MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
13
|
14
|
15
|
16
|
17
|
18
|
19
|
20
|
Cushing's syndrome
|
Cushing's syndrome
|
31% - 47.6%
|
24.2%
|
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Respiratory tract infection
|
Respiratory tract infection
|
5.68% - 38%
|
6.54% - 36%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
postmarketing, 11.4% - 28%
|
10.5% - 21.2%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Acne
|
Acne
|
0.787% - 22.8%
|
0% - 13.1%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hyperhidrosis
|
Sweating increased
|
5.22% - 17.9%
|
3.03%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Otitis media
|
Otitis media
|
1.3% - 12%
|
0.9% - 11%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
Rhinitis
|
Rhinitis
|
7% - 12%
|
9%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Nausea
|
Nausea
|
1.8% - 13.1%
|
0.9% - 9.35%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
|
x
|
|
x
|
x
|
Cushingoid
|
Cushingoid
|
1.18% - 36.6%
|
0% - 4.92%
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Nasopharyngitis
|
Nasopharyngitis
|
9.3%
|
8.3%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
Contusion
|
Contusion
|
postmarketing, 4.55% - 14.8%
|
3.5% - 11.2%
|
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Oedema peripheral
|
Ankle edema
|
2.07% - 8.97%
|
2.1% - 5.61%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Joint swelling
|
Ankle edema
|
2.07% - 8.97%
|
2.1% - 5.61%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Dizziness
|
Dizziness
|
4.67% - 12.4%
|
4.67% - 6.06%
|
|
|
|
x
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
Syncope
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Lightheadedness
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Back pain
|
Back pain
|
5.68% - 11.7%
|
9.09% - 9.35%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
Insomnia
|
Insomnia
|
2.35% - 11%
|
3.1% - 6.56%
|
x
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
3.41% - 11.7%
|
3.03% - 3.74%
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
Flatulence
|
Flatulence
|
2.35% - 8.28%
|
1.94% - 6.06%
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Arthralgia
|
Arthralgia
|
1.96% - 5%
|
1.55% - 6.06%
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
Musculoskeletal discomfort
|
Arthralgia
|
1.96% - 5%
|
1.55% - 6.06%
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
Myalgia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Cough
|
Cough
|
postmarketing, 2% - 9%
|
1% - 5%
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
|
Cough increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Gastroenteritis
|
Gastroenteritis
|
5%
|
4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Asthenia
|
Fatigue
|
0% - 8.21%
|
1.94% - 7.58%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
x
|
|
x
|
x
|
x
|
Asthenia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
Fatigue
|
Fatigue
|
0% - 8.21%
|
1.94% - 7.58%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
x
|
|
x
|
x
|
x
|
Candida infection
|
Candida infection
|
3% - 4%
|
2%
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
Oral candidiasis
|
1.3%
|
0.4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
Candida albicans infection
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
|
|
Diarrhoea
|
Diarrhoea
|
2% - 10%
|
2%
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Muscle spasms
|
Cramp muscle
|
4%
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Viral infection
|
Viral infection
|
3% - 6%
|
3%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Vomiting
|
Vomiting
|
2% - 7.09%
|
3% - 7.58%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Ear infection
|
Ear infection
|
2% - 5%
|
4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Abdominal pain upper
|
Abdominal pain upper
|
3.15% - 3.92%
|
1.94%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Epigastric pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hirsutism
|
Hirsutism
|
0% - 5.15%
|
0% - 1.87%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Pain
|
Pain
|
postmarketing, 2.27% - 11.7%
|
7.48% - 9.09%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Ache
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Blood cortisol decreased
|
Blood cortisol decreased
|
2.36% - 4.31%
|
0.388%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Abdominal pain
|
Abdominal pain
|
2% - 16.8%
|
2% - 16.8%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
2% - 16.8%
|
2% - 16.8%
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Epistaxis
|
Epistaxis
|
2% - 8%
|
1% - 5%
|
|
|
x
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
|
|
Dysphonia
|
Hoarseness
|
2-4%
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Dysphonia
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Vision blurred
|
Vision blurred
|
3%
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
Nasal congestion
|
Nasal congestion
|
2.7%
|
0.4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
Viral upper respiratory tract infection
|
Viral upper respiratory tract infection
|
2.2%
|
1.3%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
Rhinitis allergic
|
Rhinitis allergic
|
2.2%
|
1.3%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
Conjunctivitis
|
Conjunctivitis
|
1% - 4%
|
2%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Dermatitis
|
Rash
|
postmarketing, 1% - 4.1%
|
3% - 6.06%
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Dermatitis
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
x
|
x
|
Rash
|
Rash
|
postmarketing, 1% - 4.1%
|
3% - 6.06%
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Menstrual disorder
|
Menstrual disorder
|
2%
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Nasal discomfort
|
Nasal irritation
|
2%
|
1%
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Abdominal distension
|
Abdominal distension
|
1.57% - 2.35%
|
0.775%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Viral diarrhoea
|
Viral diarrhoea
|
1.8%
|
0.4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
Lipohypertrophy
|
Buffalo hump
|
0.69% - 3.45%
|
0% - 1.87%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Pharyngitis
|
Pharyngitis
|
postmarketing, 2.7% - 4%
|
1.7% - 3%
|
|
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Oral candidiasis
|
Oral candidiasis
|
1.3%
|
0.4%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
x
|
Fluid retention
|
Fluid retention
|
0.784% - 1.61%
|
1.16% - 1.64%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Constipation
|
Constipation
|
0.394% - 1.96%
|
0.775%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Urinary tract infection
|
Urinary tract infection
|
0.394% - 1.96%
|
0.388%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Flushing
|
Flushing
|
0% - 1.61%
|
1.16% - 1.64%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hyperadrenocorticism
|
Hyperadrenocorticism
|
postmarketing
|
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
|
x
|
x
|
|
x
|
Angioedema
|
Angioedema
|
postmarketing
|
|
|
x
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Anosmia
|
Anosmia
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Anxiety
|
Anxiety
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Mental disorder
|
Mental disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
Bronchospasm
|
Bronchospasm
|
postmarketing, 2%
|
1%
|
|
|
x
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Bronchoconstriction
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Bronchitis
|
Bronchitis
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Infection
|
Infection
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
|
x
|
Dermatitis contact
|
Dermatitis contact
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Endocrine disorder
|
Endocrine disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
Eye disorder
|
Eye disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
|
x
|
Congenital eye disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Glaucoma
|
Glaucoma
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
|
Cardiac disorder
|
Cardiac disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
x
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
|
Type IV hypersensitivity reaction
|
Type IV hypersensitivity reaction
|
postmarketing
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Immune system disorder
|
Immune system disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
|
x
|
Irritability
|
Irritability
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Mediastinal disorder
|
Mediastinal disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
|
x
|
Necrosis ischaemic
|
Necrosis ischaemic
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Osteonecrosis
|
Necrosis ischaemic
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Nervous system disorder
|
Nervous system disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Nervousness
|
Nervousness
|
postmarketing
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Tension
|
Nervousness
|
postmarketing
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Osteoporosis
|
Osteoporosis
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
x
|
|
x
|
|
|
Palpitations
|
Palpitations
|
postmarketing, 2% - 8.28%
|
|
x
|
x
|
x
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
Pharyngeal disorder
|
Pharyngeal disorder
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
x
|
Pruritus
|
Pruritus
|
postmarketing
|
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
|
x
|
|
|
Benign intracranial hypertension
|
Benign intracranial hypertension
|
postmarketing
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Psychotic disorder
|
Psychotic disorder
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Sinusitis
|
Sinusitis
|
postmarketing, 8%
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
Swelling
|
Swelling
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Urticaria
|
Urticaria
|
postmarketing, 6%
|
|
x
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
|
Wheezing
|
Wheezing
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
Agitation
|
Agitation
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hyperkinesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Mood swings
|
Mood swings
|
postmarketing, 3.53% - 6.45%
|
3.28% - 4.26%
|
x
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Affect lability
|
Mood swings
|
postmarketing, 3.53% - 6.45%
|
3.28% - 4.26%
|
x
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Cataract
|
Cataract
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
|
Growth retardation
|
Growth retardation
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
x
|
|
x
|
|
|
Skin irritation
|
Skin irritation
|
postmarketing
|
|
|
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
Skin disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Psychiatric symptom
|
Psychiatric symptom
|
postmarketing
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Intraocular pressure increased
|
Intraocular pressure increased
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
|
|
Nasal septum perforation
|
Nasal septum perforation
|
postmarketing
|
|
|
x
|
x
|
x
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
Oropharyngeal discomfort
|
Throat sore
|
postmarketing
|
|
|
x
|
x
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Oropharyngeal pain
|
Throat sore
|
postmarketing
|
|
|
x
|
x
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
Throat irritation
|
Burning in throat
|
postmarketing
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Throat irritation
|
postmarketing
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
|
|
Abscess
|
Abscess
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Adrenal insufficiency
|
Adrenal insufficiency
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Alopecia
|
Alopecia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Amnesia
|
Amnesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Anaemia
|
Anaemia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Decreased appetite
|
Anorexia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Appetite absent
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Anorectal disorder
|
Anus disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Arthritis
|
Arthritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Arthritis aggravated
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Coagulopathy
|
Clotting
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
Coagulopathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Bone disorder
|
Bone disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Breast disorder
|
Breast disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Neck pain
|
Neck pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Chest pain
|
Chest pain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Allergic granulomatous angiitis
|
Allergic granulomatous angiitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
Leukocytoclastic vasculitis
|
Allergic granulomatous angiitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
Confusional state
|
Confusional state
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Feeling abnormal
|
Confusional state
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Bad taste
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Dyspnoea
|
Dyspnoea
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
x
|
x
|
Dysuria
|
Dysuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Ear pain
|
Ear pain
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
x
|
|
x
|
|
|
Ecchymosis
|
Ecchymosis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Eczema
|
Eczema
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Enteritis
|
Enteritis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Congenital eye disorder
|
Congenital eye disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Eye infection
|
Eye infection
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Multiple fractures
|
Fracture
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Fracture
|
Fracture
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Glossitis
|
Glossitis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Haematuria
|
Haematuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Haemorrhage
|
Haemorrhage
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
Haemoglobin
|
Haemorrhage
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
|
|
Haemorrhoids
|
Haemorrhoids
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Herpes simplex
|
Herpes simplex
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Hypertension
|
Hypertension
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hypokalaemia
|
Hypokalaemia
|
|
|
x
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Influenza
|
Influenza
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Intestinal obstruction
|
Intestinal obstruction
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Leukocytosis
|
Leukocytosis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Metrorrhagia
|
Metrorrhagia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hypertonia
|
Hypertonia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Nocturia
|
Nocturia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Paraesthesia
|
Paraesthesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Purpura
|
Purpura
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Vascular purpura
|
Purpura
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
x
|
Pyuria
|
Pyuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Sneezing
|
Sneezing
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Gastric disorder
|
Gastric disorder
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Stridor
|
Stridor
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Shock
|
Syncope
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Syncope
|
Syncope
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Loss of consciousness
|
Syncope
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Tachycardia
|
Tachycardia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Thirst
|
Thirst
|
|
|
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Tooth disorder
|
Tooth disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Tremor
|
Tremor
|
|
|
x
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
x
|
Ulcer
|
Ulcer
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
Pollakiuria
|
Pollakiuria
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Angiopathy
|
Angiopathy
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
Vertigo
|
Vertigo
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Visual impairment
|
Disorder sight
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Abnormal vision
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Weight increased
|
Weight increased
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
|
x
|
|
x
|
x
|
Dry mouth
|
Dry mouth
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
|
x
|
|
|
|
Rash pustular
|
Rash pustular
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Drug withdrawal syndrome
|
Withdrawal symptom
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Migraine
|
Migraine
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
|
Tongue disorder
|
Tongue oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Tongue oedema
|
Tongue oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Red blood cell sedimentation rate increased
|
Red blood cell sedimentation rate increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Impaired healing
|
Impaired healing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
Blood alkaline phosphatase increased
|
Phosphatase alkaline increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Skin striae
|
Skin striae
|
0% - 2.27%
|
0% - 1.87%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Malnutrition
|
Malnutrition
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Scab
|
Scab
|
|
|
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Malaise
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Discomfort
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Ill-defined disorder
|
Malaise
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Myalgia
|
Myalgia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Hair growth abnormal
|
Hair growth increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Increased appetite
|
Increased appetite
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Tenderness
|
Tenderness
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Gravitational oedema
|
Gravitational oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Lymphadenopathy
|
Lymphadenopathy cervical
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
|
|
Bronchospasm paradoxical
|
Bronchospasm paradoxical
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Secondary adrenocortical insufficiency
|
Secondary adrenocortical insufficiency
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
|
x
|
Gastrointestinal fistula
|
Gastrointestinal fistula
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Hyperkinesia
|
Hyperkinesia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
Face oedema
|
Face oedema
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Sexual dysfunction
|
Sexual dysfunction
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
C-reactive protein increased
|
C-reactive protein increased
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Ear pruritus
|
Ear pruritus
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Infestation
|
Infestation NOS
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
x
|
Sleep disorder
|
Sleep disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Crohn's disease
|
Crohns disease aggravated
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
Local reaction
|
Local reaction
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
Oropharyngeal candidiasis
|
Oropharyngeal candidiasis
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Procedural complication
|
Procedural complication
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Somnolence
|
Somnolence
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|