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Estradiol

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: G03CA03, L02AA02

Side effects

Options: Show MedDRA Preferred Terms,   display all 56 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Respiratory tract infection 16.1% - 24.7% 26.4% x x x
Localized exfoliation very common x
Headache postmarketing — 5% - 50% 2.7% - 23.6% x x x x x x x x x x x x x x x x x x x
Endometrial disorder 1.8% - 15.1% 1.4% - 8.21%
Vulvovaginal mycotic infection 8.29% 2.91% x
Vulvovaginal pruritus 7.8% 1.94%
Application site reaction postmarketing — 0.6% - 56.7% 0% - 58.6% x x x x
Accidental injury 4.49% - 13.9% 4.6% - 11% x x x
Breast tenderness postmarketing — 2.46% - 17% 0% - 5.26% x x x x x x x x x x x
Back pain postmarketing, 0% - 10.6% 1.3% - 6.38% x x x x x x x x x x x
Cervical polyp 6.25% 1.91%
Nasopharyngitis 1.32% - 19.6% 1.3% - 15.3% x x x x x
Genital candidiasis uncommon, 5.49% - 7% 2.13% x x x
Breast pain female 3% - 9% 0% x
Breast pain postmarketing — 1% - 34.8% 2.99% - 9.6% x x x x x x x
Upper respiratory tract infection 1.6% - 17% 1.6% - 16.7% x x x x x x
Influenza 0% - 13.3% 0% - 10.3% x x x x x
Metrorrhagia postmarketing — 0% - 10.6% 0% - 4.46% x x x x x x x x x x x x x x x
Sinusitis 1.77% - 13.1% 1.4% - 18.4% x x x x x x x
Menstrual disorder common x
Pain postmarketing, 0% - 12.5% 4.46% - 12.6% x x x x x x x x x x x x x
Vaginal discomfort 5% x
Weight fluctuation common x
Cervical discharge common x
Sinus headache 0% - 10.9% 5.1% x x
Influenza like illness 0% - 7.77% 6.37% x x
Perineal pain 1% - 8% 0%
Bronchitis 3.45% - 7.87% 4.31% - 6.9% x x x
Leukorrhea 1% - 10.6% 1% - 1.15% x x x x
Dyspepsia 0% - 9.23% 1.15% - 6.37% x x x x x x
Pain in extremity postmarketing, 0% - 7.69% 2.78% - 5.73% x x x x
Abdominal pain postmarketing — 0% - 16% 1.4% - 8.13% x x x x x x x x x
Rhinitis 2% - 6% 1% - 6.8% x
Vaginal haemorrhage postmarketing — 1.2% - 16.7% 0% - 4.6% x x x x x x x x x x x x x
Fungal infection 0% - 10% 1.15% x x x
Constipation postmarketing, 1.12% - 6.67% 2.55% - 4.6% x x x x x
Arthralgia postmarketing, 0% - 12.4% 0% - 13.8% x x x x x x x x x x x
Neck pain 0% - 6.38% 1.27% x x
Gastroenteritis 0% - 4.44% 2.3% x x x
Infection 1.15% - 17.3% 2.3% - 7.46% x x x x x x x x
Flatulence postmarketing, 1% - 7% 1% - 5.75% x x x x x x
Vaginal moniliasis postmarketing, 6.19% - 10.7% 2.78% x x x x x x x
Uterine pain 1.77% - 4.46% 0.926% x
Vulvovaginitis 0.893% - 5.31% 6.48%
Sinus congestion 0% - 6.52% 4.46% x x
Depression postmarketing — 0% - 10.6% 0% - 9.2% x x x x x x x x x x x x x x
Candida infection 1% - 5% 2%
Arthritis postmarketing, 2% - 5.29% 7.18%
Bone pain 2% - 4%
Urinary tract infection 0.885% - 7% 1.85% - 2.3% x x x x
Pneumonia 0.575% - 4.49% 4.6% x x x
Reproductive tract disorder 2.65% - 2.68% 8.33%
Pharyngitis 0.5% - 7% 1.15% - 3% x x x x
Nausea postmarketing — 0% - 6.74% 1.32% - 6.49% x x x x x x x x x x x x x x x x x x
Nipple pain postmarketing, 0.735% - 6.76% 0% x x
Oedema peripheral 0% - 4.44% 0% - 4.6% x x x x
Breast neoplasm 1.12% - 5.56% 6.9% x x x
Abnormal withdrawal bleeding postmarketing, common x x x x x x x x x
Influenza-like symptoms 2% - 3%
Family stress 2% - 3%
Vaginal mycosis 0.82% - 6.4% 3.2% x
Asthenia postmarketing, 0% - 7.87% 4.1% - 4.6% x x x x
Cough increased 1.12% - 4.44% 2.3% x x x
Conjunctivitis 0% - 3.33% 2.3% x x x
Asthma 1.12% - 3.37% 1.15% x x x
Pruritus genital postmarketing, 4% - 6% 0% x x x
Vaginal inflammation postmarketing, 0% - 8.9% 4.1% - 6.9% x x x x x x x x x
Insomnia postmarketing, 0% - 6.38% 5.73% - 8.05% x x x x x x x x
Myalgia postmarketing, 1.72% - 5.62% 2.87% - 4.6% x x x x
Cyst 0% - 6.67% 3.45% x x x x x
Pruritus postmarketing — 0.5% - 7.8% 0% - 6% x x x x x x
Otitis media 0% - 3.37% 2.3% x x x
Vasodilation 0% - 6.74% 14.9% x x x
Vaginal discharge postmarketing, 1.47% - 3.52% 0.73% - 8.33% x x x
Ear and labyrinth disorders 0% - 6.52% 3.18%
Anxiety NEC 0% - 6.38% 2.55% x x
Weight increased postmarketing, 0% - 8.51% 0% - 4.6% x x x x x x x x x
Chest pain postmarketing, 1.12% - 4.49% 4.6% x x x x
Hypersensitivity postmarketing, 0.575% - 4.49% 2.3% x x x
Libido increased postmarketing, uncommon x x
Cramp muscle uncommon x x x
Breast enlargement postmarketing — 1.12% - 6.74% 3.45% x x x x x x x
Vaginal irritation postmarketing, 0.885% - 1.79% 3.7% x x
Oedema postmarketing — 0.5% - 13% 6% x x x x x x x x x x x x x x
Abdominal cramps postmarketing x x x x x x x
Abdominal distension postmarketing — 2.68% - 7.08% 2.78% x x x
Alopecia postmarketing, uncommon x
Amenorrhoea postmarketing x
Anaphylactic shock postmarketing x x x x x x x x x
Angioedema postmarketing x x x x x x x x x
Anxiety postmarketing, 0% - 10% 0% - 3.45% x x x
Aphasia postmarketing
Breast cancer postmarketing x x x x
Breast disorder postmarketing x x x x x x x x
Breast swelling postmarketing x x
Transient ischaemic attack postmarketing x
Cholecystitis postmarketing x
Cholelithiasis postmarketing x x
Chorea postmarketing x x x x x x x x x
Contusion postmarketing x
Cough postmarketing
Libido decreased postmarketing
Diarrhoea postmarketing, 1.12% - 5.37% 0% - 2.3% x x x x x x x x
Dizziness postmarketing — 0.575% - 7.78% 0% - 2.87% x x x x x x x x x x x x x
Dysgeusia postmarketing
Dyspnoea postmarketing x
Eczema postmarketing x
Endometrial hyperplasia postmarketing, 0% - 0.704% 0% x x x
Epilepsy postmarketing x x x x x x x
Erythema multiforme postmarketing x x x x x x x x x x
Erythema nodosum postmarketing x x x x x x x x x x x
Rash postmarketing — 2.87% - 8.89% 5.5% - 5.75% x x x x x x x x x x x x x
Fatigue postmarketing x x x
Body temperature increased postmarketing x
Fibrocystic breast disease postmarketing x x x x x x x x x
Flushing postmarketing
Gallbladder disorder postmarketing x x x x x x x x x x x
Gynaecomastia postmarketing x
Haemangioma postmarketing x x x x x
Hemiparesis postmarketing x
Haemorrhage postmarketing x x
Hirsutism postmarketing — 0.575% - 4.49% 0% x x x x x x x x x x x
Hyperhidrosis postmarketing
Hypoaesthesia postmarketing, 0% - 3.37% 2.3% x x x
Hypocalcaemia postmarketing x x x x x x x
Inflammation postmarketing x x
Intestinal obstruction postmarketing x
Irritability postmarketing x x x x x x x x x x x
Jaundice cholestatic postmarketing x x x x x x x x x
Arthropathy postmarketing, 0% - 4.49% 2.3% x x x
Cramps of lower extremities postmarketing x x x x x x x x
Lethargy postmarketing
Breast mass postmarketing x
Chloasma postmarketing x x x x x x x x x x
Meningioma postmarketing
Menorrhagia postmarketing x x
Myocardial infarction postmarketing x x x x x x x x
Myoclonus postmarketing
Nervousness postmarketing, 2.4% 1.4% x x x x x x x x x x x x
Night sweats postmarketing
Ovarian cyst postmarketing x x x
Palpitations postmarketing, 0.6% 1.4% x x x
Pancreatitis postmarketing x x x x x x x
Paraesthesia postmarketing x
Pelvic pain postmarketing
Phlebitis postmarketing
Porphyrin metabolism disorder postmarketing x x x x x x x x
Prurigo postmarketing x x x
Anal pruritus postmarketing
Pulmonary embolism postmarketing x x x x x x x x x x
Purpura postmarketing x x
Retinal vein occlusion postmarketing x
Pigmentation skin postmarketing x
Muscle spasms postmarketing x
Cerebrovascular accident postmarketing x x x x x x x x x
Sunburn postmarketing x
Swelling postmarketing x x
Syncope postmarketing x
Tachycardia postmarketing x x
Thrombophlebitis postmarketing x x x x x x x x x x
Thrombosis postmarketing x x x
Tremor postmarketing x
Ulcer postmarketing x
Erythema postmarketing x x x x x
Urethral disorder postmarketing
Pollakiuria postmarketing
Urticaria postmarketing x x x x x x x x x x x x
Uterine leiomyoma postmarketing, uncommon x x x x x x x x
Uterine haemorrhage postmarketing
Vomiting postmarketing, uncommon x x x x x x x x x x x x
Vulval disorder postmarketing
Weight decreased postmarketing
Dry mouth postmarketing
Mood swings postmarketing
Breast engorgement postmarketing
Breast discharge postmarketing x x x x x x x x x
Deep vein thrombosis postmarketing x x x
Migraine postmarketing — 0% - 6.74% 2.3% x x x x x x x x x x x x x
Oedema genital postmarketing
Ventricular extrasystoles postmarketing x
Myocardial ischaemia postmarketing
Liver function test abnormal postmarketing x x
Skin discolouration postmarketing x
Dry skin postmarketing x
Uterine enlargement postmarketing x
Uterine cancer postmarketing x
Ocular hyperaemia postmarketing
Menstruation irregular postmarketing x
Malnutrition postmarketing, 12% 10.5% x
Contact lens intolerance postmarketing x x
Malaise postmarketing x
Decreased appetite postmarketing
Discomfort postmarketing x x x
Tenderness postmarketing x x x x x x x x
Dry throat postmarketing
Eye irritation postmarketing
Upset stomach postmarketing
Superficial phlebothrombosis postmarketing x x x x x x x
Galactorrhoea postmarketing x x x x x x x
Chest discomfort postmarketing x
Migraine aggravated postmarketing x x
Dermatitis hemorrhagic postmarketing x x x x x x
Menopausal symptoms postmarketing
Vaginal pain postmarketing x x
Heart rate irregular postmarketing x
Facial rash postmarketing x
Hepatitis acute postmarketing
Fluid retention postmarketing x x x
Ectropion of cervix postmarketing x x x x x x
Glucose tolerance impaired postmarketing x
Papule postmarketing x
Malignant mesenchymoma postmarketing
Anaphylactoid reaction postmarketing x x
Exacerbation of asthma postmarketing x x x x x x x
Enlargement abdomen postmarketing
Blindness postmarketing x
Endometrial cancer postmarketing x x x x x x x x x x x x
Blood pressure increased postmarketing x x x x x x x x x x x x
Dementia postmarketing x x x x x x
Application site rash postmarketing x
Drug effect decreased postmarketing
Pre-existing disease postmarketing x
Face oedema postmarketing
Visual disturbance postmarketing x x
Bradyphrenia postmarketing
Vaginal ulceration postmarketing x x
Gait disturbance postmarketing
Hot flush postmarketing, 0% - 6.38% 3.82% x x
Toxic shock syndrome postmarketing x
Generalised erythema postmarketing x
Drug ineffective postmarketing x
Retinal vascular thrombosis postmarketing x x x x x x x
Medical device complication postmarketing x
Ovarian cancer postmarketing x x x x x x x
Change in blood pressure postmarketing
Abdominal bloating postmarketing, common x x x x x x x x x
Feeling abnormal postmarketing x
Vaginismus postmarketing x x
Mood alteration NOS postmarketing x x x x x x x x x
Bleeding breakthrough postmarketing x x x x x x x x x x x
Abnormal vision postmarketing
Congenital anomaly
Amnesia
Bacterial infection
Mental disorder x x x x
Blepharitis
Clotting x
Bone disorder
Bronchospasm
Neoplasm malignant x x x x x x x x
Basal cell carcinoma
Cardiovascular disorder x x x x x x x
Carpal tunnel syndrome
Cerebrovascular disorder
Uterine cervical erosion x x
Common cold
Confusional state
Connective tissue disorder x x x x
Coronary artery thrombosis x x
Cystitis x x
Dysphagia
Dermatitis
Dermatitis contact
Diverticulitis
Dysmenorrhoea postmarketing, 0% - 6.52% 0% x x x x x x x x x x
Ear disorder
Ear pain 0% - 2.91% 0%
Embolism x
Emotional disturbance NOS
Endocrine disorder
Endometriosis x x
Epistaxis x
Eye disorder
Eye infection
Foetal disorder
Gastritis
Gastrooesophageal reflux disease
Gastrointestinal disorder x x x x x
Goitre
Cardiac disorder x
Haematoma
Haematuria
Haemoptysis x
Haemorrhoids
Hepatitis
Hereditary angioedema
Herpes simplex
Herpes zoster
Hypercalcaemia x x
Hyperaesthesia
Hyperglycaemia x x
Hypernatraemia x x
Hypertension 0% - 6.74% 1.27% - 3.45% x x x x x x
Immune system disorder x x
Incontinence
Jaundice x
Laryngitis
Leg pain x x
Hepatic neoplasm x
Mediastinal disorder x x x
Hypertonia
Musculoskeletal pain x x
Nail disorder
Nasal congestion
Neoplasm x x x
Nervous system disorder x x x x
Neuritis x x
Numbness
Optic neuritis x x
Osteoarthritis
Polyp x x
Polyuria
Tension headache
Shock x
Skin disorder
Skin ulcer
Thromboembolism x x
Tinnitus
Tooth disorder
Toothache
Urinary incontinence
Urinary tract disorder
Vaginal disorder
Vaginal itching x x
Varicose vein x x
Angiopathy x x x
Vertigo
Viral infection
Disorder sight
Muscle strain
Agitation
Hepatic function abnormal x x
Neck stiffness
Glucose tolerance decreased x x
Skin hypertrophy
Phosphatase alkaline increased
Alanine aminotransferase increased
Withdrawal bleed
Benign vaginal neoplasm
Eyelid oedema
Porphyria cutanea tarda x
Allergic contact dermatitis x x
Unspecified disorder of skin and subcutaneous tissue x x
Increased appetite
Abdominal discomfort x x x
Abdominal pain upper x
Abdominal pain lower x
Ache
Slurred speech
Rash erythematous x
Muscle contractions involuntary
Vein pain x
Breast oedema x
Vaginitis ulcerative
Leg edema
Arthritis aggravated
Skin tenderness
Superficial thrombophlebitis of leg
Breast malformation
Hepatobiliary disease
Eruption x x
Dry eye x
Redness x x x
Embolism venous x
Pulse irregular
Increased tendency to bruise x
Rigors
Gastrointestinal symptom NOS
Jerky movement NOS
Joint sprain
Pruritus generalised x
Lymphadenopathy
Rash generalised x
Tooth abscess
Vulvovaginal discomfort x
Application site irritation x x
Carbohydrate tolerance decreased x
Speech loss
Toxic reaction (NOS)
Pelvic venous thrombosis x
Mass x
Bladder infection
Drug interaction
Ear infection
Sweating increased
Acne
Infestation NOS x x x x x
Blood and lymphatic system disorders
Blood oestrogen increased x
Arthropod bite
Application site erythema
Breast cancer invasive NOS x
Pharyngolaryngeal pain
Peripheral swelling
Breast discomfort x
Raised liver function tests
Pleural infection
Hearing impaired
Vulva discomfort
Somnolence
Loss of libido

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Oestradiol hemihydrate / ZUMENON TABLETS

Side effects:13
Source:medicines.org.au

ESTRADIOL / CLIMARA

Side effects:21
Source:FDA

ESTRADIOL

Side effects:25
Source:FDA Structured Product Label

ESTRADIOL

Side effects:26
Source:FDA Structured Product Label

ESTRADIOL / EVAMIST

Side effects:32
Source:FDA

Estradiol

Side effects:34
Source:FDA Structured Product Label

ESTRADIOL

Side effects:38
Source:FDA Structured Product Label

ESTRADIOL / ESTROGEL

Side effects:49
Source:Health Canada

VAGIFEM / Vagifem, Vaginal tablet

Side effects:51
Source:Medsafe

estradiol transdermal system / Alora

Side effects:53
Source:FDA

estradiol

Side effects:55
Source:FDA Structured Product Label

ESTRADIOL / ESTRADERM

Side effects:55
Source:FDA

ESTRADIOL

Side effects:57
Source:FDA Structured Product Label

oestradiol / Estradot, Transdermal patch

Side effects:65
Source:Medsafe

ESTRADIOL

Side effects:66
Source:FDA Structured Product Label

ESTRADIOL

Side effects:69
Source:FDA Structured Product Label

ESTRADIOL

Side effects:85
Source:FDA Structured Product Label

ESTRADIOL / ALORA

Side effects:91
Source:FDA

ESTRADIOL / ALORA

Side effects:93
Source:FDA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label