Orlistat
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
Headache
|
Headache
|
common, 30.6%
|
27.6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
uncommon, 26.1% - 38.1%
|
25.8% - 32.8%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
25.5%
|
21.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal colic
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
25.5%
|
21.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Influenza
|
Influenza
|
uncommon, 39.7%
|
36.2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Back pain
|
Back pain
|
uncommon, 13.9%
|
12.1%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Flatulence
|
Flatulence
|
2.1% - 23.9%
|
0.2% - 1.4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pain
|
Pain
|
uncommon, 10.8%
|
10.3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Menstruation irregular
|
Menstruation irregular
|
9.8%
|
7.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lower respiratory tract infection
|
Lower respiratory tract infection
|
uncommon, 7.8%
|
6.6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urinary tract infection
|
Urinary tract infection
|
uncommon, 5.9% - 7.5%
|
4.8% - 7.3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthritis
|
Arthritis
|
5.4%
|
4.8%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysentery
|
Dysentery
|
uncommon, 5.3%
|
4.4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
uncommon, 5.2%
|
5%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Discomfort
|
Discomfort
|
3.3% - 25.5%
|
1.9% - 21.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Asthenia
|
Fatigue
|
3.1% - 7.2%
|
1.7% - 6.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
common
|
|
|
|
|
|
|
|
|
|
|
x
|
Fatigue
|
Fatigue
|
3.1% - 7.2%
|
1.7% - 6.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
common
|
|
|
|
|
|
|
|
|
|
|
x
|
Nausea
|
Nausea
|
common, 3.6% - 8.1%
|
2.7% - 7.3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Soft stools
|
common
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Faecal incontinence
|
Faecal incontinence
|
1.8% - 7.7%
|
0.2% - 0.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
Myalgia
|
uncommon, 4.2%
|
3.3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal discomfort
|
Myalgia
|
uncommon, 4.2%
|
3.3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Sleep disorder
|
Sleep disorder
|
3.9%
|
3.3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting
|
Vomiting
|
uncommon, 3.8%
|
3.5%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ear infection
|
Otitis
|
2.9% - 4.3%
|
2.5% - 3.4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth disorder
|
Tooth disorder
|
2.9% - 4.3%
|
2.3% - 3.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depression
|
Depression
|
3.4%
|
2.5%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Proctalgia
|
Proctalgia
|
uncommon, 3.3% - 5.2%
|
1.9% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vaginal inflammation
|
Vaginal inflammation
|
2.6% - 3.8%
|
1.9% - 3.6%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal infection
|
Vaginal inflammation
|
2.6% - 3.8%
|
1.9% - 3.6%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingival disorder
|
Gingival disorder
|
2% - 4.1%
|
1.5% - 2.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anxiety
|
Anxiety
|
uncommon, 2.8% - 4.7%
|
2.1% - 2.9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema peripheral
|
Foot edema
|
2.8%
|
1.9%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Local swelling
|
Foot edema
|
2.8%
|
1.9%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy
|
Arthropathy
|
2.3%
|
2.2%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoarthritis
|
Arthropathy
|
2.3%
|
2.2%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry skin
|
Dry skin
|
2.1%
|
1.4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tendonitis
|
Tendonitis
|
2%
|
1.9%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chest pain
|
Chest pain
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Cholecystitis
|
Cholecystitis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Cholelithiasis
|
Cholelithiasis
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Diverticulitis
|
Diverticulitis
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Eczema
|
Eczema
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Oedema
|
Oedema
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Enteritis
|
Enteritis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Eructation
|
Eructation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastritis
|
Gastritis
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Haemorrhoids
|
Haemorrhoids
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Muscle spasms
|
Cramps of lower extremities
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Cramp muscle
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Nail disorder
|
Nail disorder
|
uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Paraesthesia
|
Paraesthesia
|
uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Anal pruritus
|
Anal pruritus
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Pruritus genital
|
Anal pruritus
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Anorectal discomfort
|
Anal pruritus
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Burning anal
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Anal irritation
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Thirst
|
Thirst
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Vertigo
|
Vertigo
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Xeroderma
|
Xeroderma
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Dry mouth
|
Dry mouth
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Biliary colic
|
Biliary colic
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Increased appetite
|
Increased appetite
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Abdominal discomfort
|
Abdominal discomfort
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Upset stomach
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Gastrointestinal sounds abnormal
|
Borborygmi
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Faeces discoloured
|
Faeces discoloured
|
uncommon
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Abdominal distension
|
Fullness abdominal
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Abdominal distension
|
postmarketing, uncommon
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Hair texture abnormal
|
Hair texture abnormal
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Dyschezia
|
Dyschezia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Rectal haemorrhage
|
Rectal haemorrhage
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Hyperhidrosis
|
Sweating increased
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Insomnia
|
Insomnia
|
uncommon
|
|
|
|
|
|
|
|
|
|
|
x
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angioedema
|
Angioedema
|
postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Bronchospasm
|
Bronchospasm
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
|
x
|
Epilepsy
|
Epilepsy
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
Dermatitis
|
Rash
|
postmarketing — 4.3%
|
4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
postmarketing — 4.3%
|
4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood disorder
|
Blood disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
Hepatitis
|
Hepatitis
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypoglycaemia
|
Hypoglycaemia
|
postmarketing, uncommon
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Hypothyroidism
|
Hypothyroidism
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
|
Nephropathy
|
Nephropathy
|
postmarketing
|
|
x
|
x
|
|
|
|
|
|
x
|
|
|
Lower gastrointestinal haemorrhage
|
Lower gastrointestinal haemorrhage
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
|
Obesity
|
Obesity
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
Pancreatitis
|
Pancreatitis
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
x
|
|
|
Neuropathy peripheral
|
Neuropathy peripheral
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
x
|
Pruritus
|
Pruritus
|
postmarketing, uncommon
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Convulsion
|
Convulsion
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Urticaria
|
Urticaria
|
postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatic failure
|
Hepatic failure
|
postmarketing
|
|
|
|
|
|
|
|
|
x
|
|
|
Dermatitis bullous
|
Bullous eruption
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Diabetes mellitus
|
Diabetic
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Drug interaction
|
Drug interaction
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
International normalised ratio increased
|
International normalised ratio increased
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Alopecia
|
Alopecia
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Amenorrhoea
|
Amenorrhoea
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Asthma
|
Asthma
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Autoimmune disorder
|
Autoimmune disorder
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Mental disorder
|
Mental disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Breast disorder
|
Breast disorder
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Cardiovascular disorder
|
Cardiovascular disorder
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Infection
|
Infection
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Cough
|
Cough
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Diverticulum
|
Diverticulum
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Dysmenorrhoea
|
Dysmenorrhoea
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Body temperature increased
|
Body temperature increased
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Multiple fractures
|
Fracture
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Fracture
|
Fracture
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
Gastrointestinal symptom NOS
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Reaction gastrointestinal
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Haemorrhage
|
Haemorrhage
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Haemoglobin
|
Haemorrhage
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hypokalaemia
|
Hypokalaemia
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Immune system disorder
|
Immune system disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Arthropod bite
|
Insect bite NOS
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Menopausal disorder
|
Menopausal disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Menopausal symptoms
|
Menopausal disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Neoplasm
|
Neoplasm
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Nervous system disorder
|
Nervous system disorder
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Palpitations
|
Palpitations
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Pharyngitis
|
Pharyngitis
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Polyuria
|
Polyuria
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urine output increased
|
Polyuria
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Renal failure
|
Renal failure
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Sinusitis
|
Sinusitis
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Malnutrition
|
Malnutrition
|
|
|
|
x
|
|
|
|
|
|
|
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Malaise
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Feeling abnormal
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Ill-defined disorder
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Decreased appetite
|
Decreased appetite
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Appetite absent
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Abdominal pain lower
|
Abdominal pain lower
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Dysgeusia
|
Taste bitter
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Abdominal pain upper
|
Epigastric pain not food-related
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Vein disorder
|
Vein disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Faeces hard
|
Faeces hard
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Vision blurred
|
Vision blurred
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Hypovitaminosis
|
Avitaminosis
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Onychoclasis
|
Onychoclasis
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Acne
|
Acne
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Infestation
|
Infestation NOS
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Autonomic neuropathy
|
Unspecified disorder of autonomic nervous system
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Rash papular
|
Rash papular
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 28 |
Source: | EMA |
---|
Side effects: | 46 |
Source: | EMA |
---|
Side effects: | 34 |
Source: | FDA |
---|
Side effects: | 39 |
Source: | FDA |
---|
Side effects: | 40 |
Source: | FDA |
---|
Side effects: | 48 |
Source: | FDA |
---|
Side effects: | 49 |
Source: | FDA |
---|
Side effects: | 53 |
Source: | FDA Structured Product Label |
---|
Side effects: | 60 |
Source: | Health Canada |
---|
Side effects: | 101 |
Source: | medicines.org.au |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|