Entacapone

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.)

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2
Dyskinesia def 25% 15% x x
Nausea def 14% 8% x x
Diarrhoea def 10% 4% x x
Hyperkinesia def 10% 5% x x
Urine colour abnormal def 10% 0% x
Hypokinesia def 9% 8% x x
Abdominal pain def 8% 4% x x
Dizziness def 8% 6% x x
Pain def 2% - 8% 1% - 4% x x
Constipation def 6% 4% x x
Fatigue def 6% 4% x x
Back pain def 2% - 4% 1% - 2% x x
Vomiting def 4% 1% x x
Dyspnoea def 3% 1% x x
Dry mouth def 3% 0% x x
Anxiety def 2% 1% x x
Asthenia def 2% 1% x x
Dyspepsia def 2% 1% x x
Flatulence def 2% 0% x x
Purpura def 2% 1% x x
Sweating def 2% 1% x x
Sweating increased 2% 1% x x
Somnolence def 2% 0% x x
Bacterial infection def 1% 0% x x
Dysgeusia def 1% 0% x x
Gastritis def 1% 0% x x
Gastrointestinal disorder def 1% 0% x x
Infection def 1% 0% x x
Agitation def 1% 0% x x
Ageusia def x
Albuminuria def x
Amnesia def x
Angina pectoris def x
Anorexia def x
Arthralgia def x
Arthritis def x
Ataxia def x
Atrial fibrillation def x
Mental disorder def x x
Coagulopathy def x x
Bronchitis def x
Bundle branch block def x
Bursitis def x
Cardiovascular disorder def x
Carpal tunnel syndrome def x
Cholangitis def x
Cholecystitis def x
Cholelithiasis def x
Colitis def x
Confusional state def x
Conjunctivitis def x
Cystitis def x
Dysphagia def x
Delusion def x
Dermatitis def x
Fungal skin infection def x
Diplopia def x
Diverticulitis def x
Dysuria def x
Eczema def x
Oedema def x
Endocrine disorder def x
Toxic epidermal necrolysis def x
Epistaxis def x
Erythema multiforme def x
Oesophagitis def x
Rash def x
Congenital eye disorder def x
Body temperature increased def x
Flushing def x
Gastroenteritis def x
Hallucination def x
Cardiac valve disease def x
Haematuria def x
Haemorrhage def x x
Hepatitis def x
Herpes NOS def x
Herpes simplex def x
Hyperbilirubinaemia def x
Hypercholesterolaemia def x
Hyperglycaemia def x
Hypersensitivity def x
Hypertension def x
Hyperthyroidism def x
Hypoaesthesia def x
Hypoglycaemia def x
Hypotension def x
Orthostatic hypotension def x
Incontinence def x
Intermittent claudication def x
Leg pain x
Leukopenia def x
Hypotonia def x
Musculoskeletal disorder def x x
Nervous system disorder def x x
Nervousness def x
Neuroleptic malignant syndrome def x
Nightmare def x
Nocturia def x
Neuropathy peripheral def x x
Pharyngitis def x
Pneumonia def x
Prostatic disorder def x
Pruritus def x
Respiratory disorder def x x
Rhabdomyolysis def x
Salivary hypersecretion def x
Sinusitis def x
Skin disorder def x
Speech disorder def x
Syncope def x
Tendonitis def x
Thrombocytopenia def x
Tooth disorder def x
Erythema def x
Urinary incontinence def x
Urinary tract disorder def x x
Urticaria def x
Weight decreased def x
Hepatic failure def x
Photopsia x
Cataract def x
Hepatic function abnormal x
Generalised oedema x
Necrolysis epidermal x
Paranoid reaction x
Phosphatase alkaline increased x
Microvascular angina def x
Malaise def x
Cardiac fibrillation x
Thinking abnormal x
Abnormal dreams x
Muscle contractions involuntary x
Cerebration impaired def x
Faeces discoloured x
Urine abnormality x
Skin cold clammy x
Hepatic enzyme increased x
Erectile dysfunction def x
Change of bowel habit x
Extrasystoles def x
Sticky skin x
Rash maculo-papular def x
Bradycardia def x
Sexual dysfunction x
Renal pain x
Hot flush def x
Aspiration x
Sleep disorder def x
Malignant syndrome NOS x
Unspecified disorder of autonomic nervous system def x
Fibroadenosis of breast x
Claudication def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N04BX02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. ENTACAPONE : 37 side effects (FDA XML label)
  2. ENTACAPONE / COMTAN : 152 side effects (Health Canada)