Levonorgestrel

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7
Abdominal pain def Abdominal pain def postmarketing x x x x x
Gastrointestinal pain def Abdominal pain def postmarketing x x x x x
Alopecia def Alopecia def postmarketing x x x x
Amenorrhoea def Amenorrhoea def postmarketing x x x x
Angioedema def Angioedema def postmarketing x x
Arrhythmia def Arrhythmia def postmarketing x
Asthma def Asthma def postmarketing x x
Back pain def Back pain def postmarketing x x x x
Mental disorder def Mental disorder def postmarketing x
Breast cancer def Breast cancer def postmarketing x
Breast disorder def Breast disorder def postmarketing x x
Breast feeding def Breast feeding def postmarketing x x
Bronchitis def Bronchitis def postmarketing x x
Neoplasm malignant def Neoplasm malignant def postmarketing x
Candidiasis def Candidiasis def postmarketing x
Cervicitis def Cervicitis def postmarketing x x x x
Connective tissue disorder def Connective tissue disorder def postmarketing x
Cystitis def Cystitis def postmarketing x x
Bladder pain def Cystitis def postmarketing x x
Cystitis noninfective def Cystitis def postmarketing x x
Cyst def Cyst def postmarketing x x x x x
Libido decreased def Libido decreased def postmarketing x x x x
Disturbance in sexual arousal Libido decreased def postmarketing x x x x
Diarrhoea def Diarrhoea def postmarketing x x x x
Dizziness def Dizziness def postmarketing x x x x x
Syncope def x
Lightheadedness x
Dysmenorrhoea def Dysmenorrhoea def postmarketing x x x x x
Dysuria def Dysuria def postmarketing x
Eczema def Eczema def postmarketing x x x
Oedema def Oedema def postmarketing x x x
Endocrine disorder def Endocrine disorder def postmarketing x
Hormone level abnormal Endocrine disorder def postmarketing x
Endometriosis def Endometriosis def postmarketing x
Endometritis def Endometritis def postmarketing x
Dermatitis def Rash def postmarketing x x x x x
Dermatitis def x
Rash def Rash def postmarketing x x x x x
Asthenia def Fatigue def postmarketing x x x x x
Asthenia def x x
Fatigue def Fatigue def postmarketing x x x x x
Body temperature increased def Body temperature increased def postmarketing x
Gastrointestinal disorder def Gastrointestinal disorder def postmarketing x x
Headache def Headache def postmarketing x x x x x x x
Cardiac disorder def Cardiac disorder def postmarketing x
Haemorrhage def Haemorrhage def postmarketing x x x x x x
Haemoglobin def Haemorrhage def postmarketing x x x x x x
Haemorrhoids def Haemorrhoids def postmarketing x
Hirsutism def Hirsutism def postmarketing x x x
Hypersensitivity def Hypersensitivity def postmarketing x
Hypertension def Hypertension def postmarketing x x x x
Hypertrichosis def Hypertrichosis def postmarketing x x
Immune system disorder def Immune system disorder def postmarketing x
Incontinence def Incontinence def postmarketing x
Influenza def Influenza def postmarketing x x x
Pain in extremity def Leg pain postmarketing x
Mastitis def Mastitis def postmarketing x
Breast pain def Breast pain def postmarketing x x x x
Mediastinal disorder def Mediastinal disorder def postmarketing x
Chloasma Chloasma postmarketing x
Menstrual disorder def Menstrual disorder def postmarketing x
Metrorrhagia def Metrorrhagia def postmarketing x x x x x
Musculoskeletal pain def Musculoskeletal pain def postmarketing x
Nausea def Nausea def postmarketing x x x x x x x
Neoplasm def Neoplasm def postmarketing x x
Nervous system disorder def Nervous system disorder def postmarketing x x
Nervousness def Nervousness def postmarketing x x x x
Tension def Nervousness def postmarketing x x x x
Tension def postmarketing x
Oligomenorrhoea def Oligomenorrhoea def postmarketing x x x x x
Ear infection def Otitis def postmarketing x x
Otitis media def Otitis media def postmarketing x
Ovarian cyst def Ovarian cyst def postmarketing x x x x
Corpus luteum cyst x
Ovarian disorder def Ovarian disorder def postmarketing x
Pain def Pain def postmarketing x x x x x x x
Ache def x
Pelvic pain def Pelvic pain def postmarketing x x x x x
Pharyngitis def Pharyngitis def postmarketing x x x
Pneumonia def Pneumonia def postmarketing x
Polyp def Polyp def postmarketing x
Pruritus def Pruritus def postmarketing x x x x
Respiratory tract infection def Respiratory tract infection def postmarketing x x
Rhinitis def Rhinitis def postmarketing x x x
Sciatica def Sciatica def postmarketing x
Seborrhoeic dermatitis def Seborrhoeic dermatitis def postmarketing x
Sinusitis def Sinusitis def postmarketing x x x
Skin disorder def Skin disorder def postmarketing x
Hyperhidrosis def Sweating def postmarketing x
Sweating increased postmarketing x
Tendonitis def Tendonitis def postmarketing x
Tooth disorder def Tooth disorder def postmarketing x
Toothache def Toothache def postmarketing x
Upper respiratory tract infection def Upper respiratory tract infection def postmarketing x x
Pollakiuria def Pollakiuria def postmarketing x
Urinary incontinence def Urinary incontinence def postmarketing x
Urinary tract infection def Urinary tract infection def postmarketing x
Urethral disorder def Urinary tract disorder def postmarketing x
Urinary tract disorder def Urinary tract disorder def postmarketing x
Urticaria def Urticaria def postmarketing x x x
Uterine disorder def Uterine disorder def postmarketing x
Uterine leiomyoma def Uterine leiomyoma def postmarketing x
Uterine perforation def Uterine perforation def postmarketing x
Vaginal neoplasm def Vaginal neoplasm def postmarketing x
Vertigo def Vertigo def postmarketing x
Vomiting def Vomiting def postmarketing x x x x x x
Vulval disorder def Vulval disorder def postmarketing x x
Weight increased def Weight increased def postmarketing x x x x
Mood swings Mood swings postmarketing x x x
Affect lability Mood swings postmarketing x x x
Migraine def Migraine def postmarketing x x x x x
Vaginal haemorrhage def Bleeding vaginal def postmarketing x x x
Dry skin def Dry skin def postmarketing x
Menstruation irregular def Menstruation irregular def postmarketing x
Fibroadenoma of breast def Fibroadenoma of breast def postmarketing x
Fibroadenoma def postmarketing x
Fibroadenosis of breast x
Vaginal discharge def Vaginal discharge def postmarketing x x x
Galactorrhoea Galactorrhoea postmarketing x
Medical device complication IUD complication postmarketing x
Abdominal distension def Enlargement abdomen def postmarketing x
Abdominal bloating def postmarketing x
Abdominal distension def x x
Vaginal infection def Vaginal infection def postmarketing x
Vaginal inflammation def x
Acne def Acne def postmarketing x x x x x
Exacerbation of acne x
Aortic dissection def Dissecting aortic aneurysm, thoracic postmarketing x
Genital infection Genital infection postmarketing x
Infestation Infestation NOS postmarketing x
Genital discharge Genital discharge postmarketing x
Leukorrhea def x
Flatulence def Abdominal bloating def postmarketing x
Flatulence def x
Gas in stomach x
Dyspareunia def Dyspareunia def postmarketing x x x x
Breast neoplasm def Breast neoplasm def postmarketing x x
Acute tonsillitis Acute tonsillitis x
Anaemia def Anaemia def x x x
Hypochromic anaemia def Hypochromic anaemia def x
Decreased appetite Anorexia def x
Anxiety def Anxiety def x
Appendicitis def Appendicitis def x
Acute appendicitis def x
Chest pain def Chest pain def x
Constipation def Constipation def x x
Cough def Cough def x
Dermatitis contact def Dermatitis contact def x
Dyspepsia def Dyspepsia def x
Dyspnoea def Dyspnoea def x
Folliculitis def Folliculitis def x
Haematoma def Haematoma def x
Herpes virus infection def Herpes NOS def x
Herpes simplex def Herpes simplex def x
Hypertrophy def Hypertrophy def x
Hypoaesthesia def Hypoaesthesia def x
Numbness def x
Hypomenorrhoea Hypomenorrhoea x
Muscle spasms def Cramps of lower extremities x
Cramp muscle def x
Menorrhagia def Menorrhagia def x
Fungal infection def Fungal infection def x
Sensory loss Numbness def x
Palpitations def Palpitations def x x
Papilloma def Papilloma def x
Polymenorrhoea Polymenorrhoea x
Premenstrual syndrome def Premenstrual syndrome def x
Pruritus genital Pruritus genital x
Purpura def Purpura def x
Vascular purpura Purpura def x
Gastric disorder def Gastric disorder def x
Shock def Syncope def x
Syncope def Syncope def x
Loss of consciousness def Syncope def x
Tonsillitis def Tonsillitis def x
Ulcer def Ulcer def x
Vaginal inflammation def Vaginal inflammation def x
Varicose vein def Varicose vein def x
Visual impairment def Visual impairment def x
Visual acuity reduced Visual impairment def x
Blindness def Visual impairment def x
Vulvovaginitis def Vulvovaginitis def x x
Weight decreased def Weight decreased def x
Polydipsia def Polydipsia def x
Genital ulceration Genital ulceration x
Application site reaction Application site reaction x
Uterine enlargement def Uterine enlargement def x
Haemoglobin decreased def Haemoglobin decreased def x
Haematuria def Blood urine x
Blood urine Blood urine x
Blood urine present Blood urine x
Myalgia def Myalgia def x
Musculoskeletal discomfort Myalgia def x
Muscle twitching def Muscle twitching def x
Increased appetite Increased appetite x
Abdominal pain lower Abdominal pain lower x
Menometrorrhagia Menometrorrhagia x
Tenderness def Tenderness def x x x x x
Cervix disorder def Uterine cervical lesion x
Menstruation delayed Menstruation delayed x
Perineal pain def Perineal pain def x
Breast tenderness Breast tenderness x x x
Erythema def Redness def x
Depressed mood def Depressed mood def x x
Benign breast neoplasm def Benign breast neoplasm def x
Crying def Tearfulness x
Tearfulness Tearfulness x
Chapped lips Chapped lips x
Blood glucose increased Blood glucose increased x
Glucose increased x
Protein urine present Urinary protein increased x
Insomnia def Insomnia def x
Somnolence def Somnolence def x
Indication Labels
Coitus interruptus def x
Ectopic pregnancy def x
Fertilization def x
Infection def x
IUD expelled def x
Nulliparous x
Pelvic inflammatory disease def x
Sexual assault x
Sexually transmitted disease def x
Unintended pregnancy def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: G03AC03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. LEVONORGESTREL : 11 side effects (FDA XML label)
  2. LEVONORGESTREL : 18 side effects (FDA XML label)
  3. LEVONORGESTREL / PLAN B : 56 side effects (Health Canada)
  4. LEVONORGESTREL / NORPLANT II : 81 side effects (Drugs@FDA)
  5. LEVONORGESTREL / MIRENA : 38 side effects (Drugs@FDA)
  6. levonorgestrel-releasing intrauterine system / Mirena : 38 side effects (FDA MedWatch)
  7. LEVONORGESTREL / MIRENA : 109 side effects (Health Canada)