Tamoxifen citrate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 15)
1 2 3 4 5 6 7 8 9 10
Menopausal symptoms def Hot flush def 48% - 80% 48% - 68% x x x x x x x x x x
Hot flush def Hot flush def 48% - 80% 48% - 68% x x x x x x x x x x
Amenorrhoea def Amenorrhoea def 16% - 69% x x x x x
Vaginal discharge def Vaginal discharge def postmarketing, 15% - 55% 15% - 35% x x x x x x x x x
Flushing def Flushing def 33% - 46% x x x x x x x
Fluid retention Fluid retention 30% - 32% 30% x x x x x x
Nausea def Nausea def 4% - 26% 24% x x x x x x x x x
Menstruation irregular def Menstruation irregular def postmarketing, 19% - 25% 19% x x x x x x
Haemorrhage def Haemorrhage def postmarketing, 22% - 23% 22% x x x x x x x x x
Haemoglobin def Haemorrhage def postmarketing, 22% - 23% 22% x x x x x x x x x
Weight decreased def Weight decreased def 18% - 23% 18% x x x x x x
Vaginal haemorrhage def Bleeding vaginal def postmarketing, 22% - 23% 22% x x x x x x x x x
Vaginal haemorrhage def x
Ichthyosis def Ichthyosis def 15% - 19% 15% x x x x x x
Ichthyosis acquired Ichthyosis def 15% - 19% 15% x x x x x x
Oligomenorrhoea def Oligomenorrhoea def 1% - 9% x x x x x
Infection def Infection def 5.1% - 6% 5.1% x x x x x x
Menstrual disorder def Menstrual disorder def 4% - 6% x x x x x x
Pain def Pain def 0% - 6% x x x x x x x x x x
Bone pain def Bone pain def 6% x x x x x x x x x x
Sepsis def Sepsis def 5.1% - 6% 5.1% x x x x x
Alopecia def Alopecia def 4.4% - 5.2% 4.4% x x x x x x x x x x
Aspartate aminotransferase increased def Aspartate aminotransferase increased def 3% - 5% 3% x x x x x
Constipation def Constipation def 3.2% - 4.4% 3.2% x x x x x x x
Cough def Cough def 1% - 4% x x x x x x
Cough increased x
Oedema def Oedema def 1% - 4% x x x x x x x x x x
Asthenia def Fatigue def 1% - 4% x x x x x x
Asthenia def x
Fatigue def Fatigue def 1% - 4% x x x x x x
Cyst def Cyst def 2% - 3% x x x x x x x x x
Musculoskeletal pain def Musculoskeletal pain def 0% - 3% x x x
Ovarian cyst def Ovarian cyst def 2% - 3% x x x x x x x x x
Hypersensitivity def Hypersensitivity def postmarketing, 2.1% - 2.5% 2.1% x x x x x x x x x
Abdominal pain def Abdominal cramps def 1% - 2% x x x x x
Abdominal pain def x x
Decreased appetite Anorexia def 1% - 2% x x x x x x
Appetite absent x
Muscle spasms def Cramp muscle def 1% - 2% x x x x x x x
Cramps of lower extremities x
Thrombocytopenia def Thrombocytopenia def 1% - 2% 1% x x x x x x x x x
Blood creatinine increased Creatinine increased def 1% - 2% 1% x x x x x x
Blood bilirubin increased def Blood bilirubin increased def 1% - 2% 1% x x x x x
Thrombosis def Thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Clot blood def x
Venous thrombosis def Venous thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Deep vein thrombosis def Deep vein thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Platelet count decreased Platelet count decreased 0.3% - 0.7% 0.3% x x x x x
Embolism def Embolism def 0.2% - 0.5% 0.2% x x x x x x x x
Thromboembolic event x x x x
Pulmonary embolism def Pulmonary embolism def 0.2% - 0.5% 0.2% x x x x x x x x
Phlebitis def Phlebitis def 0% - 0.4% 0% x x x x x
Phlebitis superficial Phlebitis superficial 0% - 0.4% 0% x x x x x
Angioedema def Angioedema def postmarketing x x x x x x x x
Erythema multiforme def Erythema multiforme def postmarketing x x x x x x x x x
Dermatitis def Rash def postmarketing x x x x x x x x x
Rash def Rash def postmarketing x x x x x x x x x
Headache def Headache def postmarketing x x x x x x x x x x
Pancreatitis def Pancreatitis def postmarketing x x x x x x x x x
Pemphigoid def Pemphigoid def postmarketing x x x x x x x x x
Pneumonia def Pneumonia def postmarketing x x x x x x x x x
Erythema def Erythema def postmarketing x x x x x x x x x x
Redness def x
Interstitial lung disease def Interstitial pneumonia postmarketing x x x x x x x x
Drug interaction def Drug interaction def postmarketing x x x x x
Gastrointestinal pain def Abdominal pain def x x
Adenocarcinoma def Adenocarcinoma def x x x x x x
Anaemia def Anaemia def x x x x x
Angina pectoris def Angina pectoris def x
Anxiety def Anxiety def x x
Arrhythmia def Arrhythmia def x
Arthralgia def Arthralgia def x x
Musculoskeletal discomfort Arthralgia def x x
Myalgia def x x
Arthritis def Arthritis def x x
Back pain def Back pain def x x
Bronchitis def Bronchitis def x
Candidiasis def Candidiasis def x
Cardiovascular disorder def Cardiovascular disorder def x
Chest pain def Chest pain def x x
Cholelithiasis def Cholelithiasis def x
Cholestasis def Cholestasis def x x x x
Corneal opacity def Corneal opacity def x
Diarrhoea def Diarrhoea def x x x
Dizziness def Dizziness def x x x x x x x x x
Lightheadedness x
Dyspepsia def Dyspepsia def x x
Dyspnoea def Dyspnoea def x
Endometriosis def Endometriosis def x x x x
Hepatic steatosis def Liver fatty def x x x
Gastrointestinal disorder def Gastrointestinal disorder def x
Cardiac disorder def Cardiac disorder def x
Hepatitis def Hepatitis def x x x
Hypercalcaemia def Hypercalcaemia def x x x x x x x x x x
Hypercholesterolaemia def Hypercholesterolaemia def x
Hyperlipidaemia def Hyperlipidaemia def x
Hypertension def Hypertension def x x
Hypertriglyceridaemia def Hypertriglyceridaemia def x x
Blood triglycerides increased Hypertriglyceridaemia def x x
Incontinence def Incontinence def x
Infarction def Infarction def x
Influenza def Influenza def x x
Arthropathy def Arthropathy def x x
Osteoarthritis def Arthropathy def x x
Leiomyoma def Leiomyoma def x x x x
Uterine leiomyoma def Leiomyoma def x x x x
Uterine leiomyoma def x x x x
Lens disorder def Lens disorder def x x
Leukopenia def Leukopenia def x x x x
Genital discharge Leukorrhea def x x
Cutaneous lupus erythematosus def Cutaneous lupus erythematosus def x
Lymphoedema def Lymphoedema def x
Macular degeneration def Macular degeneration def x
Breast pain def Breast pain def x x
Menopause def Menopause def x x x
Myocardial infarction def Myocardial infarction def x
Acute coronary syndrome def Myocardial infarction def x
Metastasis def Metastasis def x x
Neuritis def Neuritis def x
Neuropathy peripheral def Neuritis def x
Neuropathy def x
Neutropenia def Neutropenia def x x x x
Night sweats def Night sweats def x
Optic nerve disorder def Optic nerve disorder def x
Optic neuritis def Optic neuritis def x
Osteoporosis def Osteoporosis def x x
Pancreatic disorder def Pancreatic disorder def x
Paraesthesia def Paraesthesia def x x
Peliosis hepatis def Peliosis hepatis def x x x
Pelvic pain def Pelvic pain def x
Pharyngitis def Pharyngitis def x x
Polyp def Polyp def x x x x
Porphyria def Porphyria def x
Priapism def Priapism def x
Pruritus def Pruritus def x x x x x x x x x x
Vulvovaginal pruritus Pruritus vulvae def x x x x x x x x x
Puberty def Puberty def x x
Precocious puberty def Precocious puberty def x x
Purpura def Purpura def x x x
Vascular purpura Purpura def x x x
Retinal disorder def Retinal disorder def x x x x
Sinusitis def Sinusitis def x
Cerebrovascular accident def Cerebrovascular accident def x x x x x x x x x x
Hyperhidrosis def Sweating def x x
Swelling def Swelling def x
Urinary incontinence def Urinary incontinence def x
Urinary tract infection def Urinary tract infection def x x
Uterine disorder def Uterine disorder def x
Vaginal inflammation def Vaginal inflammation def x
Vaginal infection def Vaginal inflammation def x
Vasculitis def Vasculitis def x
Vasodilation procedure Vasodilation def x
Vomiting def Vomiting def x x x x x
Vulvovaginitis def Vulvovaginitis def x x
Weight increased def Weight increased def x x
Dry mouth def Dry mouth def x
Oedema peripheral def Oedema peripheral def x x x x x x x x x
Cataract def Cataract def x x x x x x x x x x
Cataract specified x
Hepatic function abnormal Hepatic function abnormal x
High density lipoprotein decreased High density lipoprotein decreased x
Myocardial ischaemia def Myocardial ischaemia def x
Uterine cancer def Uterine cancer def
Endometrial adenocarcinoma def x x x
Bone cancer metastatic def Bone cancer metastatic def x x
Uterine polyp def Uterine polyp def x
Porphyria non-acute Porphyria cutanea tarda def x
Myalgia def Myalgia def x x
Visual acuity reduced Visual acuity reduced x x x x
Nail disorder def Nail changes def x
Breast cancer male def Breast cancer male def x x x x x
Vulvovaginal dryness Vaginal dryness def x x x x x x x
Albright's disease Albright's disease x x x
Erectile dysfunction def Erectile dysfunction def x x x x x x
Disease progression def Disease progression def x
Soft tissue disorder Soft tissue disorder x x x x x x x x x
Hepatic cyst Hepatic cyst x x x
Macular oedema def Macular oedema def x x x
Sarcoma uterus def Sarcoma uterus def x x x x x
Systemic lupus erythematosus def Lupus erythematosus def x
Blindness def Blindness def x
Visual impairment def Visual disturbance x x x
Breast disorder male Breast disorder male x x x x x
Throat irritation Throat irritation x
Vulvovaginal candidiasis def Vulvovaginal candidiasis def x
Febrile neutropenia def Febrile neutropenia def x
Neoplasm malignant def Second primary malignancy def x
Tumour flare Tumour flare x x
Tumour pain def Tumour pain def x x x x x x x x x x
Pancytopenia def Myelosuppression def x
Liver function test abnormal Raised liver function tests x
Becker's muscular dystrophy def Becker's muscular dystrophy def x
Insomnia def Insomnia def x x
Endometrial cancer def Endometrial adenocarcinoma def x x x
Breast neoplasm def Breast neoplasm def x x
Mood swings Mood alteration NOS def x
Metastatic neoplasm def Metastatic disease def x
Loss of libido Loss of libido x x x x x
Indication Labels
Adjuvant therapy def x x x x x x
Brain neoplasm def x
Breast cancer def x x x x x x x
Breast cancer invasive NOS def x x x x x x
Breast cancer stage IV def x x x x x x
Breast ductal carcinoma def x x x x x x
Carcinoid tumour def x
Carcinoma def x x x x x x
Carcinoma in situ def x x x x x x
Carcinoma in situ of breast ductal def x x x x x x
Contralateral breast cancer x x x x x x
Endometrial cancer def x
Hyperplasia def x x x x x
Lobular breast carcinoma (in situ) def x x x x x
Malignant melanoma def x
Malignant neoplasm of pancreas def x
Menarche def x x x x x
Neoplasm def x x x x x x x
Neoplasm malignant def x x x x x x x
Sarcoma def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L02BA01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. tamoxifen citrate / Nolvadex : 19 side effects (FDA MedWatch)
  2. TAMOXIFEN (TAMOXIFEN CITRATE) / GEN-TAMOXIFEN TAB 10MG : 51 side effects (Health Canada)
  3. TAMOXIFEN (TAMOXIFEN CITRATE) / PMS-TAMOXIFEN : 57 side effects (Health Canada)
  4. tamoxifen citrate / Nolvadex : 65 side effects (FDA CDER)
  5. tamoxifen : 66 side effects (FDA XML label)
  6. Tamoxifen : 69 side effects (FDA XML label)
  7. TAMOXIFEN (TAMOXIFEN CITRATE) / NOLVADEX-D TAB 20MG : 69 side effects (Health Canada)
  8. TAMOXIFEN CITRATE / NOLVADEX : 70 side effects (Drugs@FDA)
  9. Tamoxifen : 115 side effects (FDA XML label)
  10. Tamoxifen : 124 side effects (BC Cancer)