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Estradiol

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: G03CA03, L02AA02

Side effects

Options: Show MedDRA Preferred Terms,   display all 56 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Respiratory tract infection 16.1% - 24.7% 26.4% x x x
Localized exfoliation very common x
Headache postmarketing — 5% - 50% 2.7% - 23.6% x x x x x x x x x x x x x x x x x x x
Endometrial disorder 1.8% - 15.1% 1.4% - 8.21% x
Vulvovaginal mycotic infection 8.29% 2.91% x
Vulvovaginal pruritus 7.8% 1.94%
Application site reaction postmarketing — 0.6% - 56.7% 0% - 58.6% x x x x x
Accidental injury 4.49% - 13.9% 4.6% - 11% x x x
Breast tenderness postmarketing — 2.46% - 17% 0% - 5.26% x x x x x x x x x
Back pain postmarketing, 0% - 10.6% 1.3% - 6.38% x x x x x x x x x x x x
Cervical polyp 6.25% 1.91%
Nasopharyngitis 1.32% - 19.6% 1.3% - 15.3% x x x x x x
Genital candidiasis uncommon, 5.49% - 7% 2.13% x x x
Breast pain female 3% - 9% 0% x
Breast pain postmarketing — 1% - 34.8% 2.99% - 9.6% x x x x x x x x
Upper respiratory tract infection 1.6% - 17% 1.6% - 16.7% x x x x x x x x
Influenza 0% - 13.3% 0% - 10.3% x x x x x x
Metrorrhagia postmarketing — 0% - 10.6% 0% - 4.46% x x x x x x x x x x x x x x
Sinusitis 1.77% - 13.1% 1.4% - 18.4% x x x x x x x x
Menstrual disorder common x
Pain postmarketing, 0% - 12.5% 4.46% - 12.6% x x x x x x x x x x x x x x
Vaginal discomfort 5% x
Weight fluctuation common x
Cervical discharge common x
Sinus headache 0% - 10.9% 5.1% x x
Influenza like illness 0% - 7.77% 6.37% x x
Perineal pain 1% - 8% 0%
Bronchitis 3.45% - 7.87% 4.31% - 6.9% x x x x
Leukorrhea 1% - 10.6% 1% - 1.15% x x x x x
Dyspepsia 0% - 9.23% 1.15% - 6.37% x x x x x x x
Pain in extremity postmarketing, 0% - 7.69% 2.78% - 5.73% x x x x x
Abdominal pain postmarketing — 0% - 16% 1.4% - 8.13% x x x x x x x x x
Rhinitis 2% - 6% 1% - 6.8% x x
Vaginal haemorrhage postmarketing — 1.2% - 16.7% 0% - 4.6% x x x x x x x x x x x
Fungal infection 0% - 10% 1.15% x x x
Constipation postmarketing, 1.12% - 6.67% 2.55% - 4.6% x x x x x x
Arthralgia postmarketing, 0% - 12.4% 0% - 13.8% x x x x x x x x x x x x x
Neck pain 0% - 6.38% 1.27% x x
Gastroenteritis 0% - 4.44% 2.3% x x x
Infection 1.15% - 17.3% 2.3% - 7.46% x x x x x x x x x
Flatulence postmarketing, 1% - 7% 1% - 5.75% x x x x x x x x
Vaginal moniliasis postmarketing, 6.19% - 10.7% 2.78% x x x x x x
Uterine pain 1.77% - 4.46% 0.926%
Vulvovaginitis 0.893% - 5.31% 6.48%
Sinus congestion 0% - 6.52% 4.46% x x
Depression postmarketing — 0% - 10.6% 0% - 9.2% x x x x x x x x x x x x x x
Candida infection 1% - 5% 2%
Arthritis postmarketing, 2% - 5.29% 7.18% x
Bone pain 2% - 4% x
Urinary tract infection 0.885% - 7% 1.85% - 2.3% x x x x
Pneumonia 0.575% - 4.49% 4.6% x x x
Reproductive tract disorder 2.65% - 2.68% 8.33%
Pharyngitis 0.5% - 7% 1.15% - 3% x x x x x
Nausea postmarketing — 0% - 6.74% 1.32% - 6.49% x x x x x x x x x x x x x x x x x x
Nipple pain postmarketing, 0.735% - 6.76% 0% x x
Oedema peripheral 0% - 4.44% 0% - 4.6% x x x
Breast neoplasm 1.12% - 5.56% 6.9% x x x
Abnormal withdrawal bleeding postmarketing, common x x x x x x x x x
Influenza-like symptoms 2% - 3% x
Family stress 2% - 3% x
Vaginal mycosis 0.82% - 6.4% 3.2% x
Asthenia postmarketing, 0% - 7.87% 4.1% - 4.6% x x x x x
Cough increased 1.12% - 4.44% 2.3% x x x
Conjunctivitis 0% - 3.33% 2.3% x x x
Asthma 1.12% - 3.37% 1.15% x x x
Pruritus genital postmarketing, 4% - 6% 0% x x
Vaginal inflammation postmarketing, 0% - 8.9% 4.1% - 6.9% x x x x x x x x x
Insomnia postmarketing, 0% - 6.38% 5.73% - 8.05% x x x x x x x x x
Myalgia postmarketing, 1.72% - 5.62% 2.87% - 4.6% x x x
Cyst 0% - 6.67% 3.45% x x x x
Pruritus postmarketing — 0.5% - 7.8% 0% - 6% x x x x x x x x
Otitis media 0% - 3.37% 2.3% x x x x
Vasodilation 0% - 6.74% 14.9% x x x
Vaginal discharge postmarketing, 1.47% - 3.52% 0.73% - 8.33% x x
Ear and labyrinth disorders 0% - 6.52% 3.18%
Anxiety NEC 0% - 6.38% 2.55% x x
Weight increased postmarketing, 0% - 8.51% 0% - 4.6% x x x x x x x x x
Chest pain postmarketing, 1.12% - 4.49% 4.6% x x x x
Hypersensitivity postmarketing, 0.575% - 4.49% 2.3% x x x x x
Libido increased postmarketing, uncommon x
Cramp muscle uncommon x x x
Breast enlargement postmarketing — 1.12% - 6.74% 3.45% x x x x x
Vaginal irritation postmarketing, 0.885% - 1.79% 3.7% x
Oedema postmarketing — 0.5% - 13% 6% x x x x x x x x x x x x x
Abdominal cramps postmarketing x x x x x x x x
Abdominal distension postmarketing — 2.68% - 7.08% 2.78% x x
Alopecia postmarketing, uncommon x x
Amenorrhoea postmarketing x
Anaphylactic shock postmarketing x x x x x x x x
Angioedema postmarketing x x x x x x x x
Anxiety postmarketing, 0% - 10% 0% - 3.45% x x x x x
Aphasia postmarketing x
Breast cancer postmarketing x x x x
Breast disorder postmarketing x x x x x x x x
Breast swelling postmarketing x x
Transient ischaemic attack postmarketing
Cholecystitis postmarketing
Cholelithiasis postmarketing x
Chorea postmarketing x x x x x x x x x x
Contusion postmarketing x
Cough postmarketing
Libido decreased postmarketing x
Diarrhoea postmarketing, 1.12% - 5.37% 0% - 2.3% x x x x x x x x x
Dizziness postmarketing — 0.575% - 7.78% 0% - 2.87% x x x x x x x x x x x x x x
Dysgeusia postmarketing
Dyspnoea postmarketing x
Eczema postmarketing x
Endometrial hyperplasia postmarketing, 0% - 0.704% 0% x x x
Epilepsy postmarketing x x x x x x x
Erythema multiforme postmarketing x x x x x x x x x
Erythema nodosum postmarketing x x x x x x x x x x
Rash postmarketing — 2.87% - 8.89% 5.5% - 5.75% x x x x x x x x x x x
Fatigue postmarketing x x x
Body temperature increased postmarketing
Fibrocystic breast disease postmarketing x x x x x x x x
Flushing postmarketing x
Gallbladder disorder postmarketing x x x x x x x x x x x
Gynaecomastia postmarketing x
Haemangioma postmarketing x x x x x x
Hemiparesis postmarketing
Haemorrhage postmarketing x x
Hirsutism postmarketing — 0.575% - 4.49% 0% x x x x x x x x x x x
Hyperhidrosis postmarketing
Hypoaesthesia postmarketing, 0% - 3.37% 2.3% x x x x
Hypocalcaemia postmarketing x x x x x x x
Inflammation postmarketing x
Intestinal obstruction postmarketing
Irritability postmarketing x x x x x x x x x
Jaundice cholestatic postmarketing x x x x x x x x x
Arthropathy postmarketing, 0% - 4.49% 2.3% x x x
Cramps of lower extremities postmarketing x x x x x x x x
Lethargy postmarketing
Breast mass postmarketing
Chloasma postmarketing x x x x x x x x x x
Meningioma postmarketing x
Menorrhagia postmarketing
Myocardial infarction postmarketing x x x x x x x x
Myoclonus postmarketing x
Nervousness postmarketing, 2.4% 1.4% x x x x x x x x x x x
Night sweats postmarketing x
Ovarian cyst postmarketing x x
Palpitations postmarketing, 0.6% 1.4% x x x
Pancreatitis postmarketing x x x x x x
Paraesthesia postmarketing x x
Pelvic pain postmarketing x
Phlebitis postmarketing x
Porphyrin metabolism disorder postmarketing x x x x x x x x x
Prurigo postmarketing x x
Anal pruritus postmarketing x
Pulmonary embolism postmarketing x x x x x x x x x
Purpura postmarketing x x
Retinal vein occlusion postmarketing x x
Pigmentation skin postmarketing x
Muscle spasms postmarketing x
Cerebrovascular accident postmarketing x x x x x x x x
Sunburn postmarketing
Swelling postmarketing x
Syncope postmarketing x
Tachycardia postmarketing x
Thrombophlebitis postmarketing x x x x x x x x x x
Thrombosis postmarketing x
Tremor postmarketing x
Ulcer postmarketing
Erythema postmarketing x x x x
Urethral disorder postmarketing x
Pollakiuria postmarketing x
Urticaria postmarketing x x x x x x x x x
Uterine leiomyoma postmarketing, uncommon x x x x x x x x x
Uterine haemorrhage postmarketing x
Vomiting postmarketing, uncommon x x x x x x x x x x x
Vulval disorder postmarketing x
Weight decreased postmarketing x
Dry mouth postmarketing
Mood swings postmarketing
Breast engorgement postmarketing x
Breast discharge postmarketing x x x x x x x x
Deep vein thrombosis postmarketing x x x
Migraine postmarketing — 0% - 6.74% 2.3% x x x x x x x x x x x x x x
Oedema genital postmarketing x
Ventricular extrasystoles postmarketing x
Myocardial ischaemia postmarketing x
Liver function test abnormal postmarketing x x
Skin discolouration postmarketing x
Dry skin postmarketing
Uterine enlargement postmarketing
Uterine cancer postmarketing
Ocular hyperaemia postmarketing
Menstruation irregular postmarketing
Malnutrition postmarketing, 12% 10.5% x
Contact lens intolerance postmarketing x
Malaise postmarketing x
Decreased appetite postmarketing
Discomfort postmarketing x x
Tenderness postmarketing x x x x x x x x x x
Dry throat postmarketing
Eye irritation postmarketing
Upset stomach postmarketing x
Superficial phlebothrombosis postmarketing x x x x x x x
Galactorrhoea postmarketing x x x x x x x
Chest discomfort postmarketing x
Migraine aggravated postmarketing x
Dermatitis hemorrhagic postmarketing x x x x x x x
Menopausal symptoms postmarketing
Vaginal pain postmarketing x
Heart rate irregular postmarketing
Facial rash postmarketing
Hepatitis acute postmarketing x
Fluid retention postmarketing x
Ectropion of cervix postmarketing x x x x x x
Glucose tolerance impaired postmarketing x x
Papule postmarketing x
Malignant mesenchymoma postmarketing x
Anaphylactoid reaction postmarketing x
Exacerbation of asthma postmarketing x x x x x x x
Enlargement abdomen postmarketing x
Blindness postmarketing
Endometrial cancer postmarketing x x x x x x x x x x x x
Blood pressure increased postmarketing x x x x x x x x x x x
Dementia postmarketing x x x x x x
Application site rash postmarketing x
Drug effect decreased postmarketing x
Pre-existing disease postmarketing x x
Face oedema postmarketing x
Visual disturbance postmarketing x
Bradyphrenia postmarketing x
Vaginal ulceration postmarketing x
Gait disturbance postmarketing x
Hot flush postmarketing, 0% - 6.38% 3.82% x x x x
Toxic shock syndrome postmarketing
Generalised erythema postmarketing
Drug ineffective postmarketing x
Retinal vascular thrombosis postmarketing x x x x x x x
Medical device complication postmarketing
Ovarian cancer postmarketing x x x x x x x
Change in blood pressure postmarketing
Abdominal bloating postmarketing, common x x x x x x x x x
Feeling abnormal postmarketing x
Vaginismus postmarketing x
Mood alteration NOS postmarketing x x x x x x x x
Bleeding breakthrough postmarketing x x x x x x x x x x x
Abnormal vision postmarketing x
Congenital anomaly
Amnesia
Bacterial infection
Mental disorder x x x
Blepharitis
Clotting
Bone disorder
Bronchospasm
Neoplasm malignant x x x x x x x x
Basal cell carcinoma
Cardiovascular disorder x x x x x x x x
Carpal tunnel syndrome
Cerebrovascular disorder
Uterine cervical erosion x x
Common cold x
Confusional state
Connective tissue disorder x x x x x
Coronary artery thrombosis x
Cystitis x x
Dysphagia
Dermatitis x
Dermatitis contact
Diverticulitis
Dysmenorrhoea postmarketing, 0% - 6.52% 0% x x x x x x x x x x x
Ear disorder
Ear pain 0% - 2.91% 0%
Embolism x
Emotional disturbance NOS
Endocrine disorder
Endometriosis x x
Epistaxis
Eye disorder
Eye infection x
Foetal disorder
Gastritis x
Gastrooesophageal reflux disease
Gastrointestinal disorder x x x x x
Goitre
Cardiac disorder x
Haematoma
Haematuria
Haemoptysis
Haemorrhoids x
Hepatitis
Hereditary angioedema
Herpes simplex
Herpes zoster
Hypercalcaemia x x x
Hyperaesthesia
Hyperglycaemia x
Hypernatraemia x
Hypertension 0% - 6.74% 1.27% - 3.45% x x x x x x
Immune system disorder x
Incontinence
Jaundice
Laryngitis
Leg pain x
Hepatic neoplasm
Mediastinal disorder x x x
Hypertonia
Musculoskeletal pain x
Nail disorder
Nasal congestion
Neoplasm x x x x
Nervous system disorder x x x
Neuritis x
Numbness
Optic neuritis x
Osteoarthritis
Polyp x
Polyuria
Tension headache
Shock
Skin disorder
Skin ulcer
Thromboembolism x
Tinnitus
Tooth disorder x
Toothache x
Urinary incontinence x
Urinary tract disorder
Vaginal disorder
Vaginal itching x x
Varicose vein x
Angiopathy x x
Vertigo
Viral infection
Disorder sight
Muscle strain
Agitation
Hepatic function abnormal x
Neck stiffness
Glucose tolerance decreased x
Skin hypertrophy x
Phosphatase alkaline increased
Alanine aminotransferase increased
Withdrawal bleed
Benign vaginal neoplasm
Eyelid oedema
Porphyria cutanea tarda
Allergic contact dermatitis x
Unspecified disorder of skin and subcutaneous tissue x
Increased appetite
Abdominal discomfort x
Abdominal pain upper
Abdominal pain lower
Ache x
Slurred speech
Rash erythematous
Muscle contractions involuntary
Vein pain
Breast oedema
Vaginitis ulcerative
Leg edema x
Arthritis aggravated
Skin tenderness
Superficial thrombophlebitis of leg
Breast malformation
Hepatobiliary disease
Eruption x x
Dry eye x
Redness x
Embolism venous x
Pulse irregular
Increased tendency to bruise
Rigors
Gastrointestinal symptom NOS x
Jerky movement NOS
Joint sprain
Pruritus generalised x
Lymphadenopathy
Rash generalised x
Tooth abscess
Vulvovaginal discomfort
Application site irritation
Carbohydrate tolerance decreased x
Speech loss
Toxic reaction (NOS) x
Pelvic venous thrombosis x
Mass
Bladder infection
Drug interaction
Ear infection
Sweating increased
Acne
Infestation NOS x x x x x
Blood and lymphatic system disorders
Blood oestrogen increased
Arthropod bite
Application site erythema
Breast cancer invasive NOS x
Pharyngolaryngeal pain
Peripheral swelling
Breast discomfort x
Raised liver function tests
Pleural infection
Hearing impaired
Vulva discomfort
Somnolence
Loss of libido

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Oestradiol hemihydrate / ZUMENON TABLETS

Side effects:13
Source:medicines.org.au

ESTRADIOL / CLIMARA

Side effects:21
Source:FDA

ESTRADIOL

Side effects:25
Source:FDA Structured Product Label

ESTRADIOL

Side effects:26
Source:FDA Structured Product Label

ESTRADIOL

Side effects:28
Source:FDA Structured Product Label

ESTRADIOL / EVAMIST

Side effects:32
Source:FDA

Estradiol

Side effects:34
Source:FDA Structured Product Label

ESTRADIOL

Side effects:38
Source:FDA Structured Product Label

ESTRADIOL

Side effects:44
Source:FDA Structured Product Label

ESTRADIOL / ESTROGEL

Side effects:49
Source:Health Canada

estradiol transdermal system / Alora

Side effects:53
Source:FDA

estradiol

Side effects:55
Source:FDA Structured Product Label

ESTRADIOL

Side effects:65
Source:FDA Structured Product Label

oestradiol / Estradot, Transdermal patch

Side effects:65
Source:Medsafe

ESTRADIOL

Side effects:66
Source:FDA Structured Product Label

ESTRADIOL / ESTRING

Side effects:72
Source:Health Canada

Estradiol / Estrogel

Side effects:77
Source:FDA

ESTRADIOL

Side effects:85
Source:FDA Structured Product Label

ESTRADIOL / ALORA

Side effects:91
Source:FDA

ESTRADIOL

Side effects:96
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label