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Sunitinib

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L01XE04

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Blister Blister 18% x x x x
Dermatitis bullous Blister 18% x x x x
Lipase increased Lipase increased 16% x x x x x
Dizziness Dizziness 15% x x x x x
Neuropathy peripheral Neuropathy peripheral 10% x x x
Blood uric acid increased Hyperuricaemia 10% x x
Blood uric acid increased x
Hyperuricaemia Hyperuricaemia 10% x x
Hypertension Hypertension 8% x
Hypophosphataemia Hypophosphataemia 5% - 10% x x x
Periorbital oedema Periorbital oedema 7% x x x x
Lacrimation increased Lacrimation increased 6% x x x x
Asthenia Asthenia 5% x x x x x
Fatigue 1% - 10% x x x x x
Diarrhoea Diarrhoea 5% x x x x x
Hyponatraemia Hyponatraemia 5% x x x
Sodium decreased x x x
Amylase increased Amylase increased 5% x x x x x
Nausea Nausea 4% x x x x x
Abdominal pain Abdominal pain 2% - 3% x x x x
Gastrointestinal pain Abdominal pain 2% - 3% x x x x
Decreased appetite Anorexia 3% x x x x x
Decreased appetite x x x
Anaemia Anaemia 2% x x x x
Dyspnoea Dyspnoea 2% x x x x
Blood glucose decreased Glucose decreased 2% x x x
Back pain Back pain 1% - 2% x x x x
Blood glucose increased Glucose increased 1% - 2% x x x
Hypothyroidism Hypothyroidism postmarketing, 2% - 4-7% x x x x x
Primary hypothyroidism x x x
Dermatitis Rash 1% x x x x x
Dermatitis x
Rash Rash 1% x x x x x
Fatigue Fatigue 1% - 10% x x x x x
Hypokalaemia Hypokalaemia 1% x x x
Thrombocytopenia Thrombocytopenia postmarketing, 1% x x x x
Vomiting Vomiting 1% - 2% x x x x x
Bone pain Bone pain 1% x x
Mucosal inflammation Mucosal inflammation 1% - 2% x x x x x
Blood potassium increased Potassium increased 1% x x x
Adrenal insufficiency Adrenal insufficiency 1% x x
Convulsion Convulsion 1% x
Bradycardia Bradycardia 1% x
Abscess Abscess postmarketing x x x
Angioedema Angioedema postmarketing x x x x
Bronchitis Bronchitis postmarketing x x x
Neoplasm malignant Neoplasm malignant postmarketing x x
Candida infection Candida infection postmarketing x x
Oral candidiasis x
Cellulitis Cellulitis postmarketing x x x
Cerebral infarction Cerebral infarction postmarketing x x x x
Transient ischaemic attack Transient ischaemic attack postmarketing x x x x
Cholecystitis Cholecystitis postmarketing x x x x
Acalculous cholecystitis postmarketing x x x
Infection Infection postmarketing x x x x x
Connective tissue disorder Connective tissue disorder postmarketing x x x x
Endocrine disorder Endocrine disorder postmarketing x x x
Erythema multiforme Erythema multiforme postmarketing x x x
Stevens-Johnson syndrome x
Oesophagitis Oesophagitis postmarketing x x x x
Fistula Fistula postmarketing x x x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x x
Cardiac disorder Cardiac disorder postmarketing x x x
Cardiac failure Cardiac failure postmarketing x x x
Haemorrhage Haemorrhage postmarketing, 2% x x x x x
Haemoglobin Haemorrhage postmarketing, 2% x x x x x
Hypersensitivity Hypersensitivity postmarketing x x x x
Hyperthyroidism Hyperthyroidism postmarketing x x x
Thyrotoxicosis x
Immune system disorder Immune system disorder postmarketing x x x x
Renal failure acute Renal failure acute postmarketing x x x x
Myopathy Myopathy postmarketing x x x x
Nasopharyngitis Nasopharyngitis postmarketing x x x x
Neoplasm Neoplasm postmarketing x x x
Nephrotic syndrome Nephrotic syndrome postmarketing x x x
Nervous system disorder Nervous system disorder postmarketing x x x
Neutropenia Neutropenia postmarketing, 2% x x x x
Osteomyelitis Osteomyelitis postmarketing x x x
Pneumonia Pneumonia postmarketing x x x
Proteinuria Proteinuria postmarketing x x
Protein urine present Proteinuria postmarketing x x
Pulmonary embolism Pulmonary embolism postmarketing x x x
Respiratory tract infection Respiratory tract infection postmarketing x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x x
Septic shock Septic shock postmarketing x x x
Skin infection Skin infection postmarketing x x x x
Cerebrovascular accident Cerebrovascular accident postmarketing x x x x x
Thyroiditis Thyroiditis postmarketing x x x x
Destructive thyroiditis x
Tumour lysis syndrome Tumour lysis syndrome postmarketing x x x
Urinary tract infection Urinary tract infection postmarketing x x x
Urethral disorder Urinary tract disorder postmarketing x x x x
Urinary tract disorder Urinary tract disorder postmarketing x x x x
Angiopathy Angiopathy postmarketing x x x x
Pyoderma gangrenosum Pyoderma gangrenosum postmarketing x x x x
Malnutrition Malnutrition postmarketing x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x
Skin disorder x
Necrotising fasciitis Necrotising fasciitis postmarketing x x x
Cellulitis gangrenous Necrotising fasciitis postmarketing x x x
Sepsis Sepsis postmarketing x x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x
Tumour necrosis Tumour necrosis postmarketing x x x x
Oral herpes Oral herpes postmarketing x x x
Thyroid disorder Dysfunction thyroid postmarketing x x x
Infestation Infestation NOS postmarketing x x x x
Embolism Thromboembolic event postmarketing x x x
Cardiomyopathy Cardiomyopathy postmarketing x x x
Myocardial disorder postmarketing x x x
Renal failure Renal impairment postmarketing x x x x
Renal failure x
Renal impairment Renal impairment postmarketing x x x x
Ageusia Ageusia postmarketing x x x
Thrombotic microangiopathy Thrombotic microangiopathy postmarketing x x x x
Abdominal distension Abdominal distension x
Alopecia Alopecia x x x x x
Arrhythmia Arrhythmia x
Arthralgia Arthralgia x x x x
Musculoskeletal discomfort Arthralgia x x x x
Myalgia x x x x
Bacterial infection Bacterial infection x
Mental disorder Mental disorder x
Burkitt's lymphoma Burkitt's lymphoma x
Oral candidiasis Oral candidiasis x
Cheilitis Cheilitis x
Chest pain Chest pain x x
Constipation Constipation x x x x x
Cough Cough x x x x
Sudden death Sudden death x
Dysphagia Dysphagia x
Dehydration Dehydration x x x
Depression Depression x x x x
Disseminated intravascular coagulation Disseminated intravascular coagulation x
Diverticulitis Diverticulitis x
Dysgeusia Dysgeusia x x x x
Taste altered x x x
Dyspepsia Dyspepsia x x x x x
Eczema Eczema x
Oedema Oedema x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis x
Epistaxis Epistaxis x x x x x
Eructation Eructation x
Gastrooesophageal reflux disease Reflux esophagitis x
Gastrooesophageal reflux disease x x
Eye disorder Eye disorder x
Body temperature increased Body temperature increased x x x x x
Flank pain Flank pain x x
Flatulence Flatulence x x x x
Flushing Flushing x
Gingival bleeding Gingival bleeding x
Gingivitis Gingivitis x x
Glossodynia Glossodynia x x x x x
Glossitis Glossitis x x
Headache Headache x x x x
Cardiac failure congestive Cardiac failure congestive x x
Haematemesis Haematemesis x x
Haematochezia Haematochezia x x
Blood disorder Blood disorder x
Haematoma Haematoma x x
Peritoneal haemorrhage Peritoneal haemorrhage x
Haemoptysis Haemoptysis x x x x
Haemorrhoids Haemorrhoids x x
Hepatitis Hepatitis x
Hypercalcaemia Hypercalcaemia x
Ca++ increased x
Hyperaesthesia Hyperaesthesia x
Hyperglycaemia Hyperglycaemia x x x
Hyperkalaemia Hyperkalaemia x x x
Hypernatraemia Hypernatraemia x x x
Hypoaesthesia Hypoaesthesia x
Hypocalcaemia Hypocalcaemia x
Hypoglycaemia Hypoglycaemia x
Infarction Infarction x
Intestinal perforation Intestinal perforation x
Left ventricular failure Left ventricular failure x
Pulmonary oedema Left ventricular failure x
Leukopenia Leukopenia x x x
Liver abscess Liver abscess x
Lymphopenia Lymphopenia x x x
Mediastinal disorder Mediastinal disorder x
Melaena Melaena x x
Metrorrhagia Metrorrhagia x x
Multi-organ failure Multi-organ failure x
Musculoskeletal pain Musculoskeletal pain x
Fungal infection Fungal infection x
Nail disorder Nail disorder x
Nasal congestion Nasal congestion x
Metastasis Metastasis x
Pain Pain x x x x
Pain in extremity Pain in extremity x x x x x
Pancreatitis Pancreatitis x x x
Pancytopenia Pancytopenia x
Myelosuppression x x
Paraesthesia Paraesthesia x
Pericardial effusion Pericardial effusion x
Pleural effusion Pleural effusion x
Pneumothorax Pneumothorax x
Prurigo Prurigo x
Pruritus Pruritus x x
Proctalgia Proctalgia x
Shock Shock x
Congenital skin disorder Congenital skin disorder x x
Skin lesion Skin lesion x
Muscle spasms Muscle spasms x
Stevens-Johnson syndrome Stevens-Johnson syndrome x
Stomatitis Stomatitis x x x x x
Mouth ulceration x x x
Aphthous stomatitis Aphthous stomatitis x x
Thrombosis Thrombosis x
Torsade de pointes Torsade de pointes x
Erythema Erythema x x x
Upper respiratory tract infection Upper respiratory tract infection x
Viral infection Viral infection x
Weight decreased Weight decreased x x x x
Dry mouth Dry mouth x x x x
Chills Chills x x x x
Hepatic failure Hepatic failure x x
Oedema peripheral Oedema peripheral x x x
Hepatic function abnormal Hepatic function abnormal x
Lower respiratory tract infection Lower respiratory tract infection x
Mouth ulceration Mouth ulceration x x x
Rectal abscess Rectal abscess x
Deep vein thrombosis Deep vein thrombosis x x
Gingival abscess Gingival abscess x
Blood creatinine increased Creatinine increased x
Blood creatinine increased x
Gastrointestinal perforation Gastrointestinal perforation x
Hair colour changes Hair discoloration x
Hair colour changes x x x x
Impaired healing Impaired healing x
Pulmonary haemorrhage Pulmonary haemorrhage x x
Myocardial ischaemia Myocardial ischaemia x
Muscular weakness Muscular weakness x
Blood alkaline phosphatase increased Phosphatase alkaline increased x x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged x
Aspartate aminotransferase increased Aspartate aminotransferase increased x x x
Alanine aminotransferase increased Alanine aminotransferase increased x x
Skin discolouration Skin discolouration x x x x x
Pigmentation disorder x
Dry skin Dry skin x x x x x
Hypogeusia Hypogeusia x x
Blindness cortical Blindness cortical x
Haemoglobin decreased Haemoglobin decreased x x
Eyelid oedema Eyelid oedema x
Apoptosis Apoptosis x
Skin hyperpigmentation Skin hyperpigmentation x
Leukoderma Leukoderma x
Anal fistula Anal fistula x
Rash macular Rash macular x
Oral pain Oral pain x x x x
Myalgia Myalgia x x x x
Dyspnoea exertional Dyspnoea exertional x
Nasal dryness Nasal dryness x
Abdominal discomfort Abdominal discomfort x
Abdominal pain upper Abdominal pain upper x x
Rash erythematous Rash erythematous x
Rash follicular Rash follicular x
Tongue ulceration Tongue ulceration x x
Hepatotoxicity Hepatotoxicity x
Skin exfoliation Skin exfoliation x
Pancreatic abscess Pancreatic abscess x
Oesophageal candidiasis Oesophageal candidiasis x
Gingival pain Gingival pain x x
Hypoalbuminaemia Hypoalbuminaemia x
Blood magnesium decreased Mg reduced x x x
Subcutaneous abscess Subcutaneous abscess x
Wound haemorrhage Wound haemorrhage x
Left ventricular dysfunction Left ventricular dysfunction x x
Abdominal abscess Abdominal abscess x
Dermatitis psoriasiform Dermatitis psoriasiform x
Perineal abscess Perineal abscess x
Perirectal abscess Perirectal abscess x
Rectal haemorrhage Rectal haemorrhage x
Anal abscess Anal abscess x
Blood bilirubin increased Blood bilirubin increased x
Bilirubin total increased x
Splinter haemorrhages Splinter haemorrhages x
Platelet count decreased Platelet count decreased x x
Oral discomfort Oral discomfort x x x
Rash maculo-papular Rash maculo-papular x
Blood pressure increased Blood pressure increased x
Rash generalised Rash generalised x
Tooth abscess Tooth abscess x
Influenza like illness Influenza like illness x x
Chromaturia Urine color abnormal x
Chromaturia x
Face oedema Face oedema x
Laryngeal pain Laryngeal pain x
Pigmentation disorder Pigmentation disorder x
Yellow skin Yellow skin x x
Abscess limb Abscess limb x
Blood thyroid stimulating hormone increased Thyrotropin high x
Blood thyroid stimulating hormone increased x
Blood sodium increased Sodium high x
Menopausal symptoms Hot flush x
Hot flush Hot flush x
Primary hypothyroidism Primary hypothyroidism x x x
Acne Acne x
Ejection fraction decreased Ejection fraction decreased x x
Febrile neutropenia Febrile neutropenia x
White blood cell count decreased White blood cell count decreased x
Lymphocyte count decreased Lymphocyte count decreased x
Mucosal dryness Mucosal dryness x x
Limb discomfort Limb discomfort x
Blood albumin decreased Albumin low x
Blood potassium decreased Potassium low x x x
Blood calcium decreased Calcium low x x x
Hyperkeratosis Hyperkeratosis x
Liver function test abnormal Raised liver function tests x x
Depressed level of consciousness Alertness decreased x
Insomnia Insomnia x x x x
Blood phosphorus decreased Phosphorus low x
Acute coronary syndrome Acute coronary syndrome x
Abdominal sepsis Abdominal sepsis x
Respiratory failure Respiratory failure x
Rash papular Rash papular x
Exfoliative rash Exfoliative rash x
Oropharyngeal pain Oropharyngeal pain x x
Osteonecrosis of jaw Osteonecrosis of jaw x
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome x x
Blindness Unspecified visual loss x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

sunitinib

Side effects:74
Source:BC Cancer

SUNITINIB

Side effects:119
Source:FDA Structured Product Label

sunitinib / sunitinib

Side effects:217
Source:EMA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label