Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.)
Information about indications was extracted from the indications and usage sections of the labels.
|
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
(show all 61)
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
|
Headache def
|
Headache def
|
postmarketing, 1% - 38%
|
1% - 34%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Somnolence def
|
Somnolence def
|
1% - 26.1%
|
1% - 8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervousness def
|
Nervousness def
|
2% - 21.3%
|
3% - 5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tension def
|
Nervousness def
|
2% - 21.3%
|
3% - 5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Decreased appetite
|
Anorexia def
|
1% - 20%
|
1% - 4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Decreased appetite
|
17% - 20%
|
1% - 2%
|
|
|
|
|
|
|
|
|
|
|
|
Appetite absent
|
17% - 20%
|
1% - 2%
|
|
|
|
|
|
|
|
|
|
|
|
Asthenia def
|
Asthenia def
|
postmarketing, 1% - 19%
|
3.3% - 9%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorgasmia def
|
Anorgasmia def
|
3% - 19%
|
0% - 1%
|
x
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
Ejaculation delayed
|
Ejaculation delayed
|
16% - 19%
|
1%
|
|
|
|
|
|
|
x
|
|
|
|
|
Ejaculation disorder def
|
Abnormal ejaculation
|
postmarketing, 0% - 19%
|
0% - 1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth def
|
Dry mouth def
|
postmarketing, 0% - 17%
|
0% - 6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tremor def
|
Tremor def
|
0% - 10.2%
|
0% - 2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation def
|
Constipation def
|
3% - 10%
|
3% - 5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erectile dysfunction def
|
Erectile dysfunction def
|
postmarketing — 0% - 10%
|
0% - 1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Accommodation disorder
|
Accommodation disorder
|
frequent, 0% - 9.1%
|
0%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Libido decreased def
|
Libido decreased def
|
1.1% - 9%
|
1% - 2%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Disturbance in sexual arousal
|
Libido decreased def
|
1.1% - 9%
|
1% - 2%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Abdominal pain def
|
Abdominal pain def
|
2.2% - 8%
|
3% - 4%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
|
Gastrointestinal pain def
|
Abdominal pain def
|
2.2% - 8%
|
3% - 4%
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
|
Diarrhoea def
|
Diarrhoea def
|
6% - 8%
|
5% - 6%
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Soft stools
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orgasm abnormal def
|
Orgasm abnormal def
|
1% - 8%
|
0% - 1%
|
|
|
|
|
|
|
x
|
|
|
|
|
Delayed orgasm def
|
3%
|
1%
|
|
|
|
|
|
|
x
|
|
|
|
|
Yawning def
|
Yawning def
|
0% - 8%
|
0% - 1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting def
|
Vomiting def
|
1.1% - 7.9%
|
1.1% - 3%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia def
|
Dyspepsia def
|
2.2% - 7%
|
2.2% - 6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Nightmare def
|
Nightmare def
|
3% - 7%
|
1% - 2%
|
|
|
|
x
|
|
|
x
|
|
|
x
|
|
Pharyngitis def
|
Pharyngitis def
|
7%
|
6%
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Abnormal dreams
|
Abnormal dreams
|
3% - 7%
|
1% - 2%
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Vivid dreams
|
3% - 7%
|
1% - 2%
|
|
|
|
|
|
|
x
|
|
|
|
|
Influenza def
|
Influenza def
|
6%
|
5%
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
|
Visual impairment def
|
Visual impairment def
|
frequent, 4% - 6%
|
1% - 3%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual acuity reduced
|
Visual impairment def
|
frequent, 4% - 6%
|
1% - 3%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blindness def
|
Visual impairment def
|
frequent, 4% - 6%
|
1% - 3%
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vision blurred def
|
Vision blurred def
|
4% - 6%
|
1% - 3%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
x
|
|
|
Difficulty focusing eyes
|
4%
|
1%
|
|
|
|
|
|
|
x
|
|
|
|
|
Infection def
|
Infection def
|
postmarketing, 2.2% - 5.6%
|
2.2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Vasodilation procedure
|
Vasodilation def
|
0% - 5.6%
|
0% - 2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Albuminuria def
|
Albuminuria def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amenorrhoea def
|
Amenorrhoea def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Amnesia def
|
Amnesia def
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Anuria def
|
Anuria def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia def
|
Arthralgia def
|
frequent
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
|
Musculoskeletal discomfort
|
Arthralgia def
|
frequent
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
|
Myalgia def
|
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
|
Balanitis def
|
Balanitis def
|
rare — frequent
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Bronchitis def
|
Bronchitis def
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Neck pain def
|
Neck pain def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Cervicitis def
|
Cervicitis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state def
|
Confusional state def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Feeling abnormal
|
Confusional state def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough def
|
Cough def
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Cough increased
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Cystitis def
|
Cystitis def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bladder pain def
|
Cystitis def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bladder pain def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cystitis noninfective def
|
Cystitis def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cyst def
|
Cyst def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia def
|
Dysgeusia def
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Dysuria def
|
Dysuria def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Urination impaired
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Ecchymosis def
|
Ecchymosis def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Oedema def
|
Oedema def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Endometriosis def
|
Endometriosis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eructation def
|
Eructation def
|
infrequent — 2%
|
0%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
Rash def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash def
|
Rash def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased def
|
Body temperature increased def
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Fibrocystic breast disease def
|
Fibrocystic breast disease def
|
rare — frequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gynaecomastia def
|
Gynaecomastia def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria def
|
Haematuria def
|
infrequent, frequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage def
|
Haemorrhage def
|
postmarketing — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoglobin def
|
Haemorrhage def
|
postmarketing — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaemia def
|
Hyperaemia def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertension def
|
Hypertension def
|
1.1% - 5%
|
1% - 4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertrophy def
|
Hypertrophy def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia def
|
Hypoaesthesia def
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Hypomenorrhoea
|
Hypomenorrhoea
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotension def
|
Hypotension def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orthostatic hypotension def
|
Orthostatic hypotension def
|
infrequent, frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
|
Incontinence def
|
Incontinence def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nephrolithiasis def
|
Calculus of kidney def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Genital discharge
|
Leukorrhea def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mastitis def
|
Mastitis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast pain def
|
Breast pain def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menopause def
|
Menopause def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menorrhagia def
|
Menorrhagia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Metrorrhagia def
|
Metrorrhagia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Mydriasis def
|
Mydriasis def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Nocturia def
|
Nocturia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oliguria def
|
Oliguria def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orchitis def
|
Orchitis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Orchitis noninfective
|
Orchitis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Ovarian cyst def
|
Ovarian cyst def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Polyuria def
|
Polyuria def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine output increased
|
Polyuria def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Prostatic disorder def
|
Prostatic disorder def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Prostatitis def
|
Prostatitis def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus def
|
Pruritus def
|
frequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyelonephritis def
|
Pyelonephritis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyuria def
|
Pyuria def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salpingitis def
|
Salpingitis def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms def
|
Muscle spasms def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cramps of lower extremities
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Cramp muscle def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tachycardia def
|
Tachycardia def
|
postmarketing, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Trismus def
|
Trismus def
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Urinary incontinence def
|
Urinary incontinence def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Uterine haemorrhage def
|
Uterine haemorrhage def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal inflammation def
|
Vaginal inflammation def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal infection def
|
Vaginal inflammation def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo def
|
Vertigo def
|
frequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight increased def
|
Weight increased def
|
frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Pollakiuria def
|
Micturition urgency def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria def
|
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
x
|
|
Micturition urgency def
|
Micturition urgency def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mood swings
|
Mood swings
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Affect lability
|
Mood swings
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast engorgement def
|
Breast engorgement def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast discharge def
|
Breast discharge def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Migraine def
|
Migraine def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Crystalluria
|
Crystalluria
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Crystal urine
|
Crystalluria
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercalciuria def
|
Crystalluria calcium
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercalciuria def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal impairment def
|
Kidney function abnormal
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Renal impairment def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Chest pain def
|
Retrosternal pain
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Uterine spasm
|
Uterine spasm
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Increased appetite
|
Increased appetite
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Thinking abnormal
|
Thinking abnormal
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
|
|
Mental disability
|
Thinking abnormal
|
frequent
|
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
|
|
Vulvovaginal dryness
|
Vaginal dryness def
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Prostatomegaly
|
Enlarged prostate
|
infrequent, frequent
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Calculus urinary def
|
Urolithiasis def
|
rare — frequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal pain
|
Renal pain
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast enlargement
|
Breast enlargement
|
rare — frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal haemorrhage def
|
Vaginal haemorrhage def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence def
|
Flatulence def
|
4%
|
3%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight decreased def
|
Weight decreased def
|
2% - 4%
|
0% - 1%
|
|
|
x
|
|
|
x
|
|
x
|
x
|
x
|
|
Hypertonia def
|
Hypertonia def
|
3%
|
2%
|
|
|
x
|
|
x
|
x
|
x
|
|
x
|
x
|
|
Muscle twitching def
|
Muscle twitching def
|
infrequent, 2% - 3%
|
0% - 1%
|
x
|
|
x
|
|
x
|
x
|
x
|
|
x
|
|
|
Sinusitis def
|
Sinusitis def
|
2%
|
1%
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
|
Ageusia def
|
Ageusia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alopecia def
|
Alopecia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia def
|
Anaemia def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angina pectoris def
|
Angina pectoris def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arrhythmia def
|
Arrhythmia def
|
rare — infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthritis def
|
Arthritis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rheumatoid arthritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthma def
|
Asthma def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Ataxia def
|
Ataxia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bruxism def
|
Bruxism def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bursitis def
|
Bursitis def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Candidiasis def
|
Candidiasis def
|
rare, infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
rare, infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
Oral candidiasis def
|
rare, infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Colitis def
|
Colitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis def
|
Conjunctivitis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Dysphagia def
|
Dysphagia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dehydration def
|
Dehydration def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis contact def
|
Dermatitis contact def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Diplopia def
|
Diplopia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eczema def
|
Eczema def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Epistaxis def
|
Epistaxis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophagitis def
|
Oesophagitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Exophthalmos def
|
Exophthalmos def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastritis def
|
Gastritis def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastroenteritis def
|
Gastroenteritis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingivitis def
|
Gingivitis def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glossitis def
|
Glossitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glycosuria def
|
Glycosuria def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hallucination def
|
Hallucination def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhoids def
|
Haemorrhoids def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hostility def
|
Hostility def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercholesterolaemia def
|
Hypercholesterolaemia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperaesthesia def
|
Hyperaesthesia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia def
|
Hyperglycaemia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperlipidaemia def
|
Hyperlipidaemia def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Hyperventilation def
|
Hyperventilation def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoglycaemia def
|
Hypoglycaemia def
|
rare, infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokalaemia def
|
Hypokalaemia def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Inappropriate antidiuretic hormone secretion def
|
Inappropriate antidiuretic hormone secretion def
|
postmarketing, infrequent
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
Libido increased def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Arthropathy def
|
Arthropathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoarthritis def
|
Arthropathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Laryngospasm def
|
Laryngospasm def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Laryngitis def
|
Laryngitis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukocytosis def
|
Leukocytosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukopenia def
|
Leukopenia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Melaena def
|
Melaena def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotonia def
|
Hypotonia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle relaxant therapy
|
Hypotonia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle rigidity def
|
Muscle rigidity def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myoclonus def
|
Myoclonus def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuralgia def
|
Neuralgia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear infection def
|
Otitis def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis media def
|
Otitis media def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pelvic pain def
|
Pelvic pain def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia def
|
Pneumonia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psoriasis def
|
Psoriasis def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Psychotic disorder def
|
Psychotic disorder def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperacusis def
|
Hyperacusis def
|
rare, infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Scotoma def
|
Scotoma def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Convulsion def
|
Seizures def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Convulsion def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Stomatitis def
|
Stomatitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Withdrawal syndrome def
|
Withdrawal syndrome def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Dizziness def
|
Syncope def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Shock def
|
Syncope def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Shock def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope def
|
Syncope def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness def
|
Syncope def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tenosynovitis def
|
Tenosynovitis def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Thirst def
|
Thirst def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombocytopenia def
|
Thrombocytopenia def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombophlebitis def
|
Thrombophlebitis def
|
postmarketing — infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ulcer def
|
Ulcer def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria def
|
Urticaria def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Angiopathy def
|
Angiopathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary retention def
|
Urinary retention def
|
infrequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral vascular disorder def
|
Peripheral vascular disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stupor def
|
Stupor def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depressed level of consciousness def
|
Stupor def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apathy def
|
Apathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Flat affect
|
Apathy def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Photophobia def
|
Photophobia def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cataract def
|
Cataract def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
Mouth ulceration def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal stiffness
|
Neck stiffness
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stiffness
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Nuchal rigidity
|
Neck stiffness
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Corneal lesion
|
Corneal lesion
|
rare, infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue disorder
|
Tongue oedema
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue oedema
|
Tongue oedema
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin hypertrophy
|
Skin hypertrophy
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mania def
|
Manic psychosis
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mania def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mucous membrane disorder
|
Mucous membrane disorder
|
infrequent
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Bone pain def
|
Bone pain def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Eye pain def
|
Eye pain def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Paranoia def
|
Paranoid reaction
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia oral
|
Circumoral paresthesia
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood alkaline phosphatase increased def
|
Phosphatase alkaline increased
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased def
|
Aspartate aminotransferase increased def
|
infrequent
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
Alanine aminotransferase increased def
|
Alanine aminotransferase increased def
|
rare, infrequent
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
Dry skin def
|
Dry skin def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity reaction def
|
Photosensitivity reaction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
Malaise def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Discomfort def
|
Malaise def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ill-defined disorder
|
Malaise def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Euphoric mood def
|
Euphoric mood def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal ulcer
|
Gastrointestinal ulcer
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary congestion
|
Pulmonary congestion
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory tract congestion
|
Pulmonary congestion
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rectal haemorrhage def
|
Rectal haemorrhage def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry eye
|
Dry eye
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extrasystoles def
|
Extrasystoles def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular bigeminy def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Akathisia def
|
Akathisia def
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash maculo-papular def
|
Rash maculo-papular def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation def
|
Hyperkinesia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia def
|
Hyperkinesia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral coldness
|
Cold hands
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cold feet
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradycardia def
|
Bradycardia def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuropathy peripheral def
|
Neuropathy def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphadenopathy def
|
Lymphadenopathy def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
Coordination abnormal
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Face oedema def
|
Face oedema def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Onychoclasis
|
Onychoclasis
|
rare, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acne def
|
Acne def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood uric acid increased
|
Hyperuricaemia def
|
rare, infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperuricaemia def
|
Hyperuricaemia def
|
rare, infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombocytosis def
|
Thrombocytosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscular weakness def
|
Myasthenia def
|
infrequent
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Parosmia def
|
Parosmia def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphonia def
|
Voice disturbance
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Exostosis def
|
Bone spur def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal distension def
|
Abdominal distension def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Congenital anomaly def
|
Congenital anomaly def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Developmental delay
|
Congenital anomaly def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Adjustment disorder def
|
Adjustment disorder def
|
rare
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
Agranulocytosis def
|
Agranulocytosis def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alcohol poisoning
|
Alcohol intoxication def
|
rare
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Anaphylactic shock def
|
Anaphylactic shock def
|
postmarketing, rare
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aplastic anaemia def
|
Aplastic anaemia def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aneurysm def
|
Aneurysm def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angioedema def
|
Angioedema def
|
postmarketing
|
|
|
|
|
|
x
|
|
|
|
|
|
|
Aortic aneurysm def
|
Aortic aneurysm def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aphasia def
|
Aphasia def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apnoea def
|
Apnoea def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Appendicitis def
|
Appendicitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinus arrhythmia def
|
Sinus arrhythmia def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Arteritis def
|
Arteritis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rheumatoid arthritis def
|
Rheumatoid arthritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atelectasis def
|
Atelectasis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation def
|
Atrial fibrillation def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrioventricular block def
|
Atrioventricular block def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bacteraemia def
|
Bacteraemia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blepharitis def
|
Blepharitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bundle branch block def
|
Bundle branch block def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Capillary fragility
|
Capillary fragility
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm malignant def
|
Carcinoma def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Cardiovascular disorder def
|
Cardiovascular disorder def
|
rare
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Catatonia def
|
Catatonia def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cellulitis def
|
Cellulitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cheilitis def
|
Cheilitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholecystitis def
|
Cholecystitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholelithiasis def
|
Cholelithiasis def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cyanosis def
|
Cyanosis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Deafness def
|
Deafness def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Delirium def
|
Delirium def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Delusion def
|
Delusion def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis exfoliative def
|
Dermatitis exfoliative def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus def
|
Diabetes mellitus def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Duodenitis def
|
Duodenitis def
|
rare
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Dyskinesia def
|
Dyskinesia def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Buccoglossal syndrome
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Movements involuntary def
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eosinophilia def
|
Eosinophilia def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toxic epidermal necrolysis def
|
Toxic epidermal necrolysis def
|
postmarketing
|
|
|
|
x
|
|
x
|
|
|
x
|
x
|
|
|
Necrolysis epidermal
|
postmarketing
|
|
|
|
x
|
|
x
|
|
|
x
|
x
|
|
|
Erythema multiforme def
|
Erythema multiforme def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
Stevens-Johnson syndrome def
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Erythema nodosum def
|
Erythema nodosum def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Oesophageal disorder def
|
Oesophageal disorder def
|
rare
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Oesophageal spasm def
|
Oesophageal spasm def
|
rare
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Eye haemorrhage def
|
Eye haemorrhage def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
VIIth nerve paralysis
|
Facial paralysis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fasciitis def
|
Fasciitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Hepatic steatosis def
|
Liver fatty def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pathological fracture def
|
Pathological fracture def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Furuncle def
|
Furunculosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrooesophageal reflux disease def
|
Gastrooesophageal reflux disease def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Gastrointestinal haemorrhage def
|
Gastrointestinal haemorrhage def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingival bleeding def
|
Gingival bleeding def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glaucoma def
|
Glaucoma def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Goitre def
|
Goitre def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gout def
|
Gout def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Granuloma def
|
Granuloma def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Breath odour def
|
Breath odour def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Cardiac arrest def
|
Cardiac arrest def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure def
|
Cardiac failure def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure congestive def
|
Cardiac failure congestive def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematemesis def
|
Haematemesis def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematoma def
|
Haematoma def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Haemochromatosis def
|
Haemochromatosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoptysis def
|
Haemoptysis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatitis def
|
Hepatitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hiccups def
|
Hiccups def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hirsutism def
|
Hirsutism def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperbilirubinaemia def
|
Hyperbilirubinaemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkalaemia def
|
Hyperkalaemia def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperthyroidism def
|
Hyperthyroidism def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary gland enlargement
|
Salivary gland enlargement
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Hyponatraemia def
|
Hyponatraemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoproteinaemia def
|
Hypoproteinaemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypothyroidism def
|
Hypothyroidism def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conversion disorder def
|
Hysteria def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Ileitis def
|
Ileitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infarction def
|
Infarction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal obstruction def
|
Intestinal obstruction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ischaemia def
|
Ischaemia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Jaundice def
|
Jaundice def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Keratitis def
|
Keratitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Labyrinthitis def
|
Labyrinthitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Laryngeal oedema def
|
Laryngeal oedema def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Lung disorder def
|
Lung disorder def
|
postmarketing
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
|
Lymphocytosis def
|
Lymphocytosis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Heat rash
|
Miliaria def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Miosis def
|
Miosis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mitral valve disease def
|
Mitral valve disease def
|
rare
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Motion sickness def
|
Motion sickness def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Multiple myeloma def
|
Multiple myeloma def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Plasmacytoma def
|
Multiple myeloma def
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myopathy def
|
Myopathy def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myocardial infarction def
|
Myocardial infarction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute coronary syndrome def
|
Myocardial infarction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Necrosis def
|
Necrosis def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuritis def
|
Neuritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuroleptic malignant syndrome def
|
Neuroleptic malignant syndrome def
|
postmarketing
|
|
|
x
|
|
|
|
x
|
x
|
|
|
x
|
|
Malignant syndrome NOS
|
postmarketing
|
|
|
x
|
|
|
|
x
|
x
|
|
|
x
|
|
Neutropenia def
|
Neutropenia def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Night sweats def
|
Night sweats def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Nodule def
|
Nodule def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nystagmus def
|
Nystagmus def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Obstruction def
|
Obstruction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoporosis def
|
Osteoporosis def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteosclerosis def
|
Osteosclerosis def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis externa def
|
Otitis externa def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pallor def
|
Pallor def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis def
|
Pancreatitis def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancytopenia def
|
Pancytopenia def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Optic neuritis def
|
Papilloedema def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Papilloedema def
|
Papilloedema def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paresis def
|
Paresis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Parotitis def
|
Parotitis def
|
rare
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Periodontitis def
|
Periodontitis def
|
rare
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Petechiae def
|
Petechiae def
|
rare
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Pleurisy def
|
Pleurisy def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Polycythaemia vera def
|
Polycythaemia vera def
|
rare
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Proctitis def
|
Proctitis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Prurigo def
|
Prurigo def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Pulmonary embolism def
|
Pulmonary embolism def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary eosinophilia def
|
Pulmonary eosinophilia def
|
postmarketing
|
|
|
x
|
|
|
|
x
|
|
|
|
x
|
|
Purpura def
|
Purpura def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vascular purpura
|
Purpura def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorectal disorder def
|
Rectal disorder def
|
rare
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
Renal failure def
|
Renal failure def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinal haemorrhage def
|
Retinal haemorrhage def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rhabdomyolysis def
|
Rhabdomyolysis def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
Salivation def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Scleritis def
|
Scleritis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Seborrhoeic dermatitis def
|
Seborrhoeic dermatitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sleep apnoea syndrome def
|
Sleep apnoea syndrome def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stevens-Johnson syndrome def
|
Stevens-Johnson syndrome def
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Cerebrovascular accident def
|
Cerebrovascular accident def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctival haemorrhage
|
Subconjunctival hemorrhage
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Supraventricular tachycardia def
|
Supraventricular tachycardia def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thyroid neoplasm def
|
Thyroid nodule def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thyroiditis def
|
Thyroiditis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tinnitus def
|
Tinnitus def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Torsade de pointes def
|
Torsade de pointes def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Torticollis def
|
Torticollis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Erythema def
|
Erythema def
|
postmarketing, rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Azotaemia def
|
Uremia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Uveitis def
|
Uveitis def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Varicose vein def
|
Varicose vein def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Venous insufficiency def
|
Venous insufficiency def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Ventricular fibrillation def
|
Ventricular fibrillation def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Ventricular tachycardia def
|
Ventricular tachycardia def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin odour abnormal
|
Body odor def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Atrioventricular block first degree def
|
Atrioventricular block first degree def
|
rare
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Akinesia
|
Akinesia
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash pustular def
|
Rash pustular def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vesiculobullous rash
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperphosphataemia def
|
Hyperphosphataemia def
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypophosphataemia def
|
Hypophosphataemia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alcohol abuse def
|
Alcohol abuse def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokinesia def
|
Hypokinesia def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic function abnormal
|
Hepatic function abnormal
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Plantar fasciitis def
|
Plantar fasciitis def
|
rare
|
|
|
x
|
|
x
|
x
|
|
|
x
|
x
|
x
|
|
Deep vein thrombosis def
|
Deep vein thrombosis def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alcohol intolerance def
|
Alcohol intolerance def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin atrophy def
|
Skin atrophy def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bleeding time prolonged
|
Bleeding time prolonged
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Buccoglossal syndrome
|
Buccoglossal syndrome
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood urea increased
|
Blood urea increased
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood creatine phosphokinase increased
|
Creatine phosphokinase increased def
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood creatinine increased
|
Creatinine increased def
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue discolouration
|
Tongue discolouration
|
rare
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctival oedema
|
Conjunctival oedema
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular extrasystoles def
|
Ventricular extrasystoles def
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular bigeminy def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hair colour changes
|
Hair discoloration
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
|
Impaired healing
|
Impaired healing
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperchlorhydria
|
Hyperchlorhydria
|
rare
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Gastric pH decreased
|
Hyperchlorhydria
|
rare
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Hypocholesterolaemia def
|
Hypocholesterolaemia def
|
rare
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Blood lactate dehydrogenase increased
|
Lactic dehydrogenase activity increased
|
postmarketing
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatocellular injury
|
Hepatocellular injury
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver injury
|
Hepatocellular injury
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cytolytic hepatitis
|
Hepatocellular injury
|
postmarketing
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver tenderness
|
Liver tenderness
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Biliary colic def
|
Biliary colic def
|
rare
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
Dermatitis bullous def
|
Vesiculobullous rash
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyporeflexia
|
Hyporeflexia
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperreflexia
|
Hyperreflexia
|
rare
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin discolouration def
|
Skin discolouration def
|
rare
|
|
|
x
|
x
|
x
|
|