MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
Malignant neoplasm progression
|
Neoplasm malignant aggravated
|
17% - 20%
|
20%
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia
|
Anaemia
|
postmarketing — 4.4% - 22%
|
3.6% - 5.2%
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
|
|
Urinary tract infection
|
Urinary tract infection
|
12% - 15%
|
|
x
|
|
|
|
x
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Insomnia
|
Insomnia
|
10% - 13%
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Insomnia NEC
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pain in extremity
|
Pain in extremity
|
3.9% - 16%
|
4.8% - 9.9%
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Confusional state
|
Confusional state
|
rare, 11% - 13%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Feeling abnormal
|
Confusional state
|
rare, 11% - 13%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise
|
postmarketing — 0.7% - 7.2%
|
0.5% - 1%
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cough
|
Cough
|
uncommon, 10% - 12%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypokalaemia
|
Hypokalaemia
|
uncommon, 10% - 16%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation
|
Agitation
|
8% - 11%
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Headache
|
Headache
|
postmarketing — 3.9% - 20.4%
|
2.5% - 11.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anxiety
|
Anxiety
|
uncommon, 8% - 12%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anxiety NEC
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Osteoarthritis
|
Osteoarthritis
|
5.7% - 9.1%
|
4.5% - 9.7%
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Candida infection
|
Candida infection
|
4% - 12%
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypophosphataemia
|
Hypophosphataemia
|
common — 1% - 51%
|
0.2% - 3%
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertension
|
Hypertension
|
uncommon — 5.1% - 12.7%
|
5.4% - 12.4%
|
|
|
|
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Influenza
|
Influenza
|
5% - 7%
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Constipation
|
Constipation
|
uncommon — 5% - 23%
|
6.9%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
postmarketing — 5.2% - 17%
|
4.7% - 7.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
postmarketing — 4.5% - 28%
|
4.5% - 7.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Non-cardiac chest pain
|
Non-cardiac chest pain
|
3.5% - 7.7%
|
3%
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Back pain
|
Back pain
|
1.7% - 18.2%
|
11.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
Arthralgia
|
postmarketing — 3% - 27.3%
|
18.3% - 20.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal discomfort
|
Arthralgia
|
postmarketing — 3% - 27.3%
|
18.3% - 20.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
postmarketing — 4% - 22.7%
|
2.7% - 6.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspnoea
|
Dyspnoea
|
uncommon — 1% - 20%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oesophagitis
|
Oesophagitis
|
common
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Flushing
|
Flushing
|
common
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Nasopharyngitis
|
Nasopharyngitis
|
common
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Pain
|
Pain
|
uncommon — 1.5% - 24.2%
|
0.5% - 3.5%
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Tachycardia
|
Tachycardia
|
common
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Thirst
|
Thirst
|
common
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Blood urea increased
|
Blood urea increased
|
common
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Bone pain
|
Bone pain
|
postmarketing — 3.2% - 12%
|
1% - 2.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chills
|
Rigors
|
common, 1% - 8%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills
|
postmarketing, 1.5% - 18.2%
|
0.5% - 3%
|
x
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal stiffness
|
Stiffness
|
common
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Musculoskeletal stiffness
|
0% - 4.6%
|
|
|
x
|
x
|
x
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Musculoskeletal chest pain
|
Musculoskeletal chest pain
|
common
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Renal failure
|
Renal impairment
|
postmarketing, common
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Renal failure
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal impairment
|
Renal impairment
|
postmarketing, common
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Neck pain
|
Neck pain
|
1.4% - 6.6%
|
1.1% - 5%
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Breast cancer
|
Breast cancer
|
4.3%
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Advanced breast cancer
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Joint stiffness
|
Joint stiffness
|
common, 1.1% - 3.5%
|
2%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Infection
|
Infection
|
postmarketing, 4% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
uncommon, 2% - 9%
|
3.5% - 6.7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Syncope
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Dyspepsia
|
Dyspepsia
|
uncommon — 1.7% - 7.1%
|
1.6% - 5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal pain
|
Shoulder pain
|
0% - 6.9%
|
0% - 5.6%
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Musculoskeletal pain
|
postmarketing — 0.4% - 12.4%
|
0.3% - 7.9%
|
|
|
|
|
x
|
x
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lethargy
|
Lethargy
|
common, 1% - 5%
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Muscle spasms
|
Muscle spasms
|
1.5% - 5.6%
|
1.7% - 5%
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Cramp muscle
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm
|
Neoplasm
|
3.2%
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Prostate cancer
|
Prostate cancer
|
3.1%
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Oedema peripheral
|
Oedema peripheral
|
uncommon — 1% - 5.6%
|
3.5% - 5.3%
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Leg edema
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Edema of lower extremities
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
C-reactive protein increased
|
C-reactive protein increased
|
1.4% - 4.6%
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Pain in jaw
|
Pain in jaw
|
2% - 3.9%
|
2.5%
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Hyperhidrosis
|
Hyperhidrosis
|
common, 2% - 2.6%
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Sweating increased
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation
|
Atrial fibrillation
|
uncommon, 2% - 3.3%
|
1.9% - 2.6%
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Asthenia
|
Fatigue
|
postmarketing — 2.1% - 17.6%
|
1.2% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
postmarketing — 1% - 6.1%
|
1% - 3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
postmarketing — 2.1% - 17.6%
|
1.2% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Creatinine renal clearance decreased
|
Creatinine renal clearance decreased
|
2% - 2.1%
|
1.7% - 2.4%
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Myalgia
|
Myalgia
|
postmarketing — 4% - 22.7%
|
2.7% - 6.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
uncommon — 2% - 14%
|
7.9%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
uncommon — 2% - 14%
|
7.9%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
Anorexia
|
common, 0.6% - 14%
|
0% - 1.1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
uncommon, 2% - 3%
|
2.5%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash
|
Rash
|
uncommon, 2% - 3%
|
2.5%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
postmarketing — 0.3% - 38%
|
0.1% - 4.6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypotension
|
Hypotension
|
uncommon, 2% - 11%
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting
|
Vomiting
|
postmarketing — 2% - 17%
|
3.2% - 4.5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vertigo
|
Vertigo
|
1.3% - 4.3%
|
1% - 4%
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal discomfort
|
Abdominal discomfort
|
1.1% - 2%
|
0.5%
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Abdominal distension
|
Abdominal distension
|
0.6% - 2%
|
0%
|
|
x
|
x
|
x
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Abdominal pain upper
|
Abdominal pain upper
|
0.9% - 4.6%
|
1.5% - 3.1%
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Blood creatinine increased
|
Blood creatinine increased
|
0.7% - 2%
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Flank pain
|
Flank pain
|
0.6% - 2%
|
0%
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Chest pain
|
Chest pain
|
uncommon, 1.3% - 2.4%
|
1.1% - 1.8%
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Palpitations
|
Palpitations
|
0% - 2.6%
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Hypermagnesaemia
|
Hypermagnesaemia
|
1% - 2%
|
0.5% - 2%
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye pain
|
Eye pain
|
0% - 2%
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Hypoaesthesia
|
Hypoaesthesia
|
uncommon, 2.2% - 5.6%
|
2%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Numbness
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Leukopenia
|
Leukopenia
|
uncommon
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Paraesthesia
|
Paraesthesia
|
uncommon — 0% - 2%
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Paraesthesia NEC
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pruritus
|
Pruritus
|
uncommon
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sleep disorder
|
Sleep disturbance
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Sleep disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Stomatitis
|
Stomatitis
|
uncommon
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Swelling
|
Swelling
|
uncommon
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Shock
|
Syncope
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Shock
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Syncope
|
Syncope
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Loss of consciousness
|
Syncope
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Thrombocytopenia
|
Thrombocytopenia
|
uncommon
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Injection site reaction
|
Injection site reaction
|
uncommon
|
|
|
x
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash macular
|
Rash macular
|
uncommon
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Induration
|
Induration
|
uncommon
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Erythema
|
Redness
|
uncommon
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
Erythema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Somnolence
|
Somnolence
|
uncommon
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypocalcaemia
|
Hypocalcaemia
|
very rare — 1% - 3%
|
0.2% - 1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypomagnesaemia
|
Hypomagnesaemia
|
uncommon, 1% - 9%
|
1% - 2%
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute phase reaction
|
Acute phase reaction
|
postmarketing — 0% - 3.9%
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angioedema
|
Angioedema
|
postmarketing, rare
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthritis
|
Arthritis
|
postmarketing — 2.2% - 4%
|
1.5%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
Coagulopathy
|
Coagulopathy
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Bronchospasm
|
Bronchospasm
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchoconstriction
|
postmarketing, uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neoplasm malignant
|
Neoplasm malignant
|
postmarketing, 14% - 21%
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis
|
Conjunctivitis
|
postmarketing, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dehydration
|
Dehydration
|
postmarketing, 0.6% - 2.5%
|
0.6% - 2.3%
|
x
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
postmarketing
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Episcleritis
|
Episcleritis
|
very rare, postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Femur fracture
|
Femur fracture
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Haematuria
|
Haematuria
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia
|
Hyperaesthesia
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkalaemia
|
Hyperkalaemia
|
postmarketing, rare
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypernatraemia
|
Hypernatraemia
|
postmarketing, rare
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Inflammation
|
Inflammation
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Iridocyclitis
|
Iridocyclitis
|
postmarketing
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Iritis
|
Iritis
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Renal failure acute
|
Renal failure acute
|
postmarketing, uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Oral disorder
|
Oral disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Plasma cell myeloma
|
Plasma cell myeloma
|
postmarketing, 3.2%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Plasmacytoma
|
Plasma cell myeloma
|
postmarketing, 3.2%
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteonecrosis
|
Osteonecrosis
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Necrosis ischaemic
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pancytopenia
|
Pancytopenia
|
rare
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Proteinuria
|
Proteinuria
|
postmarketing, uncommon
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Protein urine present
|
Proteinuria
|
postmarketing, uncommon
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Scleritis
|
Scleritis
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tremor
|
Tremor
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urticaria
|
Urticaria
|
postmarketing, uncommon
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Uveitis
|
Uveitis
|
very rare — uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight increased
|
Weight increased
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth
|
Dry mouth
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Joint swelling
|
Joint swelling
|
postmarketing — 0.6% - 3%
|
0%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
Interstitial lung disease
|
Interstitial lung disease
|
postmarketing, rare
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise
|
Malaise
|
postmarketing — 0.7% - 7.2%
|
0.5% - 1%
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Discomfort
|
Malaise
|
postmarketing — 0.7% - 7.2%
|
0.5% - 1%
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ill-defined disorder
|
Malaise
|
postmarketing — 0.7% - 7.2%
|
0.5% - 1%
|
|
|
|
|
x
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vision blurred
|
Vision blurred
|
postmarketing, uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthma
|
Exacerbation of asthma
|
postmarketing
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Influenza like illness
|
Influenza-like symptoms
|
postmarketing, 6.7% - 8%
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Influenza like illness
|
postmarketing, 0.8% - 11%
|
0.4% - 2.7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orbital oedema
|
Orbital oedema
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradycardia
|
Bradycardia
|
rare
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Osteonecrosis of jaw
|
Osteonecrosis of jaw
|
postmarketing, uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arrhythmia
|
Arrhythmia
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Sensory loss
|
Numbness
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Convulsion
|
Convulsion
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Tetany
|
Tetany
|
very rare
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Agranulocytosis
|
Agranulocytosis
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alopecia
|
Alopecia
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial flutter
|
Atrial flutter
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Mental disorder
|
Mental disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Bone disorder
|
Bone disorder
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Dysphagia
|
Dysphagia
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depression
|
Depression
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
Anxiety depression
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Endophthalmitis
|
Endophthalmitis
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Ocular hyperaemia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Panophthalmitis
|
Endophthalmitis
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Eye disorder
|
Eye disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Gastritis
|
Gastritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastrooesophageal reflux disease
|
Gastrooesophageal reflux disease
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Reaction gastrointestinal
|
|
|
x
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Cardiac disorder
|
Cardiac disorder
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Hypogonadism
|
Hypogonadism
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Immune system disorder
|
Immune system disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Renal failure chronic
|
Renal failure chronic
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Musculoskeletal disorder
|
Musculoskeletal disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Necrosis ischaemic
|
Necrosis ischaemic
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Metastasis
|
Metastasis
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nervous system disorder
|
Nervous system disorder
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Neutropenia
|
Neutropenia
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Night sweats
|
Night sweats
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Osteomyelitis
|
Osteomyelitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Osteopenia
|
Osteopenia
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Pleural effusion
|
Pleural effusion
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Toothache
|
Toothache
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
Pollakiuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Angiopathy
|
Angiopathy
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Weight decreased
|
Weight decreased
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Spinal fracture
|
Spinal fracture
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cataract
|
Cataract
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Electrolyte imbalance
|
Electrolyte abnormality
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
|
Blood electrolytes abnormal
|
Electrolyte abnormality
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
|
Muscular weakness
|
Muscular weakness
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Ocular hyperaemia
|
Ocular hyperaemia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Malnutrition
|
Malnutrition
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
x
|
x
|
x
|
|
x
|
|
x
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Cardiac fibrillation
|
Cardiac fibrillation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Abdominal pain lower
|
Abdominal pain lower
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Blood creatinine decreased
|
Creatinine low
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oropharyngeal discomfort
|
Throat sore
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oropharyngeal pain
|
Throat sore
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Azotaemia
|
Azotaemia
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Mucosal inflammation
|
Mucosal inflammation
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood creatinine abnormal
|
Serum creatinine abnormal
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nephropathy toxic
|
Nephropathy toxic
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal cancer
|
Renal cancer
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infestation
|
Infestation NOS
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
Local reaction
|
Local reaction
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Infusion related reaction
|
Infusion related reaction
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Infusion site reaction
|
Infusion site reaction
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Bone density decreased
|
Bone mass decreased
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Atypical femur fracture
|
Atypical femur fracture
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Blood calcium decreased
|
Blood calcium decreased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|