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Estradiol

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: G03CA03, L02AA02

Side effects

Options: Hide MedDRA Preferred Terms ,   display only 20 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56
Respiratory tract infection Respiratory tract infection 16.1% - 24.7% 26.4% x x x x x
Skin exfoliation Localized exfoliation very common x x
Headache Headache postmarketing — 5% - 50% 2.7% - 23.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Endometrial disorder Endometrial disorder 1.8% - 15.1% 1.4% - 8.21% x x x
Vulvovaginal mycotic infection Vulvovaginal mycotic infection 8.29% 2.91% x x
Vaginal moniliasis postmarketing, 6.19% - 10.7% 2.78% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vaginal mycosis 0.82% - 6.4% 3.2% x x
Vulvovaginal pruritus Vulvovaginal pruritus 7.8% 1.94% x
Vaginal itching x x x x x x x
Application site reaction Application site reaction postmarketing — 0.6% - 56.7% 0% - 58.6% x x x x x x x x x x x
Injury Accidental injury 4.49% - 13.9% 4.6% - 11% x x x x x x
Breast tenderness Breast tenderness postmarketing — 2.46% - 17% 0% - 5.26% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Back pain Back pain postmarketing, 0% - 10.6% 1.3% - 6.38% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cervical polyp Cervical polyp 6.25% 1.91% x
Nasopharyngitis Nasopharyngitis 1.32% - 19.6% 1.3% - 15.3% x x x x x x x x x x x x x x x
Common cold x
Genital candidiasis Genital candidiasis uncommon, 5.49% - 7% 2.13% x x x x x x x x
Breast pain Breast pain female 3% - 9% 0% x x
Breast pain postmarketing — 1% - 34.8% 2.99% - 9.6% x x x x x x x x x x x x x x x x x x x x x x x x
Upper respiratory tract infection Upper respiratory tract infection 1.6% - 17% 1.6% - 16.7% x x x x x x x x x x x x x x x x x x x x x
Influenza Influenza 0% - 13.3% 0% - 10.3% x x x x x x x x x x x x
Metrorrhagia Metrorrhagia postmarketing — 0% - 10.6% 0% - 4.46% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bleeding breakthrough postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Sinusitis Sinusitis 1.77% - 13.1% 1.4% - 18.4% x x x x x x x x x x x x x x x x x x x x x x x
Menstrual disorder Menstrual disorder common x x
Pain Pain postmarketing, 0% - 12.5% 4.46% - 12.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Ache x
Vulvovaginal discomfort Vaginal discomfort 5% x x x
Vaginal irritation postmarketing, 0.885% - 1.79% 3.7% x x x x x
Vulvovaginal discomfort x
Vulva discomfort x
Weight fluctuation Weight fluctuation common x
Cervical discharge Cervical discharge common x x
Sinus headache Sinus headache 0% - 10.9% 5.1% x x x x x
Influenza like illness Influenza like illness 0% - 7.77% 6.37% x x x x x
Influenza-like symptoms 2% - 3% x x x
Perineal pain Perineal pain 1% - 8% 0% x
Bronchitis Bronchitis 3.45% - 7.87% 4.31% - 6.9% x x x x x x x x x x x
Vaginal discharge Leukorrhea 1% - 10.6% 1% - 1.15% x x x x x x x x x x x x x x
Vaginal discharge postmarketing, 1.47% - 3.52% 0.73% - 8.33% x x x x x x x x x
Dyspepsia Dyspepsia 0% - 9.23% 1.15% - 6.37% x x x x x x x x x x x x x x x x x
Pain in extremity Pain in extremity postmarketing, 0% - 7.69% 2.78% - 5.73% x x x x x x x x x x
Leg pain x x x x x x x
Abdominal pain Abdominal pain postmarketing — 0% - 16% 1.4% - 8.13% x x x x x x x x x x x x x x x x x x x x x x x x x x
Abdominal cramps postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain postmarketing — 0% - 16% 1.4% - 8.13% x x x x x x x x x x x x x x x x x x x x x x x x x x
Rhinitis Rhinitis 2% - 6% 1% - 6.8% x x x x x x x x
Common cold x
Vaginal haemorrhage Vaginal haemorrhage postmarketing — 1.2% - 16.7% 0% - 4.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Fungal infection Fungal infection 0% - 10% 1.15% x x x x x x x x x x
Constipation Constipation postmarketing, 1.12% - 6.67% 2.55% - 4.6% x x x x x x x x x x x x x x x
Arthralgia Arthralgia postmarketing, 0% - 12.4% 0% - 13.8% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia postmarketing, 0% - 12.4% 0% - 13.8% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Myalgia postmarketing, 1.72% - 5.62% 2.87% - 4.6% x x x x x x x x x x x x
Neck pain Neck pain 0% - 6.38% 1.27% x x x x x
Gastroenteritis Gastroenteritis 0% - 4.44% 2.3% x x x x x
Infection Infection 1.15% - 17.3% 2.3% - 7.46% x x x x x x x x x x x x x x x x x x x x x x x
Flatulence Flatulence postmarketing, 1% - 7% 1% - 5.75% x x x x x x x x x x x x x x x x x
Abdominal bloating postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vulvovaginal candidiasis Vaginal moniliasis postmarketing, 6.19% - 10.7% 2.78% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Uterine pain Uterine pain 1.77% - 4.46% 0.926% x x
Vulvovaginitis Vulvovaginitis 0.893% - 5.31% 6.48% x
Sinus congestion Sinus congestion 0% - 6.52% 4.46% x x x x x
Depression Depression postmarketing — 0% - 10.6% 0% - 9.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Candida infection Candida infection 1% - 5% 2% x x
Arthritis Arthritis postmarketing, 2% - 5.29% 7.18% x x x x x x x
Arthritis aggravated x
Bone pain Bone pain 2% - 4% x x
Urinary tract infection Urinary tract infection 0.885% - 7% 1.85% - 2.3% x x x x x x x x x x x x
Pneumonia Pneumonia 0.575% - 4.49% 4.6% x x x x x
Reproductive tract disorder Reproductive tract disorder 2.65% - 2.68% 8.33% x
Pharyngitis Pharyngitis 0.5% - 7% 1.15% - 3% x x x x x x x x x x x x x x
Nausea Nausea postmarketing — 0% - 6.74% 1.32% - 6.49% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperaesthesia Nipple pain postmarketing, 0.735% - 6.76% 0% x x x x x x x x
Hyperaesthesia x
Nipple pain Nipple pain postmarketing, 0.735% - 6.76% 0% x x x x x x x x
Oedema peripheral Oedema peripheral 0% - 4.44% 0% - 4.6% x x x x x x x x x
Leg edema x x x
Breast neoplasm Breast neoplasm 1.12% - 5.56% 6.9% x x x x x
Abnormal withdrawal bleeding Abnormal withdrawal bleeding postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Family stress Family stress 2% - 3% x x
Asthenia Asthenia postmarketing, 0% - 7.87% 4.1% - 4.6% x x x x x x x x x x
Fatigue postmarketing x x x x x x x x x x x x x
Cough Cough increased 1.12% - 4.44% 2.3% x x x x x
Cough postmarketing x x x x
Conjunctivitis Conjunctivitis 0% - 3.33% 2.3% x x x x x x
Asthma Asthma 1.12% - 3.37% 1.15% x x x x x
Exacerbation of asthma postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pruritus genital Pruritus genital postmarketing, 4% - 6% 0% x x x x x x
Anal pruritus postmarketing x x
Vaginal inflammation Vaginal inflammation postmarketing, 0% - 8.9% 4.1% - 6.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vaginal infection Vaginal inflammation postmarketing, 0% - 8.9% 4.1% - 6.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vaginal ulceration postmarketing x x x x
Insomnia Insomnia postmarketing, 0% - 6.38% 5.73% - 8.05% x x x x x x x x x x x x x x x x x x x x x x x x x
Myalgia Myalgia postmarketing, 1.72% - 5.62% 2.87% - 4.6% x x x x x x x x x x x x
Cyst Cyst 0% - 6.67% 3.45% x x x x x x x x
Pruritus Pruritus postmarketing — 0.5% - 7.8% 0% - 6% x x x x x x x x x x x x x x
Otitis media Otitis media 0% - 3.37% 2.3% x x x x x x x
Vasodilation procedure Vasodilation 0% - 6.74% 14.9% x x x x x
Anxiety Anxiety NEC 0% - 6.38% 2.55% x x x x x
Anxiety postmarketing, 0% - 10% 0% - 3.45% x x x x x x x x x x x x x x x x x x
Weight increased Weight increased postmarketing, 0% - 8.51% 0% - 4.6% x x x x x x x x x x x x x x x x x x x x x x x x
Chest pain Chest pain postmarketing, 1.12% - 4.49% 4.6% x x x x x x x x x x x x x
Chest discomfort postmarketing x
Hypersensitivity Hypersensitivity postmarketing, 0.575% - 4.49% 2.3% x x x x x x x x x
Libido increased Libido increased postmarketing, uncommon x x x x
Disturbance in sexual arousal Libido increased postmarketing, uncommon x x x x
Libido decreased postmarketing x x
Muscle spasms Cramp muscle uncommon x x x x x x x x x
Cramps of lower extremities postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Muscle spasms postmarketing x x x
Breast enlargement Breast enlargement postmarketing — 1.12% - 6.74% 3.45% x x x x x x x x x x x x x x x x x
Oedema Oedema postmarketing — 0.5% - 13% 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Abdominal distension Abdominal distension postmarketing — 2.68% - 7.08% 2.78% x x x x x x x x x x x
Enlargement abdomen postmarketing x x
Abdominal bloating postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Alopecia Alopecia postmarketing, uncommon x x x x x x x x x
Amenorrhoea Amenorrhoea postmarketing x x
Anaphylactic shock Anaphylactic shock postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Anaphylactoid reaction postmarketing x x x x
Angioedema Angioedema postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Aphasia Aphasia postmarketing x
Speech loss x x
Breast cancer Breast cancer postmarketing x x x x x x x x x x
Breast cancer invasive NOS x
Breast disorder Breast disorder postmarketing x x x x x x x x x x x x x x x x x x x x x x
Breast swelling Breast swelling postmarketing x x x x x x x x
Transient ischaemic attack Transient ischaemic attack postmarketing x x
Cholecystitis Cholecystitis postmarketing x x
Cholelithiasis Cholelithiasis postmarketing x x x
Chorea Chorea postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Contusion Contusion postmarketing x
Libido decreased Libido decreased postmarketing x x
Diarrhoea Diarrhoea postmarketing, 1.12% - 5.37% 0% - 2.3% x x x x x x x x x x x x x x x x x x x x
Dizziness Dizziness postmarketing — 0.575% - 7.78% 0% - 2.87% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Syncope postmarketing x x x x x
Dysgeusia Dysgeusia postmarketing x
Dyspnoea Dyspnoea postmarketing x x x x x
Eczema Eczema postmarketing x
Endometrial hyperplasia Endometrial hyperplasia postmarketing, 0% - 0.704% 0% x x x x x x
Epilepsy Epilepsy postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Erythema multiforme Erythema multiforme postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Erythema nodosum Erythema nodosum postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dermatitis Rash postmarketing — 2.87% - 8.89% 5.5% - 5.75% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dermatitis x x x
Rash Rash postmarketing — 2.87% - 8.89% 5.5% - 5.75% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Facial rash postmarketing x x x
Eruption x x x x x x
Fatigue Fatigue postmarketing x x x x x x x x x x x x x
Body temperature increased Body temperature increased postmarketing x x x x
Fibrocystic breast disease Fibrocystic breast disease postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Flushing Flushing postmarketing x
Gallbladder disorder Gallbladder disorder postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gynaecomastia Gynaecomastia postmarketing x
Haemangioma Haemangioma postmarketing x x x x x x x x x x x x x x x x x x x x x x x x
Hemiparesis Hemiparesis postmarketing x x
Haemorrhage Haemorrhage postmarketing x x x x x x
Haemoglobin Haemorrhage postmarketing x x x x x x
Hirsutism Hirsutism postmarketing — 0.575% - 4.49% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperhidrosis Hyperhidrosis postmarketing x x x
Sweating increased x
Hypoaesthesia Hypoaesthesia postmarketing, 0% - 3.37% 2.3% x x x x x x x x x
Numbness x x
Hypocalcaemia Hypocalcaemia postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Inflammation Inflammation postmarketing x x
Intestinal obstruction Intestinal obstruction postmarketing x x x
Irritability Irritability postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Jaundice cholestatic Jaundice cholestatic postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Arthropathy Arthropathy postmarketing, 0% - 4.49% 2.3% x x x x x x x
Osteoarthritis Arthropathy postmarketing, 0% - 4.49% 2.3% x x x x x x x
Osteoarthritis x
Lethargy Lethargy postmarketing x
Breast mass Breast mass postmarketing x x x
Chloasma Chloasma postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Meningioma Meningioma postmarketing x
Menorrhagia Menorrhagia postmarketing x x x x x
Myocardial infarction Myocardial infarction postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Acute coronary syndrome Myocardial infarction postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Myoclonus Myoclonus postmarketing x
Nervousness Nervousness postmarketing, 2.4% 1.4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Tension Nervousness postmarketing, 2.4% 1.4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Night sweats Night sweats postmarketing x x x x
Ovarian cyst Ovarian cyst postmarketing x x x x
Palpitations Palpitations postmarketing, 0.6% 1.4% x x x x x x x x x x x
Pancreatitis Pancreatitis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia postmarketing x x x x x x x
Pelvic pain Pelvic pain postmarketing x x x x x x
Phlebitis Phlebitis postmarketing x
Porphyrin metabolism disorder Porphyrin metabolism disorder postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Prurigo Prurigo postmarketing x x x x x
Anal pruritus Anal pruritus postmarketing x x
Anorectal discomfort Anal pruritus postmarketing x x
Pulmonary embolism Pulmonary embolism postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Purpura Purpura postmarketing x x x x
Dermatitis hemorrhagic postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vascular purpura Purpura postmarketing x x x x
Retinal vein occlusion Retinal vein occlusion postmarketing x x
Pigmentation disorder Pigmentation skin postmarketing x
Cerebrovascular accident Cerebrovascular accident postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Sunburn Sunburn postmarketing x x x
Photosensitivity reaction Sunburn postmarketing x x x
Swelling Swelling postmarketing x x x x x
Shock Syncope postmarketing x x x x x
Shock x
Syncope Syncope postmarketing x x x x x
Loss of consciousness Syncope postmarketing x x x x x
Tachycardia Tachycardia postmarketing x x x
Thrombophlebitis Thrombophlebitis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Thrombosis Thrombosis postmarketing x x x x x x x
Tremor Tremor postmarketing x
Ulcer Ulcer postmarketing x x x
Erythema Erythema postmarketing x x x x x x x x x x
Redness x x x x x x x
Urethral disorder Urethral disorder postmarketing x x x
Urinary tract disorder x
Pollakiuria Pollakiuria postmarketing x x
Urticaria Urticaria postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Uterine leiomyoma Uterine leiomyoma postmarketing, uncommon x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Uterine haemorrhage Uterine haemorrhage postmarketing x x x
Vomiting Vomiting postmarketing, uncommon x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vulval disorder Vulval disorder postmarketing x x
Weight decreased Weight decreased postmarketing x x
Dry mouth Dry mouth postmarketing x
Mood swings Mood swings postmarketing x x x x
Mood alteration NOS postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Affect lability Mood swings postmarketing x x x x
Breast engorgement Breast engorgement postmarketing x x
Breast discharge Breast discharge postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Deep vein thrombosis Deep vein thrombosis postmarketing x x x x x x
Migraine Migraine postmarketing — 0% - 6.74% 2.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Migraine aggravated postmarketing x x x x
Oedema genital Oedema genital postmarketing x x
Ventricular extrasystoles Ventricular extrasystoles postmarketing x
Myocardial ischaemia Myocardial ischaemia postmarketing x
Liver function test abnormal Liver function test abnormal postmarketing x x x
Raised liver function tests x
Skin discolouration Skin discolouration postmarketing x x
Dry skin Dry skin postmarketing x x x x
Uterine enlargement Uterine enlargement postmarketing x x
Uterine cancer Uterine cancer postmarketing x x
Endophthalmitis Ocular hyperaemia postmarketing x
Ocular hyperaemia Ocular hyperaemia postmarketing x
Menstruation irregular Menstruation irregular postmarketing x x
Malnutrition Malnutrition postmarketing, 12% 10.5% x x x x x x
Contact lens intolerance Contact lens intolerance postmarketing x x x x x x
Malaise Malaise postmarketing x x x
Discomfort Malaise postmarketing x x x
Discomfort postmarketing x x x x x
Feeling abnormal Malaise postmarketing x x x
Feeling abnormal postmarketing x
Confusional state x x
Ill-defined disorder Malaise postmarketing x x x
Decreased appetite Decreased appetite postmarketing x
Tenderness Tenderness postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dry throat Dry throat postmarketing x
Eye irritation Eye irritation postmarketing x
Abdominal discomfort Upset stomach postmarketing x
Abdominal discomfort x x x x x x
Thrombophlebitis superficial Superficial phlebothrombosis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Superficial thrombophlebitis of leg x
Galactorrhoea Galactorrhoea postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Chest discomfort Chest discomfort postmarketing x
Menopausal symptoms Menopausal symptoms postmarketing x x x
Hot flush postmarketing, 0% - 6.38% 3.82% x x x x x x x x x x x
Vulvovaginal pain Vaginal pain postmarketing x x x x
Heart rate irregular Heart rate irregular postmarketing x x
Pulse irregular x x
Hepatitis acute Hepatitis acute postmarketing x
Fluid retention Fluid retention postmarketing x x x x x x x x
Ectropion of cervix Ectropion of cervix postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x
Glucose tolerance impaired Glucose tolerance impaired postmarketing x x x x
Papule Papule postmarketing x
Malignant mesenchymoma Malignant mesenchymoma postmarketing x
Anaphylactoid reaction Anaphylactoid reaction postmarketing x x x x
Blindness Blindness postmarketing x x
Endometrial cancer Endometrial cancer postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Blood pressure increased Blood pressure increased postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dementia Dementia postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x
Application site rash Application site rash postmarketing x
Drug effect decreased Drug effect decreased postmarketing x
Pre-existing disease Pre-existing disease postmarketing x x x x
Face oedema Face oedema postmarketing x
Visual impairment Visual disturbance postmarketing x x x x x x x x
Abnormal vision postmarketing x x x
Disorder sight x
Bradyphrenia Bradyphrenia postmarketing x
Vaginal ulceration Vaginal ulceration postmarketing x x x x
Vaginitis ulcerative x
Gait disturbance Gait disturbance postmarketing x
Hot flush Hot flush postmarketing, 0% - 6.38% 3.82% x x x x x x x x x x x
Toxic shock syndrome Toxic shock syndrome postmarketing x x x
Generalised erythema Generalised erythema postmarketing x x
Drug ineffective Drug ineffective postmarketing x x x
Retinal vascular thrombosis Retinal vascular thrombosis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Medical device complication Medical device complication postmarketing x x
Ovarian cancer Ovarian cancer postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Blood pressure fluctuation Change in blood pressure postmarketing x x x
Vaginismus Vaginismus postmarketing x x x x
Congenital anomaly Congenital anomaly x
Developmental delay Congenital anomaly x
Amnesia Amnesia x
Bacterial infection Bacterial infection x
Mental disorder Mental disorder x x x x x x x x x x
Blepharitis Blepharitis x
Coagulopathy Clotting x x x
Bone disorder Bone disorder x
Bronchospasm Bronchospasm x
Neoplasm malignant Neoplasm malignant x x x x x x x x x x x x x x x x x x x
Basal cell carcinoma Basal cell carcinoma x
Cardiovascular disorder Cardiovascular disorder x x x x x x x x x x x x x x
Carpal tunnel syndrome Carpal tunnel syndrome x x
Cerebrovascular disorder Cerebrovascular disorder x
Uterine cervical erosion Uterine cervical erosion x x x x x x x
Confusional state Confusional state x x
Connective tissue disorder Connective tissue disorder x x x x x x x x x x x x
Coronary artery thrombosis Coronary artery thrombosis x x x x x
Cystitis Cystitis x x x x x x x x
Bladder infection x
Bladder pain Cystitis x x x x x x x x
Cystitis noninfective Cystitis x x x x x x x x
Dysphagia Dysphagia x x
Dermatitis contact Dermatitis contact x
Allergic contact dermatitis x x x x
Diverticulitis Diverticulitis x
Dysmenorrhoea Dysmenorrhoea postmarketing, 0% - 6.52% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Ear disorder Ear disorder x
Ear pain Ear pain 0% - 2.91% 0% x x x
Embolism Embolism x x
Thromboembolism x x x x x x
Emotional disorder Emotional disturbance NOS x
Endocrine disorder Endocrine disorder x x
Endometriosis Endometriosis x x x x x x x
Epistaxis Epistaxis x x x
Eye disorder Eye disorder x
Eye infection Eye infection x
Foetal disorder Foetal disorder x
Gastritis Gastritis x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease x
Gastrointestinal disorder Gastrointestinal disorder x x x x x x x x x x x x x x x
Gastrointestinal symptom NOS x x
Goitre Goitre x
Cardiac disorder Cardiac disorder x x x
Haematoma Haematoma x
Haematuria Haematuria x
Haemoptysis Haemoptysis x x x
Haemorrhoids Haemorrhoids x x x
Hepatitis Hepatitis x
Hereditary angioedema Hereditary angioedema x
Herpes simplex Herpes simplex x x
Herpes zoster Herpes zoster x
Hypercalcaemia Hypercalcaemia x x x x
Hyperglycaemia Hyperglycaemia x x x x x
Hypernatraemia Hypernatraemia x x x x x
Hypertension Hypertension 0% - 6.74% 1.27% - 3.45% x x x x x x x x x x x x x x
Immune system disorder Immune system disorder x x x x x x
Incontinence Incontinence x
Jaundice Jaundice x x x
Laryngitis Laryngitis x
Hepatic neoplasm Hepatic neoplasm x x x
Mediastinal disorder Mediastinal disorder x x x x x x x x
Hypertonia Hypertonia x
Musculoskeletal pain Musculoskeletal pain x x x x x
Nail disorder Nail disorder x
Nasal congestion Nasal congestion x
Neoplasm Neoplasm x x x x x x x
Nervous system disorder Nervous system disorder x x x x x x x x x x
Neuritis Neuritis x x x x x
Neuropathy peripheral Neuritis x x x x x
Sensory loss Numbness x x
Optic neuritis Optic neuritis x x x x x
Polyp Polyp x x x
Polyuria Polyuria x
Urine output increased Polyuria x
Tension headache Tension headache x
Skin disorder Skin disorder x
Unspecified disorder of skin and subcutaneous tissue x x x x x
Skin ulcer Skin ulcer x
Embolism venous Thromboembolism x x x x x x
Embolism venous x x
Tinnitus Tinnitus x
Tooth disorder Tooth disorder x x x
Toothache Toothache x x x
Urinary incontinence Urinary incontinence x x x
Urinary tract disorder Urinary tract disorder x
Vaginal disorder Vaginal disorder x
Varicose vein Varicose vein x x x x
Angiopathy Angiopathy x x x x x x x x
Vertigo Vertigo x
Viral infection Viral infection x
Muscle strain Muscle strain x
Agitation Agitation x
Hepatic function abnormal Hepatic function abnormal x x x x x
Musculoskeletal stiffness Neck stiffness x
Nuchal rigidity Neck stiffness x
Glucose tolerance decreased Glucose tolerance decreased x x x x x
Skin hypertrophy Skin hypertrophy x x
Blood alkaline phosphatase increased Phosphatase alkaline increased x
Alanine aminotransferase increased Alanine aminotransferase increased x
Withdrawal bleed Withdrawal bleed x x
Benign vaginal neoplasm Benign vaginal neoplasm x
Eyelid oedema Eyelid oedema x
Porphyria non-acute Porphyria cutanea tarda x x x
Increased appetite Increased appetite x
Abdominal pain upper Abdominal pain upper x x x x
Abdominal pain lower Abdominal pain lower x x x
Dysarthria Slurred speech x x
Rash erythematous Rash erythematous x x
Muscle contractions involuntary Muscle contractions involuntary x
Vascular pain Vein pain x
Breast oedema Breast oedema x
Pain of skin Skin tenderness x
Breast malformation Breast malformation x
Hepatobiliary disease Hepatobiliary disease x
Dry eye Dry eye x x
Increased tendency to bruise Increased tendency to bruise x x x
Chills Rigors x
Dyskinesia Jerky movement NOS x x
Ligament sprain Joint sprain x
Pruritus generalised Pruritus generalised x x x x x
Lymphadenopathy Lymphadenopathy x
Rash generalised Rash generalised x x
Tooth abscess Tooth abscess x
Application site irritation Application site irritation x x x x x x x x x
Carbohydrate tolerance decreased Carbohydrate tolerance decreased x x
Toxicity to various agents Toxic reaction (NOS) x
Pelvic venous thrombosis Pelvic venous thrombosis x x
Mass Mass x x x
Drug interaction Drug interaction x
Ear infection Ear infection x
Acne Acne x x
Infestation Infestation NOS x x x x x x x x x x x x x
Blood oestrogen increased Blood oestrogen increased x
Arthropod bite Arthropod bite x
Application site erythema Application site erythema x x x
Laryngeal pain Pharyngolaryngeal pain x
Local swelling Peripheral swelling x
Breast discomfort Breast discomfort x x
Pleural infection Pleural infection x
Deafness Hearing impaired x x
Hearing impaired Hearing impaired x x
Somnolence Somnolence x x x x
Loss of libido Loss of libido x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Indication Labels
Alcohol abuse x x
Angiopathy x x
Atrophy x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bone mass decreased x x
Breast cancer x x x x x x x
Breast feeding x x
Carcinoma x x
Cerebrovascular accident x x
Clotting x
Coronary heart disease x
Cushing's syndrome x
Deep vein thrombosis x x
Dyspareunia x x
Dysuria x x
Endometrial hyperplasia x x x x x
Endometriosis x x
Fracture x x x x x
Haemorrhage x x x
Headache x x
Hot flush x x x
Hyperparathyroidism x
Hyperprolactinaemia x
Hypersensitivity x x x
Hypogonadism x x x x x x x x x x x x x x x x x x x x x x x
Hypogonadism female x
Inflammation x x
Liver disorder x x
Menopausal symptoms x x x x x x x
Menopause x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Metastatic disease x x x x x
Micturition burning x x
Micturition urgency x x
Migraine x x
Myocardial infarction x x
Natural menopause x x
Neoplasm malignant x x
Oestrogen deficiency x x x x x x x x x x
Osteopenia x x x x
Osteoporosis x x x x x x x x x x x x x x x x
Osteoporosis postmenopausal x x x x x x x x x x x x x x x x x x x x x x
Osteoporotic fracture x
Phlebitis x x
Porphyrin metabolism disorder x x
Postmenopausal syndrome x x x x x x x x x x
Postmenopause x x x x
Premature menopause x x x
Primary ovarian failure x x x x x x x x x x x x x x x x x x x x x x x
Prostate carcinoma x x x x x x x
Pruritus x x x
Pruritus vulvae x
Pulmonary embolism x x
Skin irritation x
Sleep disturbance x
Surgical menopause x
Sweating x x
Thrombophlebitis x x
Thyrotoxicosis x
Type 1 diabetes mellitus x
Unspecified visual loss x x
Vaginal haemorrhage x x
Vaginitis atrophic x x x x x x
Varicose vein x x
Warmth x x

Oestradiol hemihydrate / ZUMENON TABLETS

Side effects:13
Source:medicines.org.au

Estradiol

Side effects:34
Source:FDA Structured Product Label

ESTRADIOL

Side effects:25
Source:FDA Structured Product Label

ESTRADIOL

Side effects:26
Source:FDA Structured Product Label

VAGIFEM / Vagifem, Vaginal tablet

Side effects:51
Source:Medsafe

ESTRADIOL

Side effects:44
Source:FDA Structured Product Label

ESTRADIOL / CLIMARA

Side effects:21
Source:FDA

ESTRADIOL

Side effects:44
Source:FDA Structured Product Label

ESTRADIOL

Side effects:46
Source:FDA Structured Product Label

ESTRADIOL

Side effects:46
Source:FDA Structured Product Label

estradiol

Side effects:52
Source:FDA Structured Product Label

oestradiol / Estradot, Transdermal patch

Side effects:65
Source:Medsafe

Oestradiol transdermal patch / ESTRADOT

Side effects:66
Source:medicines.org.au

ESTRADIOL

Side effects:69
Source:FDA Structured Product Label

ESTRADIOL

Side effects:72
Source:FDA Structured Product Label

ESTRADIOL

Side effects:26
Source:FDA Structured Product Label

ESTRADIOL

Side effects:38
Source:FDA Structured Product Label

ESTRADIOL

Side effects:28
Source:FDA Structured Product Label

ESTRADIOL / ESTRING

Side effects:72
Source:Health Canada

ESTRADIOL / EVAMIST

Side effects:32
Source:FDA

estradiol transdermal system / Alora

Side effects:53
Source:FDA

ESTRADIOL

Side effects:85
Source:FDA Structured Product Label

ESTRADIOL

Side effects:65
Source:FDA Structured Product Label

ESTRADIOL / EVAMIST

Side effects:65
Source:FDA

ESTRADIOL HEMIHYDRATE / ESTRASORB

Side effects:57
Source:FDA

estradiol

Side effects:58
Source:FDA Structured Product Label

ESTRADIOL

Side effects:67
Source:FDA Structured Product Label

ESTRADIOL

Side effects:66
Source:FDA Structured Product Label

ESTRADIOL

Side effects:57
Source:FDA Structured Product Label

ESTROGENS, ESTERIFIED

Side effects:57
Source:FDA Structured Product Label

estradiol

Side effects:55
Source:FDA Structured Product Label

ESTRADIOL

Side effects:56
Source:FDA Structured Product Label

ESTRADIOL / ESTRADERM

Side effects:55
Source:FDA

estradiol

Side effects:55
Source:FDA Structured Product Label

ESTRADIOL

Side effects:56
Source:FDA Structured Product Label

ESTRADIOL

Side effects:56
Source:FDA Structured Product Label

ESTRADIOL / ESTRADERM

Side effects:57
Source:FDA

estradiol

Side effects:58
Source:FDA Structured Product Label

ESTRADIOL

Side effects:60
Source:FDA Structured Product Label

ESTRADIOL / ELESTRIN

Side effects:66
Source:FDA

ESTRADIOL

Side effects:67
Source:FDA Structured Product Label

Estradiol / Estrogel

Side effects:77
Source:FDA

ESTRADIOL

Side effects:85
Source:FDA Structured Product Label

ESTRADIOL / VIVELLE

Side effects:86
Source:FDA

ESTRADIOL / ALORA

Side effects:91
Source:FDA

ESTRADIOL / ALORA

Side effects:93
Source:FDA

estradiol transdermal system / Alora

Side effects:94
Source:FDA

ESTRADIOL

Side effects:96
Source:FDA Structured Product Label

ESTRADIOL

Side effects:115
Source:FDA Structured Product Label

ESTRADIOL / ESTROGEL

Side effects:49
Source:Health Canada

ESTRADIOL / ESTRADERM-100

Side effects:92
Source:Health Canada

ESTRADIOL / ESTRADOT 100

Side effects:95
Source:Health Canada

ESTRADIOL (ESTRADIOL HEMIHYDRATE) / CLIMARA 75

Side effects:117
Source:Health Canada

ESTRADIOL / VAGIFEM

Side effects:124
Source:Health Canada

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label