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Valproate

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N03AG01

Side effects

Options: Show MedDRA Preferred Terms,   display all 91 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Headache 2.7% - 39% 21% - 32% x x x x x x x x x x
Nausea 1.7% - 48% 9% - 22.5% x x x x x x x x x x x x x x x x x x x x
Asthenia postmarketing, 0% - 27% 5% - 10.1% x x x x x x x x x x x x x x x x x x x
Fatigue common, 4% - 19% 15% x
Tremor 1.4% - 57% 0% - 6.2% x x x x x x x x x x x x x x x x x x x x
Somnolence 1% - 31% 2% - 19.1% x x x x x x x x x x x x x x x x x
Diplopia 16% 9% x x x x x x x x x x x x x x x x x x x x
Vomiting 5% - 27% 1% - 12.4% x x x x x x x x x x x x x x x x x x x x
Infection 12% - 20% 6% - 14% x x x x x x x x x x x x x x x
Diarrhoea 7% - 23% 3% - 18% x x x x x x x x x x x x x x x x x x x x
Dizziness 5.2% - 25% 4% - 13% x x x x x x x x x x x x x x x x x x x x
Thrombocytopenia 1% - 24% x x x x x x x x x x x x x x x x x x x
Influenza 12% 9% x x x x x x x x x x x x x x x
Insomnia 9% - 15% x x x x x x x x x x x x x x x x
Anorexia 4% - 12% 0% x x x x x x x x x x x x x x x x x x x x
Pain common, 1% - 23% 4% - 20% x x x x x x x
Dyspepsia 7% - 23% 4% - 11% x x x x x x x x x x x x x x x x x x x
Abdominal pain 3% - 23% 4% - 9% x x x x x x x x x x x x x x x x
Nervousness 7% - 11% x x x x x x x x x x x x x x x
Amblyopia 4% - 12% 9% x x x x x x x x x x x x x x x
Ataxia 8% 1% x x x x x x x x x x x x x x x x x x x x
Back pain 8% 5.6% - 6.2% x x x x x x x x x x x x x x x x x
Vision blurred 4% - 12% 9% x x x x x x x x x x x x
Alopecia 2.4% - 24% 1% x x x x x x x x x x x x x x x x x x x x
Nystagmus 1% - 8% 1% x x x x x x x x x x x x x x x x x x x x
Coagulopathy common, 7% x
Rash 2% - 6% 3% - 5.6% x x x x x x x x x x x x x x x x x x x x
Body temperature increased common, 1% - 14% 4% x x x x x x x x x x x x x x x x x x x
Pharyngitis 2% - 8% 5% - 9.3% x x x x x x x x x x x x x x x x
Weight decreased 6% 0% x x x x x x x x x x x x x x x x x x x
Mood swings 6% - 8% 1% - 4% x x x x x x x x x x x x x x
Accidental injury 6% - 11% 5% - 11.2% x x x x x x x x x x
Increased appetite 6% 4% x x x x x x x x x x x x x x x x x x x x
Thinking abnormal 6% 0% - 4% x x x x x x x x x x x x x
Oedema peripheral 3% - 8% x x x x x x x x x x x x x x x x
Muscle twitching 3% - 8% 0% x x x x x x x x x x x x x x x x x
Amnesia 4% - 7% 0% - 1% x x x x x x x x x x x x x x
Bronchitis 5% 1% x x x x x x x x x x x x x
Constipation 5% - 17% 1% - 8.2% x x x x x x x x x x x x x x x x x x x x
Rhinitis 5% 4% x x x x x x x x x x x x x x x x
Sleep disturbance common, 4% x
Influenza-like symptoms common, 2% x
Depression 4% - 5% x x x x x x x x x x x x
Ecchymosis 4% - 5% x x x x x x x x x x x x x x x x
Endocrine disorder common, 4% x
Metabolic disorder common, 3% x
Tinnitus 1% - 7% x x x x x x x x x x x x x x x x
Weight increased 2% - 9% 2% x x x x x x x x x x x x x x x x x x x
Paraesthesia 0.9% - 7.1% x x x x x x x x x x x x x x x x x
Dyspnoea 1% - 5% x x x x x x x x x x x x x x x
Neonatal and infancy disorder common, 1% x
Drug interaction uncommon, 0.25% x x x x x x x x x x x x
Aggression postmarketing x x x x x x x x
Agranulocytosis postmarketing x x x x x x x x x x x x x x x
Anaphylactic shock postmarketing x x x x x x x x x x x x x x x
Anaemia postmarketing x x x x x x x x x x x x x x x x x x x
Aplastic anaemia postmarketing x x x x x x x x x x x x x x x x
Autism postmarketing x x x x x x
Enuresis postmarketing x x x x x x x x x x x x x x x x x x
Eosinophilia postmarketing x x x x x x x x x x x x x x x x x
Toxic epidermal necrolysis postmarketing x x x x x x x x x x x x x x x x x x
Erythema multiforme postmarketing x x x x x x x x x x x x x x x x x
Folate deficiency postmarketing x x x x x x x x x x x x x x x x
Fracture postmarketing x x x x
Hostility postmarketing x x x x x x
Hypersensitivity postmarketing x x x x x x x x x x x x x x x x
Hyponatraemia postmarketing x x x x x x x x x x x x x x x x x
Inappropriate antidiuretic hormone secretion postmarketing x x x x x x x x x x x x x x x x
Leukopenia postmarketing x x x x x x x x x x x x x x x x x x x
Lymphocytosis postmarketing x x x x x x x x x x x x x x x x x
Osteopenia postmarketing x x x x
Osteoporosis postmarketing x x x x
Pancytopenia postmarketing x x x x x x x x x x x x x x x x
Polycystic ovaries postmarketing x x x x x x x x x x x x x x x x
Psychotic disorder postmarketing x x x
Stevens-Johnson syndrome postmarketing x x x x x x x x x x x x x x x x x x
Swelling postmarketing x x x x x x x x x x x x x x x x
Urinary tract infection postmarketing x x x x x x x x x x x x x x x x x
Bone pain postmarketing x x x x x x x x x x x x x x x x
Menstruation irregular postmarketing x x x x x x x x x x x x x x x x x x
Porphyria acute postmarketing x x x x x x x x x x x x x x x x
Amenorrhea secondary postmarketing x x x x x x x x x x x x x x x x x x
Galactorrhoea postmarketing x x x x x x x x x x x x x x x x x
Cutaneous vasculitis postmarketing x x x x x x x x x x x x x x x x
Photosensitivity postmarketing x x x x x x x x x x x x x x x x x
Hyperkinesia postmarketing x x x x x x x x
Developmental delay postmarketing x x x x x x x x
Bradycardia postmarketing x x x x x x x x x x x x x x x x
Hypofibrinogenaemia postmarketing x x x x x x x x x x x x x x x x
Emotional distress postmarketing x x x x x x x x x x x x x x x x x
Hearing impaired postmarketing x x x x x x x x x x x x x x
Autism spectrum disorder postmarketing x x x x x x
Breast enlargement postmarketing x x x x x x x x x x x x x x x x x
Abdominal cramps x x x x x x x x x x x x x x x x
Congenital anomaly x x
Pancreatitis acute x x x x x x x x x x x x
Amenorrhoea x x x x x x x x x x x x x x x x
Anaemia macrocytic
Angioedema
Anxiety x x x x x x x x x x x x x x x x
Arrhythmia x x x x x x x
Arthralgia x x x x x x x x x x x x x x x x
Behavior disorder x
Mental disorder
Blister x
Breast disorder
Catatonia
Neck pain x x x x x x x x x
Chest pain x x x x x x x x x x x x x x x x x
Cognitive disorder
Coma x x x x x x x x x x x x x x x
Confusional state x x x x x x x x x x x x x x x x x x x
Conjunctivitis x x x x x x x x x x x x x x x x
Connective tissue disorder
Contusion x x x x x x x x x x x x x
Cystitis x x x x x x x x x x x x x x x
Cyst
Deafness x x x x x x x x x x x x x x x x x
Dysphagia x x x x x x x
Drug eruption
Drowsiness x
Dysarthria x x x x x x x x x x x x x x x x x
Dysgeusia x x x x x x x x x x x x x x x x
Dysmenorrhoea x x x x x x x x x x x x x x x x
Dysuria x x x x x x x x x
Ear disorder x x x x x x
Ear pain x x x x x x x x x x
Oedema x x x x x x x x x x x x x x x x x
Enzyme induction x
Epistaxis x x x x x x x x x x x x x x x x x
Eructation x x x x x x x x x x x x x x x x
Erythema nodosum x x x x x x x
Extrapyramidal disorder
Eye disorder x x x x x x x
Fanconi syndrome x x x x x x x x x x x x
Faecal incontinence x x x x x x x x x x x x x x x x
Flatulence x x x x x x x x x x x x x x x x x
Furunculosis x x x x x x x x x x x x x x x x
Gastroenteritis x x x x x x x x x x x x x x x x
Gastrointestinal disorder x x x x x x x x x
Gingival bleeding x x x x x x x
Glossitis x x x x x x x x x x x x x x x x
Hallucination x x x x x x x x x x x x x x x x x
Block heart x
Haematemesis x x x x x x x x x x x x x x x x
Haematoma x x x x x x x x x x x x x
Haemorrhage x x x x x x x x x x x x x x
Hiccups x x x x x x x
Hypertension x x x x x x x x x x x x x x x x x
Hypoaesthesia x x x x x x x x x x x x x
Hypoproteinaemia x x x x x x x
Hypotension x x x x x x x x x x x x x x x x
Orthostatic hypotension x x x x x x x x x x x x x x x x
Body temperature decreased x x x x x x x x x x x
Hypothyroidism
Immune system disorder x
Incontinence
Infertility male
Arthropathy x x x x x x x x x x x x x x x x
Learning disorder
Cramps of lower extremities x x x x x x x x x x x x x x x x x
Lethargy x
Discoid lupus erythematosus x x x x x x x x x x x x x
Mediastinal disorder
Menstrual disorder x x x x x x x
Metrorrhagia x x x x x x x x x x x x x x x
Hypertonia x x x x x x x x x x x x x x x x x
Fungal infection x x x x x x x
Myelodysplastic syndrome
Necrosis
Neoplasm
Nervous system disorder
Neutropenia x
Otitis media x x x x x x x x x x x x x x x x x
Palpitations x x x x x x x x x x x x x x x x x
Pancreatitis x x x x x x x x x x x x x x x x x x
Abscess periodontal x x x x x x x x x x x x x x x x x
Personality disorder x x x x x x x x x x x x x x x x
Petechiae x x x x x x x x x x x x x x x x x x x x
Pleural effusion
Pneumonia x x x x x x x x x x x x x x x x x
Polyp
Polyuria x
Pruritus x x x x x x x x x x x x x x x x x
Aplasia pure red cell
Seborrhoeic dermatitis x x x x x x x x x x x x x x x x
Sinusitis x x x x x x x x x x x x x x x x
Speech disorder x x x x x x x x x x x x
Stomatitis x x x x x x x x x x x x x x x
Sweating x x x x x x x
Tachycardia x x x x x x x x x x x x x x x x x
Tooth disorder x x x x x x x
Pollakiuria x x x x x x x x x x x x x x x x
Urinary incontinence x x x x x x x x x x x x x x x x x
Urinary tract disorder
Urticaria x
Vaginal inflammation x x x x x x x x x x x x x x x x
Angiopathy
Vasculitis x
Vasodilation x x x x x x x x x
Vertigo x x x x x x x x x x x x x x x x x
Viral infection x x x x x x x
Dry mouth x x x x x x x x x x x x x x x
Encephalopathy x x x x x x x x x x x x x
Chills x x x x x x x x x x x x x x x x
Polydipsia x
Hepatic failure x x x
Stupor x x
Agitation x x x x x x x x x x x x x x x x
Photophobia x x x x x x x
Hypokinesia x x x x x x x x x x x x x x x x
Hepatic function abnormal x x x x x x x x x x x x
Mouth ulceration x x x x x x x
Neck stiffness x x x x x x x x x x x x x x x x
Amylase increased
Bleeding time prolonged x x x x x x x
CNS depression NOS x
Drug level increased x x x x x x x
Injection site inflammation
Injection site reaction
Bone marrow depression x
Eye pain x x x x x x x x x x x x x x x x
Injection site pain
Prothrombin level increased
Vesiculobullous rash x x x x x x x
Hyperreflexia x x x x x x x x x x x x x x x x
Aspartate aminotransferase increased x x x x x x x x x x x x x x x x
Alanine aminotransferase increased x x x x x x x x x x x x x x x x
Dry skin x x x x x x x x x x x x x x x x x
Vascular anomaly x
Spontaneous bruising x
Liver injury
Malnutrition x x x x x x x x x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue
Fatal outcomes x x x x x x x x x x x x x
Malaise x x x x x x x x x x x x x x x x
Myalgia x x x x x x x x x x x x x x x x
Abdominal pain upper
Asterixis x x x x x x x x x x x x x x
Teratogenicity
Disturbance in attention
Abnormal behaviour
Excitement x
Memory impairment
Abnormal dreams x x x x x x x x x x x x x x x x x
Euphoric mood
Hepatotoxicity x x x x x x x x x x x x x
Cerebral atrophy x x x x x x x x x x x x x
Hepatic enzyme increased x
Parkinsonism x x x x x x x x x x x x x
Hepatobiliary disease
Petit mal status, epileptic x
Coagulation factor decreased
Dry eye x x x x x x x x x x x x x x x x
Lupus erythematosus x x x x x x x x x x x x
Rash maculo-papular x x x x x x x x x x x x x x x
Liver function test normal x
Pruritus generalised x x x x x x x x x x x x x
Serum amylase increased x
Dementia x x x x x x x x x x x x
Coordination abnormal x x x x x x x x x x x x x x x x x x x
Spots before eyes x x x x x x x x x x
Face oedema x x x x x x x x
Hypovolaemia x x
Distress gastrointestinal x
Cough increased x x x x x x x x x x x x x x x x x
Gait disturbance x x x x x x x x x x x x x x x x x
Tardive dyskinesia x x x x x x x x x x x x x x x x
Sweating increased x
Cerebellar atrophy x
Blood and lymphatic system disorders
Ear and labyrinth disorders
Administration site reaction
Sleep disorder x x x x x x x
Mental status changes x
Thyroid function abnormal x x x x x x x x x x x x x
Myasthenia x x x x x x x x x x x x x x x x
Epidermal necrosis x x x x x x x x x x x x
Pharmacokinetic interaction x
Gastrointestinal tract irritation x
Vaginal haemorrhage x x x x x x x x
Catatonic reaction x x x x x x x x x x x x x x x x
Abnormal vision x x x x x x x x x x x x x x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.