Sirolimus

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 14)
1 2 3 4 5 6 7 8 9 10
Abdominal distension def x
Abdominal pain def x x x x x x x x x x
Abscess def x x x
Acidosis def x x x x x x x x x
Albuminuria def x x x x x x x
Anaemia def x x x x x x x x x x
Angioedema def x x x x
Anorexia def x x x x x x x x x
Anxiety def x x x x x x x x x
Arthralgia def x x x x x x x x x x
Ascites def x x x x
Asthenia def x x x x x x x x x
Asthma def x x x x x x x x x
Atelectasis def x x x x x x x x x
Atrial fibrillation def x x x x x x x x
Azoospermia def x x
Back pain def x x x x x x x x x
Bacterial infection def x
Benign neoplasm of skin def x
Bronchiolitis def x x x x x x x x
Obliterative bronchiolitis def x x x x x x x x
Bronchitis def x x x x x x x x
Neoplasm malignant def x x x x x x x x x x
Candidiasis def x x x x x x x x
Oral candidiasis def x x x x x x x x
Carcinoma def x x x x x x x x x x
Basal cell carcinoma def x x
Squamous cell carcinoma def x x
Cellulitis def x x x
Chest pain def x x x x x x x x x
Confusional state def x x x x x x x x x
Conjunctivitis def x x x x x x x
Constipation def x x x x x x x x x x
Cough def x x x x x x x x x
Cytomegalovirus infection def x
Deafness def x x x x x x
Dysphagia def x x x x x x x x
Dehydration def x x x x x x x x x
Dermatitis def x x x x x x x x x x
Dermatitis exfoliative def x x x
Fungal skin infection def x x x x x x x x
Diabetes mellitus def x x x x x x x x x
Diarrhoea def x x x x x x x x x x
Dizziness def x x x x x x x x x
Dyspepsia def x x x x x x x x x
Dyspnoea def x x x x x x x x x
Dysuria def x x x x x x x
Ear pain def x x x x x x x
Ecchymosis def x x x x x x x x x
Oedema def x x x x x x x x x x
Effusion def x x x x x x x x x x
Embolism def x x x
Enterocolitis def x
Epistaxis def x x x x x x x x x x
Eructation def x x x x x x x x x
Oesophagitis def x x x x x x x x x
Rash def x x x x x x x x x x
Fasting def x
Fertilization def x
Body temperature increased def x x x x x x x x x x
Fibrosis def x x x x x x x
Flatulence def x x x x x x x x x
Gastritis def x x x x x x x x
Gastroenteritis def x x x x x x x x
Gingival hyperplasia def x x x x x x x x x x
Gingivitis def x x x x x x x x x
Focal segmental glomerulosclerosis def x x
Glycosuria def x x x x x x x x x
Gout def x
Transplant rejection def x
Hallucination def x
Headache def x x x x x x x x x x
Cardiomegaly def x
Cardiac failure def x x x x x x x x x
Cardiac failure congestive def x x x x x x x x x
Haematuria def x x x x x x x
Haemolytic uraemic syndrome def x x x x
Haemoptysis def x
Haemorrhage def x x x x x x x x x x
Hernia def x x x x x x x x
Herpes NOS def x x x x x x x x x x
Herpes simplex def x x x x x x x x x x
Herpes zoster def x x x x x x x x x x
Hiccups def x
Hirsutism def x x x x x x x x x
Hydronephrosis def x x x x x x x
Hyperbilirubinaemia def x
Hypercalcaemia def x x x x x x x x x
Hypercholesterolaemia def x x x x x x x x x x
Hyperglycaemia def x x x x x x x x x x
Hyperkalaemia def x x x x x x x x x x
Hyperlipidaemia def x x x x x x x x x x
Hyperplasia def x x x x x x x x x x
Hypersensitivity def x x x x
Hypertension def x x x x x x x x x x
Hypertriglyceridaemia def x x
Hypertrophy def x x x x x x x x x
Hypoaesthesia def x x x x x x x x x
Hypocalcaemia def x x x x x x x x x
Hypoglycaemia def x x x x x x x x x
Hypokalaemia def x x x x x x x x x x
Hyponatraemia def x x x x x x x x x
Hypoproteinaemia def x
Hypotension def x x x x x x x x x
Orthostatic hypotension def x x x x x x x x x
Immunosuppression def x
Incontinence def x x x x x x
Infection def x x x x x x x x x x
Influenza def x x x
Arthropathy def x x x x x x x x x
Nephropathy def x x x x x x x x
Cramps of lower extremities x x x x x x x x x
Leukocytosis def x x x x x x x x x
Progressive multifocal leukoencephalopathy def x
Leukopenia def x x x x x x x x x x
Lung disorder def x x x x x x x x
Lymphoedema def x x x x
Lymphocele def x x x x x x x x x x
Lymphoma def x x x x x x x x x
Lymphoproliferative disorder def x x x x x x x x x
Malignant melanoma def x x x x x x x x x x
Menorrhagia def x
Metrorrhagia def x
Cramp muscle def x x x x x x x x x
Hypertonia def x x x x x x x x x
Hypotonia def x x x x x x x x x
Mycobacterial infection def x x x x x x x x
Nail disorder def x
Nausea def x x x x x x x x x x
Necrosis def x x x x x x x x x x
Neoplasm def x
Nephrotic syndrome def x x x
Nervousness def x
Neutropenia def x x x x x
Nocturia def x x x x x x x
Oliguria def x x x x x x x
Osteonecrosis def x x x x x x x x x
Osteoporosis def x x x x x x x x x
Otitis def x x x x x x
Otitis media def x x x x x x
Pain def x x x x x x x x x x
Palpitations def x x x x x x x x x
Pancreatitis def x x x x x x x x
Pancytopenia def x x x x x x x x
Parathyroid disorder def x
Paraesthesia def x x x x x x x x x
Pelvic pain def x x x x x x x x x
Pericardial effusion def x x
Peritonitis def x x x x x x x x
Pharyngitis def x x x x x x x x x
Pleural disorder def x x x x x x x x x x
Pleural effusion def x x x x x x x x x x
Pneumonia def x x x x x x x x x x
Pneumocystis carinii pneumonia def x
Polycythaemia def x x x x x x x x x
Polyuria def x
Proteinuria def x x x
Pruritus def x x x x x x x x x
Alveolar proteinosis def x x
Pulmonary oedema def x x x x x x x x x
Pulmonary embolism def x x x
Pulmonary fibrosis def x x x x x x x
Purpura def x x x x x x x x x x
Thrombotic thrombocytopenic purpura def x x x x x x x x x x
Pyelonephritis def x x x x x x x x x
Pyuria def x x x x x x
Rectal disorder def x x x x x
Respiratory tract infection def x x x x x x
Rhinitis def x x x x x x x x x
Sinusitis def x x x x x x x x x
Skin disorder def x
Neoplasm skin def x
Skin ulcer def x x x x x x x x x
Stomatitis def x x x x x x x x x x
Sweating def x x x x x x x x x
Syncope def x x x x x x x x
Tachycardia def x x x x x x x x x x
Testicular disorder def x x x x x x x
Tetany def x x x x x x x x x
Thrombocytopenia def x x x x x x x x x x
Thromboembolism def x x x x x x
Thrombophlebitis def x x x x x x x x x
Thrombosis def x x x x x x x x x x
Tinnitus def x x x x x x x
Tremor def x x x x x x x x x
Tuberculosis def x x
Ulcer def x x x x x x x x x
Upper respiratory tract infection def x x x x x x
Pollakiuria def x x x x x x
Urinary incontinence def x x x x x x
Urinary tract infection def x x x x x
Urinary tract disorder def x
Angiopathy def x x x x x x x x x
Vasculitis def x x x
Vasodilation def x x x x x x x x x
Venous thrombosis def x x x x
Visual impairment def x x x x x x x
Vomiting def x x x x x x x x x
Weight increased def x x x x x x x x x
Weight decreased def x x x x x x x x x
Wound infection def x
Urinary retention def x x x x x x
Peripheral vascular disorder def x x x x x x x x x
Chills def x x x x x x x
Agitation def x
Mood swings x x x x x x x x
Oedema peripheral def x x x x x x x x x x
Hyperphosphataemia def x x x x x x x x x
Hypophosphataemia def x x x x x x x x x x
Cataract def x x x x x x x
Hepatic function abnormal x x x x x x
Benign neoplasm def x
Mouth ulceration def x x x x x x x x x
Deep vein thrombosis def x x x x
Allergic cutaneous angiitis def x x x
Hormone level abnormal x
Arterial anomaly x
Blood urea increased x x x x x x x x x
Cataract specified x
Creatine phosphokinase increased def x x x x x x x x x
Creatinine increased def x x x x x x x x x x
Generalised oedema x x x x
Scrotal oedema x x x x x x x
Impaired healing x x x x x x x x x x
Pulmonary haemorrhage def x x
Skin hypertrophy x x x x x x x x x
Hypomagnesaemia def x x x x x x x x x
Kidney function abnormal x x x x x
Renal tubular disorder def x x x x x x
Lactic dehydrogenase activity increased x x x x x x x x x x
Hepatocellular injury x
Liver function test abnormal x x x x x x x x x x
Skin melanoma def x x x x
Hepatic necrosis def x x x x x x x x
Bone pain def x
Circumoral paresthesia x
Phosphatase alkaline increased x x x x x x x x x
Aspartate aminotransferase increased def x x x x x x x x x x
Alanine aminotransferase increased def x x x x x x x x x x
Microangiopathy x x
Glomerulosclerosis def x x
Interstitial lung disease def x x x x x x x x
Malaise def x x x x x x x x x
Myalgia def x x x x x x x x x
Cardiac fibrillation x x x x x x x x
Increased appetite x
Bladder pain def x x x x x x x
Urine abnormality x
Infection susceptibility increased x x
Hypoxia def x x x x x x x x x
Erectile dysfunction def x x x x x x x
Bronchiolitis obliterans with organizing pneumonia def x x x x x x x x
Sepsis def x x x x x x x x x x
Organising pneumonia x x x x x x x x
Hepatobiliary disease def x x
Leukoencephalopathy def x
Uraemic syndrome x x x x x x x x x x
Anaphylactoid reaction x x x x x
Enlargement abdomen def x x x x
Hepatic artery thrombosis x
Chronic allograft nephropathy x x x
Post transplant lymphoproliferative disorder def x
Laboratory test abnormal x
Neuropathy def x x x x x x x x x
Lymphadenopathy def x x x x x x x x
Face oedema def x x x x
Fluid overload def x x x x x x x x x
Renal pain x x x x x x
Cough increased x x x x x x x x x
Nephropathy toxic x x x x x x x x
Cholesterol serum elevated x
Skin carcinoma def x x x x x x x x x x
Acne def x x x x x x x x x x
Hyperuricaemia def x x x x x x
Serum triglycerides increased x x x x
Local reaction x
Thrombocytopenic purpura def x x x x x x x x x x
Carcinogenicity x
Graft loss x x x x
Insomnia def x x x x x x x x x
Ileus def x x x x x x x x x
Death x x x x
Renal tubular necrosis x x x x x x
Venous thromboembolism def x x x x x x
Thrombotic microangiopathy def x x
Somnolence def x x x x x x x x x
Indication Labels
Adverse reaction def x
Elderly def x
Withdrawn x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L04AA10

Legend

Color scheme: standard – alternative

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infrequent (0.1% to 1%)    
rare (<0.1%)    
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no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. SIROLIMUS : 120 side effects (FDA XML label)
  2. sirolimus / RAPAMUNE : 146 side effects (FDA MedWatch)
  3. SIROLIMUS / RAPAMUNE : 165 side effects (Drugs@FDA)
  4. SIROLIMUS / RAPAMUNE : 192 side effects (Drugs@FDA)
  5. sirolimus / Rapamune : 196 side effects (FDA CDER)
  6. sirolimus / Rapamune : 198 side effects (FDA MedWatch)
  7. sirolimus / Rapamune : 201 side effects (FDA MedWatch)
  8. sirolimus / Rapamune : 209 side effects (FDA MedWatch)
  9. SIROLIMUS / RAPAMUNE : 211 side effects (Drugs@FDA)
  10. SIROLIMUS / RAPAMUNE ORAL SOLUTION : 256 side effects (Health Canada)