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Copolymer 1

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L03AX13

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Injection site reaction Injection site reaction 6.5% x x x
Fibrocystic breast disease Fibrocystic breast disease infrequent x x x
Flank pain Flank pain infrequent x x x
Nephrolithiasis Calculus of kidney infrequent x x x
Breast pain Breast pain infrequent x x
Nocturia Nocturia infrequent x x x
Ovarian cyst Ovarian cyst infrequent x x x
Priapism Priapism infrequent x x x
Pyelonephritis Pyelonephritis infrequent x x x
Urethritis Urethritis infrequent x x x
Urethritis noninfective Urethritis infrequent x x x
Vaginal inflammation Vaginal inflammation infrequent x x x
Vaginal infection Vaginal inflammation infrequent x x x
Breast engorgement Breast engorgement infrequent x x x
Sexual dysfunction Sexual dysfunction infrequent x x x
Cervical dysplasia Cervix carcinoma stage 0 infrequent x x x
Cervix carcinoma stage 0 Cervix carcinoma stage 0 infrequent x x x
Breast enlargement Breast enlargement infrequent x x x
Angina pectoris Angina pectoris postmarketing x x x
Aphasia Aphasia postmarketing x x x
Arrhythmia Arrhythmia postmarketing x x x
Arthritis Rheumatoid arthritis postmarketing x x x
Arthritis x x x
Rheumatoid arthritis Rheumatoid arthritis postmarketing x x x
Cholelithiasis Cholelithiasis postmarketing x x x
Eructation Eructation postmarketing x x x
Glaucoma Glaucoma postmarketing x x x
Seasonal allergy Seasonal allergy postmarketing x x x
Rhinitis seasonal Seasonal allergy postmarketing x x x
Cardiomegaly Cardiomegaly postmarketing x x x
Cardiac failure congestive Cardiac failure congestive postmarketing x x x
Haemorrhage Haemorrhage postmarketing x
Haemoglobin Haemorrhage postmarketing x
Hepatitis Hepatitis postmarketing x x x
Hydrocephalus Hydrocephalus postmarketing x x x
Hypercholesterolaemia Hypercholesterolaemia postmarketing x x x
Hypersensitivity Hypersensitivity postmarketing x x x
Systemic lupus erythematosus Systemic lupus erythematosus postmarketing x x x
Meningitis Meningitis postmarketing x x x
Myelitis Myelitis postmarketing x x x
Myocardial infarction Myocardial infarction postmarketing x x x
Acute coronary syndrome Myocardial infarction postmarketing x x x
Nephrotic syndrome Nephrosis postmarketing x x x
Neuralgia Neuralgia postmarketing x x x
Ovarian cancer Ovarian carcinoma postmarketing x x x
Pericardial effusion Pericardial effusion postmarketing x x x
Pleural effusion Pleural effusion postmarketing x x x
Pulmonary embolism Pulmonary embolism postmarketing x x x
Renal failure Renal failure postmarketing x x x
Scotoma Scotoma postmarketing x x x
Convulsion Convulsion postmarketing x x x
Gastric ulcer Gastric ulcer postmarketing x
Cerebrovascular accident Cerebrovascular accident postmarketing x x x
Thrombocytopenia Thrombocytopenia postmarketing x x x
Thrombophlebitis Thrombophlebitis postmarketing x x x
Thrombosis Thrombosis postmarketing x x x
Pollakiuria Pollakiuria postmarketing x x x
Micturition urgency x x x
Genitourinary tract neoplasm Genitourinary tract neoplasm postmarketing x x x
Peripheral vascular disorder Peripheral vascular disorder postmarketing x x x
Central nervous system neoplasm Central nervous system neoplasm postmarketing x x x
Acute leukaemia Acute leukaemia postmarketing x x x
Tongue disorder Tongue oedema postmarketing x x x
Tongue oedema Tongue oedema postmarketing x x x
Injection site hypersensitivity Injection site hypersensitivity postmarketing x x x
Hepatocellular injury Hepatocellular injury postmarketing x x x
Liver injury Hepatocellular injury postmarketing x x x
Coronary artery occlusion Coronary artery occlusion postmarketing x x x
Muscle spasms Generalised spasm postmarketing x x x
Malnutrition Malnutrition postmarketing x x
Pseudolymphoma Pseudolymphoma postmarketing x x x
Abnormal dreams Abnormal dreams postmarketing x x x
Urine abnormality Urine abnormality postmarketing x x x
Urine analysis abnormal Urine abnormality postmarketing x x x
Sepsis Sepsis postmarketing x x x
Anaphylactic shock Anaphylactoid reaction postmarketing x x x
Anaphylactoid reaction Anaphylactoid reaction postmarketing x x x
Gastric ulcer haemorrhage Gastric ulcer haemorrhage postmarketing x x
Abdominal distension Enlargement abdomen postmarketing x x x
Blindness Blindness postmarketing x x x
Breast cancer Carcinoma breast postmarketing x x x
Lung neoplasm malignant Carcinoma of lung postmarketing x x x
Bladder cancer Bladder carcinoma postmarketing x x x
Cardiomyopathy Cardiomyopathy postmarketing x x x
Brain oedema Brain oedema postmarketing x x x
Abdominal pain Abdominal pain x x
Gastrointestinal pain Abdominal pain x x
Abscess Abscess x x x
Alopecia Alopecia x x
Amblyopia Amblyopia x x
Amenorrhoea Amenorrhoea x x x
Amnesia Amnesia x x
Anaemia Anaemia x x x
Angioedema Angioedema x x x
Decreased appetite Anorexia x x
Anxiety Anxiety x x x
Arthralgia Arthralgia x x x
Musculoskeletal discomfort Arthralgia x x x
Myalgia x x
Asthenia Asthenia x x x
Asthma Asthma x x x
Ataxia Ataxia x x x
Atrial fibrillation Atrial fibrillation x x x
Back pain Back pain x x x
Bacterial infection Bacterial infection x x
Mental disorder Mental disorder x
Benign neoplasm of skin Benign neoplasm of skin x x x
Bronchitis Bronchitis x x x
Bursitis Bursitis x x x
Candida infection Oral candidiasis x x x
Oral candidiasis Oral candidiasis x x x
Vulvovaginal candidiasis Vaginal moniliasis x x x
Vulvovaginal mycotic infection Vaginal moniliasis x x x
Cardiovascular disorder Cardiovascular disorder x
Cellulitis Cellulitis x x x
Neck pain Neck pain 4% - 8% x x
Chest pain Chest pain x x x
Cholecystitis Cholecystitis x x x
Colitis Colitis x x x
Coma Coma x x x
Infection Infection x x x
Confusional state Confusional state x x
Feeling abnormal Confusional state x x
Malaise x x
Conjunctivitis Conjunctivitis x x
Connective tissue disorder Connective tissue disorder x
Constipation Constipation x x
Ulcerative keratitis Ulcerative keratitis x x x
Cough Cough x
Cough increased x x
Cushing's syndrome Cushing's syndrome x x x
Cyanosis Cyanosis x x x
Cystitis Cystitis x x
Bladder pain Cystitis x x
Cystitis noninfective Cystitis x x
Cyst Cyst x x x
Deafness Deafness x x
Libido decreased Libido decreased x x x
Disturbance in sexual arousal Libido decreased x x x
Dysphagia Dysphagia x x x
Dental caries Dental caries x x x
Depersonalisation Depersonalisation x x x
Dermatitis Dermatitis x x x
Rash 15% - 37% x x x
Dermatitis contact Dermatitis contact x x x
Fungal skin infection Fungal skin infection x x x
Diarrhoea Diarrhoea x x
Diplopia Diplopia x x x
Dizziness Dizziness x x
Syncope x x x
Duodenal ulcer Duodenal ulcer x x x
Dysgeusia Dysgeusia x x
Dysmenorrhoea Dysmenorrhoea x x
Dyspepsia Dyspepsia x x
Dyspnoea Dyspnoea x x x
Dysuria Dysuria x x
Ear pain Ear pain x x
Ecchymosis Ecchymosis x x
Eczema Eczema x x x
Oedema Oedema 0% - 3% x x x
Eosinophilia Eosinophilia x x x
Epistaxis Epistaxis x x x
Erythema nodosum Erythema nodosum x x x
Oesophagitis Oesophagitis x x x
Rash Rash 15% - 37% x x x
Eye disorder Eye disorder x x x
VIIth nerve paralysis Facial paralysis x x x
Faecal incontinence Faecal incontinence x x
Body temperature increased Body temperature increased x x x
Flatulence Flatulence x x
Flushing Flushing x x x
Furuncle Furunculosis x x x
Gastritis Gastritis x x
Gastroenteritis Gastroenteritis x x x
Gastrointestinal disorder Gastrointestinal disorder x x x
Gingival bleeding Gingival bleeding x x x
Gingivitis Gingivitis x x
Goitre Goitre x x x
Gout Gout x x x
Hallucination Hallucination x x x
Headache Headache x x
Cardiac disorder Cardiac disorder x
Haematemesis Haematemesis x x x
Haematuria Haematuria x x x
Hepatomegaly Hepatomegaly x x x
Hernia Hernia x x x
Herpes simplex Herpes simplex 3% - 8% x x x
Herpes zoster Herpes zoster x x x
Hostility Hostility x x x
Hyperhidrosis Hyperhidrosis x
Sweating 10% - 31% x x
Hypertension Hypertension x x x
Hyperthyroidism Hyperthyroidism x x x
Salivary gland enlargement Salivary gland enlargement x x x
Hyperventilation Hyperventilation x x x
Hypoaesthesia Hypoaesthesia x x
Hypotension Hypotension x x x
Orthostatic hypotension Orthostatic hypotension x x x
Hypothyroidism Hypothyroidism x x x
Immune system disorder Immune system disorder x
Influenza Influenza x x x
Laryngospasm Laryngospasm x x x
Laryngitis Laryngitis x x
Leukopenia Leukopenia x x x
Lipoma Lipoma x x x
Lymphoedema Lymphoedema x x x
Mediastinal disorder Mediastinal disorder x
Melanosis Melanosis x x x
Melaena Melaena x x x
Menorrhagia Menorrhagia x x x
Metrorrhagia Metrorrhagia x x
Hypertonia Hypertonia x x
Muscle atrophy Muscle atrophy x x x
Myopathy Myopathy x x x
Mydriasis Mydriasis x x x
Myoclonus Myoclonus x x x
Nail disorder Nail disorder x x
Nausea Nausea x x x
Neoplasm Neoplasm x
Nervous system disorder Nervous system disorder x
Nervousness Nervousness x x x
Tension Nervousness x x x
Nystagmus Nystagmus x x
Optic neuritis Optic neuritis x x x
Osteomyelitis Osteomyelitis x x x
Otitis externa Otitis externa x x x
Pain Pain 25% - 28% x x x
Palpitations Palpitations x x x
Pancreatic disorder Pancreatic disorder x x x
Pancreatitis Pancreatitis x x x
Pancytopenia Pancytopenia x x x
Paraplegia Paraplegia x x x
Monoplegia Paraplegia x x x
Diplegia Paraplegia x x x
Paraesthesia Paraesthesia x x
Tooth abscess Abscess periodontal x x
Pharyngitis Pharyngitis x x
Pneumonia Pneumonia x x x
Polyp Polyp x
Pruritus Pruritus 13% - 36% x x x
Psoriasis Psoriasis x x x
Rhinitis Rhinitis x x x
Serum sickness Serum sickness x x x
Sinusitis Sinusitis x x
Skin disorder Skin disorder x x
Unspecified disorder of skin and subcutaneous tissue x
Skin mass Skin nodule 0% - 4% x x
Speech disorder Speech disorder x x x
Splenomegaly Splenomegaly x x x
Stomatitis Stomatitis x x x
Mouth ulceration x x x
Mouth ulceration Ulcerative stomatitis x x x
Mouth ulceration x x x
Suicide attempt Suicide attempt x x x
Shock Syncope x x x
Syncope Syncope x x x
Loss of consciousness Syncope x x x
Tachycardia Tachycardia x x x
Tenosynovitis Tenosynovitis x x x
Tinnitus Tinnitus x x
Tremor Tremor x x x
Unintended pregnancy Unintended pregnancy x x
Erythema Erythema x x
Urinary incontinence Urinary incontinence x x
Urinary tract infection Urinary tract infection x x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria 2% - 9% x x x
Welts 2% - 11% x x
Varicose vein Varicose vein x x x
Angiopathy Angiopathy x
Vasodilation procedure Vasodilation x
Vertigo Vertigo x x
Vomiting Vomiting x x x
Weight increased Weight increased 0% - 3% x x x
Weight decreased Weight decreased x x x
Dry mouth Dry mouth x x x
Urinary retention Urinary retention x x
Chills Chills x x x
Micturition urgency Micturition urgency x x x
Burning sensation Burning sensation x x x
Stupor Stupor x x x
Depressed level of consciousness Stupor x x x
Agitation Agitation x x
Mood swings Mood swings x x x
Affect lability Mood swings x x x
Photophobia Photophobia x x x
Rash pustular Rash pustular x x x
Vesiculobullous rash x x
Oedema peripheral Oedema peripheral 4% - 7% x x x
Peroneal nerve palsy Footdrop x x
Hypokinesia Hypokinesia x x x
Cataract Cataract x x x
Migraine Migraine x x x
Musculoskeletal stiffness Neck stiffness x
Nuchal rigidity Neck stiffness x
Injection site abscess Injection site abscess x x x
Alcohol intolerance Alcohol intolerance x x x
Injection site atrophy Injection site atrophy x x x
Skin atrophy Skin atrophy x x x
Gastrointestinal carcinoma Gastrointestinal carcinoma x x x
Tongue discolouration Tongue discolouration x x x
Generalised oedema Generalised oedema x x x
Fluid retention Generalised oedema x x x
Injection site swelling Injection site swelling x x x
Injection site fibrosis Injection site fibrosis x x x
Impaired healing Impaired healing x x x
Injection site haemorrhage Injection site haemorrhage x x
Injection site bruising x x
Skin hypertrophy Skin hypertrophy x x x
Injection site inflammation Injection site inflammation 11% - 49% x x x
Injury Accidental injury x x
Mania Manic psychosis x x x
Injection site mass Injection site mass 10% - 27% x x x
Skin necrosis Skin necrosis x x
Skin exfoliation Skin necrosis x x
Bone pain Bone pain x x x
Eye pain Eye pain x x
Injection site pain Injection site pain 38% - 73% x x x
Smear cervix abnormal Papanicolaou smear suspicious x x x
Paranoia Paranoid reaction x x x
Paraesthesia oral Circumoral paresthesia x x x
Dermatitis bullous Vesiculobullous rash x x
Dry skin Dry skin x x x
Oesophageal ulcer Oesophageal ulcer x x x
Skin striae Skin striae x x x
Photosensitivity reaction Photosensitivity reaction x x x
Malaise Malaise x x
Discomfort Malaise x x
Ill-defined disorder Malaise x x
Myalgia Myalgia x x
Tendon pain Tendon pain x x x
Muscle twitching Muscle twitching x x
Cardiac murmur Systolic murmur x x x
Increased appetite Increased appetite x x x
Proctalgia Rectal tenesmus x x x
Rectal tenesmus Rectal tenesmus x x x
Anorectal discomfort Rectal tenesmus x x x
Thinking abnormal Thinking abnormal x x
Mental disability Thinking abnormal x x
Memory impairment Memory impairment x x x
Euphoric mood Euphoric mood x x
Erectile dysfunction Erectile dysfunction x x x
Rectal haemorrhage Rectal haemorrhage x x x
Major depression Psychotic depression x x x
Xanthoma Xanthoma x x x
Dry eye Dry eye x x x
Cushingoid Cushingoid x x x
Atrophy Atrophy x
Injection site urticaria Injection site urticaria 0% - 5% x x
Dysaesthesia Dysaesthesia x x
Rash maculo-papular Rash maculo-papular x x x
Heart sounds abnormal Midsystolic click x x x
Bradycardia Bradycardia x x x
Lymphadenopathy Lymphadenopathy 6% - 12% x x x
Coordination abnormal Coordination abnormal x x
Injection site bruising Injection site bruising x x
Injection site induration Injection site induration x x
Injection site haematoma Injection site haematoma x x x
Face oedema Face oedema x x x
Renal pain Renal pain x x x
Gait disturbance Gait disturbance x x
Lhermitte's sign Lhermitte's sign x x
Skin cancer Skin carcinoma x x x
Acne Acne x x
Infestation Infestation NOS x
Sleep disorder Sleep disorder x x
Injection site erythema Injection site erythema x x x
Injection site pruritus Injection site pruritus 6% - 40% x x x
Local reaction Local reaction x
Injection site hypertrophy Injection site hypertrophy x x x
Insomnia Insomnia x x
Muscular weakness Myasthenia x x
Lipoatrophy Lipoatrophy x x
Immediate post-injection reaction Immediate post-injection reaction x x x
Ageusia Ageusia x x x
Rhinitis allergic Rhinitis allergic x x
Somnolence Somnolence x x
Vaginal haemorrhage Vaginal haemorrhage x x x
Hypoxia Hypoventilation x x x
Respiratory failure Hypoventilation x x x
Hypoventilation Hypoventilation x x x
Visual impairment Abnormal vision x x
Skin papilloma Warts x x x


Information about indications was extracted from the indications and usage sections of the labels.


Side effects:265


Side effects:315


Side effects:319
Source:Health Canada

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label