| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 
| Pain | Pain | 25.2% |  |  | x | x | x | 
| Infection | Infection | 11.9% - 27.8% |  |  | x | x | x | 
| Neutropenia | Neutropenia | postmarketing — 24.4% - 43.5% |  | x | x | x | x | 
| Cough | Cough increased | 19.1% |  |  | x | x | x | 
| Candida infection | Oral candidiasis | 18.3% |  |  | x | x | x | 
| Oral candidiasis | Oral candidiasis | 18.3% |  |  | x | x | x | 
| Hypotony of eye | Hypotony of eye | 17.8% |  |  | x | x | x | 
| Dermatitis | Rash | postmarketing — 29.6% |  | x | x | x | x | 
| Dermatitis | postmarketing |  | x |  |  |  | 
| Rash | Rash | postmarketing — 29.6% |  | x | x | x | x | 
| Body temperature increased | Body temperature increased | postmarketing, 14.1% - 58.3% |  | x | x | x | x | 
| Fever chills | postmarketing |  | x |  |  |  | 
| Diarrhoea | Diarrhoea | postmarketing, 26.1% |  | x | x | x | x | 
| Anaemia | Anaemia | postmarketing, 24.3% |  | x | x | x | x | 
| Decreased appetite | Anorexia | postmarketing, 22.6% |  | x | x | x | x | 
| Chills | Chills | postmarketing, 21.7% |  | x | x | x | x | 
| Pneumonia | Pneumonia | 8.89% |  |  | x | x | x | 
| Alopecia | Alopecia | postmarketing — 27% |  | x | x | x | x | 
| Nausea | Nausea | postmarketing — 7.41% - 68.7% |  | x | x | x | x | 
| Vomiting | Vomiting | postmarketing — 7.41% - 68.7% |  | x | x | x | x | 
| Dyspnoea | Dyspnoea | postmarketing — 8.15% - 22.6% |  | x | x | x | x | 
| Headache | Headache | postmarketing — 29.6% |  | x | x | x | x | 
| Iritis | Iritis | postmarketing, common |  | x | x | x | x | 
| Uveitis | Uveitis | postmarketing, common |  | x | x | x | x | 
| Anaphylactic shock | Anaphylactic shock | postmarketing |  | x |  |  |  | 
| Aplastic anaemia | Aplastic anaemia | postmarketing |  | x |  |  |  | 
| Haemolytic anaemia | Haemolytic anaemia | postmarketing |  | x |  |  |  | 
| Asthenia | Asthenia | postmarketing, 43.5% |  | x | x | x | x | 
| Dizziness | Dizziness | postmarketing |  | x | x | x | x | 
| Syncope |  |  |  | x | x | x | 
| Eye disorder | Eye disorder | postmarketing |  | x | x | x | x | 
| Fanconi syndrome | Fanconi syndrome | postmarketing |  | x | x | x | x | 
| Renal tubular disorder | Fanconi syndrome | postmarketing |  | x | x | x | x | 
| Flushing | Flushing | postmarketing |  | x |  |  |  | 
| Gastrointestinal disorder | Gastrointestinal disorder | postmarketing |  | x |  |  |  | 
| Glycosuria | Glycosuria | postmarketing |  | x | x | x | x | 
| Hypersensitivity | Hypersensitivity | postmarketing |  | x | x | x | x | 
| Hypokalaemia | Hypokalaemia | postmarketing |  | x | x | x | x | 
| Renal failure acute | Renal failure acute | postmarketing |  | x |  |  |  | 
| Leukopenia | Leukopenia | postmarketing |  | x | x | x | x | 
| Mediastinal disorder | Mediastinal disorder | postmarketing |  | x |  |  |  | 
| Nephrotic syndrome | Nephrotic syndrome | postmarketing |  | x |  |  |  | 
| Nervous system disorder | Nervous system disorder | postmarketing |  | x |  |  |  | 
| Pancreatitis | Pancreatitis | postmarketing |  | x | x | x | x | 
| Proteinuria | Proteinuria | postmarketing, 50.4% - 87.8% |  | x | x | x | x | 
| Protein urine present | Proteinuria | postmarketing, 50.4% - 87.8% |  | x | x | x | x | 
| Pruritus | Pruritus | postmarketing |  | x | x | x | x | 
| Renal failure | Renal failure | postmarketing |  | x |  |  |  | 
| Erythema multiforme | Stevens-Johnson syndrome | postmarketing |  | x |  |  |  | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome | postmarketing |  | x |  |  |  | 
| Pollakiuria | Pollakiuria | postmarketing |  | x |  |  |  | 
| Urethral disorder | Urinary tract disorder | postmarketing |  | x |  |  |  | 
| Urinary tract disorder | Urinary tract disorder | postmarketing |  | x |  |  |  | 
| Urticaria | Urticaria | postmarketing |  | x | x | x | x | 
| Hypophosphataemia | Hypophosphataemia | postmarketing |  | x | x | x | x | 
| Hepatic necrosis | Hepatic necrosis | postmarketing |  | x | x | x | x | 
| Skin disorder | Unspecified disorder of skin and subcutaneous tissue | postmarketing |  | x |  |  |  | 
| Skin disorder |  |  |  | x | x | x | 
| Hypouricaemia | Hypouricaemia | postmarketing |  | x |  |  |  | 
| Blood creatinine increased | Blood creatinine increased | postmarketing |  | x |  |  |  | 
| Aminoaciduria | Aminoaciduria | postmarketing |  | x |  |  |  | 
| Gingival pain | Gingival pain | postmarketing |  | x |  |  |  | 
| Fanconi syndrome acquired | Fanconi syndrome acquired | postmarketing |  | x |  |  |  | 
| Deafness | Hearing impaired | postmarketing |  | x | x | x | x | 
| Hearing impaired | Hearing impaired | postmarketing |  | x | x | x | x | 
| Abdominal pain | Abdominal pain |  |  |  | x | x | x | 
| Gastrointestinal pain | Abdominal pain |  |  |  | x | x | x | 
| Multiple congenital abnormalities | Multiple congenital abnormalities |  |  |  | x | x | x | 
| Respiratory alkalosis | Respiratory alkalosis |  |  |  | x | x | x | 
| Amblyopia | Amblyopia |  |  |  | x | x | x | 
| Amnesia | Amnesia |  |  |  | x | x | x | 
| Hypochromic anaemia | Hypochromic anaemia |  |  |  | x | x | x | 
| Angioedema | Angioedema |  |  |  | x | x | x | 
| Anxiety | Anxiety |  |  |  | x | x | x | 
| Arthralgia | Arthralgia |  |  |  | x | x | x | 
| Musculoskeletal discomfort | Arthralgia |  |  |  | x | x | x | 
| Myalgia |  |  |  | x | x | x | 
| Asthma | Asthma |  |  |  | x | x | x | 
| Ataxia | Ataxia |  |  |  | x | x | x | 
| Back pain | Back pain |  |  |  | x | x | x | 
| Bronchitis | Bronchitis |  |  |  | x | x | x | 
| Cachexia | Cachexia |  |  |  | x | x | x | 
| Neoplasm malignant | Neoplasm malignant |  |  |  |  | x | x | 
| Cardiovascular disorder | Cardiovascular disorder |  |  |  | x | x | x | 
| Cellulitis | Cellulitis |  |  |  | x | x | x | 
| Cerebrovascular disorder | Cerebrovascular disorder |  |  |  | x | x | x | 
| Neck pain | Neck pain |  |  |  | x | x | x | 
| Chest pain | Chest pain |  |  |  | x | x | x | 
| Cholangitis | Cholangitis |  |  |  | x | x | x | 
| Colitis | Colitis |  |  |  | x | x | x | 
| Confusional state | Confusional state |  |  |  | x | x | x | 
| Feeling abnormal | Confusional state |  |  |  | x | x | x | 
| Malaise |  |  |  | x | x | x | 
| Conjunctivitis | Conjunctivitis |  |  |  | x | x | x | 
| Constipation | Constipation |  |  |  | x | x | x | 
| Corneal opacity | Corneal opacity |  |  |  | x | x | x | 
| Cryptococcosis | Cryptococcosis |  |  |  | x | x | x | 
| Dysphagia | Dysphagia |  |  |  | x | x | x | 
| Dehydration | Dehydration |  |  |  | x | x | x | 
| Delirium | Delirium |  |  |  | x | x | x | 
| Dental caries | Dental caries |  |  |  | x | x | x | 
| Dermatitis exfoliative | Dermatitis exfoliative |  |  |  | x | x | x | 
| Diplopia | Diplopia |  |  |  | x | x | x | 
| Dysgeusia | Dysgeusia |  |  |  | x | x | x | 
| Dyspepsia | Dyspepsia |  |  |  | x | x | x | 
| Dysuria | Dysuria |  |  |  | x | x | x | 
| Ear disorder | Ear disorder |  |  |  | x | x | x | 
| Ear pain | Ear pain |  |  |  | x | x | x | 
| Eczema | Eczema |  |  |  | x | x | x | 
| Oedema | Oedema |  |  |  | x | x | x | 
| Epistaxis | Epistaxis |  |  |  | x | x | x | 
| Oesophagitis | Oesophagitis |  |  |  | x | x | x | 
| VIIth nerve paralysis | Facial paralysis |  |  |  | x | x | x | 
| Faecal incontinence | Faecal incontinence |  |  |  | x | x | x | 
| Flatulence | Flatulence |  |  |  | x | x | x | 
| Furuncle | Furunculosis |  |  |  | x | x | x | 
| Gastritis | Gastritis |  |  |  | x | x | x | 
| Gastrointestinal haemorrhage | Gastrointestinal haemorrhage |  |  |  | x | x | x | 
| Gingivitis | Gingivitis |  |  |  | x | x | x | 
| Hallucination | Hallucination |  |  |  | x | x | x | 
| Cardiac failure congestive | Cardiac failure congestive |  |  |  | x | x | x | 
| Haematuria | Haematuria |  |  |  | x | x | x | 
| Hemiplegia | Hemiplegia |  |  |  | x | x | x | 
| Haemoptysis | Haemoptysis |  |  |  | x | x | x | 
| Hepatitis | Hepatitis |  |  |  | x | x | x | 
| Hepatomegaly | Hepatomegaly |  |  |  | x | x | x | 
| Hepatosplenomegaly | Hepatosplenomegaly |  |  |  | x | x | x | 
| Herpes simplex | Herpes simplex |  |  |  | x | x | x | 
| Hiccups | Hiccups |  |  |  | x | x | x | 
| Hypercalcaemia | Hypercalcaemia |  |  |  | x | x | x | 
| Hyperaesthesia | Hyperaesthesia |  |  |  | x | x | x | 
| Hyperglycaemia | Hyperglycaemia |  |  |  | x | x | x | 
| Hyperkalaemia | Hyperkalaemia |  |  |  | x | x | x | 
| Hyperlipidaemia | Hyperlipidaemia |  |  |  | x | x | x | 
| Hypertension | Hypertension |  |  |  | x | x | x | 
| Hyperventilation | Hyperventilation |  |  |  | x | x | x | 
| Hypocalcaemia | Hypocalcaemia |  |  |  | x | x | x | 
| Hypoglycaemia | Hypoglycaemia |  |  |  | x | x | x | 
| Hypoglycemic reaction |  |  |  | x | x | x | 
| Hyponatraemia | Hyponatraemia |  |  |  | x | x | x | 
| Hypoproteinaemia | Hypoproteinaemia |  |  |  | x | x | x | 
| Hypotension | Hypotension |  |  |  | x | x | x | 
| Orthostatic hypotension | Orthostatic hypotension |  |  |  | x | x | x | 
| Body temperature decreased | Body temperature decreased |  |  |  | x | x | x | 
| Hypothermia | Body temperature decreased |  |  |  | x | x | x | 
| Libido increased | Libido increased |  |  |  | x | x | x | 
| Disturbance in sexual arousal | Libido increased |  |  |  | x | x | x | 
| Jaundice | Jaundice |  |  |  | x | x | x | 
| Arthropathy | Arthropathy |  |  |  | x | x | x | 
| Osteoarthritis | Arthropathy |  |  |  | x | x | x | 
| Keratitis | Keratitis |  |  |  | x | x | x | 
| Nephrolithiasis | Calculus of kidney |  |  |  | x | x | x | 
| Laryngeal oedema | Laryngeal oedema |  |  |  | x | x | x | 
| Muscle spasms | Cramps of lower extremities |  |  |  | x | x | x | 
| Leukocytosis | Leukocytosis |  |  |  | x | x | x | 
| Lung disorder | Lung disorder |  |  |  | x | x | x | 
| Mastitis | Mastitis |  |  |  | x | x | x | 
| Melaena | Melaena |  |  |  | x | x | x | 
| Miosis | Miosis |  |  |  | x | x | x | 
| Hypertonia | Hypertonia |  |  |  | x | x | x | 
| Myoclonus | Myoclonus |  |  |  | x | x | x | 
| Nail disorder | Nail disorder |  |  |  | x | x | x | 
| Nervousness | Nervousness |  |  |  | x | x | x | 
| Tension | Nervousness |  |  |  | x | x | x | 
| Nocturia | Nocturia |  |  |  | x | x | x | 
| Osteonecrosis | Osteonecrosis |  |  |  | x | x | x | 
| Otitis externa | Otitis externa |  |  |  | x | x | x | 
| Otitis media | Otitis media |  |  |  | x | x | x | 
| Pallor | Pallor |  |  |  | x | x | x | 
| Pancytopenia | Pancytopenia |  |  |  | x | x | x | 
| Paraesthesia | Paraesthesia |  |  |  | x | x | x | 
| Personality disorder | Personality disorder |  |  |  | x | x | x | 
| Pharyngitis | Pharyngitis |  |  |  | x | x | x | 
| Phlebitis | Phlebitis |  |  |  | x | x | x | 
| Pneumothorax | Pneumothorax |  |  |  | x | x | x | 
| Polyuria | Polyuria |  |  |  | x | x | x | 
| Urine output increased | Polyuria |  |  |  | x | x | x | 
| Proctitis | Proctitis |  |  |  | x | x | x | 
| Prostatic disorder | Prostatic disorder |  |  |  | x | x | x | 
| Hyperacusis | Hyperacusis |  |  |  | x | x | x | 
| Anorectal disorder | Rectal disorder |  |  |  | x | x | x | 
| Refraction disorder | Refraction disorder |  |  |  | x | x | x | 
| Retinal detachment | Retinal detachment |  |  |  | x | x | x | 
| Retinal disorder | Retinal disorder |  |  |  | x | x | x | 
| Rhinitis | Rhinitis |  |  |  | x | x | x | 
| Scotoma | Scotoma |  |  |  | x | x | x | 
| Seborrhoeic dermatitis | Seborrhoeic dermatitis |  |  |  | x | x | x | 
| Convulsion | Convulsion |  |  |  | x | x | x | 
| Shock | Shock |  |  |  | x | x | x | 
| Syncope |  |  |  | x | x | x | 
| Sinusitis | Sinusitis |  |  |  | x | x | x | 
| Skin ulcer | Skin ulcer |  |  |  | x | x | x | 
| Speech disorder | Speech disorder |  |  |  | x | x | x | 
| Spleen disorder | Spleen disorder |  |  |  | x | x | x | 
| Splenomegaly | Splenomegaly |  |  |  | x | x | x | 
| Stomatitis | Stomatitis |  |  |  | x | x | x | 
| Mouth ulceration |  |  |  | x | x | x | 
| Aphthous stomatitis | Aphthous stomatitis |  |  |  | x | x | x | 
| Hyperhidrosis | Sweating |  |  |  | x | x | x | 
| Syncope | Syncope |  |  |  | x | x | x | 
| Loss of consciousness | Syncope |  |  |  | x | x | x | 
| Tachycardia | Tachycardia |  |  |  | x | x | x | 
| Thirst | Thirst |  |  |  | x | x | x | 
| Thrombocytopenia | Thrombocytopenia |  |  |  | x | x | x | 
| Tinnitus | Tinnitus |  |  |  | x | x | x | 
| Tremor | Tremor |  |  |  | x | x | x | 
| Urethritis | Urethritis |  |  |  | x | x | x | 
| Urethritis noninfective | Urethritis |  |  |  | x | x | x | 
| Urinary incontinence | Urinary incontinence |  |  |  | x | x | x | 
| Urinary tract infection | Urinary tract infection |  |  |  | x | x | x | 
| Iridocyclitis | Anterior uveitis |  |  |  | x | x | x | 
| Angiopathy | Angiopathy |  |  |  | x | x | x | 
| Vertigo | Vertigo |  |  |  | x | x | x | 
| Weight increased | Weight increased |  |  |  | x | x | x | 
| Weight decreased | Weight decreased |  |  |  | x | x | x | 
| Dry mouth | Dry mouth |  |  |  | x | x | x | 
| Urinary retention | Urinary retention |  |  |  | x | x | x | 
| Peripheral vascular disorder | Peripheral vascular disorder |  |  |  | x | x | x | 
| Encephalopathy | Encephalopathy |  |  |  | x | x | x | 
| Agitation | Agitation |  |  |  | x | x | x | 
| Oedema peripheral | Oedema peripheral |  |  |  | x | x | x | 
| Cataract | Cataract |  |  |  | x | x | x | 
| Hepatic function abnormal | Hepatic function abnormal |  |  |  | x | x | x | 
| Mouth ulceration | Mouth ulceration |  |  |  | x | x | x | 
| Migraine | Migraine |  |  |  | x | x | x | 
| Blood urea increased | Blood urea increased |  |  |  | x | x | x | 
| Corneal lesion | Corneal lesion |  |  |  | x | x | x | 
| Tongue discolouration | Tongue discolouration |  |  |  | x | x | x | 
| Skin hypertrophy | Skin hypertrophy |  |  |  | x | x | x | 
| Hypomagnesaemia | Hypomagnesaemia |  |  |  | x | x | x | 
| Injection site reaction | Injection site reaction |  |  |  | x | x | x | 
| Injury | Accidental injury |  |  |  | x | x | x | 
| Hepatocellular injury | Hepatocellular injury |  |  |  | x | x | x | 
| Liver injury | Hepatocellular injury |  |  |  | x | x | x | 
| Mucous membrane disorder | Mucous membrane disorder |  |  |  | x | x | x | 
| Bone pain | Bone pain |  |  |  | x | x | x | 
| Eye pain | Eye pain |  |  |  | x | x | x | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased |  |  |  | x | x | x | 
| Aspartate aminotransferase increased | Aspartate aminotransferase increased |  |  |  | x | x | x | 
| Alanine aminotransferase increased | Alanine aminotransferase increased |  |  |  | x | x | x | 
| Skin discolouration | Skin discolouration |  |  |  | x | x | x | 
| Dry skin | Dry skin |  |  |  | x | x | x | 
| Photosensitivity reaction | Photosensitivity reaction |  |  |  | x | x | x | 
| Metabolic acidosis | Metabolic acidosis |  |  |  | x | x | x | 
| Pseudolymphoma | Pseudolymphoma |  |  |  | x | x | x | 
| Malaise | Sickness |  |  |  | x |  | x | 
| Malaise |  |  |  | x | x | x | 
| Discomfort | Malaise |  |  |  | x | x | x | 
| Ill-defined disorder | Malaise |  |  |  | x | x | x | 
| Myalgia | Myalgia |  |  |  | x | x | x | 
| Muscle twitching | Muscle twitching |  |  |  | x | x | x | 
| Abnormal dreams | Abnormal dreams |  |  |  | x | x | x | 
| Blood creatinine decreased | Creatinine low |  |  |  | x | x | x | 
| Sepsis | Sepsis |  |  |  | x | x | x | 
| Dry eye | Dry eye |  |  |  | x | x | x | 
| Adrenal insufficiency | Adrenal cortical hypofunction |  |  |  | x | x | x | 
| Neuropathy peripheral | Neuropathy |  |  |  | x | x | x | 
| Blindness | Blindness |  |  |  | x | x | x | 
| Lymphadenopathy | Lymphadenopathy |  |  |  | x | x | x | 
| Dementia | Dementia |  |  |  | x | x | x | 
| Coordination abnormal | Coordination abnormal |  |  |  | x | x | x | 
| Face oedema | Face oedema |  |  |  | x | x | x | 
| Gait disturbance | Gait disturbance |  |  |  | x | x | x | 
| Nephropathy toxic | Nephropathy toxic |  |  |  | x | x | x | 
| Nephrotoxicity |  |  |  | x | x | x | 
| Thrombocytopenic purpura | Thrombocytopenic purpura |  |  |  | x | x | x | 
| Cardiomyopathy | Cardiomyopathy |  |  |  | x | x | x | 
| Insomnia | Insomnia |  |  |  | x | x | x | 
| Muscular weakness | Myasthenia |  |  |  | x | x | x | 
| Neutrophil count decreased | Absolute neutrophil count decreased |  |  |  | x | x | x | 
| Somnolence | Somnolence |  |  |  | x | x | x | 
| Visual impairment | Abnormal vision |  |  |  | x | x | x |