Estradiol

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 46)
1 2 3 4 5 6 7 8 9 10
Breast pain def Breast pain def postmarketing, 1% - 29% 4% x x x
Breast pain female
Pain def Pain def postmarketing, 0% - 29% 0% - 8% x x x x
Ache def
Headache def Headache def postmarketing, 0% - 18% 5.19% - 10% x x x x x
Infection def Infection def 2% - 17% 2.91% - 4.26% x x x x
Respiratory tract infection def Respiratory tract infection def 5% - 17% 4.26% x
Upper respiratory tract infection def Upper respiratory tract infection def 5% - 17% 4.26% - 8% x x
Abdominal pain def Abdominal pain def postmarketing, 0% - 16% 4.26% - 8% x x
Abdominal cramps def postmarketing x
Gastrointestinal pain def Abdominal pain def postmarketing, 0% - 16% 4.26% - 8% x x
Oedema def Oedema def postmarketing, 0.5% - 13% 6% x x x x x
Arthralgia def Arthralgia def postmarketing, 0% - 12% 0% - 5.26% x x x x x
Musculoskeletal discomfort Arthralgia def postmarketing, 0% - 12% 0% - 5.26% x x x x x
Myalgia def 3% - 5%
Genital discharge Leukorrhea def 1% - 11% 1% x x
Back pain def Back pain def postmarketing, 2.63% - 9% 1.3% - 6.38% x x x x x
Application site reaction Application site reaction 9% x
Fungal infection def Fungal infection def 8.29% 2.91%
Arthritis def Arthritis def 4% - 7%
Arthritis aggravated
Flatulence def Flatulence def 1% - 7% 1% x x
Abdominal bloating def postmarketing x x
Pharyngitis def Pharyngitis def 0.5% - 7% 3% x x
Tenderness def Tenderness def postmarketing, 5.26% - 6.76% 0% - 5.26% x x x x x
Hyperaesthesia def Nipple pain postmarketing, 1.32% - 6.76% 0% x
Hyperaesthesia def
Nipple pain Nipple pain postmarketing, 1.32% - 6.76% 0% x
Breast tenderness Breast tenderness 5.26% - 6.76% 0% - 5.26% x x
Bronchitis def Bronchitis def 4% - 6%
Candidiasis def Candidiasis def postmarketing, 5.49% - 6% 2.13% x x
Nausea def Nausea def postmarketing, 0% - 6% 1.32% - 6.49% x x x x
Rhinitis def Rhinitis def 2% - 6% 1% x x
Common cold def
Genital candidiasis Genital candidiasis 5.49% - 6% 2.13%
Diarrhoea def Diarrhoea def postmarketing, 5.37% 0% x
Nasopharyngitis def Nasopharyngitis def 1.32% - 5.26% 1.3% - 2.63% x x x
Common cold def
Constipation def Constipation def 3% - 5% x
Dizziness def Dizziness def postmarketing, 3% - 5% x x
Syncope def
Dyspepsia def Dyspepsia def 0% - 5% x x
Sinusitis def Sinusitis def 4% - 5% 3% x x x x x
Myalgia def Myalgia def 3% - 5%
Discomfort def Discomfort def 5% x
Malaise def
Vulvovaginal discomfort Vaginal discomfort 5%
Vaginal irritation postmarketing x
Vulva discomfort
Insomnia def Insomnia def postmarketing, 4% x x
Vaginal haemorrhage def Vaginal haemorrhage def postmarketing, 4% x
Spotting vaginal
Influenza def Influenza def 0% - 3% x x
Urinary tract infection def Urinary tract infection def 2% x
Bone pain def Bone pain def 2%
Family stress Family stress 2%
Hypersensitivity def Hypersensitivity def postmarketing, 1% x
Anaphylactic shock def Anaphylactic shock def postmarketing x
Anaphylactoid reaction
Angioedema def Angioedema def postmarketing
Asthma def Asthma def postmarketing x
Exacerbation of asthma postmarketing x
Breast disorder def Breast disorder def postmarketing x x
Vulvovaginal candidiasis def Vaginal moniliasis postmarketing x x
Vulvovaginal mycotic infection Vaginal moniliasis postmarketing x x
Transient ischaemic attack def Transient ischaemic attack def postmarketing
Chest pain def Chest pain def postmarketing
Cholecystitis def Cholecystitis def postmarketing
Cholelithiasis def Cholelithiasis def postmarketing
Chorea def Chorea def postmarketing x
Cyst def Cyst def postmarketing
Libido decreased def Libido decreased def postmarketing
Disturbance in sexual arousal Libido decreased def postmarketing
Libido increased def postmarketing
Depression def Depression def postmarketing x x
Dysmenorrhoea def Dysmenorrhoea def postmarketing, 0% 0% x x
Ectropion def Ectropion def postmarketing x
Epilepsy def Epilepsy def postmarketing
Erythema multiforme def Erythema multiforme def postmarketing x x x
Erythema nodosum def Erythema nodosum def postmarketing x x x
Dermatitis def Rash def postmarketing x x x x
Dermatitis def x
Rash def Rash def postmarketing x x x x
Eruption postmarketing x x x
Facial rash
Fibrocystic breast disease def Fibrocystic breast disease def postmarketing x
Gallbladder disorder def Gallbladder disorder def postmarketing x x x
Haemangioma def Haemangioma def postmarketing
Hemiparesis Hemiparesis postmarketing
Hirsutism def Hirsutism def postmarketing x x x
Hyperaemia def Hyperaemia def postmarketing
Hypertriglyceridaemia def Hypertriglyceridaemia def postmarketing x
Blood triglycerides increased Hypertriglyceridaemia def postmarketing x
Hypertrophy def Hypertrophy def postmarketing x x
Hypocalcaemia def Hypocalcaemia def postmarketing x
Libido increased def Libido increased def postmarketing
Irritability def Irritability def postmarketing x
Jaundice def Jaundice def postmarketing x x
Jaundice cholestatic def Jaundice cholestatic def postmarketing x x
Arthropathy def Arthropathy def postmarketing
Osteoarthritis def Arthropathy def postmarketing
Osteoarthritis def
Muscle spasms def Cramps of lower extremities postmarketing x
Cramp muscle def postmarketing x x x
Muscle spasms def
Pain in extremity def Leg pain postmarketing x
Pain in extremity def 0% x x
Lens disorder def Lens disorder def postmarketing
Breast mass def Breast mass def postmarketing
Chloasma Chloasma postmarketing x x x
Menorrhagia def Menorrhagia def postmarketing
Metrorrhagia def Metrorrhagia def postmarketing, 0% x x x
Nervousness def Nervousness def postmarketing x
Tension def Nervousness def postmarketing x
Tension def
Obstruction def Obstruction def postmarketing
Ovarian cyst def Ovarian cyst def postmarketing
Pancreatitis def Pancreatitis def postmarketing
Pelvic pain def Pelvic pain def postmarketing
Porphyria def Porphyria def postmarketing x x
Prurigo def Prurigo def postmarketing
Anal pruritus def Anal pruritus def postmarketing
Pruritus genital Anal pruritus def postmarketing
Pruritus genital postmarketing
Anorectal discomfort Anal pruritus def postmarketing
Skin disorder def Skin disorder def postmarketing
Swelling def Swelling def postmarketing x x
Ulcer def Ulcer def postmarketing
Erythema def Erythema def postmarketing x x x x x
Redness def x x
Pollakiuria def Pollakiuria def postmarketing
Urticaria def Urticaria def postmarketing x
Uterine leiomyoma def Uterine leiomyoma def postmarketing x x
Uterine haemorrhage def Uterine haemorrhage def postmarketing
Vaginismus def Psychogenic vaginismus def postmarketing
Angiopathy def Angiopathy def postmarketing x
Visual impairment def Visual impairment def postmarketing
Visual disturbance x
Visual acuity reduced Visual impairment def postmarketing
Blindness def Visual impairment def postmarketing
Vomiting def Vomiting def postmarketing x x
Vulval disorder def Vulval disorder def postmarketing
Weight increased def Weight increased def postmarketing, 0% x
Weight decreased def Weight decreased def postmarketing
Breast engorgement def Breast engorgement def postmarketing
Breast discharge def Breast discharge def postmarketing x
Oedema genital def Oedema genital def postmarketing
Uterine enlargement def Uterine enlargement def postmarketing
Withdrawal bleed Withdrawal bleed postmarketing x x
Uterine cancer def Uterine cancer def postmarketing
Menstruation irregular def Menstruation irregular def postmarketing
Eyelid oedema Eyelid oedema postmarketing x
Contact lens intolerance Contact lens intolerance postmarketing
Purpura def Rash hemorrhagic postmarketing x x
Purpura def
Thrombophlebitis superficial def Superficial phlebothrombosis postmarketing x
Superficial thrombophlebitis of leg
Galactorrhoea Galactorrhoea postmarketing x
Migraine def Migraine aggravated postmarketing
Vulvovaginal pain Vaginal pain def postmarketing
Arrhythmia def Heart rate irregular postmarketing
Heart rate irregular Heart rate irregular postmarketing
Fluid retention Fluid retention postmarketing
Ectropion of cervix Ectropion of cervix postmarketing x
Glucose tolerance impaired def Glucose tolerance impaired def postmarketing
Abdominal distension def Enlargement abdomen def postmarketing
Abdominal bloating def postmarketing x x
Abdominal distension def x
Blood pressure increased Blood pressure increased postmarketing x x x x
Carbohydrate tolerance decreased Carbohydrate tolerance decreased postmarketing x
Vaginal infection def Vaginal ulceration postmarketing
Vaginal ulceration Vaginal ulceration postmarketing
Vaginitis ulcerative
Medical device complication Device complication def postmarketing
Liver function test abnormal Raised liver function tests postmarketing
Ovarian cancer def Ovarian cancer def postmarketing x
Breast enlargement Breast enlargement postmarketing
Mood swings Mood alteration NOS def postmarketing
Mood swings x
Anxiety def Anxiety def 0% x
Neck pain def Neck pain def 0% x
Sinus headache Sinus headache 0% x
Sinus congestion Sinus congestion 0% x
Malaise def Sickness 0% x
Malaise def
Abscess def Abscess def
Amenorrhoea def Amenorrhoea def
Amnesia def Amnesia def
Asthenia def Asthenia def x
Fatigue def x
Bacterial infection def Bacterial infection def
Mental disorder def Mental disorder def x
Bladder disorder def Bladder disorder def
Blepharitis def Blepharitis def
Bone disorder def Bone disorder def
Breast swelling Breast swelling x
Bronchospasm def Bronchospasm def
Basal cell carcinoma def Basal cell carcinoma def
Carpal tunnel syndrome def Carpal tunnel syndrome def
Cerebrovascular disorder def Cerebrovascular disorder def
Uterine cervical erosion def Uterine cervical erosion def x
Conjunctivitis def Conjunctivitis def
Connective tissue disorder def Connective tissue disorder def x
Coronary artery thrombosis def Coronary artery thrombosis def x
Cough def Cough def x
Cough increased x
Cystitis def Cystitis def x
Bladder infection def
Bladder pain def Cystitis def x
Cystitis noninfective def Cystitis def x
Dermatitis contact def Dermatitis contact def x
Allergic contact dermatitis def x
Diverticulitis def Diverticulitis def
Ear disorder def Ear disorder def
Ear pain def Ear pain def
Emotional disorder Emotional disturbance NOS
Endocrine disorder def Endocrine disorder def
Hormone level abnormal Endocrine disorder def
Endometriosis def Endometriosis def x
Eye disorder def Eye disorder def
Eye infection def Eye infection def
Fatigue def Fatigue def x
Foetal disorder def Foetal disorder def
Body temperature increased def Body temperature increased def
Pathological fracture def Pathological fracture def
Gastritis def Gastritis def
Gastroenteritis def Gastroenteritis def
Gastrooesophageal reflux disease def Gastrooesophageal reflux disease def
Gastrointestinal disorder def Gastrointestinal disorder def x x
Gastrointestinal symptom NOS
Genital disorder female def Genital disorder female def x
Goitre def Goitre def
Haematoma def Haematoma def
Haematuria def Haematuria def
Haemorrhoids def Haemorrhoids def
Hepatitis def Hepatitis def
Hereditary angioedema def Hereditary angioedema def
Herpes virus infection def Herpes NOS def
Herpes virus infection def
Herpes simplex def Herpes simplex def
Herpes zoster def Herpes zoster def
Hypercalcaemia def Hypercalcaemia def x x
Hyperglycaemia def Hyperglycaemia def x
Hypernatraemia def Hypernatraemia def x
Hypoaesthesia def Hypoaesthesia def
Immune system disorder def Immune system disorder def
Incontinence def Incontinence def
Intestinal obstruction def Intestinal obstruction def
Laryngitis def Laryngitis def
Mediastinal disorder def Mediastinal disorder def x
Hypertonia def Hypertonia def
Muscle rigidity def Muscle rigidity def
Musculoskeletal pain def Musculoskeletal pain def x
Nail disorder def Nail disorder def
Nasal congestion def Nasal congestion def
Nervous system disorder def Nervous system disorder def x
Neuritis def Neuritis def x
Neuropathy peripheral def Neuritis def x
Optic neuritis def Optic neuritis def x
Ear infection def Otitis def
Ear infection def
Otitis media def Otitis media def
Palpitations def Palpitations def x
Paraesthesia def Paraesthesia def
Pigmentation disorder def Pigmentation def
Pigmentation skin def
Pleural disorder def Pleural disorder def
Pneumonia def Pneumonia def
Polyuria def Polyuria def
Urine output increased Polyuria def
Postmenopausal haemorrhage Postmenopausal haemorrhage
Tension headache def Tension headache def
Vascular purpura Purpura def
Respiratory disorder def Respiratory disorder def
Shock def Shock def
Syncope def
Skin ulcer def Skin ulcer def
Hyperhidrosis def Sweating def
Sweating increased
Syncope def Syncope def
Loss of consciousness def Syncope def
Tinnitus def Tinnitus def
Tooth disorder def Tooth disorder def
Toothache def Toothache def
Urinary incontinence def Urinary incontinence def
Urethral disorder def Urinary tract disorder def
Urinary tract disorder def Urinary tract disorder def
Vaginal disorder def Vaginal disorder def
Vulvovaginal pruritus Vaginal itching x
Vaginal neoplasm def Vaginal neoplasm def
Varicose vein def Varicose vein def x
Vasodilation procedure Vasodilation def
Vertigo def Vertigo def
Viral infection def Viral infection def
Vulvovaginitis def Vulvovaginitis def x
Agitation def Agitation def
Affect lability Mood swings x
Oedema peripheral def Oedema peripheral def x
Leg edema
Hepatic function abnormal Hepatic function abnormal x
Musculoskeletal stiffness Neck stiffness
Nuchal rigidity Neck stiffness
Endometrial disorder def Endometrial disorder def x
Glucose tolerance decreased Glucose tolerance decreased x
Skin hypertrophy Skin hypertrophy
Blood alkaline phosphatase increased def Phosphatase alkaline increased
Alanine aminotransferase increased def Alanine aminotransferase increased def
Skin irritation def Skin irritation def x
Benign vaginal neoplasm Benign vaginal neoplasm
Porphyria non-acute Porphyria cutanea tarda def
Reproductive tract disorder def Reproductive tract disorder def x
Vaginal discharge def Vaginal discharge def x
Feeling abnormal Malaise def
Ill-defined disorder Malaise def
Increased appetite Increased appetite
Abdominal discomfort Abdominal discomfort x
Abdominal pain upper Abdominal pain upper
Rash erythematous Rash erythematous
Muscle contractions involuntary Muscle contractions involuntary
Thrombophlebitis def Thrombophlebitis of the leg
Menopausal symptoms def Menopausal symptoms def
Perineal pain def Perineal pain def
Breast malformation Breast malformation
Hepatobiliary disease def Hepatobiliary disease def
Anaphylactoid reaction Anaphylactoid reaction
Cold sweat Sticky skin
Sticky skin Sticky skin
Chills def Rigors
Pruritus generalised Pruritus generalised
Lymphadenopathy def Lymphadenopathy def
Tooth abscess Tooth abscess
Influenza like illness Influenza like illness x
Uterine pain def Uterine pain def x
Blood glucose increased Blood glucose increased x
Toxic shock syndrome def Toxic shock syndrome def
Drug interaction def Drug interaction def
Acne def Acne def x x
Aortic dissection def Dissecting aortic aneurysm, thoracic x
Thrombocytosis def Thrombocytosis def
Infestation Infestation NOS x x
Oropharyngeal pain Pharyngolaryngeal pain def
Blood glucose decreased Glucose low x
Breast discomfort Breast discomfort
Pleural infection def Pleural infection def
Renal cancer def Renal carcinoma def
Breast neoplasm def Breast neoplasm def
Somnolence def Somnolence def
Indication Labels
Alcohol abuse def x
Atrophy def x
Breast cancer def x
Carcinoma def x x
Diabetes mellitus def x
Endometrial cancer def x
Endometrial hyperplasia def x
Flushing def x
Hot flush def x
Hyperparathyroidism def x
Hyperplasia def x
Hyperprolactinaemia def x
Hypogonadism def x
Menopause def x x x x
Metastatic disease def x
Neoplasm malignant def x
Oestrogen deficiency x
Osteopenia def x x
Osteoporosis def x x x x x
Osteoporosis postmenopausal def x x x x
Osteoporotic fracture def x
Ovarian failure x
Postmenopausal syndrome x
Postmenopause def x x
Premature menopause def x x
Primary ovarian failure x
Prostate carcinoma def x
Prostatic disorder def x
Sleep disturbance x
Thyrotoxicosis def x
Type 1 diabetes mellitus def x
Uterine disorder def x
Vaginal inflammation def x
Vaginitis atrophic def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Codes: G03CA03, L02AA02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. ESTRADIOL / ESTRADERM : 3 side effects (Drugs@FDA)
  2. ESTRADIOL / CLIMARA : 4 side effects (Drugs@FDA)
  3. ESTRADIOL / EVAMIST : 7 side effects (Drugs@FDA)
  4. ESTRADIOL / CLIMARA : 15 side effects (Drugs@FDA)
  5. ESTRADIOL ACETATE / FEMRING : 20 side effects (Drugs@FDA)
  6. ESTRADIOL / ESTRADIOL : 28 side effects (Drugs@FDA)
  7. ESTRADIOL : 29 side effects (FDA XML label)
  8. estradiol / Vivelle-Dot : 32 side effects (FDA MedWatch)
  9. ESTRADIOL HEMIHYDRATE / ESTRASORB : 39 side effects (Drugs@FDA)
  10. ESTRADIOL / ESTROGEL : 52 side effects (Health Canada)