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More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: J05AB06, S01AD09

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Vision blurred Vision blurred 60% x
Body temperature increased Body temperature increased 9% - 35.9% x x x x
Diarrhoea Diarrhoea 24.4% - 41% x x x x
Loose stools 1.7% x
Nausea Nausea 11% - 30% x x x x
Tremor Tremor 12% - 28% x x x x
Eye irritation Eye irritation 20% x
Neutropenia Neutropenia 11.8% - 25.7% x x x x
Anaemia Anaemia 16.8% - 19.7% x x x x
Infection Infection 18% x x x x
Headache Headache 6% - 27% x x x x
Transplant rejection Transplant rejection 6% - 30% x
Hypertension Hypertension 12% - 20% x x x x
Insomnia Insomnia 6% - 20% x x x
Cough Cough 15.1% - 16% x x x
Cough increased x x
Retinal detachment Retinal detachment 15% x x x x
Renal failure Renal impairment 14% x x x
Renal failure 12% x x x
Renal impairment Renal impairment 14% x x x
Kidney function abnormal x x
Vomiting Vomiting 3% - 21% x x x
Abdominal pain Abdominal pain 7.6% - 15% x x x x
Gastrointestinal pain Abdominal pain 7.6% - 15% x x x x
Oedema Oedema 9% x x x x
Paraesthesia Paraesthesia 8% x x x
Neuropathy peripheral Neuropathy peripheral 7% - 9% x x x
Neuropathy x x
Thrombocytopenia Thrombocytopenia 5% - 6.6% x x x x
Sepsis Sepsis secondary 5.8% x x
Sepsis 3.4% - 6.1% x x x x
Confusional state Confusional state 5% x x x x
Feeling abnormal Confusional state 5% x x x x
Malaise 0.8% x x x
Pleural effusion Pleural effusion 5% x x x
Punctate keratitis Punctate keratitis 5% x
Conjunctival hyperaemia Conjunctival hyperaemia 5% x
Decreased appetite Anorexia 4.9% x x x
Decreased appetite x
Pneumocystis jirovecii pneumonia Pneumocystis jirovecii pneumonia 2.5% - 7.3% x x
Injection site infection Injection site infection 0.8% - 8% x x
Blood alkaline phosphatase increased Blood alkaline phosphatase increased 4.2% - 4.4% x x
Chest pain Chest pain 3.4% - 4.4% x x x
Pain Pain 2.5% - 4.6% x x x x
Productive cough Productive cough 2.5% - 3.6% x x
Sinus congestion Sinus congestion 2.5% - 3.4% x x
Pruritus Pruritus 2.5% - 3.2% x x x x
Hypoaesthesia Hypoaesthesia 1.7% - 3.2% x x
Blood creatinine increased Blood creatinine increased 1.7% - 3.2% x x
Creatinine increased x
Blood culture positive Blood culture positive 1.7% - 3.2% x x
Lymphadenopathy Lymphadenopathy 1.7% - 2.9% x x
Dysphagia Dysphagia 1.7% - 2.7% x x
Injection site inflammation Injection site inflammation 2.2% x x x
Anxiety Anxiety 1.7% - 2.4% x x x
Arthralgia Arthralgia 1.7% - 2.4% x x x x
Musculoskeletal discomfort Arthralgia 1.7% - 2.4% x x x x
Myalgia x x x
Leukopenia Leukopenia 0.8% - 3.2% x x x
Oesophageal candidiasis Oesophageal candidiasis 1.7% - 2.2% x x
Flatulence Flatulence 1.7% x x
Asthenia Asthenia 0.8% x x x
Fatigue x x
Malaise Malaise 0.8% x x x
Discomfort Malaise 0.8% x x x
Ill-defined disorder Malaise 0.8% x x x
Congenital anomaly Congenital anomaly postmarketing x x x
Developmental delay Congenital anomaly postmarketing x x x
Acidosis Acidosis postmarketing x x x
Anaphylactic shock Anaphylactic shock postmarketing x x x
Haemolytic anaemia Haemolytic anaemia postmarketing x x x
Anosmia Anosmia postmarketing x x x
Arthritis Arthritis postmarketing x x x
Bronchospasm Bronchospasm postmarketing x x x
Cholelithiasis Cholelithiasis postmarketing x x
Cholestasis Cholestasis postmarketing x x
Dermatitis exfoliative Dermatitis exfoliative postmarketing x x x
VIIth nerve paralysis Facial paralysis postmarketing x x x
Hallucination Hallucination postmarketing x x x x
Cardiac arrest Cardiac arrest postmarketing x x x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome postmarketing x x
Hepatitis Hepatitis postmarketing x x x
Hypercalcaemia Hypercalcaemia postmarketing x x
Hypersensitivity Hypersensitivity postmarketing x x x x
Hyponatraemia Hyponatraemia postmarketing x x x
Infertility Infertility postmarketing x x x
Irritability Irritability postmarketing x x x
IIIrd nerve paralysis IIIrd nerve paralysis postmarketing x x
Pulmonary fibrosis Pulmonary fibrosis postmarketing x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x
Spinal cord disorder Spinal cord disorder postmarketing x x x
Erythema multiforme Stevens-Johnson syndrome postmarketing x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x
Cerebrovascular accident Cerebrovascular accident postmarketing x x x
Torsade de pointes Torsade de pointes postmarketing x x x
Vasculitis Vasculitis postmarketing x x x
Ventricular tachycardia Ventricular tachycardia postmarketing x x x
Encephalopathy Encephalopathy postmarketing x x
Hepatic failure Hepatic failure postmarketing x x x
Cataract Cataract postmarketing x x x
Intracranial pressure increased Intracranial pressure increased postmarketing x x x
Renal tubular disorder Renal tubular disorder postmarketing x x
Intestinal ulcer Intestinal ulcer postmarketing x x x
Peripheral ischaemia Peripheral ischaemia postmarketing x x
Dry eye Dry eye postmarketing x x x
Dysaesthesia Dysaesthesia postmarketing x x x
Aphasia Dysphasia postmarketing x x x
Abdominal distension Abdominal distension x x x
Enlargement abdomen x x
Abscess Abscess x
Agranulocytosis Agranulocytosis x
Alopecia Alopecia x x
Amblyopia Amblyopia x
Amnesia Amnesia x x
Aplastic anaemia Aplastic anaemia x x
Hypochromic anaemia Hypochromic anaemia x
Arrhythmia Arrhythmia x x
Ascites Ascites x
Ataxia Ataxia x x
Back pain Back pain x x
Mental disorder Mental disorder x
Cachexia Cachexia x
Cellulitis Cellulitis x
Neck pain Neck pain x
Coma Coma x x
Conjunctivitis Conjunctivitis x
Connective tissue disorder Connective tissue disorder x
Constipation Constipation x x x
Deafness Deafness x x
Libido decreased Libido decreased x x
Disturbance in sexual arousal Libido decreased x x
Dehydration Dehydration x x
Dermatitis Dermatitis x x
Rash x
Dizziness Dizziness x x x
Dysgeusia Dysgeusia x x
Dyspepsia Dyspepsia x x x x
Dyspnoea Dyspnoea x x x x
Dysuria Dysuria x
Ear pain Ear pain x
Emotional disorder Emotional disturbance NOS x
Eosinophilia Eosinophilia x x
Eructation Eructation x x x
Oesophagitis Oesophagitis x x
Rash Rash x
Eye haemorrhage Eye haemorrhage x x
Fatigue Fatigue x x
Faecal incontinence Faecal incontinence x x
Gastritis Gastritis x x
Gastrointestinal disorder Gastrointestinal disorder x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage x
Glaucoma Glaucoma x x
Haematuria Haematuria x
Blood urine x
Haemorrhage Haemorrhage x x x
Haemoglobin Haemorrhage x x x
Herpes simplex Herpes simplex x x
Hyperglycaemia Hyperglycaemia x x
Hyperkalaemia Hyperkalaemia x
Hypocalcaemia Hypocalcaemia x x x
Hypokalaemia Hypokalaemia x x x
Hypotension Hypotension x x x
Inappropriate antidiuretic hormone secretion Inappropriate antidiuretic hormone secretion x
Ischaemia Ischaemia x
Jaundice Jaundice x
Jaundice cholestatic Jaundice cholestatic x
Renal failure acute Renal failure acute x
Muscle spasms Cramps of lower extremities x x
Cramp muscle x
Breast pain Breast pain x
Mediastinal disorder Mediastinal disorder x
Melaena Melaena x
Multi-organ failure Multi-organ failure x x
Hypertonia Hypertonia x x
Myoclonus Myoclonus x x
Nasopharyngitis Nasopharyngitis x
Rhinorrhoea x
Nervousness Nervousness x x
Tension Nervousness x x
Pain in extremity Pain in extremity x
Procedural pain Postoperative pain x
Pancreatitis Pancreatitis x x x
Pancytopenia Pancytopenia x x x x
Bone marrow depression x x x
Pharyngitis Pharyngitis x
Phlebitis Phlebitis x x
Pneumonia Pneumonia x
Post procedural complication Postoperative complications NOS x
Psychotic disorder Psychotic disorder x x x
Rhinitis Rhinitis x x
Convulsion Convulsion x x x x
Splenomegaly Splenomegaly x x
Aphthous stomatitis Aphthous stomatitis x x
Postoperative wound infection Postoperative wound infection x
Hyperhidrosis Sweating x x
Tachycardia Tachycardia x x
Thrombophlebitis Thrombophlebitis x x
Tinnitus Tinnitus x x x
Tongue disorder Tongue disorder x x
Trismus Trismus x
Upper respiratory tract infection Upper respiratory tract infection x x
Pollakiuria Pollakiuria x x x
Urinary tract infection Urinary tract infection x x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria x x
Angiopathy Angiopathy x
Vertigo Vertigo x
Weight decreased Weight decreased x x
Dry mouth Dry mouth x x x
Chills Chills x x
Rigors x x
Ventricular arrhythmia Ventricular arrhythmia x
Agitation Agitation x x x
Hyperkinesia x
Mood swings Mood swings x
Affect lability Mood swings x
Photophobia Photophobia x
Oedema peripheral Oedema peripheral x
Hypophosphataemia Hypophosphataemia x
Hepatic function abnormal Hepatic function abnormal x x
Lower respiratory tract infection Lower respiratory tract infection x
Stomatitis Mouth ulceration x x
Mouth ulceration Mouth ulceration x x
Migraine Migraine x x
Musculoskeletal stiffness Neck stiffness x
Nuchal rigidity Neck stiffness x
Injection site abscess Injection site abscess x x
Creatinine renal clearance decreased Creatinine renal clearance decreased x
Drug level increased Drug level increased x
Injection site swelling Injection site swelling x x
Fixed eruption Fixed eruption x
Gastrointestinal perforation Gastrointestinal perforation x
Injection site haemorrhage Injection site haemorrhage x x
Hypomagnesaemia Hypomagnesaemia x
Injection site reaction Injection site reaction x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased x
Liver function test abnormal Liver function test abnormal x
Mania Manic psychosis x
Mucous membrane disorder Mucous membrane disorder x x
Bone pain Bone pain x
Eye pain Eye pain x x
Injection site pain Injection site pain x
Rash pustular Vesiculobullous rash x
Dermatitis bullous Vesiculobullous rash x
Aspartate aminotransferase increased Aspartate aminotransferase increased x
Alanine aminotransferase increased Alanine aminotransferase increased x
Skin discolouration Skin discolouration x
Dry skin Dry skin x x x
Vitreous disorder Vitreous disorder x x x
Malnutrition Malnutrition x x x x
Photosensitivity reaction Photosensitivity reaction x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Blood urine Blood urine x
Blood urine present Blood urine x
Myalgia Myalgia x x x
Thinking abnormal Thinking abnormal x x
Mental disability Thinking abnormal x x
Abnormal dreams Abnormal dreams x x
Euphoric mood Euphoric mood x x
Blood creatinine decreased Creatinine low x x
Erectile dysfunction Erectile dysfunction x x
Wound dehiscence Wound dehiscence x
Hepatobiliary disease Hepatobiliary disease x
Rash maculo-papular Rash maculo-papular x
Hyperkinesia Hyperkinesia x
Laboratory test abnormal Laboratory test abnormal x
Blindness Blindness x x
Injection site thrombosis Injection site thrombosis x
Injection site phlebitis Injection site phlebitis x
Face oedema Face oedema x x
Myasthenic syndrome Myasthenic syndrome x
Gait disturbance Gait disturbance x
Blood glucose decreased Blood glucose decreased x x
Nephropathy toxic Nephrotoxicity x x
Device related infection Catheter infection x
Catheter related infection x
Device related sepsis Catheter sepsis x
Infestation Infestation NOS x
Blood creatine phosphokinase increased Blood creatine phosphokinase increased x
Blood magnesium decreased Blood magnesium decreased x x
Blood urea increased Serum urea increased x
Muscular weakness Myasthenia x x
Rhinorrhoea Rhinorrhoea x
Attention deficit/hyperactivity disorder Attention deficit/hyperactivity disorder x
Somnolence Somnolence x x x
Visual impairment Abnormal vision x x x


Information about indications was extracted from the indications and usage sections of the labels.


Side effects:4
Source:FDA Structured Product Label


Side effects:81
Source:FDA Structured Product Label


Side effects:114
Source:FDA Structured Product Label


Side effects:183

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label