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Valproate

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N03AG01

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 91 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Headache Headache 2.7% - 39% 21% - 32% x x x x x x x x x x x x x
Nausea Nausea 1.7% - 48% 9% - 22.5% x x x x x x x x x x x x x x x x x x x x
Asthenia Asthenia postmarketing, 0% - 27% 5% - 10.1% x x x x x x x x x x x x x x x x x x x
Fatigue common, 4% - 19% 15% x
Fatigue Fatigue common, 4% - 19% 15% x
Tremor Tremor 1.4% - 57% 0% - 6.2% x x x x x x x x x x x x x x x x x x x x
Somnolence Somnolence 1% - 31% 2% - 19.1% x x x x x x x x x x x x x x x x x x
Drowsiness x
Diplopia Diplopia 16% 9% x x x x x x x x x x x x x x x x x x x x
Vomiting Vomiting 5% - 27% 1% - 12.4% x x x x x x x x x x x x x x x x x x x x
Infection Infection 12% - 20% 6% - 14% x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea 7% - 23% 3% - 18% x x x x x x x x x x x x x x x x x x x x
Dizziness Dizziness 5.2% - 25% 4% - 13% x x x x x x x x x x x x x x x x x x x x
Thrombocytopenia Thrombocytopenia 1% - 24% x x x x x x x x x x x x x x x x x x x
Influenza Influenza 12% 9% x x x x x x x x x x x x x x x x
Insomnia Insomnia 9% - 15% x x x x x x x x x x x x x x x x x
Decreased appetite Anorexia 4% - 12% 0% x x x x x x x x x x x x x x x x x x x x
Pain Pain common, 1% - 23% 4% - 20% x x x x x
Dyspepsia Dyspepsia 7% - 23% 4% - 11% x x x x x x x x x x x x x x x x x x x
Abdominal pain Abdominal pain 3% - 23% 4% - 9% x x x x x x x x x x x x x x x
Abdominal cramps x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain 3% - 23% 4% - 9% x x x x x x x x x x x x x x x
Nervousness Nervousness 7% - 11% x x x x x x x x x x x x x x x x
Tension Nervousness 7% - 11% x x x x x x x x x x x x x x x x
Amblyopia Amblyopia 4% - 12% 9% x x x x x x x x x x x x x x x x
Ataxia Ataxia 8% 1% x x x x x x x x x x x x x x x x x x x x
Back pain Back pain 8% 5.6% - 6.2% x x x x x x x x x x x x x x x x x
Vision blurred Vision blurred 4% - 12% 9% x x x x x x x x x x x x x x
Alopecia Alopecia 2.4% - 24% 1% x x x x x x x x x x x x x x x x x x x x
Nystagmus Nystagmus 1% - 8% 1% x x x x x x x x x x x x x x x x x x x x
Coagulopathy Coagulopathy common, 7% x
Dermatitis Rash 2% - 6% 3% - 5.6% x x x x x x x x x x x x x x x x x x x x
Rash Rash 2% - 6% 3% - 5.6% x x x x x x x x x x x x x x x x x x x x
Body temperature increased Body temperature increased common, 1% - 14% 4% x x x x x x x x x x x x x x x x x x x x
Pharyngitis Pharyngitis 2% - 8% 5% - 9.3% x x x x x x x x x x x x x x x x x
Weight decreased Weight decreased 6% 0% x x x x x x x x x x x x x x x x x x x
Mood swings Mood swings 6% - 8% 1% - 4% x x x x x x x x x x x x x x x
Affect lability Mood swings 6% - 8% 1% - 4% x x x x x x x x x x x x x x x
Injury Accidental injury 6% - 11% 5% - 11.2% x x x x x x x
Increased appetite Increased appetite 6% 4% x x x x x x x x x x x x x x x x x x x x
Thinking abnormal Thinking abnormal 6% 0% - 4% x x x x x x x x x x x x x x
Mental disability Thinking abnormal 6% 0% - 4% x x x x x x x x x x x x x x
Oedema peripheral Oedema peripheral 3% - 8% x x x x x x x x x x x x x x x x x
Muscle twitching Muscle twitching 3% - 8% 0% x x x x x x x x x x x x x x x x x
Amnesia Amnesia 4% - 7% 0% - 1% x x x x x x x x x x x x x x x
Bronchitis Bronchitis 5% 1% x x x x x x x x x x x x x x
Constipation Constipation 5% - 17% 1% - 8.2% x x x x x x x x x x x x x x x x x x x x
Rhinitis Rhinitis 5% 4% x x x x x x x x x x x x x x x x x
Sleep disorder Sleep disturbance common, 4% x
Sleep disorder x x x x
Influenza like illness Influenza-like symptoms common, 2% x
Depression Depression 4% - 5% x x x x x x x x x x x x x x
Ecchymosis Ecchymosis 4% - 5% x x x x x x x x x x x x x x x x x
Spontaneous bruising x
Endocrine disorder Endocrine disorder common, 4% x
Metabolic disorder Metabolic disorder common, 3% x
Tinnitus Tinnitus 1% - 7% x x x x x x x x x x x x x x x x x
Weight increased Weight increased 2% - 9% 2% x x x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia 0.9% - 7.1% x x x x x x x x x x x x x x x x x
Dyspnoea Dyspnoea 1% - 5% x x x x x x x x x x x x x x x x
Neonatal disorder Neonatal and infancy disorder common, 1% x
Drug interaction Drug interaction uncommon, 0.25% x x x x x x x x x x x x x x x
Pharmacokinetic interaction x
Aggression Aggression postmarketing x x x x x x x x x
Agranulocytosis Agranulocytosis postmarketing x x x x x x x x x x x x x x x x
Anaphylactic shock Anaphylactic shock postmarketing x x x x x x x x x x x x x x x x
Anaemia Anaemia postmarketing x x x x x x x x x x x x x x x x x x x
Aplastic anaemia Aplastic anaemia postmarketing x x x x x x x x x x x x x x x x x
Autism Autism postmarketing x x x x x x x x
Enuresis Enuresis postmarketing x x x x x x x x x x x x x x x x x x
Eosinophilia Eosinophilia postmarketing x x x x x x x x x x x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing x x x x x x x x x x x x x x x x x x x
Erythema multiforme Erythema multiforme postmarketing x x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome postmarketing x x x x x x x x x x x x x x x x x x x
Folate deficiency Folate deficiency postmarketing x x x x x x x x x x x x x x x x x
Multiple fractures Fracture postmarketing x x
Fracture Fracture postmarketing x x
Hostility Hostility postmarketing x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing x x x x x x x x x x x x x x x x x
Hyponatraemia Hyponatraemia postmarketing x x x x x x x x x x x x x x x x x x
Inappropriate antidiuretic hormone secretion Inappropriate antidiuretic hormone secretion postmarketing x x x x x x x x x x x x x x x x x
Leukopenia Leukopenia postmarketing x x x x x x x x x x x x x x x x x x
Lymphocytosis Lymphocytosis postmarketing x x x x x x x x x x x x x x x x x
Osteopenia Osteopenia postmarketing x x
Osteoporosis Osteoporosis postmarketing x x
Pancytopenia Pancytopenia postmarketing x x x x x x x x x x x x x x x x x
Bone marrow depression x
Polycystic ovaries Polycystic ovaries postmarketing x x x x x x x x x x x x x x x x x
Psychotic disorder Psychotic disorder postmarketing x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x x x x x x x x x x x x x x x x x
Swelling Swelling postmarketing x x x x x x x x x x x x x x x x x
Urinary tract infection Urinary tract infection postmarketing x x x x x x x x x x x x x x x x x x
Bone pain Bone pain postmarketing x x x x x x x x x x x x x x x x x
Menstruation irregular Menstruation irregular postmarketing x x x x x x x x x x x x x x x x x x
Porphyria acute Porphyria acute postmarketing x x x x x x x x x x x x x x x x x
Amenorrhoea Amenorrhea secondary postmarketing x x x x x x x x x x x x x x x x x x
Amenorrhoea x x x x x x x x x x x x x x x x
Galactorrhoea Galactorrhoea postmarketing x x x x x x x x x x x x x x x x x x
Cutaneous vasculitis Cutaneous vasculitis postmarketing x x x x x x x x x x x x x x x x x
Photosensitivity reaction Photosensitivity postmarketing x x x x x x x x x x x x x x x x x x
Agitation Hyperkinesia postmarketing x x x x x x x x x
Agitation x x x x x x x x x x x x x x x x
Excitement x
Hyperkinesia Hyperkinesia postmarketing x x x x x x x x x
Developmental delay Developmental delay postmarketing x x x x x x x x x
Congenital anomaly x
Bradycardia Bradycardia postmarketing x x x x x x x x x x x x x x x x x
Hypofibrinogenaemia Hypofibrinogenaemia postmarketing x x x x x x x x x x x x x x x x
Emotional distress Emotional distress postmarketing x x x x x x x x x x x x x x x x x
Deafness Hearing impaired postmarketing x x x x x x x x x x x x x x x x
Deafness x x x x x x x x x x x x x x x x x
Hearing impaired Hearing impaired postmarketing x x x x x x x x x x x x x x x x
Autism spectrum disorder Autism spectrum disorder postmarketing x x x x x x x x
Breast enlargement Breast enlargement postmarketing x x x x x x x x x x x x x x x x x x
Congenital anomaly Congenital anomaly x
Pancreatitis acute Pancreatitis acute x x x x x x x x x x x x x x x
Anaemia macrocytic Anaemia macrocytic
Angioedema Angioedema
Anxiety Anxiety x x x x x x x x x x x x x x x x
Arrhythmia Arrhythmia x x x x
Arthralgia Arthralgia x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia x x x x x x x x x x x x x x x x
Myalgia x x x x x x x x x x x x x x x x
Abnormal behaviour Behavior disorder x
Abnormal behaviour
Mental disorder Mental disorder
Blister Blister
Dermatitis bullous Blister
Vesiculobullous rash x x x x
Breast disorder Breast disorder
Catatonia Catatonia
Catatonic reaction x x x x x x x x x x x x x x x x
Neck pain Neck pain x x x x x x x x x x x x
Chest pain Chest pain x x x x x x x x x x x x x x x x x
Cognitive disorder Cognitive disorder
Coma Coma x x x x x x x x x x x x x x x x x
Confusional state Confusional state x x x x x x x x x x x x x x x x x x x x
Feeling abnormal Confusional state x x x x x x x x x x x x x x x x x x x x
Malaise x x x x x x x x x x x x x x x x
Conjunctivitis Conjunctivitis x x x x x x x x x x x x x x x x
Connective tissue disorder Connective tissue disorder
Contusion Contusion x x x x x x x x x x x x x x x
Cystitis Cystitis x x x x x x x x x x x x x x x
Bladder pain Cystitis x x x x x x x x x x x x x x x
Cystitis noninfective Cystitis x x x x x x x x x x x x x x x
Cyst Cyst
Dysphagia Dysphagia x x x x
Drug eruption Drug eruption
Dysarthria Dysarthria x x x x x x x x x x x x x x x x x
Osteoarthritis Dysarthria x x x x x x x x x x x x x x x x x
Arthropathy x x x x x x x x x x x x x x x x
Dysgeusia Dysgeusia x x x x x x x x x x x x x x x x
Dysmenorrhoea Dysmenorrhoea x x x x x x x x x x x x x x x x
Dysuria Dysuria x x x x x x x x x x x x
Ear disorder Ear disorder x x x x x x x x
Ear pain Ear pain x x x x x x x x x x x x x x
Oedema Oedema x x x x x x x x x x x x x x x x x
Enzyme induction Enzyme induction x
Epistaxis Epistaxis x x x x x x x x x x x x x x x x x x
Eructation Eructation x x x x x x x x x x x x x x x x
Erythema nodosum Erythema nodosum x x x x
Extrapyramidal disorder Extrapyramidal disorder
Eye disorder Eye disorder x x x x
Fanconi syndrome Fanconi syndrome x x x x x x x x x x x x x x x
Renal tubular disorder Fanconi syndrome x x x x x x x x x x x x x x x
Faecal incontinence Faecal incontinence x x x x x x x x x x x x x x x x
Flatulence Flatulence x x x x x x x x x x x x x x x x x
Furuncle Furunculosis x x x x x x x x x x x x x x x x
Gastroenteritis Gastroenteritis x x x x x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder x x x x x x x x x x
Gingival bleeding Gingival bleeding x x x x
Glossitis Glossitis x x x x x x x x x x x x x x x x
Hallucination Hallucination x x x x x x x x x x x x x x x x x x
Atrioventricular block Block heart x
Haematemesis Haematemesis x x x x x x x x x x x x x x x x
Haematoma Haematoma x x x x x x x x x x x x x x x
Haemorrhage Haemorrhage x x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage x x x x x x x x x x x x x x x x
Hiccups Hiccups x x x x
Hypertension Hypertension x x x x x x x x x x x x x x x x x
Hypoaesthesia Hypoaesthesia x x x x x x x x x x x x x x x x
Hypoproteinaemia Hypoproteinaemia x x x x
Hypotension Hypotension x x x x x x x x x x x x x x x x
Orthostatic hypotension Orthostatic hypotension x x x x x x x x x x x x x x x x
Body temperature decreased Body temperature decreased x x x x x x x x x x x x x x
Hypothermia Body temperature decreased x x x x x x x x x x x x x x
Hypothyroidism Hypothyroidism
Immune system disorder Immune system disorder x
Incontinence Incontinence
Infertility male Infertility male
Arthropathy Arthropathy x x x x x x x x x x x x x x x x
Learning disorder Learning disorder
Muscle spasms Cramps of lower extremities x x x x x x x x x x x x x x x x x
Lethargy Lethargy x
Cutaneous lupus erythematosus Discoid lupus erythematosus x x x x x x x x x x x x
Mediastinal disorder Mediastinal disorder
Menstrual disorder Menstrual disorder x x x x
Metrorrhagia Metrorrhagia x x x x x x x x x x x x x x x
Hypertonia Hypertonia x x x x x x x x x x x x x x x x x
Fungal infection Fungal infection x x x
Myelodysplastic syndrome Myelodysplastic syndrome
Necrosis Necrosis
Neoplasm Neoplasm
Nervous system disorder Nervous system disorder
Neutropenia Neutropenia x
Otitis media Otitis media x x x x x x x x x x x x x x x x x x
Palpitations Palpitations x x x x x x x x x x x x x x x x x
Pancreatitis Pancreatitis x x x x x x x x x x x x x x x x x
Tooth abscess Abscess periodontal x x x x x x x x x x x x x x x x x
Personality disorder Personality disorder x x x x x x x x x x x x x x x x
Petechiae Petechiae x x x x x x x x x x x x x x x x x x x x
Pleural effusion Pleural effusion
Pneumonia Pneumonia x x x x x x x x x x x x x x x x x x
Polyp Polyp
Polyuria Polyuria
Urine output increased Polyuria
Pruritus Pruritus x x x x x x x x x x x x x x x x x
Aplasia pure red cell Aplasia pure red cell
Seborrhoeic dermatitis Seborrhoeic dermatitis x x x x x x x x x x x x x x x x
Sinusitis Sinusitis x x x x x x x x x x x x x x x x
Speech disorder Speech disorder x x x x x x x x x x x
Stomatitis Stomatitis x x x x x x x x x x x x x x x
Mouth ulceration x x x x
Hyperhidrosis Sweating x x x x
Sweating increased
Tachycardia Tachycardia x x x x x x x x x x x x x x x x x
Tooth disorder Tooth disorder x x x x
Pollakiuria Pollakiuria x x x x x x x x x x x x x x x x
Urinary incontinence Urinary incontinence x x x x x x x x x x x x x x x x x
Urethral disorder Urinary tract disorder
Urinary tract disorder Urinary tract disorder
Urticaria Urticaria x
Vaginal inflammation Vaginal inflammation x x x x x x x x x x x x x x x x
Vaginal infection Vaginal inflammation x x x x x x x x x x x x x x x x
Angiopathy Angiopathy
Vasculitis Vasculitis x
Vasodilation procedure Vasodilation x x x x x x x x x x x x
Vertigo Vertigo x x x x x x x x x x x x x x x x x x
Viral infection Viral infection x x x x
Dry mouth Dry mouth x x x x x x x x x x x x x x x
Encephalopathy Encephalopathy x x x x x x x x x x x x x x x x
Chills Chills x x x x x x x x x x x x x x x x
Polydipsia Polydipsia
Hepatic failure Hepatic failure x x
Stupor Stupor x
Depressed level of consciousness Stupor x
CNS depression NOS x
Photophobia Photophobia x x x x
Hypokinesia Hypokinesia x x x x x x x x x x x x x x x x
Hepatic function abnormal Hepatic function abnormal x x x x x x x x x x x x x x x
Mouth ulceration Mouth ulceration x x x x
Musculoskeletal stiffness Neck stiffness x x x x x x x x x x x x x x x x
Nuchal rigidity Neck stiffness x x x x x x x x x x x x x x x x
Amylase increased Amylase increased
Serum amylase increased x
Bleeding time prolonged Bleeding time prolonged x x x x
Drug level increased Drug level increased x x x x
Injection site inflammation Injection site inflammation
Injection site reaction Injection site reaction
Eye pain Eye pain x x x x x x x x x x x x x x x x
Injection site pain Injection site pain
Prothrombin level increased Prothrombin level increased
Rash pustular Vesiculobullous rash x x x x
Hyperreflexia Hyperreflexia x x x x x x x x x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased x x x x x x x x x