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More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N02AD01

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2
Agranulocytosis Agranulocytosis x
Anaphylactic shock Anaphylactic shock x
Decreased appetite Anorexia x
Apnoea Apnoea x
Asthenia Asthenia x x
Confusional state Confusional state x x
Feeling abnormal Confusional state x x
Constipation Constipation x x
Dermatitis Dermatitis x x
Diarrhoea Diarrhoea x x
Diplopia Diplopia x
Dizziness Dizziness x x
Syncope x x
Lightheadedness x x
Dysgeusia Dysgeusia x
Dyspnoea Dyspnoea x
Eosinophilia Eosinophilia x x
Toxic epidermal necrolysis Toxic epidermal necrolysis x x
Grand mal convulsion Grand mal convulsion x
Erythema multiforme Erythema multiforme x
Flushing Flushing x x
Hallucination Hallucination x x
Headache Headache x x
Hypersensitivity Hypersensitivity x x
Hypertension Hypertension x x
Hypotension Hypotension x
Irritability Irritability x x
Miosis Miosis x x
Muscle spasms Cramp muscle x
Muscle spasms x
Nausea Nausea x x
Nodule Nodule x
Nystagmus Nystagmus x
Paraesthesia Paraesthesia x x
Pruritus Pruritus x x
Shock Shock x
Syncope x x
Hyperhidrosis Sweating x
Sweating increased x
Syncope Syncope x x
Loss of consciousness Syncope x x
Tachycardia Tachycardia x x
Tinnitus Tinnitus x x
Tremor Tremor x x
Tremor muscle x x
Ulcer Ulcer x
Uterine contractions during pregnancy Uterine contractions x x
Vertigo Vertigo x
Vomiting Vomiting x x
Dry mouth Dry mouth x x
Urinary retention Urinary retention x x
Chills Chills x x
Hepatic function abnormal Hepatic function abnormal x
Disorientation Disorientation x x
Agitation Excitement x x
Respiratory depression Respiratory depression x x
Pulmonary function test decreased Respiratory depression x x
Euphoric mood Euphoric mood x x
Abdominal discomfort Abdominal distress x
Induration Induration x
Vision blurred Vision blurred x
Face oedema Face oedema x x
Visual impairment Visual disturbance x
Insomnia Insomnia x x
Drug dependence Drug dependence x
Cardiovascular insufficiency Circulatory depression x x
Somnolence Somnolence x


Information about indications was extracted from the indications and usage sections of the labels.


Side effects:49
Source:Health Canada


Side effects:49
Source:FDA Structured Product Label

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label