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Lamotrigine

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N03AX09

Side effects

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MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Diplopia Diplopia 0% - 49% 1% - 8% x x x x x x x x x x x x x x x x x x x x
Injury Accidental injury infrequent, 2% - 14% 7% - 12% x x x x x x x x x x x x x x x x x x
Somnolence Somnolence 2% - 17% 3% - 15% x x x x x x x x x x x x x x x x x x x x
Drowsiness
Vision blurred Vision blurred 0% - 25% 1% - 10% x x x x x x x x x x x x x x x x x x x x
Ataxia Ataxia 0% - 28% 1% - 10% x x x x x x x x x x x x x x x x x x x x
Dizziness Dizziness 0% - 54% 0% - 27% x x x x x x x x x x x x x x x x x x x x
Syncope rare — 2.9% x x x x x x x x x x x x x x x x x x x x
Nausea Nausea 0.7% - 25% 1% - 11% x x x x x x x x x x x x x x x x x x x x
Pharyngitis Pharyngitis 1.9% - 14% 4% - 11% x x x x x x x x x x x x x x x x x x x
Vomiting Vomiting 0% - 20% 2% - 16% x x x x x x x x x x x x x x x x x x x x
Back pain Back pain infrequent, 1% - 8% 0% - 6.2% x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea 4% - 11% 2% - 9% x x x x x x x x x x x x x x x x x x x x
Asthenia Fatigue 6% - 8% 4% - 5% x x x x x x x x x x x x x x x x x
Asthenia 0% - 8.6% 1% - 8.8% x x x x x x x x x x x x x x x x x x x x
Fatigue Fatigue 6% - 8% 4% - 5% x x x x x x x x x x x x x x x x x
Bronchitis Bronchitis 0% - 9% 5% - 7% x x x x x x x x x x x x x x x x x x
Influenza Influenza 4.9% - 7% 0% - 6% x x x x x x x x x x x x x x x x x x x x
Rhinitis Rhinitis 0.9% - 14% 4% - 9.3% x x x x x x x x x x x x x x x x x x
Cough Cough increased 2.9% - 8% 5.7% - 6% x x x x x x x x x x x x x x x x x x x
Cough 5% 3% x x x x x x x x x x x x x x x
Abdominal pain Abdominal pain 3% - 10% 0% - 5% x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain 3% - 10% 0% - 5% x x x x x x x x x x x x x x x x x x
Body temperature increased Body temperature increased 0% - 15% 3.6% - 14% x x x x x x x x x x x x x x x x x x x x
Dry mouth Dry mouth infrequent, 0% - 6% 1% - 4% x x x x x x x x x x x x x x x x x x x
Action tremor Action tremor 6% 1% x x
Coordination abnormal Coordination abnormal 6% - 12.7% 2% - 2.1% x x x x x x x x x x x x x x x x x
Menstrual disorder Menstrual disorder 5.2% 5.8% x x x x
Amblyopia Amblyopia frequent x x x x x x x x x x x x x x x x x x
Infection Infection infrequent, 2% - 20% 1% - 17% x x x x x x x x x x x x x x x x x x x x
Confusional state Confusional state frequent x x x x x x x x x x x x x x x x x x x x
Feeling abnormal Confusional state frequent x x x x x x x x x x x x x x x x x x x x
Malaise infrequent, 2% - 4.9% 1.9% x x x x x x x x x x x x x x x x x x
Dysmenorrhoea Dysmenorrhoea 0% - 7% 6% - 6.3% x x x x x x x x x x x x
Dyspepsia Dyspepsia 2% - 7% 1% - 2.1% x x x x x x x x x x x x x x x x x x
Dermatitis Rash 3% - 14% 5% - 12% x x x x x x x x x x x x x x x x x x x x
Rash Rash 3% - 14% 5% - 12% x x x x x x x x x x x x x x x x x x x x
Pain Pain frequent, 0% - 6.2% 0% - 4% x x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia frequent x x x x x x x x x x x x x x x x x x
Insomnia Insomnia 2% - 10% 1.9% - 6% x x x x x x x x x x x x x x x x x x x x
Tremor Tremor 0.9% - 10% 0% - 1.4% x x x x x x x x x x x x x x x x x x x x
Anxiety Anxiety 0% - 5% 0% - 3% x x x x x x x x x x x x x x x x x x x
Constipation Constipation 2% - 8.9% 1% - 3.1% x x x x x x x x x x x x x x x x x x x
Depression Depression 0% - 4.9% 1% - 3% x x x x x x x x x x x x x x x x
Anxiety depression x x x x
Vaginal inflammation Vaginal inflammation 0% - 4.1% 0.5% - 1% x x x x x x x x x x x x x x x x x x x
Vaginal infection Vaginal inflammation 0% - 4.1% 0.5% - 1% x x x x x x x x x x x x x x x x x x x
Mood swings Mood swings infrequent, 1% - 4% 0% - 2% x x x x x x x x x x x x x x x x x x
Affect lability Mood swings infrequent, 1% - 4% 0% - 2% x x x x x x x x x x x x x x x x x x
Gait disturbance Gait disturbance infrequent, 4% 2% x x x x x x x x x x x x x x x x
Headache Headache 1.1% - 29.1% 19% - 19.1% x x x x x x x x x x x x x x x x x x x x
Asthma Asthma 3% x
Irritability Irritability 0% - 3% 1.9% - 2% x x x x x x x x x x x x x x x x x x x x
Mediastinal disorder Mediastinal disorder 3% 2% x x
Pneumonia Pneumonia 3% 0% x x
Pruritus Pruritus 2% - 6% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Speech disorder Speech disorder 0.9% - 3% 0% - 0.2% x x x x x x x x x x x x x x x x x x x
Urinary tract infection Urinary tract infection 3% 0% x x x x x x x x x x x x x x x x x
Balance disorder Balance disorder 3% 0% x x
Unsteadiness x
Laryngeal pain Pharyngolaryngeal pain 3% 2% x x
Chest pain Chest pain 2% - 5% x x x x x x x x x x x x x x x x x x x
Amenorrhoea Amenorrhoea 2% 1% x x x x x x x x x x x x x x x x x x
Amnesia Amnesia frequent, 0% - 2% x x x x x x x x x x x x x x x x x x
Decreased appetite Anorexia 0% - 3% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Arthralgia Arthralgia 2% - 2.9% 0% - 0.2% x x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia 2% - 2.9% 0% - 0.2% x x x x x x x x x x x x x x x x x x x x
Myalgia 0.9% - 2.8% 0% - 3.1% x x x x x x x x x x x x x x x x x x x x
Balanitis Balanitis 2% 0% x x
Bronchospasm Bronchospasm rare, 2% 1% x x x x x x x x x x x x x x x x
Neck pain Neck pain 0% - 2.4% 1% - 1.2% x x x x x x x x x x x x x x x x x x x x
Connective tissue disorder Connective tissue disorder 2% 0% x x
Ear disorder Ear disorder 2% 1% x
Eczema Eczema 2% - 4% 0% - 1% x x x x x x x x x x x x x x x x x
Haemorrhage Haemorrhage rare, 2% - 3% 0% - 1% x x x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage rare, 2% - 3% 0% - 1% x x x x x x x x x x x x x x x x x
Nervousness Nervousness frequent, 1% - 2% 0% - 1% x x x x x x x x x x x x x x x x x
Tension Nervousness frequent, 1% - 2% 0% - 1% x x x x x x x x x x x x x x x x x
Nystagmus Nystagmus frequent, 0% - 2% 1% x x x x x x x x x x x x x x x x x x x x
Penis disorder Penis disorder 2% 0% x x x
Convulsion Convulsion 1.9% - 4% 0.5% - 1.2% x x x x x x x x x x x x
Sinusitis Sinusitis rare, 2% 1% x x x x x x x x x x x x x x x x x x x
Skin ulcer Skin ulcer 2% x
Angiopathy Angiopathy 2% 0% x x
Vertigo Vertigo frequent, 1% - 3% 0% - 1% x x x x x x x x x x x x x x x x x x x
Weight decreased Weight decreased infrequent, 2% - 5% x x x x x x x x x x x x x x x x x x
Myalgia Myalgia 0.9% - 2.8% 0% - 3.1% x x x x x x x x x x x x x x x x x x x x
Photosensitivity reaction Photosensitivity rare, 2% 0% x x x x x x x x x x x x x x x x
Lymphadenopathy Lymphadenopathy infrequent, 1% - 2% 0% - 1% x x x x x x x x x x x x x x x x x x
Face oedema Face oedema infrequent, 1% - 2% 0% - 1% x x x x x x x x x x x x x x x
Infestation Infestation NOS 2% 1% x x
Malnutrition Malnutrition rare, 3% 2% x x x x x x x x x x x x x x x x x x x
Blepharitis Blepharitis 1% 0% x
Dermatitis contact Dermatitis contact 0% - 2% x x x x x x x x x x x x x x x x x x
Dyspnoea Dyspnoea infrequent, 0% - 2% 0% x x x x x x x x x x x x x x x x x x x
Keratitis Keratitis 1% 0% x
Nail disorder Nail disorder 1% 0% x
Peptic ulcer Peptic ulcer 0% - 2% x x x x x x x x x x x x x x x x x x
Aphthous stomatitis Aphthous stomatitis 1% 0% x
Tooth disorder Tooth disorder infrequent, 0% - 3.2% 0% - 2% x x x
Agitation Agitation infrequent, 1% 0% x x x x x x x x x x x x x x x x x x
Hyperkinesia infrequent x x x x x x x x x x x x x x x x x x x
Eye pain Eye pain 1% 0% x
Sore eye
Hyporeflexia Hyporeflexia 0% - 2% x x x x x x x x x x x x x x x x x x
Hyperreflexia Hyperreflexia 0% - 2% x x x x x x x x x x x x x x x x x
Rectal haemorrhage Rectal haemorrhage 0% - 2% x x x x x x x x x x x x x x x x x x
Laboratory test abnormal Laboratory test abnormal 1% 0% x
Alopecia Alopecia infrequent x x x x x x x x x x x x x x x x x x x
Aphasia Aphasia infrequent x x x x x x x x x x x x x x x x x x x
Arthritis Arthritis rare, infrequent x x x x x x x x x x x x x x x x x
Conjunctivitis Conjunctivitis infrequent, 1% 0% x x x x x x x x x x x x x x x x x x x x
Libido decreased Libido decreased rare, infrequent x x x x x x x x x x x x x x x x x x x
Disturbance in sexual arousal Libido decreased rare, infrequent x x x x x x x x x x x x x x x x x x x
Libido increased infrequent x
Dysphagia Dysphagia infrequent x x x x x x x x x x x x x x x x x x x
Depersonalisation Depersonalisation infrequent x x x x x x x x x x x x x x x x x x x
Dysarthria Dysarthria infrequent x x x x x x x x x x x x x x x x x x x
Osteoarthritis Dysarthria infrequent x x x x x x x x x x x x x x x x x x x
Arthropathy rare, infrequent x x x
Dysgeusia Dysgeusia infrequent x x x x x x x x x x x x x x x x x x x
Dyskinesia Dyskinesia infrequent x x x x x x x x x x x x x x x x x x x
Movement disorder rare, infrequent x x x x x x x x x x x x x x x x x x x x
Ear pain Ear pain infrequent, 1% 0% x x x x x x x x x x x x x x x x x x x x
Ecchymosis Ecchymosis infrequent x x x x x x x x x x x x x x x x x x x
Epistaxis Epistaxis infrequent, 0% - 2% x x x x x x x x x x x x x x x x x x
Eructation Eructation rare, infrequent x x x x x x x x x x x x x x x x x
Flushing Flushing infrequent x x x x x x x x x x x x x x x x x
Gastritis Gastritis rare, infrequent x x x x x x x x x x x x x x x x x
Gingivitis Gingivitis infrequent x x x x x x x x x x x x x x x x x
Breath odour Breath odour infrequent x x x
Hallucination Hallucination infrequent x x x x x x x x x x x x x x x x x x x x
Haematuria Haematuria infrequent x x x x x x x x x x x x x x x x x x x
Hirsutism Hirsutism infrequent x x x x x x x x x x x x x x x x x x x
Hostility Hostility infrequent, frequent x x x x x x x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing, infrequent x x x x x x x x x x x x x x x x x x x x
Hypertension Hypertension rare, infrequent x x x x x x x x x x x x x x x x x x x
Orthostatic hypotension Orthostatic hypotension infrequent x x x x x x x x x x x x x x x x x x x
Libido increased Libido increased infrequent x
Muscle spasms Cramps of lower extremities rare, infrequent x x x x x x x x x x x x x x x x x
Muscle spasms rare, infrequent x x x x x x x x x x x x x x x x x
Leukopenia Leukopenia infrequent x x x x x x x x x x x x x x x x x x x x
Breast pain Breast pain rare, infrequent x x x
Menorrhagia Menorrhagia rare, infrequent x x x x x x x x x x x x x x x x x x x
Movement disorder Movement disorder rare, infrequent x x x x x x x x x x x x x x x x x x x x
Hypertonia Hypertonia infrequent x x x x x x x x x x x x x x x x x x x
Myoclonus Myoclonus infrequent x x x x x x x x x x x x x x x x x x x
Palpitations Palpitations infrequent x x x x x x x x x x x x x x x x x x x
Personality disorder Personality disorder infrequent x x x x x x x x x x x x x x x x x x x
Polyuria Polyuria infrequent x x x x x x x x x x x x x x x x x x x
Urine output increased Polyuria infrequent x x x x x x x x x x x x x x x x x x x
Psychotic disorder Psychotic disorder infrequent x x x x x x x x x x x x x x x x x x x
Salivary hypersecretion Salivary hypersecretion infrequent x x x x x x x x x x x x x x x x x
Hyperhidrosis Sweating infrequent, 0% - 2% x x x x x x x x x x x x x x x x x x
Shock Syncope rare — 2.9% x x x x x x x x x x x x x x x x x x x x
Syncope Syncope rare — 2.9% x x x x x x x x x x x x x x x x x x x x
Loss of consciousness Syncope rare — 2.9% x x x x x x x x x x x x x x x x x x x x
Tachycardia Tachycardia infrequent x x x x x x x x x x x x x x x x x x x
Tinnitus Tinnitus infrequent x x x x x x x x x x x x x x x x x x x
Pollakiuria Pollakiuria infrequent x x x x x x x x x x x x x x x x x
Micturition urgency rare x x x x x x x x x x x x x x x x x x
Urinary incontinence Urinary incontinence infrequent x x x x x x x x x x x x x x x x x x x
Urticaria Urticaria infrequent x x x x x x x x x x x x x x x x x x x
Vasodilation procedure Vasodilation infrequent x x x x x x x x x x x x x x x x x x x
Weight increased Weight increased infrequent x x x x x x x x x x x x x x x x x x
Yawning Yawning infrequent x x x x x x x x x x x x x x x x
Chills Chills infrequent x x x x x x x x x x x x x x x x x
Stupor Stupor infrequent x x x x x x x x x x x x x x x x x x x
Depressed level of consciousness Stupor infrequent x x x x x x x x x x x x x x x x x x x
CNS depression NOS infrequent x x x x x x x x x x
Apathy Apathy infrequent x x x x x x x x x x x x x x x x x x x
Flat affect Apathy infrequent x x x x x x x x x x x x x x x x x x x
Photophobia Photophobia infrequent x x x x x x x x x x x x x x x x x x x
Oedema peripheral Oedema peripheral infrequent, 0% - 2% x x x x x x x x x x x x x x x x x x
Panic attack Panic attack infrequent x x x x x x x x x x x x x x x x x x x
Stomatitis Mouth ulceration infrequent x x x x x x x x x x x x x x x x x x x
Stomatitis rare — 1% 0% x x x x x x x x x x x x x x x x x x
Mouth ulceration Mouth ulceration infrequent x x x x x x x x x x x x x x x x x x x
Migraine Migraine infrequent x x x x x x x x x x x x x x x x x
Liver function test abnormal Liver function test abnormal infrequent x x x x x x x x x x x x x x x x x x x
Paranoia Paranoid reaction infrequent x x x x x x x x x x x x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased infrequent x x x x x x x x x x x x x x x x x x
Skin discolouration Skin discolouration infrequent x x x x x x x x x x x x x x x x x
Dry skin Dry skin infrequent, 0% - 2% x x x x x x x x x x x x x x x x x x
Accommodation disorder Accommodation disorder infrequent x x x x x x x x x x x x x x x x x x x
Malaise Malaise infrequent, 2% - 4.9% 1.9% x x x x x x x x x x x x x x x x x x
Discomfort Malaise infrequent, 2% - 4.9% 1.9% x x x x x x x x x x x x x x x x x x
Ill-defined disorder Malaise infrequent, 2% - 4.9% 1.9% x x x x x x x x x x x x x x x x x x
Muscle twitching Muscle twitching infrequent x x x x x x x x x x x x x x x x x
Increased appetite Increased appetite infrequent x x x x x x x x x x x x x x x x x
Abnormal dreams Abnormal dreams infrequent x
Euphoric mood Euphoric mood infrequent x x x x x x x x x x x x x x x x x x x
Urine abnormality Urine abnormality rare, infrequent x x x
Urine analysis abnormal Urine abnormality rare, infrequent x x x
Erectile dysfunction Erectile dysfunction rare, infrequent x x x x x x x x x x x x x x x x x x x
Dry eye Dry eye rare, infrequent x x x x x x x x x x x x x x x x x x x
Akathisia Akathisia infrequent x x x x x x x x x x x x x x x x x x x
Rash maculo-papular Rash maculo-papular infrequent x x x x x x x x x x x x x x x x x x x
Suicidal ideation Suicidal ideation rare — 0% - 2% x x x x x x x x x x x x x x x x x
Hyperkinesia Hyperkinesia infrequent x x x x x x x x x x x x x x x x x x x
Menopausal symptoms Hot flush infrequent, 2% 0% x x x x x x x x x x x x x x x x x x x
Hot flush Hot flush infrequent, 2% 0% x x x x x x x x x x x x x x x x x x x
Acne Acne infrequent x x x x x x x x x x x x x x x x x x x
Sleep disorder Sleep disorder infrequent x x x x x x x x x x x x x x x x x
Muscular weakness Myasthenia infrequent x x x x x x x x x x x x x x x x x
Ejaculation disorder Abnormal ejaculation rare, infrequent x x x x x x x x x x x x x x x x x x x
Hypoaesthesia Hypoaesthesia rare — 0% - 2% x x x x x x x x x x x x x x x x x x
Abscess Abscess rare x x x
Agranulocytosis Agranulocytosis postmarketing x x x x x x x x x x x
Anaemia Anaemia rare, infrequent x x x x x x x x x x x x x x x x x x x x
Aplastic anaemia Aplastic anaemia postmarketing x x x x
Haemolytic anaemia Haemolytic anaemia postmarketing x x x x x x x x x x x
Anaemia macrocytic Anaemia macrocytic rare x x x x x x x x x x x x x x x x x x x
Angina pectoris Angina pectoris rare x x x
Angioedema Angioedema rare x x x x x x x x x x x x x x x x x
Apnoea Apnoea postmarketing x x x x x x x x x x x x x x x x x x x x
Atrial fibrillation