| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Punctate keratitis | Superficial punctate keratopathy | very common |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Malaise | Malaise | 11.1% - 11.5% | 11.1% |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x |  |  |  | x | 
| Discomfort | Malaise | 11.1% - 11.5% | 11.1% |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x |  |  |  | x | 
| Feeling abnormal | Malaise | 11.1% - 11.5% | 11.1% |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x |  |  |  | x | 
| Confusional state | very rare — common |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Ill-defined disorder | Malaise | 11.1% - 11.5% | 11.1% |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x |  |  |  | x | 
| Abdominal pain | Abdominal pain | common |  |  |  |  |  |  |  | x |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Gastrointestinal pain | Abdominal pain | common |  |  |  |  |  |  |  | x |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Conjunctivitis | Conjunctivitis | common |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dizziness | Dizziness | common |  |  | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Lightheadedness |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Asthenia | Fatigue | common |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Asthenia | 1.2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Fatigue | Fatigue | common |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Hallucination | Hallucination | very rare, common |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | x | x |  |  | x | 
| Vomiting | Vomiting | common, 2.5% - 8% | 2.5% |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pain | Stinging | common |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ache |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Somnolence | Somnolence | very rare, common |  |  |  |  |  | x | x |  | x | x | x | x | x | x |  |  | x | x |  |  | x | 
| Nausea | Nausea | common, 2.4% - 8% | 11.5% |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Body temperature increased | Body temperature increased | common, 4% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x | x | 
| Diarrhoea | Diarrhoea | postmarketing — 1.5% - 5% | 0.3% - 2.2% |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Headache | Headache | common, 0.9% - 5.9% | 11.1% |  | x |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dehydration | Dehydration | 2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Herpes simplex | Herpes simplex | 2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Nasopharyngitis | Rhinorrhoea | 2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Nasopharyngitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Rhinorrhoea | Rhinorrhoea | 2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Paraesthesia | Paraesthesia | 0.8% - 1.2% |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Aggression | Aggression | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x |  | x | x | x |  | 
| Alopecia | Alopecia | postmarketing, uncommon |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Accelerated hair loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anaphylactic shock | Anaphylactic shock | postmarketing, rare |  |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aplastic anaemia | Aplastic anaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Angioedema | Angioedema | very rare — rare |  |  |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Ataxia | Ataxia | very rare, postmarketing |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blepharitis | Blepharitis | rare |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Coma | Coma | very rare, postmarketing |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Confusional state | Confusional state | very rare — common |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dermatitis contact | Dermatitis contact | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysarthria | Dysarthria | very rare, postmarketing |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  | x | x | x | 
| Osteoarthritis | Dysarthria | very rare, postmarketing |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  | x | x | x | 
| Dyspnoea | Dyspnoea | postmarketing, rare |  |  |  |  |  | x | x |  |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Eczema | Eczema | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Erythema multiforme | Erythema multiforme | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x |  | 
| Stevens-Johnson syndrome |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Dermatitis | Rash | postmarketing — 1.3% - 1.7% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  | x | x | x | 
| Rash | Rash | postmarketing — 1.3% - 1.7% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  | x | x | x | 
| Hepatitis | Hepatitis | very rare, postmarketing |  |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypersensitivity | Hypersensitivity | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  |  |  | x | x | x |  | x | x |  | 
| Hypertension | Hypertension | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Pruritus | Pruritus | postmarketing, common |  | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Psychotic disorder | Psychotic disorder | very rare, postmarketing |  |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Renal failure | Renal failure | very rare, postmarketing |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x |  | x | x | x | x | 
| Renal impairment | very rare |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Convulsion | Convulsion | very rare — common |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tachycardia | Tachycardia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Thrombocytopenia | Thrombocytopenia | very rare, postmarketing |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Tremor | Tremor | very rare, postmarketing |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Urticaria | Urticaria | postmarketing, uncommon |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Encephalopathy | Encephalopathy | very rare, postmarketing |  |  |  |  |  |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Agitation | Agitation | very rare, postmarketing |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blood urea increased | Blood urea increased | rare |  |  |  |  |  | x | x |  | x | x | x | x | x | x |  |  |  | x |  |  | x | 
| Mania | Mania | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Photosensitivity reaction | Photosensitivity | postmarketing, common |  |  |  |  |  | x | x |  |  | x |  |  |  |  | x | x | x |  | x | x | x | 
| Photosensitivity reaction |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  |  | x |  |  |  | 
| Face oedema | Face oedema | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Altered state of consciousness | Depressed level of consciousness | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x |  |  | x | x |  | 
| Depressed level of consciousness | Depressed level of consciousness | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x |  |  | x | x |  | 
| Stupor |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Renal pain | Renal pain | very rare, postmarketing |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x |  |  | x | x | x | 
| Hallucinations, mixed | Auditory and visual hallucinations | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Leukocytoclastic vasculitis | Leukocytoclastic vasculitis | postmarketing |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x |  | x | x | x |  | 
| Anaemia | Anaemia | very rare |  |  |  |  |  | x | x | x | x | x | x | x | x | x |  |  | x | x |  |  | x | 
| Type I hypersensitivity | Type I hypersensitivity | very rare |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Jaundice | Jaundice | very rare |  |  |  |  |  | x | x |  | x | x | x | x | x | x |  |  | x | x |  |  | x | 
| Renal failure acute | Renal failure acute | very rare |  |  |  |  |  | x | x |  |  | x |  |  |  |  | x |  | x |  | x | x | x | 
| Leukopenia | Leukopenia | very rare |  |  |  |  |  | x | x |  | x | x | x | x | x | x |  |  | x | x |  |  | x | 
| Renal impairment | Renal impairment | very rare |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Decreased appetite | Anorexia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x |  |  | x | 
| Anuria | Anuria |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arthralgia | Arthralgia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | 
| Musculoskeletal discomfort | Arthralgia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | 
| Myalgia |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Cardiac tamponade | Cardiac tamponade |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Chest pain | Chest pain |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Constipation | Constipation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Delirium | Delirium |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  |  | x |  |  |  | 
| Disseminated intravascular coagulation | Disseminated intravascular coagulation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Dysgeusia | Dysgeusia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysmenorrhoea | Dysmenorrhoea |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Oedema | Oedema |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Toxic epidermal necrolysis | Toxic epidermal necrolysis |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Eye disorder | Eye disorder |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Flatulence | Flatulence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Digestion impaired |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Haematuria | Haematuria |  |  |  |  |  |  |  | x | x | x |  | x | x | x | x |  |  |  | x |  |  |  | 
| Haemolytic uraemic syndrome | Haemolytic uraemic syndrome |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Herpes virus infection | Herpes NOS |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperbilirubinaemia | Hyperbilirubinaemia |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  |  | x |  |  |  | 
| Hypokalaemia | Hypokalaemia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypotension | Hypotension |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Immune system disorder | Immune system disorder |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Inflammation | Inflammation |  |  |  |  | x |  |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Irritability | Irritability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ischaemia | Ischaemia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pain in extremity | Leg pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Lethargy | Lethargy |  |  |  | x |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Leukocytosis | Leukocytosis |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Mediastinal disorder | Mediastinal disorder |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle spasms | Cramp muscle |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Necrosis | Necrosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Nervous system disorder | Nervous system disorder |  |  |  | x |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Neutropenia | Neutropenia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | x | 
| Palpitations | Palpitations |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Uveitis | Pars planitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Phlebitis | Phlebitis |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pulmonary oedema | Pulmonary oedema |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thrombotic thrombocytopenic purpura | Thrombotic thrombocytopenic purpura |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x |  | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Aphthous stomatitis | Aphthous stomatitis |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thirst | Thirst |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Erythema | Erythema |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Upper respiratory tract infection | Upper respiratory tract infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Urethral disorder | Urinary tract disorder |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Urinary tract disorder | Urinary tract disorder |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Vasculitis | Vasculitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vertigo | Vertigo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Stupor | Stupor |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Oedema peripheral | Oedema peripheral |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Purpura fulminans | Purpura fulminans |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Application site reaction | Application site reaction |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood creatinine increased | Creatinine increased |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Blood creatinine increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Aspartate aminotransferase increased | Aspartate aminotransferase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Skin disorder | Unspecified disorder of skin and subcutaneous tissue |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Myalgia | Myalgia |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Dyspepsia | Digestion impaired |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neurological symptom | Neurologic reaction |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haemoglobinaemia | Haemoglobinaemia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin exfoliation | Skin exfoliation |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gingival pain | Gingival pain |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin burning sensation | Skin burning sensation |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oropharyngeal discomfort | Throat sore |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Oropharyngeal pain | Throat sore |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Hepatobiliary disease | Hepatobiliary disease |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Platelet count decreased | Platelet count decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x |  | 
| Chapped lips | Chapped lips |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Chills | Rigors |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urine analysis abnormal | Urine analysis abnormal |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lymphadenopathy | Lymphadenopathy |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  | x | 
| Application site irritation | Application site irritation |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Application site pain | Application site pain |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Instillation site pain | Application site pain |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Injection site phlebitis | Injection site phlebitis |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Abdominal discomfort | Distress gastrointestinal |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  | x | x |  |  |  | 
| Lip dry | Lip dry |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperhidrosis | Sweating increased |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thrombocytosis | Thrombocytosis |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Thrombocytopenic purpura | Thrombocytopenic purpura |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Liver function test abnormal | Raised liver function tests |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x |  |  |  | x |  |  |  | 
| Insomnia | Insomnia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Sensitisation | Sensitisation |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thrombophlebitis superficial | Thrombophlebitis superficial |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neutrophilia | Neutrophilia |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  |