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Entacapone

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N04BX02

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Dyskinesia Dyskinesia very common, 25% - 27% 14.8% - 15% x x x x x x x x x x
Movements involuntary x
Nausea Nausea very common, 11% - 14% 7.5% - 8% x x x x x x x x x x
Diarrhoea Diarrhoea common, 8% - 10% 4% x x x x x x x x x x
Loose stools x
Agitation Hyperkinesia common, 9.5% - 10% 5% x x x x x x x x x
Agitation very rare, 1% 0% x x x x x x x x x
Hyperkinesia Hyperkinesia common, 9.5% - 10% 5% x x x x x x x x x
Chromaturia Urine color abnormal very common, 9.5% - 10% 0% x x x x x x x x x x
Hypokinesia Hypokinesia 8.6% - 9% 7.5% - 8% x x x x x x x x
Abdominal pain Abdominal pain common, 7% - 8.1% 4% - 4.5% x x x x x x x x x x
Gastrointestinal pain Abdominal pain common, 7% - 8.1% 4% - 4.5% x x x x x x x x x x
Dizziness Dizziness common, 7.5% - 8% 6% x x x x x x x x x x
Syncope x
Constipation Constipation common, 6% - 6.3% 4% - 4.3% x x x x x x x x x x
Asthenia Fatigue common, 6% - 6.1% 3.5% - 4% x x x x x x x x x
Asthenia 2% 1% x x x x x x
Fatigue Fatigue common, 6% - 6.1% 3.5% - 4% x x x x x x x x x
Pain Pain 6% 4.5% x
Confusional state Confusional state common x x x x
Feeling abnormal Confusional state common x x x x
Malaise x
Hallucination Hallucination common, 4.1% 4% x x x x
Nightmare Nightmare common x x x
Tremor Tremor 5% 6.5% x
Myocardial ischaemia Myocardial ischaemia common x x x
Parkinsonism Parkinsonism aggravated common, 13.9% 14.8% x x x
Insomnia Insomnia common, 6.3% 7.3% x x x
Vomiting Vomiting common, 4% 1% x x x x x x x x x
Headache Headache 3.5% 4.3% x
Depression Depression 3.2% 3.3% x
Back pain Back pain 2% - 5% 1% - 3% x x x x x x x
Dyspnoea Dyspnoea 3% 1% x x x x x x x x
Muscle spasms Cramps of lower extremities 3% 3.5% x
Dry mouth Dry mouth common, 3% - 4.2% 0% - 0.3% x x x x x x x x x
Myocardial infarction Myocardial infarction uncommon, common x x x
Acute coronary syndrome Myocardial infarction uncommon, common x x x
Orthostatic hypotension Orthostatic hypotension 2.7% 3% x
Vertigo Vertigo 2.3% 3.3% x
Anxiety Anxiety 2% 1% x x x x x x
Dyspepsia Dyspepsia 2% 1% x x x x x x
Flatulence Flatulence 2% 0% x x x x x x
Purpura Purpura 2% 1% x x x x x x
Vascular purpura Purpura 2% 1% x x x x x x
Hyperhidrosis Sweating increased common, 2% - 3.6% 1% - 3% x x x x x x x x x
Sweating x
Somnolence Somnolence 2% 0% x x x x x x x
Excessive daytime sleepiness x x x x
Bacterial infection Bacterial infection 1% 0% x x x x x x
Dysgeusia Dysgeusia 1% 0% x x x x x x
Gastritis Gastritis 1% 0% x x x x x x
Gastrointestinal disorder Gastrointestinal disorder 1% 0% x x x x x x x x x x
Gastrointestinal symptom NOS x x x
Rash maculo-papular Rash maculo-papular rare x x x x
Hepatitis Hepatitis very rare, postmarketing x x x x x
Decreased appetite Anorexia very rare x x x
Mental disorder Mental disorder very rare x x x x x x x x x x
Colitis Colitis very rare x x x x
Urticaria Urticaria very rare x x x x
Weight decreased Weight decreased very rare x x x x
Albuminuria Albuminuria x
Angina pectoris Angina pectoris x x x x
Arthritis Arthritis x
Ataxia Ataxia x
Atrial fibrillation Atrial fibrillation x
Coagulopathy Coagulopathy x x x x x x x
Bundle branch block Bundle branch block x
Bursitis Bursitis x
Cardiovascular disorder Cardiovascular disorder x
Carpal tunnel syndrome Carpal tunnel syndrome x
Chest pain Chest pain x
Cholangitis Cholangitis x
Cholecystitis Cholecystitis x
Cholelithiasis Cholelithiasis x
Conjunctivitis Conjunctivitis x
Dysphagia Dysphagia x
Delusion Delusion x
Dermatitis Dermatitis x
Rash x
Fungal skin infection Fungal skin infection x
Diplopia Diplopia x
Diverticulitis Diverticulitis x
Dysuria Dysuria x
Eczema Eczema x
Endocrine disorder Endocrine disorder x
Toxic epidermal necrolysis Toxic epidermal necrolysis x
Epistaxis Epistaxis x
Erythema multiforme Erythema multiforme x
Oesophagitis Oesophagitis x
Rash Rash x
Congenital eye disorder Congenital eye disorder x
Eye disorder Congenital eye disorder x
Body temperature increased Body temperature increased x
Gastroenteritis Gastroenteritis x
Cardiac disorder Cardiac disorder x x x
Cardiac valve disease Cardiac valve disease x
Haematuria Haematuria x
Haemorrhage Haemorrhage x x x x x x x
Haemoglobin Haemorrhage x x x x x x x
Herpes simplex Herpes simplex x
Hyperbilirubinaemia Hyperbilirubinaemia x
Hypercholesterolaemia Hypercholesterolaemia x
Hyperglycaemia Hyperglycaemia x
Hypersensitivity Hypersensitivity x
Hypertension Hypertension x
Hyperthyroidism Hyperthyroidism x
Hypoaesthesia Hypoaesthesia x
Hypoglycaemia Hypoglycaemia x
Hypotension Hypotension x
Impulse-control disorder Impulse-control disorder x x x
Libido increased Libido increased x x x
Disturbance in sexual arousal Libido increased x x x
Inflammation Inflammation x
Intermittent claudication Intermittent claudication x
Pain in extremity Leg pain x
Leukopenia Leukopenia x
Liver disorder Liver disorder x
Hepatocellular injury Liver disorder x
Foetor hepaticus Liver disorder x
Hypotonia Hypotonia x
Muscle relaxant therapy Hypotonia x
Nervous system disorder Nervous system disorder x x
Nervousness Nervousness x
Tension Nervousness x
Neuroleptic malignant syndrome Neuroleptic malignant syndrome x
Nocturia Nocturia x
Pathological gambling Pathological gambling x x x x
Neuropathy peripheral Neuropathy peripheral x x x x x x x
Pharyngitis Pharyngitis x
Piloerection Piloerection x
Pneumonia Pneumonia x x
Pruritus Pruritus x
Rhabdomyolysis Rhabdomyolysis x x x x
Salivary hypersecretion Salivation x
Salivary hypersecretion x
Convulsion Convulsion x
Sinusitis Sinusitis x
Skin disorder Skin disorder x x
Unspecified disorder of skin and subcutaneous tissue x x
Sleep disorder Sleep disturbance x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Tendonitis Tendonitis x
Thrombocytopenia Thrombocytopenia x
Tooth disorder Tooth disorder x
Urinary incontinence Urinary incontinence x
Urethral disorder Urinary tract disorder x x x x x x x x x
Urinary tract disorder Urinary tract disorder x x x x x x x x x
Visual impairment Disorder sight x
Hepatic failure Hepatic failure x
Photopsia Photopsia x
Cataract Cataract x
Hepatic function abnormal Hepatic function abnormal x
Generalised oedema Generalised oedema x
Fluid retention Generalised oedema x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x
Muscular weakness Muscular weakness x
Paranoia Paranoid reaction x
Blood alkaline phosphatase increased Phosphatase alkaline increased x
Malnutrition Malnutrition x
Musculoskeletal stiffness Muscle stiffness x
Stiffness x
Malaise Malaise x
Discomfort Malaise x
Ill-defined disorder Malaise x
Myalgia Myalgia x
Musculoskeletal discomfort Myalgia x
Thinking abnormal Thinking abnormal x
Mental disability Thinking abnormal x
Cerebration impaired x
Altered state of consciousness Consciousness abnormal x
Abnormal dreams Abnormal dreams x
Muscle contractions involuntary Muscle contractions involuntary x
Disturbance in attention Cerebration impaired x
Faeces discoloured Faeces discoloured x
Cold sweat Skin cold clammy x
Hepatic enzyme increased Hepatic enzyme increased x
Erectile dysfunction Erectile dysfunction x
Hepatobiliary disease Hepatobiliary disease x x
Change of bowel habit Change of bowel habit x
Hypersexuality Hypersexuality x x x
Extrasystoles Extrasystoles x
Menorrhagia Prolonged menses x
Bradycardia Bradycardia x
Injury Inflicted injury x
Feeling of body temperature change Feeling of body temperature change x
Sexual dysfunction Sexual dysfunction x
Renal pain Renal pain x
Binge eating Binge eating x x x
Menopausal symptoms Hot flush x
Hot flush Hot flush x
Fibroadenoma of breast Fibroadenosis of breast x
Ageusia Ageusia x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

ENTACAPONE

Side effects:31
Source:FDA Structured Product Label

Entacapone

Side effects:31
Source:FDA Structured Product Label

ENTACAPONE

Side effects:31
Source:FDA Structured Product Label

ENTACAPONE

Side effects:31
Source:FDA Structured Product Label

ENTACAPONE

Side effects:31
Source:FDA Structured Product Label

ENTACAPONE

Side effects:32
Source:FDA Structured Product Label

entacapone / entacapone

Side effects:42
Source:EMA

entacapone / entacapone

Side effects:42
Source:EMA

INN: Entacne / COMTAN

Side effects:53
Source:medicines.org.au

ENTACAPONE / COMTAN

Side effects:128
Source:Health Canada

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label