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Metformin

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: A10BA02

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 38 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Diarrhoea Diarrhoea very common, 9.6% - 53.2% 2.6% - 11.7% x x x x x x x x x x x x x x x x x x
Loose stools x
Gastrointestinal disorder Gastrointestinal disorder common, 42% - 48.3% x x x
Gastrointestinal symptom NOS very common x x x x x x
Reaction gastrointestinal x x x
Nausea Nausea very common, 6.5% - 25.5% 1.5% - 8.3% x x x x x x x x x x x x x x x x x
Vomiting Vomiting very common, 3.45% - 25.5% 1.5% - 8.3% x x x x x x x x x x x x x x x x
Infection Infection 20.5% - 20.9% x x x x
Decreased appetite Anorexia very common x x x x x
Appetite absent x x
Abdominal distension Abdominal bloating very common x x x x
Abdominal distension 0.575% - 7.89% x
Distention x x x x x
Flatulence Abdominal bloating very common x x x x
Flatulence very common, 12.1% 5.5% x x x x x x x x x x x x x x
Hypoglycaemia Hypoglycaemia 13.7% 4.9% x x x x x x x x x x x
Asthenia Asthenia 9.2% 5.5% x x x x x x x
Fatigue
Injury Accidental injury 5.58% - 7.31% x x x
Dyspepsia Dyspepsia 4.2% - 12.5% 4.1% x x x x x x x x x x
Heartburn x x x x x
Abdominal discomfort Abdominal discomfort 6.4% 4.8% x x x x x
Abdominal distress x x
Upset stomach x
Gastrointestinal tract irritation
Headache Headache 4.7% - 5.7% 4.8% x x x x x x x x x x
Constipation Constipation 2.87% - 5.02% x x x x x
Abdominal pain Abdominal pain 4.02% - 7.39% x x x x x x x x x x x
Gastrointestinal pain Abdominal pain 4.02% - 7.39% x x x x x x x x x x x
Rhinitis Rhinitis 4.2% - 5.6% x x x
Dysgeusia Dysgeusia common, 3% x x x x x x x x
Taste metallic 3% x x x x x x
Dermatitis Dermatitis very rare, common x x x x
Rash very rare, common x x x x x x x x x x x x x
Rash Rash very rare, common x x x x x x x x x x x x x
Hepatitis Hepatitis very rare x x x
Acidosis Acidosis x x x
Anaemia megaloblastic Anaemia megaloblastic x x x x x x x
Angina pectoris Angina unstable x
Angina unstable Angina unstable x
Breast disorder Breast disorder
Chest pain Chest pain x
Chest discomfort x x x x x x x x
Connective tissue disorder Connective tissue disorder x
Contusion Contusion x
Dehydration Dehydration x x x x
Dizziness Dizziness x x x x x x x
Syncope
Lightheadedness x x x x x x x x
Somnolence Drowsiness x
Somnolence x x
Dyspnoea Dyspnoea x x x x x x x x
Ear pain Ear pain x
Eye disorder Eye disorder
Fatigue Fatigue
Flushing Flushing x x x x x x x x
Seasonal allergy Seasonal allergy x
Rhinitis seasonal Seasonal allergy x
Cardiac disorder Cardiac disorder x
Blood disorder Blood disorder
Hypertension Hypertension x
Hypoaesthesia Hypoaesthesia x
Hypotension Hypotension x x
Body temperature decreased Body temperature decreased x x
Hypothermia Body temperature decreased x x
Immune system disorder Immune system disorder x
Influenza Influenza x x x x x x x x
Lethargy Lethargy
Mediastinal disorder Mediastinal disorder x
Muscle spasms Cramp muscle x
Fungal infection Fungal infection x
Nail disorder Nail disorder x x x x x x x x
Nasal congestion Nasal congestion x
Nervous system disorder Nervous system disorder x x x
Neutropenia Neutropenia
Pain in extremity Pain in extremity x
Palpitations Palpitations x x x x x x x x
Pancreatitis Pancreatitis x
Paraesthesia Paraesthesia
Pruritus Pruritus x x x
Sinus headache Sinus headache x
Shock Syncope
Syncope Syncope
Loss of consciousness Syncope
Thrombocytopenia Thrombocytopenia
Tonsillitis Tonsillitis x
Toothache Toothache x
Tremor Tremor x
Erythema Erythema x x x x x
Upper respiratory tract infection Upper respiratory tract infection x x x x x
Urticaria Urticaria x x x
Angiopathy Angiopathy x
Muscle strain Muscle strain x
Chills Chills x x x x x x x x
Rigors
Oedema peripheral Oedema peripheral
Migraine Migraine
Liver function test abnormal Liver function test abnormal
Sinus congestion Sinus congestion
Viral diarrhoea Viral diarrhoea x
Ketonuria Ketonuria x x
Abnormal faeces Abnormal faeces x x x x x x x x
Malnutrition Malnutrition x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x x
Ketoacidosis Ketoacidosis x x x
Malaise Malaise x x x
Discomfort Malaise x x x
Feeling abnormal Malaise x x x
Ill-defined disorder Malaise x x x
Myalgia Myalgia x x x x x x x x x x x
Musculoskeletal discomfort Myalgia x x x x x x x x x x x
Abdominal pain upper Abdominal pain upper x
Renal impairment Function kidney decreased x
Acetonaemia Ketonemia x x
Chest discomfort Chest discomfort x x x x x x x x
Azotaemia Azotaemia x
Hepatobiliary disease Hepatobiliary disease x x
Vision blurred Vision blurred
Bradycardia Bradycardia x x
Neuropathy peripheral Neuropathy x x x x
Respiratory distress Respiratory distress x x
Tooth abscess Tooth abscess x
Acute prerenal failure Azotemia prerenal x x x x
Emotional distress Emotional distress x
Hyperhidrosis Sweating increased x x x x x x x x
White blood cell count increased White blood cell count increased
Infestation Infestation NOS x
Oedema Oedema aggravated
Vitamin B12 deficiency Vitamin B12 absorption decreased x x x x
Nasopharyngitis Rhinorrhoea
Rhinorrhoea Rhinorrhoea
Epigastric discomfort Epigastric discomfort x x
Gastrointestinal tract irritation Gastrointestinal tract irritation

Indications

Information about indications was extracted from the indications and usage sections of the labels.

METFORMIN

Side effects:7
Source:FDA Structured Product Label

metformin

Side effects:13
Source:FDA Structured Product Label

METFORMIN

Side effects:13
Source:FDA Structured Product Label

METFORMIN HYDROCHLORIDE / RATIO-METFORMIN

Side effects:14
Source:Health Canada

METFORMIN

Side effects:14
Source:FDA Structured Product Label

METFORMIN HYDROCHLORIDE / PMS-METFORMIN - TAB 500MG

Side effects:15
Source:Health Canada

Metformin hydrochloride / Diabex

Side effects:17
Source:medicines.org.au

METFORMIN HYDROCHLORIDE / CO METFORMIN, 500MG

Side effects:22
Source:Health Canada

METFORMIN HYDROCHLORIDE / NOVO-METFORMIN TAB 850MG

Side effects:22
Source:Health Canada

METFORMIN

Side effects:22
Source:FDA Structured Product Label

METFORMIN

Side effects:24
Source:FDA Structured Product Label

METFORMIN

Side effects:26
Source:FDA Structured Product Label

METFORMIN

Side effects:26
Source:FDA Structured Product Label

METFORMIN

Side effects:26
Source:FDA Structured Product Label

METFORMIN HYDROCHLORIDE / FORTAMET

Side effects:26
Source:FDA

METFORMIN

Side effects:29
Source:FDA Structured Product Label

METFORMIN HYDROCHLORIDE / GLUMETZA

Side effects:40
Source:FDA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label