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Febuxostat

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: M04AA03

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Dermatitis Rash 0.5% - 1.6% 0.7% x x x x x
Dermatitis x x x x x
Rash Rash 0.5% - 1.6% 0.7% x x x x x
Nausea Nausea 0.8% - 1.3% 0.7% x x x x x
Arthralgia Arthralgia 0.7% - 1.1% 0% x x x x x
Musculoskeletal discomfort Arthralgia 0.7% - 1.1% 0% x x x x x
Myalgia x x x x x
Abdominal distension Abdominal distension uncommon x x x x x
Abdominal pain Abdominal pain uncommon x x x x x
Gastrointestinal pain Abdominal pain uncommon x x x x x
Constipation Constipation uncommon x x x x x
Dyspepsia Dyspepsia uncommon x x x x x
Flatulence Flatulence uncommon x x x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease uncommon x x x x x
Pancreatitis Pancreatitis uncommon x x x x x
Vomiting Vomiting uncommon x x x x x
Dry mouth Dry mouth uncommon x x x x x
Stomatitis Mouth ulceration uncommon x x x x x
Mouth ulceration Mouth ulceration uncommon x x x x x
Abdominal discomfort Gastrointestinal discomfort uncommon x x x x x
Anaphylactic shock Anaphylactic shock postmarketing x x x x
Mental disorder Mental disorder postmarketing x x x x x
Connective tissue disorder Connective tissue disorder postmarketing x x x x x
Hypersensitivity Hypersensitivity postmarketing x x x x x
Immune system disorder Immune system disorder postmarketing x x x x x
Jaundice Jaundice postmarketing x x x x
Liver disorder Liver disorder postmarketing x x
Hepatocellular injury Liver disorder postmarketing x x
Foetor hepaticus Liver disorder postmarketing x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x x
Erythema multiforme Stevens-Johnson syndrome postmarketing x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x x
Tubulointerstitial nephritis Tubulointerstitial nephritis postmarketing x x x x
Urethral disorder Urinary tract disorder postmarketing x x x x x
Urinary tract disorder Urinary tract disorder postmarketing x x x x x
Hepatic failure Hepatic failure postmarketing x x
Liver function test abnormal Liver function test abnormal postmarketing x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x x
Rash generalised Rash generalised postmarketing x x x x
Psychotic behaviour Psychotic behaviour postmarketing x x
Alopecia Alopecia x x x x x
Anaemia Anaemia x x x
Angina pectoris Angina pectoris x x x
Angioedema Angioedema x x x x x
Decreased appetite Anorexia x x x x x
Decreased appetite x x x x x
Anxiety Anxiety x x x
Arthritis Arthritis x x x x x
Asthenia Asthenia x x x
Fatigue x x x x x
Atrial fibrillation Atrial fibrillation x x x x x
Blister Blister x x
Dermatitis bullous Blister x x
Breast disorder Breast disorder x x
Bronchitis Bronchitis x x x x x
Bursitis Bursitis x x
Transient ischaemic attack Transient ischaemic attack x x x
Chest pain Chest pain x x x x x
Chest discomfort x x
Cholecystitis Cholecystitis x x x
Cholelithiasis Cholelithiasis x x x x x
Infection Infection x x x
Contusion Contusion x x x
Cough Cough x x x x x
Deafness Deafness x x x
Libido decreased Libido decreased x x x x x
Disturbance in sexual arousal Libido decreased x x x x x
Dehydration Dehydration x x x
Diabetes mellitus Diabetes mellitus x x x x x
Diarrhoea Diarrhoea x x
Dizziness Dizziness x x x x x
Drug hypersensitivity Drug hypersensitivity x x
Dyspnoea Dyspnoea x x x x x
Ecchymosis Ecchymosis x x x
Eczema Eczema x x x
Oedema Oedema x x x x x
Endocrine disorder Endocrine disorder x x
Eosinophilia Eosinophilia x
Toxic epidermal necrolysis Toxic epidermal necrolysis x
Epistaxis Epistaxis x x x
Eye disorder Eye disorder x x x x x
Fatigue Fatigue x x x x x
Body temperature increased Body temperature increased x x
Flushing Flushing x x x x x
Cardiac flutter Cardiac flutter x x x
Gastritis Gastritis x x x
Gastrointestinal disorder Gastrointestinal disorder x x x x x
Guillain-Barre syndrome Guillain-Barre syndrome x x x
Gynaecomastia Gynaecomastia x x x
Headache Headache x x x x x
Cardiac disorder Cardiac disorder x x x x x
Cardiac murmur Cardiac murmur x x x
Haematemesis Haematemesis x x x
Haematochezia Haematochezia x x x
Haematuria Haematuria x x x x x
Hemiparesis Hemiparesis x x x x x
Hepatitis Hepatitis x x x x x
Hepatomegaly Hepatomegaly x x x
Herpes zoster Herpes zoster x x x
Hypercholesterolaemia Hypercholesterolaemia x x x
Hyperglycaemia Hyperglycaemia x x x
Hyperhidrosis Hyperhidrosis x x x x
Hyperlipidaemia Hyperlipidaemia x x x x x
Hypertension Hypertension x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia x x x
Blood triglycerides increased Hypertriglyceridaemia x x x
Hypoaesthesia Hypoaesthesia x x x x x
Hypokalaemia Hypokalaemia x x x
Hypotension Hypotension x x x
Incontinence Incontinence x x x
Irritability Irritability x x x
Lethargy Lethargy x x x
Leukocytosis Leukocytosis x x x
Leukopenia Leukopenia x x x
Breast pain Breast pain x x x
Mediastinal disorder Mediastinal disorder x x x
Musculoskeletal pain Musculoskeletal pain x x x x x
Myocardial infarction Myocardial infarction x x x
Acute coronary syndrome Myocardial infarction x x x
Nervous system disorder Nervous system disorder x x x x x
Nervousness Nervousness x x x x x
Tension Nervousness x x x x x
Neutropenia Neutropenia x x x
Pain Pain x x x
Palpitations Palpitations x x x x x
Pancytopenia Pancytopenia x x x x x
Paraesthesia Paraesthesia x x x x x
Peptic ulcer Peptic ulcer x x x
Petechiae Petechiae x x x x x
Proteinuria Proteinuria x x x x x
Protein urine present Proteinuria x x x x x
Prurigo Prurigo x x
Pruritus Pruritus x x x x x
Purpura Purpura x x x
Idiopathic thrombocytopenic purpura x x x
Vascular purpura Purpura x x x
Renal failure Renal failure x x x x x
Shock Shock x x
Skin lesion Skin lesion x x x x x
Sneezing Sneezing x x x
Muscle spasms Muscle spasms x x x x x
Splenomegaly Splenomegaly x x x
Cerebrovascular accident Cerebrovascular accident x x x
Tachycardia Tachycardia x x x
Thirst Thirst x x x x x
Thrombocytopenia Thrombocytopenia x x x x x
Tinnitus Tinnitus x x x x x
Tremor Tremor x x x
Erythema Erythema x x
Upper respiratory tract infection Upper respiratory tract infection x x x x x
Pollakiuria Pollakiuria x x x x x
Micturition urgency x x
Urticaria Urticaria x x x x x
Angiopathy Angiopathy x x x x x
Vertigo Vertigo x x x
Weight increased Weight increased x x
Weight decreased Weight decreased x x x x x
Idiopathic thrombocytopenic purpura Idiopathic thrombocytopenic purpura x x x
Micturition urgency Micturition urgency x x
Sinus bradycardia Sinus bradycardia x x x
Agitation Agitation x x x
Rash pustular Rash pustular x x
Panic attack Panic attack x x x
Migraine Migraine x x x
Amylase increased Amylase increased x x x
Blood urea increased Blood urea increased x x x
Blood creatinine increased Creatinine increased x x x
Electroencephalogram abnormal Electroencephalogram abnormal x x x
Hyperchlorhydria Hyperchlorhydria x x x
Gastric pH decreased Hyperchlorhydria x x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased x x x
Blood lactate dehydrogenase increased x x
Muscular weakness Muscular weakness x x
Blood alkaline phosphatase increased Phosphatase alkaline increased x x x
Prothrombin level increased Prothrombin level increased x x x
Skin discolouration Skin discolouration x x x x x
Joint swelling Joint swelling x x x
Liver injury Liver injury x
Traumatic liver injury Liver injury x
Haemoglobin decreased Haemoglobin decreased x x x
Joint stiffness Joint stiffness x x x x x
Malnutrition Malnutrition x x x x x
Prostatic specific antigen increased Prostatic specific antigen increased x x x
Rash macular Rash macular x x
Rash vesicular Rash vesicular x x
Hypouricaemia Hypouricaemia x
Myalgia Myalgia x x x x x
Muscle twitching Muscle twitching x x x
Nasal dryness Nasal dryness x x x
Hair growth abnormal Hair growth abnormal x x x
Increased appetite Increased appetite x x
Discomfort Discomfort x x x
Rash erythematous Rash erythematous x x
Rash follicular Rash follicular x x
Skin odour abnormal Skin odour abnormal x x x
Eye irritation Eye irritation x x
Chest discomfort Chest discomfort x x
Pharyngeal oedema Pharyngeal oedema x x x
Skin exfoliation Skin exfoliation x x x
Gingival pain Gingival pain x x x
Activated partial thromboplastin time prolonged Activated partial thromboplastin time prolonged x x x x x
Personality change Personality change x x x
Erectile dysfunction Erectile dysfunction x x x x x
Lacunar infarction Lacunar infarction x x x
Urticaria physical Urticaria physical x x x
Mechanical urticaria Urticaria physical x x x
Vision blurred Vision blurred x x x x x
Photosensitivity reaction Photosensitivity x x x
Influenza like illness Influenza-like symptoms x x x
Platelet count decreased Platelet count decreased x x x
Nephrolithiasis Nephrolithiasis x x x x x
Rash maculo-papular Rash maculo-papular x x
Musculoskeletal stiffness Stiffness x x x
Musculoskeletal stiffness x
Red blood cell count decreased Red blood cell count decreased x x x
Hair colour changes Hair colour changes x x x
Electrocardiogram abnormal Electrocardiogram abnormal x x x x x
Gait disturbance Gait disturbance x x x
Balance disorder Balance disorder x x x
Blood thyroid stimulating hormone increased Thyrotropin high x x x x
Blood thyroid stimulating hormone increased x x
Blood sodium increased Sodium high x x x
Menopausal symptoms Hot flush x x x x x
Hot flush Hot flush x x x x x
Throat irritation Throat irritation x x x
Dysgeusia Taste altered x x x x x
Haematocrit decreased Haematocrit decreased x x x
White blood cell count increased White blood cell count increased x x x
Infestation Infestation NOS x x x
Neutrophil count decreased Neutrophil count decreased x x x
Lymphocyte count decreased Lymphocyte count decreased x x x
Blood potassium increased Potassium increased x x x
Blood glucose increased Glucose increased x x x
Blood creatine increased Creatine increased x x x
Muscle tightness Muscle tightness x x
Insomnia Insomnia x x x x x
Respiratory tract congestion Respiratory tract congestion x x x
Paranasal sinus hypersecretion Paranasal sinus hypersecretion x x x
Urine output increased Urine output increased x x x
Mental retardation Mental disability x x x
Mental disability Mental disability x x x
Feeling abnormal Feeling abnormal x x x
Coagulation test abnormal Coagulation test abnormal x x x
Rash papular Rash papular x x
Exfoliative rash Exfoliative rash x x
Gout Gout flare x x
Hyposmia Hyposmia x x x x x
Hepatic steatosis Hepatic steatosis x x x
Somnolence Somnolence x x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

febuxostat / febuxostat

Side effects:125
Source:EMA

febuxostat

Side effects:184
Source:FDA Structured Product Label

febuxostat

Side effects:194
Source:FDA Structured Product Label

FEBUXOSTAT

Side effects:194
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label