Estrogens, conjugated

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 22)
1 2 3 4 5 6 7 8 9 10
Endometrial hypertrophy Endometrial thickening 7.8% - 18.9% x
Headache def Headache def postmarketing, 11.3% - 15.7% x x x x x x
Asthenia def Asthenia def 11.3% - 13.7% x x x x x
Fatigue def x
Weakness def x
Nervousness def Nervousness def postmarketing, 3.8% - 13.7% x x x x x
Tension def Nervousness def postmarketing, 3.8% - 13.7% x x x x x
Infection def Infection def 1.9% - 13.2% x x x x x
Respiratory tract infection def Respiratory tract infection def 2% - 13.2% x x
Upper respiratory tract infection def Upper respiratory tract infection def 2% - 13.2% x x
Myalgia def Myalgia def 3.8% - 11.8% x x x x
Musculoskeletal discomfort Myalgia def 3.8% - 11.8% x x x x
Arthralgia def postmarketing, 9.4% - 9.8% x x x x
Arthralgia def Arthralgia def postmarketing, 9.4% - 9.8% x x x x
Insomnia def Insomnia def 5.7% - 9.8% x x x x x
Abdominal pain def Abdominal pain def postmarketing, 5.9% - 9.4% x x x x x x
Abdominal cramps def postmarketing x x x
Gastrointestinal pain def Abdominal pain def postmarketing, 5.9% - 9.4% x x x x x x
Nausea def Nausea def postmarketing, 3.9% - 9.4% x x x x x x
Vasodilation procedure Vasodilation def 3.8% - 7.8% x x x
Paraesthesia def Paraesthesia def 5.9% - 7.5% x x x
Palpitations def Palpitations def 5.7% - 5.9% x x x
Pharyngitis def Pharyngitis def 1.9% - 5.9% x x x x x
Vertigo def Vertigo def 5.7% - 5.9% x x
Anxiety def Anxiety def 2% - 5.7% x
Rhinitis def Rhinitis def 3.9% - 5.7% x x x x x
Weight increased def Weight increased def 3.9% - 5.7% x x
Anaphylactic shock def Anaphylactic shock def postmarketing x x
Asthma def Asthma def postmarketing x x x
Exacerbation of asthma postmarketing x x x
Candidiasis def Candidiasis def postmarketing x x x x
Vulvovaginal candidiasis def Vaginal moniliasis postmarketing x x x x
Vulvovaginal mycotic infection Vaginal moniliasis postmarketing x x x x
Colitis def Colitis def postmarketing x
Cystitis def Cystitis def postmarketing x x
Bladder pain def Cystitis def postmarketing x x
Cystitis noninfective def Cystitis def postmarketing x x
Depression def Depression def postmarketing x x x x x
Dizziness def Dizziness def postmarketing x x x x x x
Syncope def x
Dysmenorrhoea def Dysmenorrhoea def postmarketing x x x x
Oedema def Oedema def postmarketing x x x x x x
Embolism def Embolism def postmarketing x x x
Thromboembolism def x
Epilepsy def Epilepsy def postmarketing x x
Erythema multiforme def Erythema multiforme def postmarketing x x x
Erythema nodosum def Erythema nodosum def postmarketing x x x x
Dermatitis def Rash def postmarketing x x x x
Rash def Rash def postmarketing x x x x
Eruption x x x
Fibrocystic breast disease def Fibrocystic breast disease def postmarketing x x
Gallbladder disorder def Gallbladder disorder def postmarketing x x x x x x
Gynaecomastia def Gynaecomastia def postmarketing x x
Haemangioma def Haemangioma def postmarketing x x
Hirsutism def Hirsutism def postmarketing x x x x x
Hypersensitivity def Hypersensitivity def postmarketing x x x
Hypertriglyceridaemia def Hypertriglyceridaemia def postmarketing x x
Blood triglycerides increased Hypertriglyceridaemia def postmarketing x x
Hypertrophy def Hypertrophy def postmarketing x x x x
Infarction def Infarction def postmarketing x x x
Irritability def Irritability def postmarketing x x x
Jaundice def Jaundice def postmarketing x x x x
Jaundice cholestatic def Jaundice cholestatic def postmarketing x x x x
Muscle spasms def Cramps of lower extremities postmarketing x x x
Cramp muscle def postmarketing x x x x x x
Genital discharge Leukorrhea def postmarketing x x x
Chloasma Chloasma postmarketing x x x x x
Meningioma def Meningioma def postmarketing x
Metrorrhagia def Metrorrhagia def postmarketing x x x x
Myocardial infarction def Myocardial infarction def postmarketing x x x
Acute coronary syndrome def Myocardial infarction def postmarketing x x x
Pancreatitis def Pancreatitis def postmarketing x x
Pelvic pain def Pelvic pain def postmarketing x x
Porphyria def Porphyria def postmarketing x x x
Pruritus genital Pruritus genital postmarketing x
Puberty def Puberty def postmarketing x
Precocious puberty def Precocious puberty def postmarketing x
Pulmonary embolism def Pulmonary embolism def postmarketing x x x
Cerebrovascular accident def Cerebrovascular accident def postmarketing x x x
Thrombophlebitis def Thrombophlebitis def postmarketing x x x
Thrombosis def Thrombosis def postmarketing x x x x
Clot blood def x
Erythema def Erythema def postmarketing x x x x
Urticaria def Urticaria def postmarketing x x x
Uterine leiomyoma def Uterine leiomyoma def postmarketing x x x x
Leiomyoma def x
Venous thrombosis def Venous thrombosis def postmarketing x x x
Vomiting def Vomiting def postmarketing x x x x x x
Deep vein thrombosis def Deep vein thrombosis def postmarketing x
Migraine def Migraine def postmarketing x x x x x x
Colitis ischaemic def Colitis ischaemic def postmarketing x
Discomfort def Discomfort def postmarketing x x
Tenderness def Tenderness def postmarketing x x x x x
Thrombophlebitis superficial def Superficial phlebothrombosis postmarketing x
Thrombophlebitis superficial def x
Galactorrhoea Galactorrhoea postmarketing x
Glucose tolerance impaired def Glucose tolerance impaired def postmarketing x x
Meningioma benign def Meningioma benign def postmarketing x
Endometrial cancer def Endometrial cancer def postmarketing x x
Blood pressure increased Blood pressure increased postmarketing x x x x
Ovarian cancer def Ovarian cancer def postmarketing x
Abdominal distension def Abdominal bloating def postmarketing x x x x x
Flatulence def Abdominal bloating def postmarketing x x x x x
Flatulence def x x x x x
Mood swings Mood alteration NOS def postmarketing x x
Mood swings x
Abscess def Abscess def x
Alopecia def Alopecia def x
Angioedema def Angioedema def x
Back pain def Back pain def x x x x x
Breast swelling Breast swelling x
Bronchitis def Bronchitis def x x
Neck pain def Neck pain def x
Uterine cervical erosion def Uterine cervical erosion def x
Chest pain def Chest pain def x
Chorea def Chorea def x x
Confusional state def Confusional state def x
Feeling abnormal Confusional state def x
Conjunctivitis def Conjunctivitis def x
Constipation def Constipation def x x
Coronary artery thrombosis def Coronary artery thrombosis def x
Cough def Cough def x x x x x x
Cough increased x x x x x
Diarrhoea def Diarrhoea def x x x x x
Dyspepsia def Dyspepsia def x x x x
Dyspnoea def Dyspnoea def x x
Dysuria def Dysuria def x
Ear pain def Ear pain def x
Ecchymosis def Ecchymosis def x
Ectropion def Ectropion def
Endometriosis def Endometriosis def x
Fatigue def Fatigue def x
Body temperature increased def Body temperature increased def x x
Gastrointestinal disorder def Gastrointestinal disorder def x
Haemoptysis def Haemoptysis def x
Hypercalcaemia def Hypercalcaemia def x
Hyperglycaemia def Hyperglycaemia def x
Hyperlipidaemia def Hyperlipoproteinemia def
Hypernatraemia def Hypernatraemia def x
Hypertension def Hypertension def x
Hypoaesthesia def Hypoaesthesia def x
Numbness def x
Hypocalcaemia def Hypocalcaemia def
Hypotension def Hypotension def x
Hypothyroidism def Hypothyroidism def
Influenza def Influenza def x x x x
Arthropathy def Arthropathy def x
Osteoarthritis def Arthropathy def x
Lacrimal disorder def Lacrimal disorder def x
Laryngitis def Laryngitis def x
Pain in extremity def Leg pain x
Leiomyoma def Leiomyoma def x
Breast mass def Breast mass def x
Breast pain def Breast pain def x x x x x x
Hypertonia def Hypertonia def x x
Muscle rigidity def Muscle rigidity def x
Musculoskeletal pain def Musculoskeletal pain def x
Neoplasm def Neoplasm def x x x x
Neuritis def Neuritis def x
Neuropathy peripheral def Neuritis def x
Nodule def Nodule def x
Sensory loss Numbness def x
Optic neuritis def Optic neuritis def x
Tooth abscess Abscess periodontal def x
Phlebitis def Phlebitis def x
Sinusitis def Sinusitis def x x x x x
Swelling def Swelling def x x
Shock def Syncope def x
Syncope def Syncope def x
Loss of consciousness def Syncope def x
Embolism venous Thromboembolism def x
Ulcer def Ulcer def x
Pollakiuria def Pollakiuria def x
Vulvovaginal pruritus Vaginal itching x
Varicose vein def Varicose vein def x
Visual impairment def Visual impairment def x
Visual disturbance x
Visual acuity reduced Visual impairment def x
Blindness def Visual impairment def x
Chills def Chills def x
Agitation def Agitation def x
Affect lability Mood swings x
Oedema peripheral def Oedema peripheral def x x
Hepatic function abnormal Hepatic function abnormal x
Benign neoplasm def Benign neoplasm def x
Stomatitis def Mouth ulceration def x
Mouth ulceration def Mouth ulceration def x
Musculoskeletal stiffness Neck stiffness x
Nuchal rigidity Neck stiffness x
Generalised oedema Generalised oedema x
Fluid retention Generalised oedema x
Fluid retention x
Glucose tolerance decreased Glucose tolerance decreased x
Vaginal haemorrhage def Bleeding vaginal def x x x
Vaginal haemorrhage def x x
Subcutaneous nodule Subcutaneous nodule x
Bone pain def Bone pain def x
Injection site pain Injection site pain x
Withdrawal bleed Withdrawal bleed x
Uterine cancer def Uterine cancer def x
Abdominal discomfort Abdominal discomfort x
Respiratory depression Respiratory depression x
Pulmonary function test decreased Respiratory depression x
Purpura def Rash hemorrhagic x x x
Breast tenderness Breast tenderness x
Ectropion of cervix Ectropion of cervix
Dry eye Dry eye x
Lacrimation increased def Lacrimation def x
Carbohydrate tolerance decreased Carbohydrate tolerance decreased x x
Mass def Mass def x
Blood glucose increased Blood glucose increased x
Acne def Acne def x
Haemorrhagic disorder def Hemorrhage abnormal x
Blood glucose decreased Glucose low x
Breast discomfort Breast discomfort x
Breast neoplasm def Breast neoplasm def x
Somnolence def Somnolence def x
Indication Labels
Atrophy def x x x
Breast cancer def x
Carcinoma def x x
Dyspareunia def x
Endocrine disorder def x
Endometrial hyperplasia def x
Haemorrhage def x
Hyperplasia def x
Hypogonadism def x
Menopause def x x x x x
Metastatic disease def x
Neoplasm malignant def x
Osteoporosis def x x
Osteoporosis postmenopausal def x x
Ovarian failure x
Primary ovarian failure x
Prostate carcinoma def x
Prostatic disorder def x
Uterine disorder def x
Uterine haemorrhage def x
Vaginal inflammation def x
Vaginitis atrophic def x
Vulval leukoplakia def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: G03CA57

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. CONJUGATED ESTROGENS / PMS-CONJUGATED ESTROGENS C.S.D. : 1 side effect (Health Canada)
  2. ESTROGENS, CONJUGATED SYNTHETIC B / ENJUVIA : 8 side effects (Drugs@FDA)
  3. ESTROGENS, CONJUGATED / PREMARIN : 20 side effects (Drugs@FDA)
  4. ESTROGENS, CONJUGATED SYNTHETIC A / CENESTIN : 26 side effects (Drugs@FDA)
  5. ESTROGENS, CONJUGATED SYNTHETIC A / CENESTIN : 45 side effects (Drugs@FDA)
  6. ESTROGENS, CONJUGATED / PREMARIN : 53 side effects (Drugs@FDA)
  7. CONJUGATED ESTROGENS / C.E.S. TABLETS : 56 side effects (Health Canada)
  8. ESTROGENS, CONJUGATED : 64 side effects (FDA XML label)
  9. ESTROGENS, CONJUGATED SYNTHETIC A / CENESTIN : 78 side effects (Drugs@FDA)
  10. ESTROGENS, CONJUGATED : 79 side effects (FDA XML label)