Diclofenac

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 32)
1 2 3 4 5 6 7 8 9 10
Gastrointestinal disorder def postmarketing, 8.57% - 9% 5.85% - 6%
Pruritus def postmarketing, 5% - 5.42% 7.8% - 8% x x x x x x x x x
Erythema def postmarketing, 3.85% - 4% 2.66% - 3% x x x x x x x
Atrophy def 3.85% - 4% 2.66% - 3%
Abdominal pain def postmarketing, 2.62% - 3% 1.95% - 2% x x x x x x x x x
Constipation def postmarketing, 2.62% - 3% 1.95% - 2% x x x x x x x
Diarrhoea def postmarketing, 2.62% - 3% 1.95% - 2% x x x x x x x
Gastritis def postmarketing, 2.62% - 3% 1.95% - 2% x x x x
Nausea def postmarketing, 2.97% - 3% 1.95% - 2% x x x x x x x x
Vomiting def postmarketing, 2.62% - 3% 1.95% - 2% x x x x x x x x
Dry mouth def postmarketing, 2.62% - 3% 1.95% - 2% x x x x
Abdominal pain upper 2.62% - 3% 1.95% - 2%
Nervous system disorder def postmarketing, 2% - 2.27% 3% - 3.19%
Dermatitis def postmarketing, 1.57% - 2% 0.532% - 1% x x x x x x x
Dysgeusia def postmarketing, 1.75% - 2% 0.532% - 1% x
Dyspepsia def postmarketing, 1% - 1.22% 1% - 1.42% x x x x x x x
Headache def postmarketing, 1% - 1.22% 1.77% - 2% x x x x x x x x
Paraesthesia def postmarketing, 1% - 1.05% 1% - 1.42% x x x x x x x
Dizziness def postmarketing, 0.699% - 1% 0.532% - 1% x x x x x x x x
Hypoaesthesia def 0.699% - 1% 0.532% - 1%
Hyperkinesia def 0.699% - 1% 0.532% - 1%
Somnolence def 0.699% - 1% 1% - 1.06% x x x
Agranulocytosis def postmarketing x x x x x
Alopecia def postmarketing x x x x x x
Anaemia def postmarketing x x x x x
Aplastic anaemia def postmarketing x x x x x
Haemolytic anaemia def postmarketing x x x x
Angina pectoris def postmarketing x
Angioedema def postmarketing x x x x x
Anorexia def postmarketing x
Anxiety def postmarketing x x x x x x
Arrhythmia def postmarketing x x x x
Asthenia def postmarketing x x x x x x
Asthma def postmarketing x x x x x x x
Back pain def postmarketing x
Mental disorder def postmarketing x
Blister def postmarketing
Breast disorder def postmarketing
Cardiovascular disorder def postmarketing
Chest pain def postmarketing x x
Tongue coated postmarketing x
Colitis def postmarketing x x x x x
Colitis ulcerative def postmarketing x
Conjunctivitis def postmarketing x x x x x
Convulsion def postmarketing x x x x x
Corneal oedema def postmarketing x x
Corneal opacity def postmarketing x x
Ulcerative keratitis def postmarketing x
Dermatitis exfoliative def postmarketing x x x x x
Dermatitis contact def postmarketing x
Diplopia def postmarketing x x
Drowsiness def postmarketing x x x x x
Dyspnoea def postmarketing x x x x x x
Ear pain def postmarketing
Eczema def postmarketing x x x
Oedema def postmarketing x x x x x x x x
Toxic epidermal necrolysis def postmarketing x x
Erythema multiforme def postmarketing x x x x x
Oesophageal disorder def postmarketing x x
Rash def postmarketing x x x x x x x x
Eye disorder def postmarketing
Fatigue def postmarketing x
Body temperature increased def postmarketing x x x x x
Flatulence def postmarketing x x x x x x
Gastrointestinal haemorrhage def postmarketing x x x x
Glossitis def postmarketing x x x x
Breath odour def postmarketing
Partial hearing loss postmarketing x
Cardiac disorder def postmarketing x
Cardiac failure def postmarketing x x x x
Haematemesis def postmarketing x x x x
Haematuria def postmarketing x x x x x
Haemorrhage def postmarketing x x x x x x
Haemorrhoids def postmarketing
Hepatitis def postmarketing x x x x x
Hereditary disorder def postmarketing
Hypertension def postmarketing x x x x x x
Hypotension def postmarketing x x x x x
Immune system disorder def postmarketing
Infarction def postmarketing x x x x x
Infection def postmarketing x x x x x x
Unspecified disorder of intestine def postmarketing
Iritis def postmarketing x x
Irritability def postmarketing x x
Jaundice def postmarketing x x x x x
Keratitis def postmarketing x x
Renal failure acute def postmarketing x x
Renal papillary necrosis def postmarketing x x
Lacrimal disorder def postmarketing x
Laryngospasm def postmarketing
Laryngitis def postmarketing
Cramps of lower extremities postmarketing
Leukopenia def postmarketing x x x x x
Melaena def postmarketing x x x x x
Meningitis def postmarketing x x x x x
Meningitis aseptic def postmarketing x x
Cramp muscle def postmarketing x
Muscle rigidity def postmarketing
Myocardial infarction def postmarketing x x x x x
Necrosis def postmarketing x x
Nephritis def postmarketing x x x x x
Nephritis interstitial def postmarketing x x x x x
Nephrotic syndrome def postmarketing x x
Nightmare def postmarketing x x
Palpitations def postmarketing x x x x x
Pancreatitis def postmarketing x x x x x
Pharyngitis def postmarketing x
Pneumonia def postmarketing x x x x x
Proctitis def postmarketing
Proteinuria def postmarketing x x x x x
Psychotic disorder def postmarketing x
Purpura def postmarketing x x x x x
Henoch-Schonlein purpura def postmarketing x x
Renal failure def postmarketing x x x x x
Respiratory disorder def postmarketing x
Rheumatism def postmarketing
Rhinitis def postmarketing x x x
Shock def postmarketing x
Stomatitis def postmarketing x x x x x
Ulcerative stomatitis postmarketing
Cerebrovascular accident def postmarketing x
Swelling def postmarketing x x
Thrombocytopenia def postmarketing x x x x x
Tinnitus def postmarketing x x x x x
Tremor def postmarketing x x x x x
Ulcer def postmarketing x x x x x x x x
Urinary tract disorder def postmarketing x
Urticaria def postmarketing x x x x x x
Angiopathy def postmarketing
Vertigo def postmarketing x x x x
Viral infection def postmarketing x x
Visual impairment def postmarketing x x x
Chills def postmarketing x x x
Body odor def postmarketing
Hepatic function abnormal postmarketing x
Mouth ulceration def postmarketing
Neck stiffness postmarketing
Hemorrhagic colitis postmarketing x
Creatinine increased def postmarketing x
Diarrhoea haemorrhagic postmarketing x x
Necrolysis epidermal postmarketing x x x
Hyperchlorhydria postmarketing x
Lack of drug effect postmarketing
Eye pain def postmarketing
Skin discolouration def postmarketing
Dry skin def postmarketing x
Corneal deposits postmarketing x x
Photosensitivity reaction def postmarketing x x
Malaise def postmarketing x x x x x
Myalgia def postmarketing x
Disorientation postmarketing x x
Memory impairment def postmarketing x x
Intraocular pressure increased postmarketing x x
Cerebration impaired def postmarketing x
Bullous eruption postmarketing x x
Punctate keratitis postmarketing x
Rectal haemorrhage def postmarketing x x x
Hepatobiliary disease def postmarketing
Eruption postmarketing x x
Hepatitis fulminant postmarketing x
Secondary anaemia postmarketing x
Vision blurred def postmarketing x x x x x x x
Photosensitivity def postmarketing x x x x x x
Corneal erosion postmarketing
Lacrimation def postmarketing x
Withdrawn postmarketing
Face oedema def postmarketing x x x
Swelling of eyelid postmarketing x
Stinging postmarketing x
Dissecting aortic aneurysm, thoracic postmarketing
Infestation NOS postmarketing
Eye allergy postmarketing x x
Corneal infiltrates def postmarketing
Insomnia def postmarketing x x x x x x x
Abdominal distension def x
Abscess def
Amblyopia def x
Anaphylactic shock def x x x x
Aphasia def
Arteriosclerosis def
Arthralgia def x
Bronchitis def
Carcinoma def x
Neck pain def x
Coma def x x x
Confusional state def x x x
Conjunctivitis allergic def x
Corneal disorder def x
Cough def x
Cystitis def x x x
Dental caries def
Distention def x
Dysthymic disorder def
Dysuria def x x x
Ecchymosis def x x x
Eosinophilia def x x x x x
Epistaxis def x
Eructation def x x x
Oesophagitis def x x x
Vitreous floaters def x
Flushing def x
Furunculosis def
Gastroenteritis def
Gingivitis def
Gout def
Hair disorder def
Hallucination def x x x
Cardiac failure congestive def x x x
Heartburn def x x x x
Hepatorenal syndrome def x
Hernia def
Herpes NOS def x
Herpes simplex def x
Hypercholesterolaemia def x
Hyperaemia def x
Hyperaesthesia def x
Hyperglycaemia def x x x x
Hypertrophy def
Hyperventilation def x
Hypoglycaemia def x
Influenza def x
Intestinal perforation def x
Eye pruritus x
Nephropathy def x
Laryngeal oedema def x
Hepatic cirrhosis def x
Hypertonia def
Nail disorder def
Nervousness def x x x
Neuritis def
Night blindness def x
Nodule def x
Nocturia def x
Oliguria def x x x x
Pancytopenia def x x x
Peptic ulcer def x x x x
Abscess periodontal def
Phlebitis def x
Polyuria def x x x
Rectal disorder def
Scotoma def x
Seborrhoeic dermatitis def
Sinusitis def x
Skin nodule def x
Skin ulcer def x
Speech disorder def
Stevens-Johnson syndrome def x
Aphthous stomatitis def x
Sweating def x x x x
Syncope def x x x
Tachycardia def x x x x
Testicular disorder def
Thirst def
Tic def x
Pollakiuria def x
Vasculitis def x x x
Vasodilation def
Weight decreased def x
Hepatic failure def x x
Burning sensation def x
Rash pustular def
Oedema peripheral def
Hypokinesia def x
Migraine def x
Application site reaction x x
Bleeding time prolonged x x x
Creatine phosphokinase increased def x
Ventricular extrasystoles def x
Bleeding vaginal def x
Skin hypertrophy
Kidney function abnormal x x x
Hepatic necrosis def x
Bone pain def
Purpuric rash
Vesiculobullous rash x
Aspartate aminotransferase increased def x
Alanine aminotransferase increased def x
Skin irritation def x
Ocular hyperaemia x
Eyelid oedema x
Prostatic specific antigen increased
Thinking abnormal
Respiratory depression x x x
Eye irritation x
Hepatic enzyme increased x x x
Skin exfoliation x
Erythema of eyelid x
Lip swelling x
Erectile dysfunction def x
Azotaemia def x
Sepsis def x x x
Hand osteoarthritis x
Fluid retention x
Papule def x
Redness def
Anaphylactoid reaction x
Exacerbation of asthma x
Rash maculo-papular def x
Gastrointestinal symptom NOS x
Bradycardia def
Blindness def x
Lymphadenopathy def x x x
Coordination abnormal x
Cough increased
Gait disturbance def
Skin carcinoma def x
Sweating increased x x x
Acne def x
Eyelids pruritus x
Sleep disorder def
Myasthenia def
Death x x x
Hearing impaired def x x x
Conjunctival hyperaemia x
Vaginal haemorrhage def
Indication Labels
Actinic keratosis def x
Adverse event def x
After-cataract x
Ankylosing spondylitis def x
Arthritis def x x x x
Cataract def x x
Disease progression def x
Dysmenorrhoea def x x
Elderly def x
Hypersensitivity def x
Inflammation def x x x
Keratosis def x
Localized exfoliation def x
Osteoarthritis def x x x x x
Pain def x x x
Primary dysmenorrhea x
Rheumatoid arthritis def x x x x
Spondylitis def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Codes: D11AX18, M01AB05, M02AA15, S01BC03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. DICLOFENAC : 7 side effects (FDA XML label)
  2. DICLOFENAC SODIUM / VOLTAREN : 13 side effects (Drugs@FDA)
  3. diclofenac : 26 side effects (FDA XML label)
  4. DICLOFENAC SODIUM / VOLTAREN OPHTHA : 51 side effects (Health Canada)
  5. DICLOFENAC SODIUM / SOLARAZE : 57 side effects (Drugs@FDA)
  6. diclofenac : 101 side effects (FDA XML label)
  7. DICLOFENAC : 103 side effects (FDA XML label)
  8. DICLOFENAC POTASSIUM / VOLTAREN RAPIDE TABLETS 50MG : 105 side effects (Health Canada)
  9. diclofenac : 106 side effects (FDA XML label)
  10. Diclofenac : 117 side effects (FDA XML label)