| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Respiratory tract infection | Respiratory tract infection | 16.1% - 24.7% | 26.4% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Skin exfoliation | Localized exfoliation | very common |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Headache | Headache | postmarketing — 5% - 50% | 2.7% - 23.6% | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Endometrial disorder | Endometrial disorder | 1.8% - 15.1% | 1.4% - 8.21% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Vulvovaginal mycotic infection | Vulvovaginal mycotic infection | 8.29% | 2.91% |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginal moniliasis | postmarketing, 6.19% - 10.7% | 2.78% |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | x |  | x | x | 
| Vaginal mycosis | 0.82% - 6.4% | 3.2% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vulvovaginal pruritus | Vulvovaginal pruritus | 7.8% | 1.94% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginal itching |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Application site reaction | Application site reaction | postmarketing — 0.6% - 56.7% | 0% - 58.6% |  |  |  |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  | x | x | 
| Injury | Accidental injury | 4.49% - 13.9% | 4.6% - 11% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Breast tenderness | Breast tenderness | postmarketing — 2.46% - 17% | 0% - 5.26% | x |  |  |  |  | x | x | x |  |  |  |  | x | x | x |  |  | x |  |  | 
| Back pain | Back pain | postmarketing, 0% - 10.6% | 1.3% - 6.38% |  | x | x |  |  | x |  | x |  |  | x |  |  | x | x | x | x | x | x | x | 
| Cervical polyp | Cervical polyp | 6.25% | 1.91% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nasopharyngitis | Nasopharyngitis | 1.32% - 19.6% | 1.3% - 15.3% |  |  |  |  |  | x | x | x |  |  |  |  | x |  |  |  |  | x |  |  | 
| Common cold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Genital candidiasis | Genital candidiasis | uncommon, 5.49% - 7% | 2.13% |  |  | x |  |  |  |  |  |  |  |  |  |  | x |  | x |  |  |  |  | 
| Breast pain | Breast pain female | 3% - 9% | 0% | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast pain | postmarketing — 1% - 34.8% | 2.99% - 9.6% |  | x |  |  |  |  |  |  | x |  | x |  |  | x | x | x | x |  | x | x | 
| Upper respiratory tract infection | Upper respiratory tract infection | 1.6% - 17% | 1.6% - 16.7% |  | x | x |  |  |  | x | x |  |  |  |  | x |  |  | x | x | x |  |  | 
| Influenza | Influenza | 0% - 13.3% | 0% - 10.3% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  | x | x | x | x | 
| Metrorrhagia | Metrorrhagia | postmarketing — 0% - 10.6% | 0% - 4.46% | x |  |  | x | x |  | x | x |  | x |  | x | x | x | x | x | x | x | x | x | 
| Bleeding breakthrough | postmarketing |  | x |  |  | x | x |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Sinusitis | Sinusitis | 1.77% - 13.1% | 1.4% - 18.4% |  | x |  |  |  |  |  | x |  |  | x |  |  |  | x | x | x | x | x | x | 
| Menstrual disorder | Menstrual disorder | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Pain | Pain | postmarketing, 0% - 12.5% | 4.46% - 12.6% |  | x |  | x |  |  |  | x | x | x | x | x | x |  |  | x | x | x | x | x | 
| Ache |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Vulvovaginal discomfort | Vaginal discomfort | 5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Vaginal irritation | postmarketing, 0.885% - 1.79% | 3.7% |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vulvovaginal discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vulva discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Weight fluctuation | Weight fluctuation | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Cervical discharge | Cervical discharge | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Sinus headache | Sinus headache | 0% - 10.9% | 5.1% |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Influenza like illness | Influenza like illness | 0% - 7.77% | 6.37% |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Influenza-like symptoms | 2% - 3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Perineal pain | Perineal pain | 1% - 8% | 0% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bronchitis | Bronchitis | 3.45% - 7.87% | 4.31% - 6.9% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | x | 
| Vaginal discharge | Leukorrhea | 1% - 10.6% | 1% - 1.15% |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | x | 
| Vaginal discharge | postmarketing, 1.47% - 3.52% | 0.73% - 8.33% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Dyspepsia | Dyspepsia | 0% - 9.23% | 1.15% - 6.37% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  | x | x | x | x | x | 
| Pain in extremity | Pain in extremity | postmarketing, 0% - 7.69% | 2.78% - 5.73% |  |  |  |  |  |  | x | x | x |  |  |  |  | x |  |  |  | x |  |  | 
| Leg pain |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Abdominal pain | Abdominal pain | postmarketing — 0% - 16% | 1.4% - 8.13% | x | x | x |  |  |  |  |  |  |  | x |  |  | x | x | x | x |  | x | x | 
| Abdominal cramps | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Gastrointestinal pain | Abdominal pain | postmarketing — 0% - 16% | 1.4% - 8.13% | x | x | x |  |  |  |  |  |  |  | x |  |  | x | x | x | x |  | x | x | 
| Rhinitis | Rhinitis | 2% - 6% | 1% - 6.8% |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Common cold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Vaginal haemorrhage | Vaginal haemorrhage | postmarketing — 1.2% - 16.7% | 0% - 4.6% |  |  |  | x | x |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Fungal infection | Fungal infection | 0% - 10% | 1.15% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Constipation | Constipation | postmarketing, 1.12% - 6.67% | 2.55% - 4.6% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  | x | x | x | x | 
| Arthralgia | Arthralgia | postmarketing, 0% - 12.4% | 0% - 13.8% |  | x |  |  |  | x | x | x | x |  | x | x | x |  |  | x | x | x | x | x | 
| Musculoskeletal discomfort | Arthralgia | postmarketing, 0% - 12.4% | 0% - 13.8% |  | x |  |  |  | x | x | x | x |  | x | x | x |  |  | x | x | x | x | x | 
| Myalgia | postmarketing, 1.72% - 5.62% | 2.87% - 4.6% |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  |  |  | x | x | 
| Neck pain | Neck pain | 0% - 6.38% | 1.27% |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Gastroenteritis | Gastroenteritis | 0% - 4.44% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Infection | Infection | 1.15% - 17.3% | 2.3% - 7.46% |  |  |  |  |  | x | x | x |  |  | x |  |  |  |  |  | x | x | x | x | 
| Flatulence | Flatulence | postmarketing, 1% - 7% | 1% - 5.75% |  | x |  |  |  |  | x |  | x |  | x |  |  |  |  | x | x |  | x | x | 
| Abdominal bloating | postmarketing, common |  |  |  |  |  | x |  |  |  |  | x |  | x | x |  |  |  | x | x | x | x | 
| Vulvovaginal candidiasis | Vaginal moniliasis | postmarketing, 6.19% - 10.7% | 2.78% |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | x |  | x | x | 
| Uterine pain | Uterine pain | 1.77% - 4.46% | 0.926% |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Vulvovaginitis | Vulvovaginitis | 0.893% - 5.31% | 6.48% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sinus congestion | Sinus congestion | 0% - 6.52% | 4.46% |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Depression | Depression | postmarketing — 0% - 10.6% | 0% - 9.2% |  | x |  |  | x | x |  | x |  | x | x | x | x | x |  |  | x | x | x | x | 
| Candida infection | Candida infection | 1% - 5% | 2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arthritis | Arthritis | postmarketing, 2% - 5.29% | 7.18% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Arthritis aggravated |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bone pain | Bone pain | 2% - 4% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urinary tract infection | Urinary tract infection | 0.885% - 7% | 1.85% - 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x |  |  | x | x | 
| Pneumonia | Pneumonia | 0.575% - 4.49% | 4.6% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Reproductive tract disorder | Reproductive tract disorder | 2.65% - 2.68% | 8.33% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pharyngitis | Pharyngitis | 0.5% - 7% | 1.15% - 3% |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | x | 
| Nausea | Nausea | postmarketing — 0% - 6.74% | 1.32% - 6.49% | x | x |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hyperaesthesia | Nipple pain | postmarketing, 0.735% - 6.76% | 0% |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Hyperaesthesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nipple pain | Nipple pain | postmarketing, 0.735% - 6.76% | 0% |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Oedema peripheral | Oedema peripheral | 0% - 4.44% | 0% - 4.6% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Leg edema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Breast neoplasm | Breast neoplasm | 1.12% - 5.56% | 6.9% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Abnormal withdrawal bleeding | Abnormal withdrawal bleeding | postmarketing, common |  |  |  |  | x | x |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | 
| Family stress | Family stress | 2% - 3% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Asthenia | Asthenia | postmarketing, 0% - 7.87% | 4.1% - 4.6% |  |  |  |  |  |  | x |  |  |  | x |  |  |  |  |  | x |  | x | x | 
| Fatigue | postmarketing |  |  |  |  |  |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  | 
| Cough | Cough increased | 1.12% - 4.44% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Cough | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Conjunctivitis | Conjunctivitis | 0% - 3.33% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Asthma | Asthma | 1.12% - 3.37% | 1.15% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Exacerbation of asthma | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Pruritus genital | Pruritus genital | postmarketing, 4% - 6% | 0% |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Anal pruritus | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Vaginal inflammation | Vaginal inflammation | postmarketing, 0% - 8.9% | 4.1% - 6.9% |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | x | 
| Vaginal infection | Vaginal inflammation | postmarketing, 0% - 8.9% | 4.1% - 6.9% |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | x | 
| Vaginal ulceration | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Insomnia | Insomnia | postmarketing, 0% - 6.38% | 5.73% - 8.05% |  |  | x |  |  |  | x | x | x |  | x |  |  |  |  | x |  | x | x | x | 
| Myalgia | Myalgia | postmarketing, 1.72% - 5.62% | 2.87% - 4.6% |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  |  |  | x | x | 
| Cyst | Cyst | 0% - 6.67% | 3.45% |  |  |  |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  | x | x | 
| Pruritus | Pruritus | postmarketing — 0.5% - 7.8% | 0% - 6% |  | x | x |  |  |  |  |  | x |  |  |  |  | x | x |  | x | x |  | x | 
| Otitis media | Otitis media | 0% - 3.37% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | x | 
| Vasodilation procedure | Vasodilation | 0% - 6.74% | 14.9% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Anxiety | Anxiety NEC | 0% - 6.38% | 2.55% |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Anxiety | postmarketing, 0% - 10% | 0% - 3.45% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x | x |  | x | x | 
| Weight increased | Weight increased | postmarketing, 0% - 8.51% | 0% - 4.6% |  |  | x |  |  |  | x | x | x |  | x |  |  |  | x |  | x | x | x | x | 
| Chest pain | Chest pain | postmarketing, 1.12% - 4.49% | 4.6% |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x |  |  | x | x | 
| Chest discomfort | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypersensitivity | Hypersensitivity | postmarketing, 0.575% - 4.49% | 2.3% |  |  | x |  |  |  |  |  | x |  |  |  |  |  | x | x |  | x |  | x | 
| Libido increased | Libido increased | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  | 
| Disturbance in sexual arousal | Libido increased | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  | 
| Libido decreased | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Muscle spasms | Cramp muscle | uncommon |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  | 
| Cramps of lower extremities | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Muscle spasms | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast enlargement | Breast enlargement | postmarketing — 1.12% - 6.74% | 3.45% |  |  |  |  |  |  |  |  |  |  | x |  |  | x | x | x |  |  | x | x | 
| Oedema | Oedema | postmarketing — 0.5% - 13% | 6% | x | x |  |  | x | x |  |  |  | x |  | x | x | x | x |  | x | x | x | x | 
| Abdominal distension | Abdominal distension | postmarketing — 2.68% - 7.08% | 2.78% |  |  |  |  |  |  |  |  | x |  |  |  |  | x | x |  |  |  |  |  | 
| Enlargement abdomen | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Abdominal bloating | postmarketing, common |  |  |  |  |  | x |  |  |  |  | x |  | x | x |  |  |  | x | x | x | x | 
| Alopecia | Alopecia | postmarketing, uncommon |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  |  |  | 
| Amenorrhoea | Amenorrhoea | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anaphylactic shock | Anaphylactic shock | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  | x |  | x | x | x | x | 
| Anaphylactoid reaction | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Angioedema | Angioedema | postmarketing |  |  |  |  |  |  | x |  |  | x |  |  | x | x |  | x |  |  | x | x | x | 
| Aphasia | Aphasia | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Speech loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast cancer | Breast cancer | postmarketing |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  | x |  |  | x |  |  | 
| Breast cancer invasive NOS |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast disorder | Breast disorder | postmarketing |  |  |  |  |  |  | x | x | x |  |  |  |  | x | x | x | x |  | x |  |  | 
| Breast swelling | Breast swelling | postmarketing |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Transient ischaemic attack | Transient ischaemic attack | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Cholecystitis | Cholecystitis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Cholelithiasis | Cholelithiasis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | x |  |  | 
| Chorea | Chorea | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  | x | x | x |  |  | x | x | x | x | 
| Contusion | Contusion | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Libido decreased | Libido decreased | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Diarrhoea | Diarrhoea | postmarketing, 1.12% - 5.37% | 0% - 2.3% |  |  | x |  |  |  |  |  | x |  | x |  |  | x | x | x | x | x | x | x | 
| Dizziness | Dizziness | postmarketing — 0.575% - 7.78% | 0% - 2.87% |  |  |  |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  | 
| Dysgeusia | Dysgeusia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dyspnoea | Dyspnoea | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Eczema | Eczema | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Endometrial hyperplasia | Endometrial hyperplasia | postmarketing, 0% - 0.704% | 0% |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Epilepsy | Epilepsy | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Erythema multiforme | Erythema multiforme | postmarketing |  |  |  |  | x | x |  |  |  |  | x |  | x | x | x | x |  | x | x |  |  | 
| Erythema nodosum | Erythema nodosum | postmarketing |  |  |  |  |  | x |  |  |  |  | x |  | x | x | x | x |  | x | x | x | x | 
| Dermatitis | Rash | postmarketing — 2.87% - 8.89% | 5.5% - 5.75% |  |  |  | x |  |  |  |  | x |  | x | x | x | x | x |  | x | x | x | x | 
| Dermatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Rash | Rash | postmarketing — 2.87% - 8.89% | 5.5% - 5.75% |  |  |  | x |  |  |  |  | x |  | x | x | x | x | x |  | x | x | x | x | 
| Facial rash | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Eruption |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Fatigue | Fatigue | postmarketing |  |  |  |  |  |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  | 
| Body temperature increased | Body temperature increased | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Fibrocystic breast disease | Fibrocystic breast disease | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  | x |  | x | x | x | x | 
| Flushing | Flushing | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Gallbladder disorder | Gallbladder disorder | postmarketing |  |  | x |  |  | x |  |  |  |  | x | x | x | x | x |  |  | x |  | x | x | 
| Gynaecomastia | Gynaecomastia | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haemangioma | Haemangioma | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  |  |  | x |  |  | x | 
| Hemiparesis | Hemiparesis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Haemorrhage | Haemorrhage | postmarketing |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Haemoglobin | Haemorrhage | postmarketing |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Hirsutism | Hirsutism | postmarketing — 0.575% - 4.49% | 0% |  |  |  |  | x |  |  |  |  | x | x | x | x | x | x |  | x | x | x | x | 
| Hyperhidrosis | Hyperhidrosis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sweating increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypoaesthesia | Hypoaesthesia | postmarketing, 0% - 3.37% | 2.3% |  |  |  |  |  |  |  |  | x |  | x |  |  |  |  |  |  |  | x | x | 
| Numbness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypocalcaemia | Hypocalcaemia | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Inflammation | Inflammation | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Intestinal obstruction | Intestinal obstruction | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Irritability | Irritability | postmarketing |  |  |  |  |  |  | x |  |  |  | x |  | x | x |  | x |  | x | x | x | x | 
| Jaundice cholestatic | Jaundice cholestatic | postmarketing |  |  |  |  |  | x |  |  |  |  | x |  | x | x | x |  |  | x |  | x | x | 
| Arthropathy | Arthropathy | postmarketing, 0% - 4.49% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Osteoarthritis | Arthropathy | postmarketing, 0% - 4.49% | 2.3% |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Osteoarthritis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lethargy | Lethargy | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast mass | Breast mass | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Chloasma | Chloasma | postmarketing |  |  |  |  | x | x |  |  |  |  | x |  | x | x | x |  |  | x |  | x | x | 
| Meningioma | Meningioma | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Menorrhagia | Menorrhagia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Myocardial infarction | Myocardial infarction | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x |  |  | x |  | x | x | 
| Acute coronary syndrome | Myocardial infarction | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x |  |  | x |  | x | x | 
| Myoclonus | Myoclonus | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Nervousness | Nervousness | postmarketing, 2.4% | 1.4% |  |  |  |  |  | x |  |  |  | x |  | x | x | x | x | x | x | x | x | x | 
| Tension | Nervousness | postmarketing, 2.4% | 1.4% |  |  |  |  |  | x |  |  |  | x |  | x | x | x | x | x | x | x | x | x | 
| Night sweats | Night sweats | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Ovarian cyst | Ovarian cyst | postmarketing |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Palpitations | Palpitations | postmarketing, 0.6% | 1.4% |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  | x |  |  |  | 
| Pancreatitis | Pancreatitis | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x |  | x |  | x | x | 
| Paraesthesia | Paraesthesia | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  | 
| Pelvic pain | Pelvic pain | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Phlebitis | Phlebitis | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Porphyrin metabolism disorder | Porphyrin metabolism disorder | postmarketing |  |  |  |  |  | x | x |  |  |  |  |  | x | x | x |  |  | x |  | x | x | 
| Prurigo | Prurigo | postmarketing |  |  |  | x |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anal pruritus | Anal pruritus | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Anorectal discomfort | Anal pruritus | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Pulmonary embolism | Pulmonary embolism | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | 
| Purpura | Purpura | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  |  | 
| Dermatitis hemorrhagic | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Vascular purpura | Purpura | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  |  | 
| Retinal vein occlusion | Retinal vein occlusion | postmarketing |  |  |  |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Pigmentation disorder | Pigmentation skin | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Cerebrovascular accident | Cerebrovascular accident | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x | x |  | x |  | x | x | 
| Sunburn | Sunburn | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Photosensitivity reaction | Sunburn | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Swelling | Swelling | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Shock | Syncope | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  | 
| Shock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Syncope | Syncope | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  | 
| Loss of consciousness | Syncope | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  | 
| Tachycardia | Tachycardia | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thrombophlebitis | Thrombophlebitis | postmarketing |  |  |  |  | x |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Thrombosis | Thrombosis | postmarketing |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  |  | 
| Tremor | Tremor | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ulcer | Ulcer | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Erythema | Erythema | postmarketing |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x | x | x | 
| Redness |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Urethral disorder | Urethral disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urinary tract disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pollakiuria | Pollakiuria | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urticaria | Urticaria | postmarketing |  |  |  | x |  |  | x | x |  |  |  |  | x | x |  | x |  |  | x | x | x | 
| Uterine leiomyoma | Uterine leiomyoma | postmarketing, uncommon |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | 
| Uterine haemorrhage | Uterine haemorrhage | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vomiting | Vomiting | postmarketing, uncommon |  |  |  |  |  | x |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | 
| Vulval disorder | Vulval disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Weight decreased | Weight decreased | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Dry mouth | Dry mouth | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mood swings | Mood swings | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mood alteration NOS | postmarketing |  |  |  |  | x |  | x |  |  |  |  |  | x | x |  | x |  | x |  | x | x | 
| Affect lability | Mood swings | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast engorgement | Breast engorgement | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Breast discharge | Breast discharge | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  | x |  | x | x | x | x | 
| Deep vein thrombosis | Deep vein thrombosis | postmarketing |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  | 
| Migraine | Migraine | postmarketing — 0% - 6.74% | 2.3% |  |  |  | x | x | x |  |  |  | x | x | x | x | x |  | x | x | x | x | x | 
| Migraine aggravated | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oedema genital | Oedema genital | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Ventricular extrasystoles | Ventricular extrasystoles | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Myocardial ischaemia | Myocardial ischaemia | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Liver function test abnormal | Liver function test abnormal | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x |  |  | 
| Raised liver function tests |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin discolouration | Skin discolouration | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Dry skin | Dry skin | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Uterine enlargement | Uterine enlargement | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Uterine cancer | Uterine cancer | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Endophthalmitis | Ocular hyperaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ocular hyperaemia | Ocular hyperaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Menstruation irregular | Menstruation irregular | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Malnutrition | Malnutrition | postmarketing, 12% | 10.5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Contact lens intolerance | Contact lens intolerance | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  | 
| Malaise | Malaise | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Discomfort | Malaise | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Discomfort | postmarketing |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Feeling abnormal | Malaise | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Feeling abnormal | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Confusional state |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ill-defined disorder | Malaise | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Decreased appetite | Decreased appetite | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tenderness | Tenderness | postmarketing |  |  |  |  | x | x |  |  |  | x | x |  | x |  |  |  | x | x |  | x | x | 
| Dry throat | Dry throat | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye irritation | Eye irritation | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abdominal discomfort | Upset stomach | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Abdominal discomfort |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Thrombophlebitis superficial | Superficial phlebothrombosis | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Superficial thrombophlebitis of leg |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Galactorrhoea | Galactorrhoea | postmarketing |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Chest discomfort | Chest discomfort | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Menopausal symptoms | Menopausal symptoms | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hot flush | postmarketing, 0% - 6.38% | 3.82% |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x |  | x |  |  | 
| Vulvovaginal pain | Vaginal pain | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Heart rate irregular | Heart rate irregular | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Pulse irregular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatitis acute | Hepatitis acute | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Fluid retention | Fluid retention | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ectropion of cervix | Ectropion of cervix | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Glucose tolerance impaired | Glucose tolerance impaired | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Papule | Papule | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Malignant mesenchymoma | Malignant mesenchymoma | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Anaphylactoid reaction | Anaphylactoid reaction | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Blindness | Blindness | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Endometrial cancer | Endometrial cancer | postmarketing |  | x |  | x | x |  |  |  | x | x |  |  | x | x | x |  |  | x |  | x | x | 
| Blood pressure increased | Blood pressure increased | postmarketing |  |  | x |  | x | x |  |  |  |  | x | x | x | x |  | x |  | x |  | x | x | 
| Dementia | Dementia | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x |  |  |  |  |  | x | 
| Application site rash | Application site rash | postmarketing |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Drug effect decreased | Drug effect decreased | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Pre-existing disease | Pre-existing disease | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Face oedema | Face oedema | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Visual impairment | Visual disturbance | postmarketing |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Abnormal vision | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Disorder sight |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bradyphrenia | Bradyphrenia | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginal ulceration | Vaginal ulceration | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginitis ulcerative |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gait disturbance | Gait disturbance | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Hot flush | Hot flush | postmarketing, 0% - 6.38% | 3.82% |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x |  | x |  |  | 
| Toxic shock syndrome | Toxic shock syndrome | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Generalised erythema | Generalised erythema | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Drug ineffective | Drug ineffective | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Retinal vascular thrombosis | Retinal vascular thrombosis | postmarketing |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  |  | x |  | x | x | 
| Medical device complication | Medical device complication | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | 
| Ovarian cancer | Ovarian cancer | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Blood pressure fluctuation | Change in blood pressure | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginismus | Vaginismus | postmarketing |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Congenital anomaly | Congenital anomaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Developmental delay | Congenital anomaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Amnesia | Amnesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bacterial infection | Bacterial infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mental disorder | Mental disorder |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  | x |  |  | 
| Blepharitis | Blepharitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Coagulopathy | Clotting |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bone disorder | Bone disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bronchospasm | Bronchospasm |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Neoplasm malignant | Neoplasm malignant |  |  |  |  |  | x |  |  | x |  | x | x | x |  |  |  | x | x |  | x |  |  | 
| Basal cell carcinoma | Basal cell carcinoma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiovascular disorder | Cardiovascular disorder |  |  |  | x | x |  | x |  | x | x | x |  |  |  |  |  | x |  |  | x |  |  | 
| Carpal tunnel syndrome | Carpal tunnel syndrome |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cerebrovascular disorder | Cerebrovascular disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Uterine cervical erosion | Uterine cervical erosion |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Confusional state | Confusional state |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Connective tissue disorder | Connective tissue disorder |  |  |  |  |  |  |  | x |  | x |  |  |  |  |  | x |  |  |  | x |  |  | 
| Coronary artery thrombosis | Coronary artery thrombosis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Cystitis | Cystitis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Bladder infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bladder pain | Cystitis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Cystitis noninfective | Cystitis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Dysphagia | Dysphagia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dermatitis contact | Dermatitis contact |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Allergic contact dermatitis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Diverticulitis | Diverticulitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysmenorrhoea | Dysmenorrhoea | postmarketing, 0% - 6.52% | 0% | x |  |  |  |  |  | x | x |  | x |  | x | x |  | x | x | x | x |  | x | 
| Ear disorder | Ear disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ear pain | Ear pain | 0% - 2.91% | 0% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Embolism | Embolism |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Thromboembolism |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Emotional disorder | Emotional disturbance NOS |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Endocrine disorder | Endocrine disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Endometriosis | Endometriosis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  | 
| Epistaxis | Epistaxis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye disorder | Eye disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye infection | Eye infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Foetal disorder | Foetal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gastritis | Gastritis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Gastrooesophageal reflux disease | Gastrooesophageal reflux disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  |  |  |  |  |  | x |  | x |  |  |  |  |  | x |  |  |  | x |  |  | 
| Gastrointestinal symptom NOS |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Goitre | Goitre |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac disorder | Cardiac disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Haematoma | Haematoma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haematuria | Haematuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haemoptysis | Haemoptysis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haemorrhoids | Haemorrhoids |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Hepatitis | Hepatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hereditary angioedema | Hereditary angioedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Herpes simplex | Herpes simplex |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Herpes zoster | Herpes zoster |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypercalcaemia | Hypercalcaemia |  |  |  | x |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Hyperglycaemia | Hyperglycaemia |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypernatraemia | Hypernatraemia |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypertension | Hypertension | 0% - 6.74% | 1.27% - 3.45% |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  | x | x | x | 
| Immune system disorder | Immune system disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Incontinence | Incontinence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Jaundice | Jaundice |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Laryngitis | Laryngitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatic neoplasm | Hepatic neoplasm |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mediastinal disorder | Mediastinal disorder |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  | x |  |  | 
| Hypertonia | Hypertonia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Musculoskeletal pain | Musculoskeletal pain |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Nail disorder | Nail disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nasal congestion | Nasal congestion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Neoplasm | Neoplasm |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  | x |  | x |  |  |  |  | 
| Nervous system disorder | Nervous system disorder |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  | x |  |  | 
| Neuritis | Neuritis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Neuropathy peripheral | Neuritis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Sensory loss | Numbness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Optic neuritis | Optic neuritis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Polyp | Polyp |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Polyuria | Polyuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urine output increased | Polyuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tension headache | Tension headache |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin disorder | Skin disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Unspecified disorder of skin and subcutaneous tissue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Skin ulcer | Skin ulcer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Embolism venous | Thromboembolism |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Embolism venous |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Tinnitus | Tinnitus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tooth disorder | Tooth disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Toothache | Toothache |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urinary incontinence | Urinary incontinence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urinary tract disorder | Urinary tract disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginal disorder | Vaginal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Varicose vein | Varicose vein |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Angiopathy | Angiopathy |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Vertigo | Vertigo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Viral infection | Viral infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Muscle strain | Muscle strain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Agitation | Agitation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatic function abnormal | Hepatic function abnormal |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Musculoskeletal stiffness | Neck stiffness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nuchal rigidity | Neck stiffness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Glucose tolerance decreased | Glucose tolerance decreased |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Skin hypertrophy | Skin hypertrophy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Withdrawal bleed | Withdrawal bleed |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Benign vaginal neoplasm | Benign vaginal neoplasm |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eyelid oedema | Eyelid oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Porphyria non-acute | Porphyria cutanea tarda |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Increased appetite | Increased appetite |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abdominal pain upper | Abdominal pain upper |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abdominal pain lower | Abdominal pain lower |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysarthria | Slurred speech |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rash erythematous | Rash erythematous |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Muscle contractions involuntary | Muscle contractions involuntary |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vascular pain | Vein pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast oedema | Breast oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pain of skin | Skin tenderness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast malformation | Breast malformation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatobiliary disease | Hepatobiliary disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dry eye | Dry eye |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Increased tendency to bruise | Increased tendency to bruise |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Chills | Rigors |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dyskinesia | Jerky movement NOS |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ligament sprain | Joint sprain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pruritus generalised | Pruritus generalised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Lymphadenopathy | Lymphadenopathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rash generalised | Rash generalised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Tooth abscess | Tooth abscess |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Application site irritation | Application site irritation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Carbohydrate tolerance decreased | Carbohydrate tolerance decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Toxicity to various agents | Toxic reaction (NOS) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Pelvic venous thrombosis | Pelvic venous thrombosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Mass | Mass |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Drug interaction | Drug interaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ear infection | Ear infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Acne | Acne |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Infestation | Infestation NOS |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Blood oestrogen increased | Blood oestrogen increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arthropod bite | Arthropod bite |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Application site erythema | Application site erythema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Laryngeal pain | Pharyngolaryngeal pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Local swelling | Peripheral swelling |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast discomfort | Breast discomfort |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | 
| Pleural infection | Pleural infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Deafness | Hearing impaired |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hearing impaired | Hearing impaired |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Somnolence | Somnolence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Loss of libido | Loss of libido |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |