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Rapamycin

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L04AA10

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11
Oedema peripheral Oedema peripheral 48% - 64% 42% - 48% x x x x x x x x x x x
Hypertension Hypertension very common, 23% - 49% 41% - 48% x x x x x x x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia postmarketing — 45% - 57% 23% x x x x x x x x
Blood triglycerides increased Hypertriglyceridaemia postmarketing — 45% - 57% 23% x x x x x x x x
Serum triglycerides increased x x x x x
Hypercholesterolaemia Hypercholesterolaemia postmarketing, 23% - 46% 20% - 23% x x x x x x x x
Blood creatinine increased Creatinine increased postmarketing, 22% - 40% 33% - 38% x x x x x x x x x x
Blood creatinine increased x
Constipation Constipation 28% - 38% 28% - 31% x x x x x x x x x x x
Headache Headache 10% - 34% 20% - 31% x x x x x x x x x x x
Local reaction Local reaction 34% 34% x
Body temperature increased Body temperature increased 19% - 35% 23% - 35% x x x x x x x x x x x
Hyperlipidaemia Hyperlipidaemia very common, 23% - 57% 20% - 23% x x x x x x x
Nausea Nausea 25% - 39% 22% - 29% x x x x x x x x x x x
Abdominal pain Abdominal pain very common, 22% - 36% 23% - 30% x x x x x x x x x x x
Gastrointestinal pain Abdominal pain very common, 22% - 36% 23% - 30% x x x x x x x x x x x
Pain Pain 20% - 33% 21% - 25% x x x x x x x x x x x
Asthenia Asthenia 22% - 40% 19% - 28% x x x x
Diarrhoea Diarrhoea 5.1% - 42% 14% - 27% x x x x x x x x x x x
Anaemia Anaemia very common, 21% - 37% 14% - 21% x x x x x x x x x x x
Urinary tract infection Urinary tract infection very common, 19.8% - 33% 21.5% - 26% x x x x x x x x x x x
Arthralgia Arthralgia very common, 13% - 31% 15% - 18% x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia very common, 13% - 31% 15% - 18% x x x x x x x x x x x
Myalgia x x x x
Vomiting Vomiting 19% - 31% 16% - 21% x x x x
Dyspnoea Dyspnoea 14% - 30% 23% - 30% x x x x
Dyspepsia Dyspepsia 17% - 34% 25% - 34% x x x x
Back pain Back pain 16% - 26% 17% - 20% x x x x
Tremor Tremor 18% - 31% 11% - 19% x x x x
Acne Acne very common, 11% - 31% 14% - 19% x x x x x x x x x x x
Pyelonephritis Pyelonephritis postmarketing — 19.8% - 23.1% 21.5% x x x x x x x x x x x
Hypophosphataemia Hypophosphataemia postmarketing, 15% - 23% 19% x x x x x x x x x x x
Chest pain Chest pain 12% - 24% 16% - 19% x x x x
Oedema Oedema 15% - 24% 7% - 15% x x x x x x x x x x x
Hyperkalaemia Hyperkalaemia 12% - 27% 23% - 27% x x x x x x x x x
Pharyngitis Pharyngitis 16% - 22% 22% x x x x
Weight increased Weight increased 8% - 21% 13% - 15% x x x x
Thrombocytopenia Thrombocytopenia 7% - 30% 3% - 9% x x x x x x x x x x x
Insomnia Insomnia 8% - 22% 8% x x x x
Haematuria Haematuria 13% 9% x x x x
Upper respiratory tract infection Upper respiratory tract infection 13% 23% x x
Cough Cough increased 13% 17% x x x x
Leukopenia Leukopenia postmarketing, 8% - 20% 2% - 8% x x x x x x x x x
Dizziness Dizziness 11% 8% x x x x
Syncope x x x
Hypokalaemia Hypokalaemia postmarketing, 9% - 21% 6% - 9% x x x x x x x x x x x
Dysuria Dysuria 10% 6% x x x x
Dermatitis Rash common, 2% - 20% 5% - 6% x x x x x x x x x x x
Rash Rash common, 2% - 20% 5% - 6% x x x x x x x x x x x
Hypotension Hypotension 10% 6% x x x x
Injury Accidental injury 9% 10% x
Abdominal distension Enlargement abdomen 9% 10% x x x x
Abdominal distension x
Rhinitis Rhinitis 8% 8% x x x x
Visual impairment Abnormal vision 8% 6% x x x x
Ecchymosis Ecchymosis 7% 3% x x x x
Wound infection Wound infection 5% - 8.3% 6.9% x
Sepsis Sepsis postmarketing, 3.7% - 6.7% 6.9% x x x x x x x x x x x
Hypoaesthesia Hypoaesthesia 6% 5% x x x x
Oliguria Oliguria 6% 10% x x x x
Herpes simplex Herpes simplex postmarketing, 3.7% - 12.2% 6.2% x x x x x x x x x
Paraesthesia Paraesthesia 4% 6% x x x x
Tachycardia Tachycardia postmarketing — 4% 4% x x x x x x x x x x x
Face oedema Face oedema 4% 4% x x x x
Transplant rejection Transplant rejection 3% 15% x
Acute allograft rejection x x x x x x x x
Hirsutism Hirsutism 3% 8% x x x x
Lymphocele Lymphocele postmarketing — 3% 6% x x x x x x x x x x x
Osteonecrosis Osteonecrosis postmarketing, common x x x x x x x x x x x
Stomatitis Stomatitis postmarketing, common x x x x x x x x x x x
Mouth ulceration x x x x x
Cytomegalovirus infection Cytomegalovirus infection 0.4% - 4.1% 0.8% - 5.4% x
Impaired healing Impaired healing postmarketing — 4% 6% x x x x x x x x x x x
Chills Chills 2% 8% x x x x
Herpes zoster Herpes zoster postmarketing, 1.8% - 2.2% 3.1% x x x x x x x x x x x
Neoplasm malignant Carcinoma 0.4% - 8.8% 3.1% x x x x
Neoplasm malignant postmarketing, 0% - 7% 0% - 2.3% x x x x x x x x x x x
Malignant melanoma Melanoma skin 0.4% - 8.8% 3.1% x x x x x x x
Malignant melanoma postmarketing — 0% - 1.4% 0% - 1.4% x x x x x x x x
Lymphoproliferative disorder Lymphoproliferative disorder postmarketing, 0.4% - 1.4% 0% - 3.2% x x x x x x x x x x
X-linked lymphoproliferative syndrome Lymphoproliferative disorder postmarketing, 0.4% - 1.4% 0% - 3.2% x x x x x x x x x x
Lymphoma Lymphoma postmarketing — 0.4% - 1.4% 0% x x x x x x x x x x x
Non-Hodgkin's lymphoma Lymphoma postmarketing — 0.4% - 1.4% 0% x x x x x x x x x x x
Epistaxis Epistaxis postmarketing — 1% 0% x x x x x x x x x x x
Pancreatitis Pancreatitis postmarketing, uncommon x x x x x x x x x x x
Post transplant lymphoproliferative disorder Post transplant lymphoproliferative disorder postmarketing, uncommon x x x x x x x x
Amenorrhoea Amenorrhoea postmarketing x x x x
Angioedema Angioedema postmarketing x x x x x x x x x
Ascites Ascites postmarketing x x x x x x x x
Azoospermia Azoospermia postmarketing x x x x x x x
Basal cell carcinoma Basal cell carcinoma postmarketing x x x x x x x
Squamous cell carcinoma Squamous cell carcinoma postmarketing x x x x x x x
Infection Infection postmarketing x x x x x x x x x x x
Dermatitis exfoliative Dermatitis exfoliative postmarketing, rare x x x x x x x x x
Effusion Effusion postmarketing, uncommon x x x x x x x x
Enterocolitis Enterocolitis postmarketing x x x x
Focal segmental glomerulosclerosis Focal segmental glomerulosclerosis postmarketing x x x x x x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome postmarketing x x x x x x x x x x
Hyperglycaemia Hyperglycaemia postmarketing, 13% 10% x x x x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing, rare x x x x x x x x x
Nephropathy Nephropathy postmarketing x x x x
Progressive multifocal leukoencephalopathy Progressive multifocal leukoencephalopathy postmarketing x x x x
Lymphoedema Lymphoedema postmarketing, rare x x x x x x x x x
Menorrhagia Menorrhagia postmarketing x x x x x x x x
Menstrual disorder Menstrual disorder postmarketing x x x x
Mycobacterial infection Mycobacterial infection postmarketing x x x x x x x x x x x
Nephrotic syndrome Nephrotic syndrome postmarketing, uncommon x x x x x x x x x
Neutropenia Neutropenia postmarketing x x x x x x x
Ovarian cyst Ovarian cyst postmarketing, common x x x
Pancytopenia Pancytopenia postmarketing x x x x x x x x x
Pericardial effusion Pericardial effusion postmarketing, uncommon x x x x x x x x
Pleural effusion Pleural effusion postmarketing x x x x x x x x x x x
Pneumonia Pneumonia postmarketing, 1.2% - 10.3% 3.9% x x x x x x x x x x x
Proteinuria Proteinuria postmarketing x x x x x x x x x
Protein urine present Proteinuria postmarketing x x x x x x x x x
Alveolar proteinosis Alveolar proteinosis postmarketing, rare x x x x x x
Pulmonary embolism Pulmonary embolism postmarketing x x x x x x x x x
Pulmonary fibrosis Pulmonary fibrosis postmarketing x x x x x x x x x x x
Thrombotic thrombocytopenic purpura Thrombotic thrombocytopenic purpura postmarketing x x x x x x x x x
Tuberculosis Tuberculosis postmarketing x x x x x x x x
Deep vein thrombosis Deep vein thrombosis postmarketing x x x x x x x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis postmarketing x x x x x x x x x
Pulmonary haemorrhage Pulmonary haemorrhage postmarketing x x x x x x x x x
Liver function test abnormal Liver function test abnormal postmarketing — 9% 7% x x x x x x x x x x x
Hepatic necrosis Hepatic necrosis postmarketing x x x x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased postmarketing x x x x x x x x x x x
Alanine aminotransferase increased Alanine aminotransferase increased postmarketing x x x x x x x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue rare x x
Skin disorder x
Interstitial lung disease Interstitial lung disease postmarketing x x x x x x x x x x x
Hepatotoxicity Hepatotoxicity postmarketing x x x x x x x x x x
Organising pneumonia Bronchiolitis obliterans with organizing pneumonia postmarketing x x x x x x x x x
Organising pneumonia x x
Incisional hernia Incisional hernia postmarketing x x x x x x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x x x x
Anaphylactic shock Anaphylactoid reaction postmarketing x x x x x x x x x
Anaphylactoid reaction Anaphylactoid reaction postmarketing x x x x x x x x x
Blood cholesterol increased Cholesterol serum elevated postmarketing x x x x x
Skin cancer Skin carcinoma postmarketing x
Skin cancer x x
Renal graft loss Renal graft loss postmarketing x x x
Embolism venous Venous thromboembolism postmarketing x x x x x x x x
Abscess Abscess x x x
Acidosis Acidosis x x x x x
Albuminuria Albuminuria x x x x x
Decreased appetite Anorexia x x x x
Anxiety Anxiety x x x x
Asthma Asthma x x x x
Atelectasis Atelectasis x x x x
Pneumothorax Atelectasis x x x x
Atrial fibrillation Atrial fibrillation x x x
Bacterial infection Bacterial infection x x x
Benign neoplasm of skin Benign neoplasm of skin x
Bone disorder Bone disorder x
Breast disorder Breast disorder x x
Obliterative bronchiolitis Obliterative bronchiolitis x x
Bronchitis Bronchitis x x x
Candida infection Oral candidiasis x x x
Oral candidiasis Oral candidiasis x x x
Cellulitis Cellulitis x x x
Confusional state Confusional state x x x x
Feeling abnormal Confusional state x x x x
Malaise x x x x
Conjunctivitis Conjunctivitis x x x x
Connective tissue disorder Connective tissue disorder x
Cushing's syndrome Cushing's syndrome x x x x
Cyst Cyst x
Deafness Deafness x x x
Dysphagia Dysphagia x x x x
Dehydration Dehydration x x x x
Fungal skin infection Fungal skin infection x x x
Diabetes mellitus Diabetes mellitus x x x x x
Ear pain Ear pain x x x x
Eructation Eructation x x x x
Oesophagitis Oesophagitis x x x x
Flatulence Flatulence x x x x
Gastritis Gastritis x x x
Gastroenteritis Gastroenteritis x x x
Gastrointestinal disorder Gastrointestinal disorder x x
Gingival hyperplasia Gingival hyperplasia x x x x x x x x x x
Gingivitis Gingivitis x x x x
Glycosuria Glycosuria x x x x
Gout Gout x x
Hallucination Hallucination x
Cardiac disorder Cardiac disorder x x
Cardiomegaly Cardiomegaly x x
Cardiac failure congestive Cardiac failure congestive x x x x
Haemoptysis Haemoptysis x
Haemorrhage Haemorrhage x x x x
Haemoglobin Haemorrhage x x x x
Hernia Hernia x x x x
Hiccups Hiccups x
Hydronephrosis Hydronephrosis x x x x
Hyperbilirubinaemia Hyperbilirubinaemia x
Hypercalcaemia Hypercalcaemia x x x x
Hypocalcaemia Hypocalcaemia x x x x
Hypoglycaemia Hypoglycaemia x x x x
Hyponatraemia Hyponatraemia x x x x
Hypoproteinaemia Hypoproteinaemia x
Orthostatic hypotension Orthostatic hypotension x x x x
Immune system disorder Immune system disorder x
Influenza Influenza x x x
Arthropathy Arthropathy x x x x x
Osteoarthritis Arthropathy x x x x x
Muscle spasms Cramps of lower extremities x x x x
Leukocytosis Leukocytosis x x x x
Mediastinal disorder Mediastinal disorder x x
Metrorrhagia Metrorrhagia x x x x
Hypertonia Hypertonia x x x x
Hypotonia Hypotonia x x x x
Muscle relaxant therapy Hypotonia x x x x
Nail disorder Nail disorder x
Neoplasm Neoplasm x
Nervous system disorder Nervous system disorder x
Nervousness Nervousness x
Tension Nervousness x
Nocturia Nocturia x x x x
Osteoporosis Osteoporosis x x x x
Otitis media Otitis media x x x
Palpitations Palpitations x x x x
Parathyroid disorder Parathyroid disorder x
Pelvic pain Pelvic pain x x x x
Peritonitis Peritonitis x x x
Polycythaemia Polycythaemia x x x x
Polyp Polyp x
Polyuria Polyuria x x x x
Urine output increased Polyuria x x x x
Pruritus Pruritus x x x x
Pulmonary oedema Pulmonary oedema x x x x
Pyuria Pyuria x x x
Anorectal disorder Rectal disorder x x
Sinusitis Sinusitis x x x x
Skin ulcer Skin ulcer x x x x
Hyperhidrosis Sweating x x x x
Shock Syncope x x x
Syncope Syncope x x x
Loss of consciousness Syncope x x x
Testicular disorder Testicular disorder x x x x
Tetany Tetany x x x x
Thrombophlebitis Thrombophlebitis x x x x
Thrombosis Thrombosis x x x x
Tinnitus Tinnitus x x x x
Azotaemia Uremia x
Pollakiuria Pollakiuria x x x x
Urinary incontinence Urinary incontinence x x x x
Urethral disorder Urinary tract disorder x x x
Urinary tract disorder Urinary tract disorder x x x
Angiopathy Angiopathy x x
Viral infection Viral infection x
Weight decreased Weight decreased x x x x
Wound Wound x x x x x
Urinary retention Urinary retention x x x x
Peripheral vascular disorder Peripheral vascular disorder x x x x
Hepatic failure Hepatic failure x
Agitation Agitation x
Mood swings Mood swings x x x
Affect lability Mood swings x x x
Hyperphosphataemia Hyperphosphataemia x x x x
Cataract Cataract x x x x
Cataract specified x
Epstein-Barr virus infection Epstein-Barr virus infection x x x
Mouth ulceration Mouth ulceration x x x x x
Hormone level abnormal Hormone level abnormal x
Congenital arterial malformation Arterial anomaly x
Blood urea increased Blood urea increased x x x x
Blood creatine phosphokinase increased Creatine phosphokinase increased x x x x
Generalised oedema Generalised oedema x x x x
Fluid retention Generalised oedema x x x x
Scrotal oedema Scrotal oedema x x x x
Skin hypertrophy Skin hypertrophy x x x x
Hypomagnesaemia Hypomagnesaemia x x x x
Renal impairment Kidney function abnormal x x x x x x x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased x x x x x
Blood lactate dehydrogenase increased x
Hepatocellular injury Hepatocellular injury x x
Liver injury Hepatocellular injury x x
Bone pain Bone pain x
Paraesthesia oral Circumoral paresthesia x
Blood alkaline phosphatase increased Phosphatase alkaline increased x x x x
Drug tolerance decreased Decreased tolerance x
Malnutrition Malnutrition x x
Malaise Malaise x x x x
Discomfort Malaise x x x x
Ill-defined disorder Malaise x x x x
Myalgia Myalgia x x x x
Increased appetite Increased appetite x
Bladder pain Bladder pain x x x x
Urine abnormality Urine abnormality x
Urine analysis abnormal Urine abnormality x
Infection susceptibility increased Infection susceptibility increased x x x x x x
Erectile dysfunction Erectile dysfunction x x x x
Hepatic artery thrombosis Hepatic artery thrombosis x x x x x
Chronic allograft nephropathy Chronic allograft nephropathy x x x x x x x x
Laboratory test abnormal Laboratory test abnormal x
Neuropathy peripheral Neuropathy x x x x
Lymphadenopathy Lymphadenopathy x x x
Fluid overload Fluid overload x x x x
Renal pain Renal pain x x x x
Nephropathy toxic Nephropathy toxic x x x x x x x x x x
Blood uric acid increased Hyperuricaemia x x x x x x x x
Hyperuricaemia Hyperuricaemia x x x x x x x x
Hyperlactacidaemia Hyperlactacidaemia x
Infestation Infestation NOS x
Thrombocytopenic purpura Thrombocytopenic purpura x x
Carcinogenicity Carcinogenicity x
Graft loss Graft loss x x x x x x x x
Toxicity to various agents Cyclosporine toxicity x x x x x x x
Ileus Ileus x x x x x
Pneumocystis jirovecii pneumonia Pneumocystis jirovecii pneumonia 0% - 0.4% 0% x
Renal tubular necrosis Renal tubular necrosis x x x x
Somnolence Somnolence x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

sirolimus / sirolimus

Side effects:99
Source:EMA

SIROLIMUS / RAPAMUNE

Side effects:89
Source:FDA

SIROLIMUS / RAPAMUNE

Side effects:90
Source:FDA

sirolimus

Side effects:92
Source:FDA Structured Product Label

SIROLIMUS

Side effects:102
Source:FDA Structured Product Label

SIROLIMUS

Side effects:102
Source:FDA Structured Product Label

RAPAMUNE (sirolimus) tablets / RAPAMUNE (sirolimus)

Side effects:111
Source:medicines.org.au

SIROLIMUS / RAPAMUNE

Side effects:174
Source:FDA

sirolimus / Rapamune

Side effects:175
Source:FDA

sirolimus / Rapamune

Side effects:196
Source:FDA

SIROLIMUS / RAPAMUNE ORAL SOLUTION

Side effects:227
Source:Health Canada

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label