Guanfacine
  
Side effects 
	
		
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| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 
| Dry mouth | Dry mouth | postmarketing, 2% - 60% | 0% - 6.85% | x | x | x | x | 
| Somnolence | Somnolence | postmarketing, 18% - 38% | 1.37% - 12% | x | x | x | x | 
| Drowsiness | 6% - 33% |  |  | x | x | x | 
| Dizziness | Dizziness | postmarketing, 1% - 15% | 2.74% - 8% | x | x | x | x | 
| Syncope | postmarketing |  | x | x | x | x | 
| Asthenia | Fatigue | postmarketing, 2% - 14% | 2% - 4.11% | x | x | x | x | 
| Asthenia | postmarketing, 1% - 5% | 0% | x | x | x | x | 
| Fatigue | Fatigue | postmarketing, 2% - 14% | 2% - 4.11% | x | x | x | x | 
| Decreased appetite | Decreased appetite | 5% - 7% | 3% - 4% | x |  |  |  | 
| Irritability | Irritability | 6% | 4% | x |  |  |  | 
| Lethargy | Lethargy | 6% | 3% | x |  |  |  | 
| Constipation | Constipation | postmarketing, 2% - 14% | 0% - 1% | x | x | x | x | 
| Headache | Headache | postmarketing, 0.2% - 24% | 4.11% - 19% | x | x | x | x | 
| Hypotension | Hypotension | 3% - 7% | 0% - 3% | x |  |  |  | 
| Insomnia | Insomnia | postmarketing, 0% - 12% | 6% | x | x | x | x | 
| Affect lability | Affect lability | 2% | 1% | x |  |  |  | 
| Abdominal pain | Abdominal pain | postmarketing, 10% - 11% | 3% - 9% | x | x | x | x | 
| Gastrointestinal pain | Abdominal pain | postmarketing, 10% - 11% | 3% - 9% | x | x | x | x | 
| Alopecia | Alopecia | postmarketing |  | x | x | x | x | 
| Anxiety | Anxiety | postmarketing |  | x | x | x | x | 
| Arthralgia | Arthralgia | postmarketing |  | x | x | x | x | 
| Musculoskeletal discomfort | Arthralgia | postmarketing |  | x | x | x | x | 
| Myalgia | postmarketing |  | x | x | x | x | 
| Chest pain | Chest pain | postmarketing |  | x | x | x | x | 
| Retrosternal pain |  |  |  | x | x | x | 
| Confusional state | Confusional state | postmarketing |  | x | x | x | x | 
| Feeling abnormal | Confusional state | postmarketing |  | x | x | x | x | 
| Malaise | postmarketing |  | x | x | x | x | 
| Dermatitis | Dermatitis | postmarketing |  | x | x | x | x | 
| Rash | postmarketing |  | x | x | x | x | 
| Dermatitis exfoliative | Dermatitis exfoliative | postmarketing |  | x | x | x | x | 
| Diarrhoea | Diarrhoea | postmarketing, 4% | 1% | x | x | x | x | 
| Dysgeusia | Dysgeusia | postmarketing |  | x | x | x | x | 
| Dyspepsia | Dyspepsia | postmarketing |  | x | x | x | x | 
| Dyspnoea | Dyspnoea | postmarketing |  | x | x | x | x | 
| Oedema | Oedema | postmarketing |  | x | x | x | x | 
| Rash | Rash | postmarketing |  | x | x | x | x | 
| Eye disorder | Eye disorder | postmarketing |  | x | x | x | x | 
| Hallucination | Hallucination | postmarketing |  | x |  |  |  | 
| Atrioventricular block | Block heart | postmarketing |  |  | x | x | x | 
| Atrioventricular block |  |  | x |  |  |  | 
| Cardiac failure congestive | Cardiac failure congestive | postmarketing |  |  | x | x | x | 
| Renal failure acute | Renal failure acute | postmarketing |  |  | x | x | x | 
| Muscle spasms | Cramps of lower extremities | postmarketing |  | x | x | x | x | 
| Pain in extremity | Leg pain | postmarketing |  | x | x | x | x | 
| Myocardial infarction | Myocardial infarction | postmarketing |  |  | x | x | x | 
| Acute coronary syndrome | Myocardial infarction | postmarketing |  |  | x | x | x | 
| Nausea | Nausea | postmarketing, 5% - 6% | 2% - 3% | x | x | x | x | 
| Nervousness | Nervousness | postmarketing |  |  | x | x | x | 
| Tension | Nervousness | postmarketing |  |  | x | x | x | 
| Nocturia | Nocturia | postmarketing |  |  | x | x | x | 
| Palpitations | Palpitations | postmarketing |  | x | x | x | x | 
| Paraesthesia | Paraesthesia | postmarketing |  | x | x | x | x | 
| Pruritus | Pruritus | postmarketing |  | x | x | x | x | 
| Cerebrovascular accident | Cerebrovascular accident | postmarketing |  |  | x | x | x | 
| Shock | Syncope | postmarketing |  | x | x | x | x | 
| Syncope | Syncope | postmarketing |  | x | x | x | x | 
| Loss of consciousness | Syncope | postmarketing |  | x | x | x | x | 
| Tachycardia | Tachycardia | postmarketing |  | x | x | x | x | 
| Tremor | Tremor | postmarketing |  | x | x | x | x | 
| Pollakiuria | Pollakiuria | postmarketing |  | x | x | x | x | 
| Vertigo | Vertigo | postmarketing |  | x | x | x | x | 
| Agitation | Agitation | postmarketing |  | x | x | x | x | 
| Liver function test abnormal | Liver function test abnormal | postmarketing |  |  | x | x | x | 
| Malaise | Malaise | postmarketing |  | x | x | x | x | 
| Discomfort | Malaise | postmarketing |  | x | x | x | x | 
| Ill-defined disorder | Malaise | postmarketing |  | x | x | x | x | 
| Myalgia | Myalgia | postmarketing |  | x | x | x | x | 
| Cardiac fibrillation | Cardiac fibrillation | postmarketing |  |  | x | x | x | 
| Erectile dysfunction | Erectile dysfunction | postmarketing | 0% - 1.37% | x | x | x | x | 
| Vision blurred | Vision blurred | postmarketing |  | x | x | x | x | 
| Bradycardia | Bradycardia | postmarketing, 2% | 0% | x | x | x | x | 
| Amnesia | Amnesia |  |  |  | x | x | x | 
| Sinus arrhythmia | Sinus arrhythmia |  |  | x |  |  |  | 
| Asthma | Asthma |  |  | x |  |  |  | 
| Conjunctivitis | Conjunctivitis |  |  |  | x | x | x | 
| Dysphagia | Dysphagia |  |  |  | x | x | x | 
| Enuresis | Enuresis |  |  | x |  |  |  | 
| Hypersensitivity | Hypersensitivity |  |  | x |  |  |  | 
| Orthostatic hypotension | Orthostatic hypotension |  |  | x | x | x | x | 
| Immune system disorder | Immune system disorder |  |  | x |  |  |  | 
| Iritis | Iritis |  |  |  | x | x | x | 
| Nightmare | Nightmare |  |  | x | x | x | x | 
| Pallor | Pallor |  |  | x |  |  |  | 
| Paresis | Paresis |  |  |  | x | x | x | 
| Purpura | Purpura |  |  |  | x | x | x | 
| Vascular purpura | Purpura |  |  |  | x | x | x | 
| Rhinitis | Rhinitis |  |  |  | x | x | x | 
| Convulsion | Convulsion |  |  | x |  |  |  | 
| Hyperhidrosis | Sweating |  |  |  | x | x | x | 
| Testicular disorder | Testicular disorder |  |  |  | x | x | x | 
| Tinnitus | Tinnitus |  |  |  | x | x | x | 
| Urinary incontinence | Urinary incontinence |  |  |  | x | x | x | 
| Vomiting | Vomiting |  |  | x |  |  |  | 
| Weight increased | Weight increased |  |  | x |  |  |  | 
| Hypokinesia | Hypokinesia |  |  |  | x | x | x | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  | x |  |  |  | 
| Abdominal pain upper | Abdominal pain upper |  |  | x |  |  |  | 
| Abdominal pain lower | Abdominal pain lower |  |  | x |  |  |  | 
| Abdominal discomfort | Upset stomach |  |  | x |  |  |  | 
| Skin exfoliation | Skin exfoliation |  |  |  | x | x | x | 
| Initial insomnia | Initial insomnia |  |  | x |  |  |  | 
| Middle insomnia | Middle insomnia |  |  | x |  |  |  | 
| Hypertension | Hypertensive |  |  |  | x | x | x | 
| Hypersomnia | Hypersomnia |  |  | x |  |  |  | 
| Loss of libido | Loss of libido |  |  |  | x | x | x | 
| Visual impairment | Visual impairment |  |  |  | x | x | x | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 65 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 69 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 69 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 69 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
  
 
  
	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |