Lamotrigine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 25)
1 2 3 4 5 6 7 8 9 10
Diplopia def Diplopia def 1% - 49% 1% - 8% x x x x x x x x
Headache def Headache def 19% - 29% 19% x x x x x x x x
Ataxia def Ataxia def 3% - 28% 3% - 10% x x x x x x x x
Nausea def Nausea def 2% - 25% 2% - 11% x x x x x x x x
Vision blurred def Vision blurred def 1% - 25% 1% - 10% x x x x x x x x
Infection def Infection def 0% - 20% 0% - 17% x x x x x x x x
Vomiting def Vomiting def 2% - 20% 2% - 16% x x x x x x x x
Pharyngitis def Pharyngitis def 4% - 14% 4% - 11% x x x x x x x
Rhinitis def Rhinitis def 2% - 14% 4% - 9% x x x x x x x x
Diarrhoea def Diarrhoea def 4% - 11% 3% - 9% x x x x x x x x
Abdominal pain def Abdominal pain def 3% - 10% 3% - 5% x x x x x x x x
Gastrointestinal pain def Abdominal pain def 3% - 10% 3% - 5% x x x x x x x x
Pain def Pain def rare — 1% - 10% 1% - 6% x x x x x x x x x
Tremor def Tremor def 1% - 10% 1% x x x x x x x x
Insomnia def Insomnia def 2% - 10% 2% - 6% x x x x x x x x
Asthenia def Asthenia def 4% - 8% 4% x x x x x x x x
Fatigue def 5% - 8% 4% - 5% x x x x x x
Back pain def Back pain def 6% - 8% 6% x x x x x x x x
Cough def Cough def 3% - 8% 3% - 6% x x x x x x x
Cough increased 6% - 8% 6% x x x x x x
Fatigue def Fatigue def 5% - 8% 4% - 5% x x x x x x
Bronchitis def Bronchitis def 5% - 7% 5% x x x x x x x
Dysmenorrhoea def Dysmenorrhoea def 5% - 7% 6% x x x x x x x
Dyspepsia def Dyspepsia def 1% - 7% 1% - 2% x x x x x x x x
Influenza def Influenza def 6% - 7% 6% x x x x x x x x
Affective disorder def Affective disorder def 5% - 7% 5% x x x x x x
Dry mouth def Dry mouth def 2% - 6% 1% - 4% x x x x x x x
Coordination abnormal Coordination abnormal 2% - 6% 2% x x x x x x x
Amblyopia def Amblyopia def frequent x x x x x x x x
Anxiety def Anxiety def 3% - 5% 0% - 3% x x x x x x x x
Phobia def infrequent
Chest pain def Chest pain def 5% x x x x x x x x
Confusional state def Confusional state def frequent x x x x x x x x x
Feeling abnormal Confusional state def frequent x x x x x x x x x
Malaise def infrequent x x x x x x x x x
Constipation def Constipation def 2% - 5% 1% - 3% x x x x x x x
Paraesthesia def Paraesthesia def frequent x x x x x x x x x
Weight decreased def Weight decreased def 5% x x x x x x x
Vaginal inflammation def Vaginal inflammation def 1% - 4% 1% x x x x x x
Vaginal infection def Vaginal inflammation def 1% - 4% 1% x x x x x x
Mood swings Mood swings 2% - 4% 2% x x x x x x x x
Affect lability Mood swings 2% - 4% 2% x x x x x x x x
Gait disturbance def Gait disturbance def 2% - 4% 2% x x x x x
Decreased appetite Anorexia def 1% - 3% 1% - 2% x x x x x x x x
Convulsion def Convulsion def rare, 1% - 3% 1% x x x x x x x x x
Irritability def Irritability def 2% - 3% 2% x x x x x x x x
Pruritus def Pruritus def 1% - 3% 1% - 2% x x x x x x x x
Speech disorder def Speech disorder def 0% - 3% 0% x x x x x x
Tooth disorder def Tooth disorder def 1% - 3% 1% - 2% x
Urinary tract infection def Urinary tract infection def 0% - 3% 0% x x x x x x
Vertigo def Vertigo def 1% - 3% 1% x x x x x x x
Amenorrhoea def Amenorrhoea def 1% - 2% 1% x x x x x x
Arthralgia def Arthralgia def 0% - 2% 0% x x x x x x x x
Musculoskeletal discomfort Arthralgia def 0% - 2% 0% x x x x x x x x
Myalgia def 2% 0% x x x x x x x x
Bronchospasm def Bronchospasm def 1% - 2% 1% x x x x x x
Neck pain def Neck pain def 1% - 2% 1% x x x x x x x x
Ear disorder def Ear disorder def 1% - 2% 1%
Eczema def Eczema def 1% - 2% 1% x x x x x x x
Oedema def Oedema def rare, 0% - 2% 0% - 1% x x x x x x x x
Flushing def Flushing def infrequent, 2% 0% x x x x x x x x
Haemorrhage def Haemorrhage def rare, 1% - 2% 1% x x x x x x x x
Haemoglobin def Haemorrhage def rare, 1% - 2% 1% x x x x x x x x
Nervousness def Nervousness def 1% - 2% 1% x x x x x x x
Tension def Nervousness def 1% - 2% 1% x x x x x x x
Nystagmus def Nystagmus def 2% 1% x x x x x x x x
Penis disorder def Penis disorder def 0% - 2% 0%
Sinusitis def Sinusitis def 1% - 2% 1% x x x x x x x
Myalgia def Myalgia def 2% 0% x x x x x x x x
Disturbance in attention Cerebration impaired def 1% - 2% 1% x x x x x
Mental disability Cerebration impaired def 1% - 2% 1% x x x x x
Photosensitivity reaction def Photosensitivity def 0% - 2% 0% x x x x x x
Face oedema def Face oedema def 1% - 2% 1% x x x x x
Menopausal symptoms def Hot flush def infrequent, 2% 0% x x x x x x x x
Hot flush def Hot flush def infrequent, 2% 0% x x x x x x x x
Alopecia def Alopecia def infrequent x x x x x x x x
Aphasia def Aphasia def infrequent x x x x x x x x
Arthritis def Arthritis def infrequent x x x x x x x x
Conjunctivitis def Conjunctivitis def infrequent x x x x x x x x
Libido decreased def Libido decreased def infrequent x x x x x x x x
Disturbance in sexual arousal Libido decreased def infrequent x x x x x x x x
Dysphagia def Dysphagia def infrequent x x x x x x x x
Depersonalisation def Depersonalisation def infrequent x x x x x x x x
Dysarthria def Dysarthria def infrequent x x x x x x x x
Osteoarthritis def Dysarthria def infrequent x x x x x x x x
Arthropathy def rare x
Dysgeusia def Dysgeusia def infrequent x x x x x x x x
Taste bitter
Dyskinesia def Dyskinesia def infrequent x x x x x x x x
Movement disorder def infrequent x x x x x x x x
Ear pain def Ear pain def infrequent x x x x x x x x
Ecchymosis def Ecchymosis def infrequent x x x x x x x x
Eructation def Eructation def infrequent x x x x x x x x
Gastritis def Gastritis def infrequent x x x x x x x x
Gingivitis def Gingivitis def infrequent x x x x x x x x
Breath odour def Breath odour def infrequent x
Hallucination def Hallucination def infrequent x x x x x x x x
Haematuria def Haematuria def infrequent x x x x x x x x
Hirsutism def Hirsutism def infrequent x x x x x x x x
Hostility def Hostility def infrequent x x x x x x x x
Hypertension def Hypertension def infrequent x x x x x x x x
Hypotension def Hypotension def infrequent x x x x x x x x
Orthostatic hypotension def Orthostatic hypotension def infrequent x x x x x x x x
Incontinence def Incontinence def infrequent x x x x x x x x
Muscle spasms def Cramps of lower extremities infrequent x x x x x x x x
Cramp muscle def infrequent x x x x x x x x
Muscle spasms def rare x x x x x x x x
Leukopenia def Leukopenia def infrequent x x x x x x x x
Breast pain def Breast pain def infrequent x
Menorrhagia def Menorrhagia def infrequent x x x x x x x x
Movement disorder def Movement disorder def infrequent x x x x x x x x
Hypertonia def Hypertonia def infrequent x x x x x x x x
Myoclonus def Myoclonus def infrequent x x x x x x x x
Palpitations def Palpitations def infrequent x x x x x x x x
Panic reaction def Panic reaction def infrequent x x x x x x x x
Personality disorder def Personality disorder def infrequent x x x x x x x x
Polyuria def Polyuria def infrequent x x x x x x x x
Urine output increased Polyuria def infrequent x x x x x x x x
Psychotic disorder def Psychotic disorder def infrequent x x x x x x x x
Salivary hypersecretion def Salivation def infrequent x x x x x x x x
Salivary hypersecretion def infrequent x x x x x x x x
Dizziness def Syncope def rare, infrequent x x x x x x x x x
Shock def Syncope def rare, infrequent x x x x x x x x x
Syncope def Syncope def rare, infrequent x x x x x x x x x
Loss of consciousness def Syncope def rare, infrequent x x x x x x x x x
Tachycardia def Tachycardia def infrequent x x x x x x x x
Tinnitus def Tinnitus def infrequent x x x x x x x x
Ulcer def Ulcer def rare, infrequent x x x x x x x x x
Urinary incontinence def Urinary incontinence def infrequent x x x x x x x x
Urticaria def Urticaria def infrequent x x x x x x x x
Vasodilation procedure Vasodilation def infrequent x x x x x x x x
Yawning def Yawning def infrequent x x x x x x x x
Chills def Chills def infrequent x x x x x x x x
Stupor def Stupor def infrequent x x x x x x x x
Depressed level of consciousness def Stupor def infrequent x x x x x x x x
CNS depression NOS infrequent x x x x x x x x
Apathy def Apathy def infrequent x x x x x x x x
Flat affect Apathy def infrequent x x x x x x x x
Photophobia def Photophobia def infrequent x x x x x x x x
Panic attack def Panic attack def infrequent x x x x x x x x
Stomatitis def Mouth ulceration def infrequent x x x x x x x x
Stomatitis def rare x x x x x x x x
Mouth ulceration def Mouth ulceration def infrequent x x x x x x x x
Liver function test abnormal Liver function test abnormal infrequent x x x x x x x x
Paranoia def Paranoid reaction infrequent x x x x x x x x
Aspartate aminotransferase increased def Aspartate aminotransferase increased def infrequent x x x x x x x x
Skin discolouration def Skin discolouration def infrequent x x x x x x x x
Accommodation disorder Accommodation disorder infrequent x x x x x x x x
Malaise def Malaise def infrequent x x x x x x x x x
Discomfort def Malaise def infrequent x x x x x x x x x
Ill-defined disorder Malaise def infrequent x x x x x x x x x
Muscle twitching def Muscle twitching def infrequent x x x x x x x x
Increased appetite Increased appetite infrequent x x x x x x x x
Euphoric mood def Euphoric mood def infrequent x x x x x x x x
Urine abnormality Urine abnormality infrequent x
Urine analysis abnormal Urine abnormality infrequent x
Erectile dysfunction def Erectile dysfunction def infrequent x x x x x x x x
Dry eye Dry eye infrequent x x x x x x x x
Phobia def Phobia def infrequent
Akathisia def Akathisia def infrequent x x x x x x x x
Rash maculo-papular def Rash maculo-papular def infrequent x x x x x x x x
Suicidal ideation def Suicidal ideation def infrequent x x x x x x x x
Agitation def Hyperkinesia def infrequent x x x x x x x x
Agitation def x x x x x x x
Hyperkinesia def Hyperkinesia def infrequent x x x x x x x x
Acne def Acne def infrequent x x x x x x x x
Sleep disorder def Sleep disorder def infrequent x x x x x x x x
Muscular weakness def Myasthenia def infrequent x x x x x x x x
Ejaculation disorder def Abnormal ejaculation infrequent x x x x x x x x
Abscess def Abscess def rare x x x x x x x x
Ageusia def Ageusia def rare x x x x x x x x
Agranulocytosis def Agranulocytosis def postmarketing x x x x x x x
Anaemia def Anaemia def rare, postmarketing x x x x x x x x
Aplastic anaemia def Aplastic anaemia def postmarketing x
Haemolytic anaemia def Haemolytic anaemia def postmarketing x x x x x x x
Anaemia macrocytic def Anaemia macrocytic def rare x x x x x x x x
Angina pectoris def Angina pectoris def rare x
Angioedema def Angioedema def rare x x x x x x x x
Apnoea def Apnoea def postmarketing x x x x x x x
Atrial fibrillation def Atrial fibrillation def rare x
Breast feeding def Breast feeding def rare x x x x x x x x
Bursitis def Bursitis def rare x x x x x x x x
Candidiasis def Candidiasis def rare x
Vulvovaginal candidiasis def Vaginal moniliasis rare x
Vulvovaginal mycotic infection Vaginal moniliasis rare x
Cerebellar syndrome def Cerebellar syndrome def rare x
Nervous system disorder def Cerebellar syndrome def rare x
Colitis def Colitis def rare x x x x x x x x
Muscle contracture def Muscle contracture def rare x x x x x x x x
Cystitis def Cystitis def rare x x x x x x x x
Bladder pain def Cystitis def rare x x x x x x x x
Cystitis noninfective def Cystitis def rare x x x x x x x x
Deafness def Deafness def rare x x x x x x x x
Delirium def Delirium def rare x x x x x x x x
Delusion def Delusion def rare x x x x x x x x
Dermatitis def Dermatitis def rare x x x x x x x x
Dermatitis exfoliative def Dermatitis exfoliative def rare x x x x x x x x
Fungal skin infection def Fungal skin infection def rare x x x x x x x x
Disseminated intravascular coagulation def Disseminated intravascular coagulation def postmarketing x
Dysuria def Dysuria def rare x x x x x x x x
Eosinophilia def Eosinophilia def rare x x x x x x x x
Epididymitis def Epididymitis def rare x x x x x x x x
Grand mal convulsion def Grand mal convulsion def rare x x x x x x x x
Erythema multiforme def Erythema multiforme def rare x x x x x x x x
Stevens-Johnson syndrome def x
Oesophagitis def Oesophagitis def postmarketing x x x x x x x
Extrapyramidal disorder def Extrapyramidal disorder def rare x x x x x x x x
Pathological fracture def Pathological fracture def rare x x x x x x x x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def rare x x x
Gingival bleeding def Gingival bleeding def rare x x x x x x x x
Gingival hyperplasia def Gingival hyperplasia def rare x x x x x x x x
Glossitis def Glossitis def rare x x x x x x x x
Goitre def Goitre def rare x x x x x x x x
Haematemesis def Haematemesis def rare x x x x x x x x
Hemiplegia def Hemiplegia def rare x x x x x x x x
Hepatitis def Hepatitis def rare x x x x x x x x
Herpes virus infection def Herpes NOS def rare x x x x x x x x x
Herpes zoster def Herpes zoster def rare x x x x x x x x x
Hiccups def Hiccups def rare x x x x x x x x
Hyperpathia def Hyperpathia def rare x x x x x x x x
Hyperaesthesia def Hyperpathia def rare x x x x x x x x
Hyperaesthesia def rare x x x x x x x x
Hyperbilirubinaemia def Hyperbilirubinaemia def rare x x x x x x x x
Hyperglycaemia def Hyperglycaemia def rare x x x x x x x x
Hyperplasia def Hyperplasia def rare x x x x x x x x
Hyperventilation def Hyperventilation def rare x x x x x x x x
Hypothyroidism def Hypothyroidism def rare x x x x x x x x
Immunosuppression def Immunosuppression def postmarketing x x x x x x x
Infarction def Infarction def rare x
Arthropathy def Arthropathy def rare x
Renal failure acute def Renal failure acute def rare x x x x x x x x
Lacrimal disorder def Lacrimal disorder def rare x x x x x x x x
Leukocytosis def Leukocytosis def rare x x x x x x x x
Lymphocytosis def Lymphocytosis def rare x x x x x x x x
Melaena def Melaena def rare x x x x x x x x
Meningitis def Meningitis def postmarketing x x x
Meningitis aseptic def Meningitis aseptic def postmarketing x x x
Multi-organ failure def Multi-organ failure def postmarketing x x x x x x
Hypotonia def Hypotonia def rare x x x x x x x x
Muscle relaxant therapy Hypotonia def rare x x x x x x x x
Muscle atrophy def Muscle atrophy def rare x x x x x x x x
Myocardial infarction def Myocardial infarction def rare x
Acute coronary syndrome def Myocardial infarction def rare x
Neoplasm def Neoplasm def rare x x x x x x x x
Neuralgia def Neuralgia def rare x x x x x x x x
Neuritis def Neuritis def rare x x x x x x x x
Neuropathy peripheral def Neuritis def rare x x x x x x x x
Neurosis def Neurosis def rare x x x x x x x x
Neutropenia def Neutropenia def postmarketing x
Nocturia def Nocturia def rare x x x x x x x x
Pancreatic disorder def Pancreatic disorder def postmarketing x x x x x x x
Pancreatitis def Pancreatitis def postmarketing x x x x x x x
Pancytopenia def Pancytopenia def postmarketing x
Petechiae def Petechiae def rare x x x x x x x x
Eyelid ptosis def Ptosis def rare x x x x x x x x
Uterovaginal prolapse Ptosis def rare x x x x x x x x
Renal failure def Renal failure def rare x x x x x x x x
Rhabdomyolysis def Rhabdomyolysis def postmarketing x x x x x x x
Scotoma def Scotoma def rare x x x x x x x x
Seborrhoeic dermatitis def Seborrhoeic dermatitis def rare x
Gastric disorder def Gastric disorder def rare x x x x x x x x
Gastric ulcer def Gastric ulcer def rare x x x x x x x x
Strabismus def Strabismus def rare x x x x x x x x
Cerebrovascular accident def Cerebrovascular accident def rare x x
Completed suicide Suicide def rare x
Suicide attempt def Suicide attempt def rare x
Thirst def Thirst def rare x
Thrombocytopenia def Thrombocytopenia def rare x x x x x x x x
Thrombophlebitis def Thrombophlebitis def rare x
Thrombosis def Thrombosis def rare x
Tic def Tic def postmarketing x x x x x x x
Deficiency anaemia Deficiency anaemia rare x x x x x x x x
Erythema def Erythema def rare x x x x x x x x
Uveitis def Uveitis def rare x x x x x x x x
Vasculitis def Vasculitis def postmarketing x x x x x x x
Urinary retention def Urinary retention def rare x x x x x x x x
Choreoathetosis Choreoathetosis rare x x x x x x x x
Pollakiuria def Micturition urgency def rare x x x x x x x x
Pollakiuria def x x x x x x x
Micturition urgency def Micturition urgency def rare x x x x x x x x
Rash pustular def Rash pustular def rare x x x x x x x x
Vesiculobullous rash rare x x x x x x x x
Hypokinesia def Hypokinesia def rare x x x x x x x x
Breast abscess Breast abscess rare x x x x x x x x
Alcohol intolerance def Alcohol intolerance def rare x x x x x x x x
Enterocolitis haemorrhagic Hemorrhagic colitis rare x x x x x x x x
Tongue disorder Tongue oedema rare x x x x x x x x
Tongue oedema Tongue oedema rare x x x x x x x x
Dermatitis bullous def Vesiculobullous rash rare x x x x x x x x
Alanine aminotransferase increased def Alanine aminotransferase increased def rare x x x x x x x x
Deep vein thrombosis def Deep thrombophlebitis rare x
Tendinous contracture Tendinous contracture rare x x x x x x x x
Iron deficiency anaemia def Iron deficiency anaemia def rare x x x x x x x x
Leukoderma def Leukoderma def rare x x x x x x x x
Cardiac fibrillation Cardiac fibrillation rare x
Dysphoria Dysphoria rare x x x x x x x x
Anorgasmia def Anorgasmia def rare x x x x x x x x
Iron deficiency Iron deficiency rare x x x x x x x x
Aplasia Aplasia postmarketing x
Aplasia pure red cell def Red cell aplasia postmarketing x
Atrophy def Atrophy def rare x x x x x x x x
Abdominal distension def Enlargement abdomen def rare x
Dystonia def Dystonia def rare x x x x x x x x
Systemic lupus erythematosus def Lupus erythematosus def postmarketing x x x x x x x
Oscillopsia Oscillopsia rare x x x x x x x x
Lacrimation increased def Lacrimation def rare x x x x x x x x
Paralysis def Paralysis def rare x x x x x x x x
Hypocoagulable state Hypofibrinogenemia rare x x x x x x x x
Blood fibrinogen decreased Hypofibrinogenemia rare x x x x x x x x
Renal pain Renal pain rare x x x x x x x x
Breast neoplasm def Breast neoplasm def rare x x x x x x x x
Parosmia def Parosmia def rare x x x x x x x x
Amnesia def Amnesia def x x x x x x x x
Apraxia def Apraxia def x x x x x x x
Asthma def Asthma def x
Dermatitis contact def Dermatitis contact def x x x x x x x
Dyspnoea def Dyspnoea def x x x x x x x
Toxic epidermal necrolysis def Toxic epidermal necrolysis def x x x
Necrolysis epidermal x x x
Epistaxis def Epistaxis def x x x x x x x
Flatulence def Flatulence def x x x x x x x
Blood disorder def Blood disorder def x x x x x
Hypoaesthesia def Hypoaesthesia def x x x x x x x
Menstrual disorder def Menstrual disorder def x
Peptic ulcer def Peptic ulcer def x x x x x x x
Respiratory disorder def Respiratory disorder def x x
Skin ulcer def Skin ulcer def x
Status epilepticus def Status epilepticus def x x x x x x
Stevens-Johnson syndrome def Stevens-Johnson syndrome def x
Hyperhidrosis def Sweating def x x x x x x x
Swelling def Swelling def
Weight increased def Weight increased def x x x x x x x x
Oedema peripheral def Oedema peripheral def x x x x x x x
Migraine def Migraine def x x x x x x x
Hyporeflexia Hyporeflexia x x x x x x x
Hyperreflexia Hyperreflexia x x x x x x x
Dry skin def Dry skin def x x x x x x x
Drug withdrawal syndrome def Drug withdrawal syndrome def x x
Drug withdrawal convulsions Withdrawal seizures x x x x x x
Lip swelling Lip swelling
Rectal haemorrhage def Rectal haemorrhage def x x x x x x x
Death Found dead (cause undetermined) x x x x x x
Death x x x x x x x
Sudden death def Sudden death, cause unknown x x x x x x
Organ failure Organ failure x
Suicidal behaviour Suicidal behaviour x x x x x x
Scar def Scar def x
Indication Labels
Bipolar disorder def x x x x x x x x
Bipolar I disorder x x x x x x x x
Clonic convulsion def x x x x x
Convulsions generalised def x x x x x x x
Epilepsy def x x x x x x x x x
Hypomania def x x x x x x x x
Lennox-Gastaut syndrome def x x x x x x x x
Mania def x x x x x x x x
Partial seizures def x x x x x x x
Seizures def x x x x x x x x x
Tonic-clonic seizures def x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N03AX09

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. LAMOTRIGINE / APO-LAMOTRIGINE : 4 side effects (Health Canada)
  2. LAMOTRIGINE / RATIO-LAMOTRIGINE : 57 side effects (Health Canada)
  3. Lamotrigine : 171 side effects (FDA XML label)
  4. LAMOTRIGINE : 251 side effects (FDA XML label)
  5. LAMOTRIGINE : 258 side effects (FDA XML label)
  6. LAMOTRIGINE : 259 side effects (FDA XML label)
  7. LAMOTRIGINE : 259 side effects (FDA XML label)
  8. LAMOTRIGINE : 260 side effects (FDA XML label)
  9. LAMOTRIGINE : 260 side effects (FDA XML label)
  10. LAMOTRIGINE : 266 side effects (FDA XML label)