissue injury Soft tissue injury rare x
Tenosynovitis Tenosynovitis rare x
Tetany Tetany rare x
Thrombosis Thrombosis rare x
Costochondritis Costochondritis rare x
Tooth fracture Tooth fracture rare x
Urinary tract disorder Urinary tract disorder rare x
Urticaria Urticaria rare x
Vascular headache Vascular headache rare x
Venous thrombosis Venous thrombosis rare x
Spinal fracture Spinal fracture rare x
Motor neurone disease Motor neurone disease rare x
Hypophosphataemia Hypophosphataemia rare x
Breast engorgement Breast engorgement rare x
Clubbing Clubbing rare x
Hepatitis B surface antigen positive Hepatitis B surface antigen positive rare x
Breast discharge Breast discharge rare x
Stomatitis Mouth ulceration rare x
Mouth ulceration Mouth ulceration rare x
Migraine Migraine rare x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased rare x
High density lipoprotein decreased High density lipoprotein decreased rare x
Low density lipoprotein increased rare x
Dry skin Dry skin rare x
Hypogeusia Hypogeusia rare x
Skin irritation Skin irritation rare x
Anal spasm Anal spasm rare x
Parathyroid tumour benign Parathyroid tumour benign rare x
Retinal vascular disorder Retinal vascular disorder rare x
Endophthalmitis Ocular hyperaemia rare x
Ocular hyperaemia Ocular hyperaemia rare x
Microangiopathy Microangiopathy rare x
Breast fibrosis Breast fibrosis rare x
Enlarged clitoris Enlarged clitoris rare x
Eyelid oedema Eyelid oedema rare x
Joint stiffness Joint stiffness rare x
Photosensitivity reaction Photosensitivity reaction rare x
Skin hyperpigmentation Skin hyperpigmentation rare x
Cheilosis Cheilosis rare x
Oral pain Oral pain rare x
Muscle twitching Muscle twitching rare x
Increased appetite Increased appetite rare x
Abdominal tenderness Abdominal tenderness rare x
Memory impairment Memory impairment rare x
Abnormal dreams Abnormal dreams rare x
Visual acuity reduced Visual acuity reduced rare x
Dizziness postural Dizziness postural rare x
Abdominal discomfort Upset stomach rare x
Pulmonary granuloma Pulmonary granuloma rare x
Chest discomfort Chest discomfort rare x
Hair texture abnormal Hair texture abnormal rare x
Pain in jaw Pain in jaw rare x
Aura Aura rare x
Gastric polyps Gastric polyps rare x
Dactylitis Dactylitis rare x
Hypoalbuminaemia Hypoalbuminaemia rare x
Urethral haemorrhage Urethral haemorrhage rare x
Furuncle Furuncle rare x
Rotator cuff syndrome Rotator cuff syndrome rare x
Fallopian tube cyst Fallopian tube cyst rare x
Nerve injury Nerve compression rare x
Nerve compression Nerve compression rare x
Hypochromasia Hypochromasia rare x
Chorioretinopathy Chorioretinopathy rare x
Adenomyosis Adenomyosis rare x
Genital candidiasis Genital candidiasis rare x
Hepatic cancer Hepatic cancer rare x
Benign breast neoplasm Benign breast neoplasm rare x
Platelet count decreased Platelet count decreased rare x
Rectal ulcer Rectal ulcer rare x
Nipple disorder Nipple disorder rare x
Rash maculo-papular Rash maculo-papular rare x
Chest X-ray abnormal Chest X-ray abnormal rare x
Electrocardiogram T wave abnormal Electrocardiogram T wave abnormal rare x
Pruritus generalised Pruritus generalised rare x
Inner ear disorder Inner ear disorder rare x
Skin oedema Skin oedema rare x
Feeling drunk Feeling drunk rare x
Vertigo positional Vertigo positional rare x
Onychoclasis Onychoclasis rare x
Visual impairment Visual disturbance rare x
Low density lipoprotein increased Low density lipoprotein increased rare x
Genital injury Genital injury rare x
Skeletal injury Skeletal injury rare x
Vascular stenosis Vascular stenosis rare x
Presyncope Presyncope rare x
5'nucleotidase increased 5'nucleotidase increased rare x
Ultrasound breast abnormal Ultrasound breast abnormal rare x
Limb injury Limb injury rare x
Venous thrombosis limb Venous thrombosis limb rare x
Blood creatinine abnormal Blood creatinine abnormal rare x
Blood albumin decreased Blood albumin decreased rare x
Bone density decreased Bone density decreased rare x
Urinary bladder polyp Urinary bladder polyp rare x
Hypertonic bladder Hypertonic bladder rare x
Extremity contracture Extremity contracture rare x
Thoracic vertebral fracture Thoracic vertebral fracture rare x
Adnexa uteri cyst Adnexa uteri cyst rare x
Blood urine present Blood urine present rare x
Ear discomfort Ear discomfort rare x
Musculoskeletal discomfort Musculoskeletal discomfort rare x
Adnexa uteri mass Adnexa uteri mass rare x
Lymphostasis Lymphostasis rare x
Pedal pulse decreased Pedal pulse decreased rare x
Breast fibroma Breast fibroma rare x
Exostosis Exostosis rare x
Conjunctival hyperaemia Conjunctival hyperaemia rare x
Ultrasound ovary abnormal Ultrasound ovary abnormal rare x
Malformation venous Malformation venous rare x
Mental disorder Mental disorder x
Bone disorder Bone disorder x
Breast disorder Breast disorder x
Vulvovaginal candidiasis Vaginal moniliasis x
Vulvovaginal mycotic infection Vaginal moniliasis x
Infection Infection x
Cyst Cyst x
Endocrine disorder Endocrine disorder x
Eye disorder Eye disorder x
Gastrointestinal disorder Gastrointestinal disorder x
Cardiac disorder Cardiac disorder x
Cardiomegaly Cardiomegaly x
Cardiac failure Cardiac failure x
Immune system disorder Immune system disorder x
Mediastinal disorder Mediastinal disorder x
Nervous system disorder Nervous system disorder x
Pain Pain x
Supraventricular extrasystoles Supraventricular extrasystoles x
Pruritus genital Pruritus genital x
Cor pulmonale Cor pulmonale x
Tricuspid valve incompetence Tricuspid valve incompetence x
Urinary tract infection Urinary tract infection x
Uterine haemorrhage Uterine haemorrhage x
Vaginal inflammation Vaginal inflammation x
Vaginal infection Vaginal inflammation x
Vaginal infection x
Angiopathy Angiopathy x
Vulval disorder Vulval disorder x
Vulvovaginitis Vulvovaginitis x
Varicose veins vulval Varicose veins vulval x
Malnutrition Malnutrition x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Uterine mass Uterine mass x
Vulvovaginal pain Vaginal pain x
Perineal injury Perineal laceration x
Hepatobiliary disease Hepatobiliary disease x
Uterine cervical squamous metaplasia Uterine cervical squamous metaplasia x
Sinus arrest Sinus arrest x
Infestation Infestation NOS x
Vaginal wall congestion Vaginal wall congestion x
Vaginal erosion Vaginal erosion x
Retinal vein thrombosis Retinal vein thrombosis x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

lasofoxifene / lasofoxifene tartrate

Side effects:314
Source:EMA

Color scheme:

standard – alternative

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    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
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    no frequency information
    not found on label