Tamoxifen citrate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 15)
1 2 3 4 5 6 7 8 9 10
Hot flush def 48% - 80% 48% - 68% x x x x x x x x x x
Amenorrhoea def 16% - 69% x x x x x
Vaginal discharge def postmarketing, 15% - 55% 15% - 35% x x x x x x x x x
Flushing def 33% - 46% x x x x x x x
Fluid retention 30% - 32% 30% x x x x x x
Nausea def 4% - 26% 24% x x x x x x x x x
Menstruation irregular def postmarketing, 19% - 25% 19% x x x x x x
Haemorrhage def postmarketing, 22% - 23% 22% x x x x x x x x x
Weight decreased def 18% - 23% 18% x x x x x x
Bleeding vaginal def postmarketing, 22% - 23% 22% x x x x x x x x x
Ichthyosis def 15% - 19% 15% x x x x x x
Oligomenorrhoea def 1% - 9% x x x x x
Infection def 5.1% - 6% 5.1% x x x x x x
Menstrual disorder def 4% - 6% x x x x x x
Pain def 0% - 6% x x x x x x x x x x
Bone pain def 6% x x x x x x x x x x
Sepsis def 5.1% - 6% 5.1% x x x x x
Alopecia def 4.4% - 5.2% 4.4% x x x x x x x x x x
Aspartate aminotransferase increased def 3% - 5% 3% x x x x x
Constipation def 3.2% - 4.4% 3.2% x x x x x x x
Cough def 1% - 4% x x x x x x
Oedema def 1% - 4% x x x x x x x x x x
Fatigue def 1% - 4% x x x x x x
Cyst def 2% - 3% x x x x x x x x x
Musculoskeletal pain def 0% - 3% x x x
Ovarian cyst def 2% - 3% x x x x x x x x x
Hypersensitivity def postmarketing, 2.1% - 2.5% 2.1% x x x x x x x x x
Abdominal cramps def 1% - 2% x x x x x
Anorexia def 1% - 2% x x x x x x
Cramp muscle def 1% - 2% x x x x x x x
Thrombocytopenia def 1% - 2% 1% x x x x x x x x x
Creatinine increased def 1% - 2% 1% x x x x x x
Blood bilirubin increased def 1% - 2% 1% x x x x x
Thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Venous thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Deep vein thrombosis def 0.2% - 0.8% 0.2% x x x x x x x x
Platelet count decreased 0.3% - 0.7% 0.3% x x x x x
Embolism def 0.2% - 0.5% 0.2% x x x x x x x x
Pulmonary embolism def 0.2% - 0.5% 0.2% x x x x x x x x
Phlebitis def 0% - 0.4% 0% x x x x x
Phlebitis superficial 0% - 0.4% 0% x x x x x
Angioedema def postmarketing x x x x x x x x
Erythema multiforme def postmarketing x x x x x x x x x
Rash def postmarketing x x x x x x x x x
Headache def postmarketing x x x x x x x x x x
Pancreatitis def postmarketing x x x x x x x x x
Pemphigoid def postmarketing x x x x x x x x x
Pneumonia def postmarketing x x x x x x x x x
Erythema def postmarketing x x x x x x x x x x
Interstitial pneumonia postmarketing x x x x x x x x
Drug interaction def postmarketing x x x x x
Abdominal pain def x x
Adenocarcinoma def x x x x x x
Anaemia def x x x x x
Angina pectoris def x
Anxiety def x x
Arrhythmia def x
Arthralgia def x x
Arthritis def x x
Asthenia def x
Back pain def x x
Bronchitis def x
Candidiasis def x
Cardiovascular disorder def x
Chest pain def x x
Cholelithiasis def x
Cholestasis def x x x x
Corneal opacity def x
Diarrhoea def x x x
Dizziness def x x x x x x x x x
Dyspepsia def x x
Dyspnoea def x
Endometriosis def x x x x
Liver fatty def x x x
Gastrointestinal disorder def x
Cardiac disorder def x
Hepatitis def x x x
Hypercalcaemia def x x x x x x x x x x
Hypercholesterolaemia def x
Hyperlipidaemia def x
Hypertension def x x
Hypertriglyceridaemia def x x
Incontinence def x
Infarction def x
Influenza def x x
Arthropathy def x x
Cramps of lower extremities x
Leiomyoma def x x x x
Lens disorder def x x
Leukopenia def x x x x
Leukorrhea def x x
Cutaneous lupus erythematosus def x
Lymphoedema def x
Macular degeneration def x
Breast pain def x x
Menopause def x x x
Myocardial infarction def x
Metastasis def x x
Neuritis def x
Neutropenia def x x x x
Night sweats def x
Optic nerve disorder def x
Optic neuritis def x
Osteoporosis def x x
Pancreatic disorder def x
Paraesthesia def x x
Peliosis hepatis def x x x
Pelvic pain def x
Pharyngitis def x x
Polyp def x x x x
Porphyria def x
Priapism def x
Pruritus def x x x x x x x x x x
Pruritus vulvae def x x x x x x x x x
Puberty def x x
Precocious puberty def x x
Purpura def x x x
Retinal disorder def x x x x
Sinusitis def x
Cerebrovascular accident def x x x x x x x x x x
Sweating def x x
Swelling def x
Urinary incontinence def x
Urinary tract infection def x x
Uterine disorder def x
Uterine leiomyoma def x x x x
Vaginal inflammation def x
Vasculitis def x
Vasodilation def x
Vomiting def x x x x x
Vulvovaginitis def x x
Weight increased def x x
Dry mouth def x
Oedema peripheral def x x x x x x x x x
Cataract def x x x x x x x x x x
Hepatic function abnormal x
Cataract specified x
High density lipoprotein decreased x
Myocardial ischaemia def x
Uterine cancer def
Bone cancer metastatic def x x
Uterine polyp def x
Porphyria cutanea tarda def x
Lightheadedness x
Myalgia def x x
Visual acuity reduced x x x x
Nail changes def x
Breast cancer male def x x x x x
Vaginal dryness def x x x x x x x
Albright's disease x x x
Erectile dysfunction def x x x x x x
Disease progression def x
Soft tissue disorder x x x x x x x x x
Hepatic cyst x x x
Macular oedema def x x x
Clot blood def x
Redness def x
Sarcoma uterus def x x x x x
Lupus erythematosus def x
Neuropathy def x
Blindness def x
Visual disturbance x x x
Breast disorder male x x x x x
Cough increased x
Throat irritation x
Vulvovaginal candidiasis def x
Febrile neutropenia def x
Second primary malignancy def x
Tumour flare x x
Tumour pain def x x x x x x x x x x
Myelosuppression def x
Thromboembolic event x x x x
Raised liver function tests x
Becker's muscular dystrophy def x
Insomnia def x x
Endometrial adenocarcinoma def x x x
Breast neoplasm def x x
Appetite absent x
Mood alteration NOS def x
Metastatic disease def x
Vaginal haemorrhage def x
Loss of libido x x x x x
Indication Labels
Adjuvant therapy def x x x x x x
Brain neoplasm def x
Breast cancer def x x x x x x x
Breast cancer invasive NOS def x x x x x x
Breast cancer stage IV def x x x x x x
Breast ductal carcinoma def x x x x x x
Carcinoid tumour def x
Carcinoma def x x x x x x
Carcinoma in situ def x x x x x x
Carcinoma in situ of breast ductal def x x x x x x
Contralateral breast cancer x x x x x x
Endometrial cancer def x
Hyperplasia def x x x x x
Lobular breast carcinoma (in situ) def x x x x x
Malignant melanoma def x
Malignant neoplasm of pancreas def x
Menarche def x x x x x
Neoplasm def x x x x x x x
Neoplasm malignant def x x x x x x x
Sarcoma def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L02BA01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. tamoxifen citrate / Nolvadex : 19 side effects (FDA MedWatch)
  2. TAMOXIFEN (TAMOXIFEN CITRATE) / GEN-TAMOXIFEN TAB 10MG : 51 side effects (Health Canada)
  3. TAMOXIFEN (TAMOXIFEN CITRATE) / PMS-TAMOXIFEN : 57 side effects (Health Canada)
  4. tamoxifen citrate / Nolvadex : 65 side effects (FDA CDER)
  5. tamoxifen : 66 side effects (FDA XML label)
  6. Tamoxifen : 69 side effects (FDA XML label)
  7. TAMOXIFEN (TAMOXIFEN CITRATE) / NOLVADEX-D TAB 20MG : 69 side effects (Health Canada)
  8. TAMOXIFEN CITRATE / NOLVADEX : 70 side effects (Drugs@FDA)
  9. Tamoxifen : 115 side effects (FDA XML label)
  10. Tamoxifen : 124 side effects (BC Cancer)