Raloxifene

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Haemorrhage def Haemorrhage def 2.5% - 88.5% 2.4% x x x
Haemoglobin def Haemorrhage def 2.5% - 88.5% 2.4% x x x
Vaginal haemorrhage def Bleeding vaginal def 6.2% - 88.5% x x x
Vaginal haemorrhage def 2.5% 2.4% x x
Breast pain def Breast pain def 4.4% - 37.5% x x x
Pain def Pain def 0% - 37.5% 3.6% x x x
Menopausal symptoms def Hot flush def 3.1% - 28.7% 6.4% - 18.3% x x x
Hot flush def Hot flush def 3.1% - 28.7% 6.4% - 18.3% x x x
Abdominal pain def Abdominal pain def 6.6% - 18.7% x x x
Gastrointestinal pain def Abdominal pain def 6.6% - 18.7% x x x
Arthralgia def Arthralgia def 10.7% - 15.5% 10.1% - 14% x x
Musculoskeletal discomfort Arthralgia def 10.7% - 15.5% 10.1% - 14% x x
Myalgia def 7.7% 6.2% x x
Infection def Infection def 0% - 15.1% 3.9% - 14.6% x x
Influenza def Influenza def 13.5% - 14.6% 11.4% - 13.5% x x x
Flatulence def Flatulence def 1.6% - 12.5% 2.4% x x
Sinusitis def Sinusitis def 7.9% - 10.3% 6.5% - 7.5% x x
Rhinitis def Rhinitis def 10.2% 10.1% x x
Bronchitis def Bronchitis def 9.5% 8.6% x x
Cough def Cough def 6% - 9.3% 5.7% - 9.2% x x
Cough increased 6% - 9.3% 5.7% - 9.2% x x
Headache def Headache def 9.2% 8.5% x x
Nausea def Nausea def 8.3% - 8.8% 7.8% - 8.6% x x
Weight increased def Weight increased def 8.8% 6.8% x x
Myalgia def Myalgia def 7.7% 6.2% x x
Pharyngitis def Pharyngitis def 5.3% - 7.6% 5.1% - 7.2% x x
Diarrhoea def Diarrhoea def 7.2% 6.9% x x
Muscle spasms def Cramps of lower extremities 5.9% - 7% 1.9% - 3.7% x x x
Cramp muscle def 5.9% - 7% 1.9% - 3.7% x x x
Muscle spasms def x x
Dyspepsia def Dyspepsia def 5.9% 5.8% x x
Dermatitis def Rash def 5.5% 3.8% x x
Rash def Rash def 5.5% 3.8% x x
Insomnia def Insomnia def 5.5% 4.3% x x
Oedema def Oedema def 3.3% - 5.2% 1.9% - 4.4% x x x
Oedema peripheral def Oedema peripheral def 3.3% - 5.2% 1.9% - 4.4% x x x
Vomiting def Vomiting def 3.4% - 4.8% 3.3% - 4.3% x x
Cystitis def Cystitis def 3.3% - 4.6% 3.1% - 4.5% x x
Bladder pain def Cystitis def 3.3% - 4.6% 3.1% - 4.5% x x
Cystitis noninfective def Cystitis def 3.3% - 4.6% 3.1% - 4.5% x x
Vaginal inflammation def Vaginal inflammation def 4.3% 3.6% x x
Vaginal infection def Vaginal inflammation def 4.3% 3.6% x x
Vertigo def Vertigo def 4.1% 3.7% x x
Arthritis def Arthritis def 4% 3.6% x x
Chest pain def Chest pain def 0% - 4% 3.6% x x
Urinary tract infection def Urinary tract infection def 4% 3.9% x x
Body temperature increased def Body temperature increased def 3.1% - 3.9% 2.6% - 3.8% x x
Tendon disorder Tendon disorder 3.6% 3.1% x x
Gastrointestinal disorder def Gastrointestinal disorder def 3.3% 2.1% x x
Genital discharge Leukorrhea def 3.3% 1.7% x x
Uterine disorder def Uterine disorder def 3.3% 2.3% x x x
Hyperhidrosis def Sweating def 2.5% - 3.1% 1.7% - 2% x x
Endometrial disorder def Endometrial disorder def 3.1% 1.9% x x
Gastroenteritis def Gastroenteritis def 2.6% 2.1% x x
Pneumonia def Pneumonia def 2.6% 1.5% x x
Urethral disorder def Urinary tract disorder def 2.5% 2.1% x x
Urinary tract disorder def Urinary tract disorder def 2.5% 2.1% x x
Neuralgia def Neuralgia def 2.4% 1.9% x x
Migraine def Migraine def 2.4% 2.1% x x
Dizziness def Syncope def 2.3% 2.1% x x
Shock def Syncope def 2.3% 2.1% x x
Syncope def Syncope def 2.3% 2.1% x x
Loss of consciousness def Syncope def 2.3% 2.1% x x
Conjunctivitis def Conjunctivitis def 2.2% 1.7% x x
Laryngitis def Laryngitis def 2.2% 1.4% x x
Varicose vein def Varicose vein def 2.2% 1.5% x x
Hypoaesthesia def Hypoaesthesia def 2.1% 2% x x
Retinal vein occlusion def Retinal vein occlusion def postmarketing x x
Cerebrovascular accident def Cerebrovascular accident def postmarketing x x x
Embolism def Thromboembolism def postmarketing x x x
Embolism def x x x
Thromboembolic event x x
Embolism venous Thromboembolism def postmarketing x x x
Venous thromboembolism def postmarketing x x x
Venous occlusion def Venous occlusion def postmarketing x x
Death Death postmarketing x x
Bladder cancer def Bladder cancer def x
Cholelithiasis def Cholelithiasis def x x
Coronary artery disease def Coronary heart disease def x x x
Diabetes mellitus def Diabetes mellitus def x
Fasting def Fasting def x
Flushing def Flushing def x
Cardiac disorder def Cardiac disorder def x x x
Pulmonary embolism def Pulmonary embolism def x x x
Thrombosis def Thrombosis def x x x
Vasodilation procedure Vasodilation def x
Venous thrombosis def Venous thrombosis def x x x
Deep vein thrombosis def Deep vein thrombosis def x x x
Tenderness def Tenderness def x x
Endometrial cancer def Endometrial cancer def x x
Ovarian cancer def Ovarian cancer def x x
Retinal vein thrombosis Retinal vein thrombosis x x
Indication Labels
Breast cancer def x x
Breast cancer invasive NOS def x x
Calcium low x
Carcinoma def x x
Carcinoma in situ def x x
Hyperplasia def x x
Lobular breast carcinoma (in situ) def x x
Lobular carcinoma of breast def x x
Menarche def x x
Neoplasm malignant def x x
Oestrogen deficiency x
Osteoporosis def x x x
Osteoporosis postmenopausal def x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: G03XC01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. RALOXIFENE (RALOXIFENE HYDROCHLORIDE) / EVISTA (60MG) : 27 side effects (Health Canada)
  2. RALOXIFENE : 73 side effects (FDA XML label)
  3. Raloxifene : 73 side effects (FDA XML label)