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Estradiol

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: G03CA03, L02AA02

Side effects

Options: Show MedDRA Preferred Terms,   display all 56 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Respiratory tract infection 16.1% - 24.7% 26.4% x x
Localized exfoliation very common
Headache postmarketing — 5% - 50% 2.7% - 23.6% x x x x x x x x x x x x x x x x x x x
Endometrial disorder 1.8% - 15.1% 1.4% - 8.21% x
Vulvovaginal mycotic infection 8.29% 2.91% x
Vulvovaginal pruritus 7.8% 1.94%
Application site reaction postmarketing — 0.6% - 56.7% 0% - 58.6% x x
Accidental injury 4.49% - 13.9% 4.6% - 11% x x
Breast tenderness postmarketing — 2.46% - 17% 0% - 5.26% x x x x x x x x x x
Back pain postmarketing, 0% - 10.6% 1.3% - 6.38% x x x x x x x x x x x
Cervical polyp 6.25% 1.91%
Nasopharyngitis 1.32% - 19.6% 1.3% - 15.3% x x x x x x
Genital candidiasis uncommon, 5.49% - 7% 2.13% x x
Breast pain female 3% - 9% 0% x
Breast pain postmarketing — 1% - 34.8% 2.99% - 9.6% x x x x x x x x
Upper respiratory tract infection 1.6% - 17% 1.6% - 16.7% x x x x x x x x
Influenza 0% - 13.3% 0% - 10.3% x x x x
Metrorrhagia postmarketing — 0% - 10.6% 0% - 4.46% x x x x x x x x x x x x x x x
Sinusitis 1.77% - 13.1% 1.4% - 18.4% x x x x x x x x x
Menstrual disorder common
Pain postmarketing, 0% - 12.5% 4.46% - 12.6% x x x x x x x x x x x x x x
Vaginal discomfort 5% x
Weight fluctuation common
Cervical discharge common
Sinus headache 0% - 10.9% 5.1% x x
Influenza like illness 0% - 7.77% 6.37% x x
Perineal pain 1% - 8% 0%
Bronchitis 3.45% - 7.87% 4.31% - 6.9% x x x x x
Leukorrhea 1% - 10.6% 1% - 1.15% x x x x x
Dyspepsia 0% - 9.23% 1.15% - 6.37% x x x x x x
Pain in extremity postmarketing, 0% - 7.69% 2.78% - 5.73% x x x
Abdominal pain postmarketing — 0% - 16% 1.4% - 8.13% x x x x x x x x x
Rhinitis 2% - 6% 1% - 6.8% x x x
Vaginal haemorrhage postmarketing — 1.2% - 16.7% 0% - 4.6% x x x x x x x x x x x
Fungal infection 0% - 10% 1.15% x x x x
Constipation postmarketing, 1.12% - 6.67% 2.55% - 4.6% x x x x x
Arthralgia postmarketing, 0% - 12.4% 0% - 13.8% x x x x x x x x x x x x x
Neck pain 0% - 6.38% 1.27% x x
Gastroenteritis 0% - 4.44% 2.3% x x
Infection 1.15% - 17.3% 2.3% - 7.46% x x x x x x x x x
Flatulence postmarketing, 1% - 7% 1% - 5.75% x x x x x x
Vaginal moniliasis postmarketing, 6.19% - 10.7% 2.78% x x x x x x x
Uterine pain 1.77% - 4.46% 0.926% x
Vulvovaginitis 0.893% - 5.31% 6.48%
Sinus congestion 0% - 6.52% 4.46% x x
Depression postmarketing — 0% - 10.6% 0% - 9.2% x x x x x x x x x x x x x x
Candida infection 1% - 5% 2% x
Arthritis postmarketing, 2% - 5.29% 7.18% x x x
Bone pain 2% - 4% x
Urinary tract infection 0.885% - 7% 1.85% - 2.3% x x x x x x
Pneumonia 0.575% - 4.49% 4.6% x x
Reproductive tract disorder 2.65% - 2.68% 8.33%
Pharyngitis 0.5% - 7% 1.15% - 3% x x x x x x
Nausea postmarketing — 0% - 6.74% 1.32% - 6.49% x x x x x x x x x x x x x x x x x x
Nipple pain postmarketing, 0.735% - 6.76% 0% x x x
Oedema peripheral 0% - 4.44% 0% - 4.6% x x x
Breast neoplasm 1.12% - 5.56% 6.9% x x
Abnormal withdrawal bleeding postmarketing, common x x x x x x x
Influenza-like symptoms 2% - 3% x
Family stress 2% - 3% x
Vaginal mycosis 0.82% - 6.4% 3.2% x
Asthenia postmarketing, 0% - 7.87% 4.1% - 4.6% x x x
Cough increased 1.12% - 4.44% 2.3% x x
Conjunctivitis 0% - 3.33% 2.3% x x
Asthma 1.12% - 3.37% 1.15% x x
Pruritus genital postmarketing, 4% - 6% 0% x x
Vaginal inflammation postmarketing, 0% - 8.9% 4.1% - 6.9% x x x x x x x x x
Insomnia postmarketing, 0% - 6.38% 5.73% - 8.05% x x x x x x x x x
Myalgia postmarketing, 1.72% - 5.62% 2.87% - 4.6% x x x x x
Cyst 0% - 6.67% 3.45% x x
Pruritus postmarketing — 0.5% - 7.8% 0% - 6% x x x x
Otitis media 0% - 3.37% 2.3% x x x
Vasodilation 0% - 6.74% 14.9% x x
Vaginal discharge postmarketing, 1.47% - 3.52% 0.73% - 8.33% x x
Ear and labyrinth disorders 0% - 6.52% 3.18% x x
Anxiety NEC 0% - 6.38% 2.55% x x
Weight increased postmarketing, 0% - 8.51% 0% - 4.6% x x x x x x x x
Chest pain postmarketing, 1.12% - 4.49% 4.6% x x x x x x
Hypersensitivity postmarketing, 0.575% - 4.49% 2.3% x x x
Libido increased postmarketing, uncommon x
Cramp muscle uncommon x x x x
Breast enlargement postmarketing — 1.12% - 6.74% 3.45% x x x x x
Vaginal irritation postmarketing, 0.885% - 1.79% 3.7% x
Oedema postmarketing — 0.5% - 13% 6% x x x x x x x x x x x x x
Abdominal cramps postmarketing x x x x x x x
Abdominal distension postmarketing — 2.68% - 7.08% 2.78% x x
Alopecia postmarketing, uncommon
Amenorrhoea postmarketing x
Anaphylactic shock postmarketing x x x x x x x x
Angioedema postmarketing x x x x x x x x
Anxiety postmarketing, 0% - 10% 0% - 3.45% x x x x x
Aphasia postmarketing
Breast cancer postmarketing x x x
Breast disorder postmarketing x x x x x x x x x
Breast swelling postmarketing x x x
Transient ischaemic attack postmarketing x
Cholecystitis postmarketing x
Cholelithiasis postmarketing x
Chorea postmarketing x x x x x x x x
Contusion postmarketing
Cough postmarketing x x
Libido decreased postmarketing x
Diarrhoea postmarketing, 1.12% - 5.37% 0% - 2.3% x x x x x x
Dizziness postmarketing — 0.575% - 7.78% 0% - 2.87% x x x x x x x x x x x x x x
Dysgeusia postmarketing
Dyspnoea postmarketing
Eczema postmarketing
Endometrial hyperplasia postmarketing, 0% - 0.704% 0% x x
Epilepsy postmarketing x x x x x x x
Erythema multiforme postmarketing x x x x x x x x x x
Erythema nodosum postmarketing x x x x x x x x x x
Rash postmarketing — 2.87% - 8.89% 5.5% - 5.75% x x x x x x x x x x x
Fatigue postmarketing x x x x
Body temperature increased postmarketing x
Fibrocystic breast disease postmarketing x x x x x x x x
Flushing postmarketing
Gallbladder disorder postmarketing x x x x x x x x x x x x
Gynaecomastia postmarketing x
Haemangioma postmarketing x x x x
Hemiparesis postmarketing x
Haemorrhage postmarketing x
Hirsutism postmarketing — 0.575% - 4.49% 0% x x x x x x x x x x x
Hyperhidrosis postmarketing
Hypoaesthesia postmarketing, 0% - 3.37% 2.3% x x x
Hypocalcaemia postmarketing x x x x x x x
Inflammation postmarketing
Intestinal obstruction postmarketing x
Irritability postmarketing x x x x x x x x x x
Jaundice cholestatic postmarketing x x x x x x x x x
Arthropathy postmarketing, 0% - 4.49% 2.3% x x x
Cramps of lower extremities postmarketing x x x x x x x x
Lethargy postmarketing
Breast mass postmarketing x
Chloasma postmarketing x x x x x x x x x x
Meningioma postmarketing
Menorrhagia postmarketing x
Myocardial infarction postmarketing x x x x x x x
Myoclonus postmarketing
Nervousness postmarketing, 2.4% 1.4% x x x x x x x x x x x
Night sweats postmarketing
Ovarian cyst postmarketing x x x
Palpitations postmarketing, 0.6% 1.4% x x x
Pancreatitis postmarketing x x x x x x x
Paraesthesia postmarketing
Pelvic pain postmarketing x x
Phlebitis postmarketing
Porphyrin metabolism disorder postmarketing x x x x x x x x
Prurigo postmarketing x x
Anal pruritus postmarketing x
Pulmonary embolism postmarketing x x x x x x x x
Purpura postmarketing
Retinal vein occlusion postmarketing x
Pigmentation skin postmarketing
Muscle spasms postmarketing x x
Cerebrovascular accident postmarketing x x x x x x x x
Sunburn postmarketing x
Swelling postmarketing
Syncope postmarketing x x x
Tachycardia postmarketing x
Thrombophlebitis postmarketing x x x x x x x x x x
Thrombosis postmarketing x x x
Tremor postmarketing x
Ulcer postmarketing x
Erythema postmarketing x x x
Urethral disorder postmarketing x
Pollakiuria postmarketing x
Urticaria postmarketing x x x x x x x x x x x
Uterine leiomyoma postmarketing, uncommon x x x x x x x
Uterine haemorrhage postmarketing x
Vomiting postmarketing, uncommon x x x x x x x x x x x x
Vulval disorder postmarketing x
Weight decreased postmarketing x
Dry mouth postmarketing
Mood swings postmarketing
Breast engorgement postmarketing x
Breast discharge postmarketing x x x x x x x x
Deep vein thrombosis postmarketing x
Migraine postmarketing — 0% - 6.74% 2.3% x x x x x x x x x x x x x x
Oedema genital postmarketing x
Ventricular extrasystoles postmarketing x
Myocardial ischaemia postmarketing
Liver function test abnormal postmarketing
Skin discolouration postmarketing
Dry skin postmarketing
Uterine enlargement postmarketing x
Uterine cancer postmarketing x
Ocular hyperaemia postmarketing
Menstruation irregular postmarketing x
Malnutrition postmarketing, 12% 10.5% x x
Contact lens intolerance postmarketing x
Malaise postmarketing x x
Decreased appetite postmarketing
Discomfort postmarketing x
Tenderness postmarketing x x x x x x x x x x
Dry throat postmarketing
Eye irritation postmarketing
Upset stomach postmarketing
Superficial phlebothrombosis postmarketing x x x x x x x
Galactorrhoea postmarketing x x x x x x x
Chest discomfort postmarketing x
Migraine aggravated postmarketing x
Dermatitis hemorrhagic postmarketing x x x x x x x x
Menopausal symptoms postmarketing
Vaginal pain postmarketing x
Heart rate irregular postmarketing x
Facial rash postmarketing x
Hepatitis acute postmarketing
Fluid retention postmarketing x x
Ectropion of cervix postmarketing x x x x x x
Glucose tolerance impaired postmarketing x x
Papule postmarketing
Malignant mesenchymoma postmarketing
Anaphylactoid reaction postmarketing
Exacerbation of asthma postmarketing x x x x x x x
Enlargement abdomen postmarketing x
Blindness postmarketing x
Endometrial cancer postmarketing x x x x x x x x x x
Blood pressure increased postmarketing x x x x x x x x x x x x x x
Dementia postmarketing x x x x
Application site rash postmarketing x
Drug effect decreased postmarketing
Pre-existing disease postmarketing x x
Face oedema postmarketing
Visual disturbance postmarketing x x
Bradyphrenia postmarketing
Vaginal ulceration postmarketing x
Gait disturbance postmarketing
Hot flush postmarketing, 0% - 6.38% 3.82% x x x
Toxic shock syndrome postmarketing x
Generalised erythema postmarketing x
Drug ineffective postmarketing
Retinal vascular thrombosis postmarketing x x x x x x x
Medical device complication postmarketing x
Ovarian cancer postmarketing x x x x x x
Change in blood pressure postmarketing
Abdominal bloating postmarketing, common x x x x x x x x x
Feeling abnormal postmarketing x
Vaginismus postmarketing x
Mood alteration NOS postmarketing x x x x x x x x x
Bleeding breakthrough postmarketing x x x x x x x x x x x
Abnormal vision postmarketing x x
Congenital anomaly
Amnesia x
Bacterial infection x
Mental disorder x x x
Blepharitis
Clotting
Bone disorder
Bronchospasm
Neoplasm malignant x x x x x x x x x
Basal cell carcinoma
Cardiovascular disorder x x x x x x x
Carpal tunnel syndrome x
Cerebrovascular disorder
Uterine cervical erosion x x x
Common cold
Confusional state
Connective tissue disorder x x x x x
Coronary artery thrombosis x x
Cystitis x x x
Dysphagia
Dermatitis x x
Dermatitis contact
Diverticulitis
Dysmenorrhoea postmarketing, 0% - 6.52% 0% x x x x x x x x x x x
Ear disorder
Ear pain 0% - 2.91% 0% x x
Embolism
Emotional disturbance NOS x
Endocrine disorder x
Endometriosis x x x
Epistaxis
Eye disorder x
Eye infection
Foetal disorder
Gastritis x
Gastrooesophageal reflux disease
Gastrointestinal disorder x x x x x
Goitre
Cardiac disorder x
Haematoma
Haematuria
Haemoptysis
Haemorrhoids x x
Hepatitis
Hereditary angioedema x
Herpes simplex x
Herpes zoster x
Hypercalcaemia x x x x
Hyperaesthesia x
Hyperglycaemia x x
Hypernatraemia x x
Hypertension 0% - 6.74% 1.27% - 3.45% x x x x x
Immune system disorder x x
Incontinence
Jaundice
Laryngitis x
Leg pain x x
Hepatic neoplasm
Mediastinal disorder x x x
Hypertonia
Musculoskeletal pain x x
Nail disorder
Nasal congestion x
Neoplasm x x x
Nervous system disorder x x x
Neuritis x x
Numbness
Optic neuritis x x
Osteoarthritis x
Polyp
Polyuria x
Tension headache x
Shock
Skin disorder
Skin ulcer
Thromboembolism x x
Tinnitus x
Tooth disorder x
Toothache x x
Urinary incontinence x x
Urinary tract disorder x
Vaginal disorder x
Vaginal itching x x x
Varicose vein x
Angiopathy x x x
Vertigo x
Viral infection x
Disorder sight
Muscle strain x
Agitation
Hepatic function abnormal x x
Neck stiffness
Glucose tolerance decreased x x
Skin hypertrophy x
Phosphatase alkaline increased
Alanine aminotransferase increased
Withdrawal bleed
Benign vaginal neoplasm
Eyelid oedema
Porphyria cutanea tarda
Allergic contact dermatitis x
Unspecified disorder of skin and subcutaneous tissue x x
Increased appetite
Abdominal discomfort x x
Abdominal pain upper x
Abdominal pain lower
Ache
Slurred speech
Rash erythematous
Muscle contractions involuntary
Vein pain
Breast oedema
Vaginitis ulcerative
Leg edema x
Arthritis aggravated
Skin tenderness
Superficial thrombophlebitis of leg
Breast malformation x
Hepatobiliary disease x
Eruption x x
Dry eye
Redness x x
Embolism venous
Pulse irregular
Increased tendency to bruise
Rigors x
Gastrointestinal symptom NOS x
Jerky movement NOS
Joint sprain x
Pruritus generalised
Lymphadenopathy
Rash generalised
Tooth abscess x
Vulvovaginal discomfort
Application site irritation x x
Carbohydrate tolerance decreased
Speech loss
Toxic reaction (NOS) x
Pelvic venous thrombosis
Mass
Bladder infection x
Drug interaction x
Ear infection x
Sweating increased x
Acne x
Infestation NOS x x x x x x
Blood and lymphatic system disorders x
Blood oestrogen increased
Arthropod bite x
Application site erythema x
Breast cancer invasive NOS x
Pharyngolaryngeal pain x
Peripheral swelling x
Breast discomfort
Raised liver function tests
Pleural infection x
Hearing impaired
Vulva discomfort
Somnolence x x
Loss of libido

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Oestradiol hemihydrate / ZUMENON TABLETS

Side effects:13
Source:medicines.org.au

ESTRADIOL / CLIMARA

Side effects:21
Source:FDA

ESTRADIOL

Side effects:25
Source:FDA Structured Product Label

ESTRADIOL

Side effects:26
Source:FDA Structured Product Label

ESTRADIOL

Side effects:28
Source:FDA Structured Product Label

ESTRADIOL / EVAMIST

Side effects:32
Source:FDA

Estradiol

Side effects:34
Source:FDA Structured Product Label

ESTRADIOL

Side effects:38
Source:FDA Structured Product Label

ESTRADIOL / ESTROGEL

Side effects:49
Source:Health Canada

estradiol transdermal system / Alora

Side effects:53
Source:FDA

estradiol

Side effects:55
Source:FDA Structured Product Label

ESTRADIOL / ESTRADERM

Side effects:55
Source:FDA

ESTRADIOL HEMIHYDRATE / ESTRASORB

Side effects:57
Source:FDA

ESTRADIOL

Side effects:65
Source:FDA Structured Product Label

ESTRADIOL

Side effects:66
Source:FDA Structured Product Label

ESTRADIOL

Side effects:69
Source:FDA Structured Product Label

ESTRADIOL / ESTRING

Side effects:72
Source:Health Canada

ESTRADIOL / ALORA

Side effects:91
Source:FDA

ESTRADIOL (ESTRADIOL HEMIHYDRATE) / CLIMARA 75

Side effects:117
Source:Health Canada

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label