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Trametinib

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: None found

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1
Lymphopenia Lymphopenia 6% - 59% x
Hyperglycaemia Hyperglycaemia 2% - 67% x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased 2% - 56% x
Hyponatraemia Hyponatraemia 2% - 55% x
Hypophosphataemia Hypophosphataemia 0% - 47% x
Asthenia Fatigue 2% - 57% x
Asthenia x
Fatigue Fatigue 2% - 57% x
Anaemia Anaemia 0% - 55% x
Headache Headache 0% - 37% x
Arthralgia Arthralgia 0% - 44% x
Musculoskeletal discomfort Arthralgia 0% - 44% x
Myalgia 0% - 24% x
Nausea Nausea 0% - 46% x
Leukopenia Leukopenia 0% - 62% x
Hypoalbuminaemia Hypoalbuminaemia 0% - 53% x
Blood alkaline phosphatase increased Phosphatase alkaline increased 2% - 67% x
Myalgia Myalgia 0% - 24% x
Neutropenia Neutropenia 2% - 55% x
Hypokalaemia Hypokalaemia 2% - 29% x
Aspartate aminotransferase increased Aspartate aminotransferase increased 0% - 60% x
Hyperkalaemia Hyperkalaemia 0% - 22% x
Hypertension Hypertension 3% - 15% x
Refractory hypertension x
Vomiting Vomiting 0% - 43% x
Chills Chills 0% - 58% x
Decreased appetite Decreased appetite 0% - 30% x
Diarrhoea Diarrhoea 0% - 43% x
Dermatitis Rash 0% - 57% x
Rash Rash 0% - 57% x
Body temperature increased Body temperature increased 0% - 71% x
Reaction febrile x
Oedema peripheral Oedema peripheral 0% - 31% x
Back pain Back pain 0% - 18% x
Alanine aminotransferase increased Alanine aminotransferase increased 0% - 42% x
Blood creatinine increased Creatinine increased 0% - 24% x
Constipation Constipation 0% - 22% x
Pain in extremity Pain in extremity 0% - 19% x
Thrombocytopenia Thrombocytopenia 0% - 31% x
Cough Cough 0% - 29% x
Insomnia Insomnia 0% - 18% x
Dizziness Dizziness 0% - 16% x
Hypocalcaemia Hypocalcaemia 0% - 20% x
Urinary tract infection Urinary tract infection 0% - 13% x
Abdominal pain Abdominal pain 1% - 33% x
Gastrointestinal pain Abdominal pain 1% - 33% x
Actinic keratosis Actinic keratosis 0% - 15% x
Seborrhoeic keratosis Actinic keratosis 0% - 15% x
Hypercalcaemia Hypercalcaemia 0% - 19% x
Night sweats Night sweats 0% - 24% x
Dry mouth Dry mouth 0% - 11% x
Lymphoedema Lymphoedema 0% - 32% x
Dehydration Dehydration 0% - 11% x
Hyperbilirubinaemia Hyperbilirubinaemia 0% - 15% x
Stomatitis Stomatitis 0% - 15% x
Mouth ulceration x
Hypomagnesaemia Hypomagnesaemia 0% - 18% x
Pruritus Pruritus 0% - 13% x
Haemorrhage Haemorrhage 0% - 16% x
Haemoglobin Haemorrhage 0% - 16% x
Renal failure Renal failure 0% - 7% x
Muscle spasms Muscle spasms 0% - 16% x
Erythema Erythema 0% - 15% x
Dermatitis acneiform Dermatitis acneiform 0% - 19% x
Paronychia Paronychia 0% - 10% x
Arrhythmia Arrhythmia x
Mental disorder Mental disorder x
Bone disorder Bone disorder x
Neoplasm malignant Neoplasm malignant x
Cellulitis Cellulitis x
Infection Infection x
Conjunctival haemorrhage Conjunctival haemorrhage x
Connective tissue disorder Connective tissue disorder x
Cyst Cyst x
Dysgeusia Dysgeusia x
Oedema Oedema x
Epistaxis Epistaxis x
Eye disorder Eye disorder x
Eye haemorrhage Eye haemorrhage x
Folliculitis Folliculitis x
Gastrointestinal disorder Gastrointestinal disorder x
Gingival bleeding Gingival bleeding x
Cardiac disorder Cardiac disorder x
Cardiac failure congestive Cardiac failure congestive x
Haematochezia Haematochezia x
Haematuria Haematuria x
Hyperhidrosis Hyperhidrosis x
Renal failure acute Renal failure acute x
Mediastinal disorder Mediastinal disorder x
Malignant melanoma Malignant melanoma x
Melaena Melaena x
Neoplasm Neoplasm x
Nervous system disorder Nervous system disorder x
Pancreatitis Pancreatitis x
Polyp Polyp x
Prurigo Prurigo x
Rhabdomyolysis Rhabdomyolysis x
Aphthous stomatitis Aphthous stomatitis x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Angiopathy Angiopathy x
Vitreous haemorrhage Vitreous haemorrhage x
Rash pustular Rash pustular x
Mouth ulceration Mouth ulceration x
Haemorrhage intracranial Haemorrhage intracranial x
Dry skin Dry skin 0% - 18% x
Blindness transient Blindness transient x
Malnutrition Malnutrition x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Rash macular Rash macular x
Rash vesicular Rash vesicular x
Abdominal discomfort Abdominal discomfort x
Abdominal pain upper Abdominal pain upper x
Abdominal pain lower Abdominal pain lower x
Abdominal tenderness Abdominal tenderness x
Rash erythematous Rash erythematous x
Gastric haemorrhage Gastric haemorrhage x
Disease progression Disease progression x
Haemorrhoidal haemorrhage Haemorrhoidal haemorrhage x
Rectal haemorrhage Rectal haemorrhage x
Dry eye Dry eye x
Mucosal inflammation Mucosal inflammation x
Vision blurred Vision blurred x
Skin papilloma Skin papilloma x
Rash maculo-papular Rash maculo-papular x
Bradycardia Bradycardia x
Rash generalised Rash generalised x
Brain stem haemorrhage Brain stem haemorrhage x
Ejection fraction decreased Ejection fraction decreased x
Left ventricular ejection fraction decreased x
Infestation Infestation NOS x
Hyperkeratosis Hyperkeratosis x
Cardiomyopathy Cardiomyopathy x
Skin toxicity Skin toxicity x
Ocular toxicity Ocular toxicity x
Rash papular Rash papular x
Embolism venous Venous thromboembolism x
Oropharyngeal pain Oropharyngeal pain 0% - 13% x
Cerebral haemorrhage Cerebral haemorrhage x
Vaginal haemorrhage Vaginal haemorrhage x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TRAMETINIB

Side effects:131
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label