Hydrochlorothiazide

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 15)
1 2 3 4 5 6 7 8 9 10
Anaemia def Anaemia def postmarketing x x x x x x x x x
Hepatitis def Hepatitis def postmarketing
Jaundice def Jaundice def postmarketing x x x x x x x x
Rhabdomyolysis def Rhabdomyolysis def postmarketing
Swelling def Swelling def postmarketing
Urticaria def Urticaria def postmarketing x x x x x x x x
Essential hypertension def Essential hypertension def postmarketing x
Blood urea increased Blood urea increased postmarketing
Swelling face Swelling face postmarketing
Hepatic enzyme increased Hepatic enzyme increased postmarketing
Blood creatinine increased Serum creatinine increased postmarketing
Abdominal distension def Abdominal distension def
Distention def x
Abdominal pain def Abdominal pain def
Gastrointestinal pain def Abdominal pain def
Alopecia def Alopecia def x x x x x x x
Anaphylactic shock def Anaphylactic shock def x x x x x x x x
Aplastic anaemia def Aplastic anaemia def x x x x x x x x
Haemolytic anaemia def Haemolytic anaemia def x x x x x x x x
Angina pectoris def Angina pectoris def x
Decreased appetite Anorexia def x x x x x x x x
Anxiety def Anxiety def
Arthritis def Arthritis def
Asthenia def Asthenia def x x
Fatigue def x
Weakness def x x x x x x x x x
Bursitis def Bursitis def
Transient ischaemic attack def Transient ischaemic attack def
Chest pain def Chest pain def
Cytogenetic abnormality def Cytogenetic abnormality def x
Colitis def Colitis def x
Conjunctivitis def Conjunctivitis def
Constipation def Constipation def x x x x x x x x x
Cough def Cough def x
Pancytopenia def Cytopenia def x
Bone marrow depression def x
Dermatitis def Dermatitis def x x x x x x x
Rash def x x x x x x x x
Dermatitis exfoliative def Dermatitis exfoliative def x x x x x x x
Diarrhoea def Diarrhoea def x x x x x x x x x x
Dizziness def Dizziness def x x x x x x x x x
Syncope def x
Dyspepsia def Dyspepsia def
Heartburn def
Dyspnoea def Dyspnoea def
Ear pain def Ear pain def
Ecchymosis def Ecchymosis def
Emotional disorder Emotional disturbance NOS
Toxic epidermal necrolysis def Toxic epidermal necrolysis def x x x x x x x
Necrolysis epidermal x x x x x x x
Epistaxis def Epistaxis def
Erythema multiforme def Erythema multiforme def x x x x x x x
Rash def Rash def x x x x x x x x
Fatigue def Fatigue def x
Assisted fertilisation Fertilization def x
Body temperature increased def Body temperature increased def x x x x x x x x
Flatulence def Flatulence def x
Flushing def Flushing def
Gastroenteritis def Gastroenteritis def
Glycosuria def Glycosuria def x x x x x x x x
Gout def Gout def
Headache def Headache def x x x x x x x x x x
Cardiac arrest def Cardiac arrest def
Cardiac murmur def Cardiac murmur def
Hyperglycaemia def Hyperglycaemia def x x x x x x x x
Hyperprolactinaemia def Hyperprolactinaemia def x
Hypersensitivity def Hypersensitivity def x x x x x x x x x
Hypertensive crisis Hypertensive crisis
Hypotension def Hypotension def x x x x x x x x x
Hypotensive x
Orthostatic hypotension def Orthostatic hypotension def x x x x x x x x
Infarction def Infarction def
Infection def Infection def
Influenza def Influenza def
Jaundice cholestatic def Jaundice cholestatic def x x x x x x x x
Leukopenia def Leukopenia def x x x x x x x x x
Muscle spasms def Cramp muscle def x x x x x x x x
Muscle spasms def x x x x x x x x
Musculoskeletal pain def Musculoskeletal pain def
Myocardial infarction def Myocardial infarction def
Acute coronary syndrome def Myocardial infarction def
Nausea def Nausea def x x x x x x x x x x
Nephritis def Nephritis def x x x x x x x x
Tubulointerstitial nephritis Nephritis interstitial def x x x x x x x x
Nervousness def Nervousness def
Tension def Nervousness def
Hypoaesthesia def Numbness def
Sensory loss Numbness def
Ovarian disorder def Ovarian disorder def x
Pain def Pain def
Ache def
Pancreatitis def Pancreatitis def x x x x x x x x x
Paraesthesia def Paraesthesia def x x x x x x x x
Pharyngitis def Pharyngitis def
Pneumonia def Pneumonia def x x x x x x x x
Prostatic disorder def Prostatic disorder def
Pruritus def Pruritus def
Pulmonary oedema def Pulmonary oedema def x x x x x x x
Purpura def Purpura def x x x x x x x x
Vascular purpura Purpura def x x x x x x x x
Renal artery stenosis Renal artery stenosis x
Respiratory tract infection def Respiratory tract infection def x
Rhinitis def Rhinitis def
Salmonellosis def Salmonellosis def x
Sialoadenitis def Sialoadenitis def x x x x x x x x x
Sleep disorder def Sleep disturbance
Arterial stenosis def Arterial stenosis def x
Cerebrovascular accident def Cerebrovascular accident def
Hyperhidrosis def Sweating def x
Sweating increased x
Shock def Syncope def x
Syncope def Syncope def x
Loss of consciousness def Syncope def x
Tachycardia def Tachycardia def
Thrombocytopenia def Thrombocytopenia def x x x x x x x x
Tracheobronchitis Tracheobronchitis
Tremor def Tremor def
Erythema def Erythema def x x x x x x x
Upper respiratory tract infection def Upper respiratory tract infection def x
Urinary tract infection def Urinary tract infection def
Vasculitis def Vasculitis def x x x x x x x x
Vertigo def Vertigo def x x x x x x x x
Visual impairment def Visual impairment def
Visual acuity reduced Visual impairment def
Blindness def Visual impairment def
Vomiting def Vomiting def x x x x x x x x x x
Weight increased def Weight increased def x
Wheezing def Wheezing def
Dry mouth def Dry mouth def x
Chills def Chills def
Agitation def Agitation def x x x x x x x x
Oedema peripheral def Oedema peripheral def
Swelling of limb
Upper limb oedema
Muscular weakness def Muscular weakness def
Respiratory arrest Respiratory arrest
Joint stiffness def Joint stiffness def
Xanthopsia Xanthopsia x x x x x x x
Myalgia def Myalgia def
Musculoskeletal discomfort Myalgia def
Tenderness def Tenderness def x x
Coombs test positive Coombs test positive x
Pulmonary congestion Pulmonary congestion
Respiratory tract congestion Pulmonary congestion
Erectile dysfunction def Erectile dysfunction def x x x x x x x
Oropharyngeal discomfort Throat sore def x
Oropharyngeal pain Throat sore def x
Cutaneous vasculitis Cutaneous vasculitis x x x x x x x
Conduction disorder def Conduction disorder def
Electrolyte imbalance def Electrolyte imbalance def x x x x x x x
Vision blurred def Vision blurred def x x x x x x x
Photosensitivity reaction def Photosensitivity def x x x x x x x x
Abdominal discomfort Gastric irritation x x x x x x x x
Social avoidant behaviour Withdrawn x x x x x x x x
Musculoskeletal stiffness Stiffness
Bradycardia def Bradycardia def x
Respiratory distress def Respiratory distress def x x x x x x x x
Musculoskeletal chest pain Musculoskeletal chest pain
Face oedema def Face oedema def
Hypovolaemia def Hypovolaemia def x
Sexual dysfunction Sexual dysfunction
Vasculitis necrotising def Angiitis necrotising def x x x x x x x x
Sedation Sedation x
Drug interaction def Drug interaction def x
Ear infection def Ear infection def
Blood uric acid increased Hyperuricaemia def x x x x x x x x
Hyperuricaemia def Hyperuricaemia def x x x x x x x x
Somnolence def Somnolence def
Indication Labels
Agranulocytosis def x
Angioedema def x
Angiopathy def x
Cardiac failure def x x x x x
Cardiac failure congestive def x x x x x
Cardiovascular disorder def x x x x
Chronic renal insufficiency def x
Collagen-vascular disease x
Death x
Discomfort def x x x x x
Eclampsia def x
Fluid loss x
Fluid overload def x x x x x
Fluid retention x
Generalised oedema x x x x
Glomerulonephritis def x x x x x
Glomerulonephritis acute x x x x
Gravid x x x
Gravitational oedema x x x x x
Hepatic cirrhosis def x x x x x
Hyperkalaemia def x x x
Hypertension def x x x x x x x x x
Hypertensive x
Nephropathy def x
Nephrotic syndrome def x x x x x
Normal pregnancy def x x x x x
Oedema def x x x x x x x
Pre-eclampsia def x x x x x x
Premenstrual syndrome def x
Premenstrual tension def x
Renal failure def x x x x
Renal failure chronic def x x x x
Renal impairment def x
Tension def x
Toxemia def x x x x x x x
Uterine disorder def x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: C03AA03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. lisinopril-hydrochlorothiazide / Prinzide : 26 side effects (FDA MedWatch)
  2. methyldopa-hydrochlorothiazide / Aldoril : 30 side effects (FDA MedWatch)
  3. HYDROCHLOROTHIAZIDE / PMS-HYDROCHLOROTHIAZIDE : 41 side effects (Health Canada)
  4. HYDROCHLOROTHIAZIDE : 53 side effects (FDA XML label)
  5. HYDROCHLOROTHIAZIDE : 54 side effects (FDA XML label)
  6. HYDROCHLOROTHIAZIDE : 54 side effects (FDA XML label)
  7. HYDROCHLOROTHIAZIDE : 55 side effects (FDA XML label)
  8. HYDROCHLOROTHIAZIDE : 55 side effects (FDA XML label)
  9. HYDROCHLOROTHIAZIDE : 55 side effects (FDA XML label)
  10. hydrochlorothiazide : 55 side effects (FDA XML label)