Phenytoin

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 13)
1 2 3 4 5 6 7 8 9 10
Acidosis def Acidosis def x x
Ageusia def Ageusia def x x
Agranulocytosis def Agranulocytosis def x x x x x x x x
Albuminuria def Albuminuria def x x
Alkalosis def Alkalosis def x x
Amblyopia def Amblyopia def x
Amnesia def Amnesia def x x
Anaphylactic shock def Anaphylactic shock def x x x
Anaphylactoid reaction x x
Anaemia def Anaemia def x x x x x x x x x x
Hypochromic anaemia def Hypochromic anaemia def x x
Anaemia megaloblastic def Anaemia megaloblastic def x x x x x x x x
Decreased appetite Anorexia def x x
Aphasia def Aphasia def x x
Apnoea def Apnoea def x x
Arthralgia def Arthralgia def x x x x x x x
Musculoskeletal discomfort Arthralgia def x x x x x x x
Myalgia def x x
Asthenia def Asthenia def x
Asthma def Asthma def x x
Ataxia def Ataxia def x x x x x x x x x
Atelectasis def Atelectasis def x x
Atrial flutter def Atrial flutter def x x
Back pain def Back pain def x
Bronchitis def Bronchitis def x x
Bundle branch block def Bundle branch block def x x
Cachexia def Cachexia def x x
Candidiasis def Candidiasis def x x
Vulvovaginal candidiasis def Vaginal moniliasis x x
Vulvovaginal mycotic infection Vaginal moniliasis x x
Cerebral infarction def Cerebral infarction def x x
Chorea def Chorea def x x x x x x x x
Coma def Coma def x x x
Confusional state def Confusional state def x x x x x x x x x x
Feeling abnormal Confusional state def x x x x x x x x x x
Malaise def x x
Conjunctivitis def Conjunctivitis def x x
Constipation def Constipation def x x x x x x x x x x
Convulsion def Convulsion def x x
Cough def Cough def x x
Cough increased x x
Cryptococcosis def Cryptococcosis def x
Cyanosis def Cyanosis def x x
Deafness def Deafness def x x
Dysphagia def Dysphagia def x x
Dehydration def Dehydration def x x
Delirium def Delirium def x x
Depersonalisation def Depersonalisation def x x
Dermatitis def Dermatitis def x x x x x x x x
Rash def x x x x x x x x x x
Dermatitis contact def Dermatitis contact def x x
Diabetes insipidus def Diabetes insipidus def x x
Diabetes mellitus def Diabetes mellitus def x x
Diarrhoea def Diarrhoea def x x
Diplopia def Diplopia def x
Dizziness def Dizziness def x x x x x x x x x
Syncope def x x
Dysarthria def Dysarthria def x x x
Slurred speech x x x x x x x x
Osteoarthritis def Dysarthria def x x x
Dysgeusia def Dysgeusia def x x x x
Taste metallic x
Taste altered x
Dyskinesia def Dyskinesia def x x x x x x x x
Dyspepsia def Dyspepsia def x x
Dyspnoea def Dyspnoea def x x
Dysuria def Dysuria def x x
Ear pain def Ear pain def x x
Ecchymosis def Ecchymosis def x
Oedema def Oedema def x x
Encephalitis def Encephalitis def x x
Eosinophilia def Eosinophilia def x x x x x
Toxic epidermal necrolysis def Toxic epidermal necrolysis def x x x x x
Necrolysis epidermal x x x x x
Epilepsy def Epilepsy def x x x
Epistaxis def Epistaxis def x x
Rash def Rash def x x x x x x x x x x
Extrapyramidal disorder def Extrapyramidal disorder def x x
Extravasation def Extravasation def x x
Body temperature increased def Body temperature increased def x x x x x x x x x x
Flatulence def Flatulence def x x
Cardiac flutter Cardiac flutter x x
Gastritis def Gastritis def x x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def x
Gingival hyperplasia def Gingival hyperplasia def x x x x x x x x
Headache def Headache def x x x x x x x x x
Cardiac arrest def Cardiac arrest def x x
Cardiomegaly def Cardiomegaly def x x
Cardiac failure def Cardiac failure def x x
Cardiac failure congestive def Cardiac failure congestive def x x
Haematoma def Haematoma def x x
Subdural haematoma def Subdural haematoma def x x
Hemiplegia def Hemiplegia def x x
Haemoptysis def Haemoptysis def x x
Haemorrhage def Haemorrhage def x x
Haemoglobin def Haemorrhage def x x
Hepatitis def Hepatitis def x x x x x x x x
Hostility def Hostility def x x
Hyperaesthesia def Hyperaesthesia def x x
Hyperglycaemia def Hyperglycaemia def x x
Hyperkalaemia def Hyperkalaemia def x x
Hyperplasia def Hyperplasia def x x x x x x x x
Hypersensitivity def Hypersensitivity def x x x x x x
Hypertension def Hypertension def x x
Hypertrichosis def Hypertrichosis def x x x x x x x x
Hypertrophy def Hypertrophy def x x x x x x x x
Hyperventilation def Hyperventilation def x x
Hypoaesthesia def Hypoaesthesia def x x
Hypocalcaemia def Hypocalcaemia def x x
Hypokalaemia def Hypokalaemia def x x
Hypotension def Hypotension def x x x x
Hypotensive x
Orthostatic hypotension def Orthostatic hypotension def x x
Incontinence def Incontinence def x x
Infarction def Infarction def x x
Infection def Infection def x x
Inflammation def Inflammation def x x x x
Influenza def Influenza def x x
Ketosis def Ketosis def x x
Muscle spasms def Cramps of lower extremities x x
Cramp muscle def x x
Lethargy def Lethargy def x
Leukocytosis def Leukocytosis def x x
Leukopenia def Leukopenia def x x x x x x x x x x
Systemic lupus erythematosus def Systemic lupus erythematosus def x x x x x x x x
Lupus erythematosus def x x x x x x x x
Lymphoma def Lymphoma def x x x x x x x x
Meningitis def Meningitis def x x
Hypotonia def Hypotonia def x x
Muscle relaxant therapy Hypotonia def x x
Myopathy def Myopathy def x x
Mydriasis def Mydriasis def x x
Myoclonus def Myoclonus def x x
Nausea def Nausea def x x x x x x x x x
Necrosis def Necrosis def x x
Nervousness def Nervousness def x x x x x x x x x x
Tension def Nervousness def x x x x x x x x x x
Neurosis def Neurosis def x x
Nodule def Nodule def x x
Nystagmus def Nystagmus def x x x x x x x x x
Oliguria def Oliguria def x x
Osteomalacia def Osteomalacia def x x
Osteoporosis def Osteoporosis def x x
Pain def Pain def x x
Palpitations def Palpitations def x x
Pancytopenia def Pancytopenia def x x x x x x x x
Paraesthesia def Paraesthesia def x x x x x
Tingling sensation def x
Pelvic pain def Pelvic pain def x
Polyarteritis nodosa def Polyarteritis nodosa def x x x x x x x
Personality disorder def Personality disorder def x x
Petechiae def Petechiae def x x
Pharyngitis def Pharyngitis def x x
Pneumonia def Pneumonia def x x
Pneumonia aspiration def Pneumonia aspiration def x
Pneumothorax def Pneumothorax def x x
Polyuria def Polyuria def x x
Urine output increased Polyuria def x x
Pruritus def Pruritus def x
Psychotic disorder def Psychotic disorder def x x
Pulmonary embolism def Pulmonary embolism def x x
Hyperacusis def Hyperacusis def x x
Extensor plantar response def Extensor plantar response def x x
Renal failure def Renal failure def x x
Rhinitis def Rhinitis def x x
Salivary hypersecretion def Salivation def x x
Salivary hypersecretion def x x
Scotoma def Scotoma def x x
Shock def Shock def x x x x
Syncope def x x
Sinusitis def Sinusitis def x x
Skin mass Skin nodule def x x
Speech disorder def Speech disorder def x x
Hyperhidrosis def Sweating def x x
Syncope def Syncope def x x
Loss of consciousness def Syncope def x x
Tachycardia def Tachycardia def x
Thrombocytopenia def Thrombocytopenia def x x x x x x x x x x
Thrombophlebitis def Thrombophlebitis def x x
Tinnitus def Tinnitus def x
Tongue disorder Tongue disorder x
Tongue oedema x x
Tremor def Tremor def x x x x x x x x x
Urinary incontinence def Urinary incontinence def x x
Urticaria def Urticaria def x x
Vaginal inflammation def Vaginal inflammation def x x
Vaginal infection def Vaginal inflammation def x x
Vasodilation procedure Vasodilation def x
Ventricular fibrillation def Ventricular fibrillation def x x
Vertigo def Vertigo def x
Vomiting def Vomiting def x x x x x x x x x
Dry mouth def Dry mouth def x
Urinary retention def Urinary retention def x x
Encephalopathy def Encephalopathy def x x
Chills def Chills def x x
Sinus bradycardia def Sinus bradycardia def x x
Stupor def Stupor def x
Depressed level of consciousness def Stupor def x
CNS depression NOS x x x x
Agitation def Agitation def x
Hyperkinesia def x x
Mood swings Mood swings x x
Affect lability Mood swings x x
Photophobia def Photophobia def x x
Rash pustular def Rash pustular def x x
Hypophosphataemia def Hypophosphataemia def x x x x
Hypokinesia def Hypokinesia def x x
Hepatic function abnormal Hepatic function abnormal x x x x x
Migraine def Migraine def x x
Generalised oedema Generalised oedema x x
Fluid retention Generalised oedema x x
Oedema genital def Oedema genital def x
Tongue oedema Tongue oedema x x
Ventricular extrasystoles def Ventricular extrasystoles def x x
Intracranial pressure increased def Intracranial pressure increased def x x
Hepatocellular injury Hepatocellular injury x x x x x x x x
Liver injury Hepatocellular injury x x x x x x x x
Cytolytic hepatitis Hepatocellular injury x x x x x x x x
Liver function test abnormal Liver function test abnormal x x
Eye pain def Eye pain def x x
Urethral pain def Urethral pain def x x
Paraesthesia oral Circumoral paresthesia x x
Hyporeflexia Hyporeflexia x
Hyperreflexia Hyperreflexia x x
Skin discolouration def Skin discolouration def x
Polyneuropathy def Polyneuropathy def x x x x x x x x
Photosensitivity reaction def Photosensitivity reaction def x x
Photosensitivity def x x
Pseudolymphoma def Pseudolymphoma def x x x x x x x x
Malaise def Malaise def x x
Discomfort def Malaise def x x
Discomfort def x
Ill-defined disorder Malaise def x x
Myalgia def Myalgia def x x
Muscle twitching def Muscle twitching def x x
Cardiac fibrillation Cardiac fibrillation x x
Proctalgia def Rectal tenesmus def x x
Rectal tenesmus def Rectal tenesmus def x x
Anorectal discomfort Rectal tenesmus def x x
Asterixis def Asterixis def x x x x x x x x
Thinking abnormal Thinking abnormal x x
Mental disability Thinking abnormal x x
Tenderness def Tenderness def x x
Rash morbilliform Rash morbilliform x x x x x x
Sputum increased Sputum increased x x
Increased bronchial secretion Sputum increased x x
Hypoxia def Hypoxia def x x
Sepsis def Sepsis def x x
Extrasystoles def Extrasystoles def x x
Anaphylactoid reaction Anaphylactoid reaction x x
Akathisia def Akathisia def x x
Dystonia def Dystonia def x x x x x x x x
Rash maculo-papular def Rash maculo-papular def x x
Hyperkinesia def Hyperkinesia def x x
Bradycardia def Bradycardia def x x
Lymphadenopathy def Lymphadenopathy def x x x x x x x x x x
Coordination abnormal Coordination abnormal x
Paralysis def Paralysis def x x
Face oedema def Face oedema def x x
Drug rash with eosinophilia and systemic symptoms Hypersensitive syndrome x x x x x
Macrocytosis Macrocytosis x x x x x x x x
Aspiration Aspiration x x
Poisoning def Intoxication x
Insomnia def Insomnia def x x x x x x x x x x
Muscular weakness def Myasthenia def x x
Ileus def Ileus def x x
Death Death x
Parosmia def Parosmia def x x
Brain oedema def Brain oedema def x x
Embolism def Embolus def x x
Somnolence def Somnolence def x x x x
Cerebral haemorrhage def Cerebral haemorrhage def x
Indication Labels
Grand mal convulsion def x x x x x x x
Seizures def x x x x x x x x x x
Status epilepticus def x x x x
Status epilepticus grand mal x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N03AB02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. PHENYTOIN : 43 side effects (FDA XML label)
  2. Phenytoin : 47 side effects (FDA XML label)
  3. Phenytoin : 48 side effects (FDA XML label)
  4. Phenytoin : 49 side effects (FDA XML label)
  5. Phenytoin : 50 side effects (FDA XML label)
  6. PHENYTOIN : 53 side effects (FDA XML label)
  7. PHENYTOIN : 54 side effects (FDA XML label)
  8. Phenytoin : 57 side effects (FDA XML label)
  9. PHENYTOIN : 167 side effects (FDA XML label)
  10. PHENYTOIN : 196 side effects (FDA XML label)