Topiramate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 36)
1 2 3 4 5 6 7 8 9 10
Paraesthesia def postmarketing, 3% - 40% x x x x x x x x x x
Infection def frequent, 1% - 18% x x x x x x x x x x
Respiratory tract infection def 16% - 18% x x x x x x x x x
Upper respiratory tract infection def 16% - 18% x x x x x x x x x
Weight decreased def postmarketing, 6% - 17% x x x x x x x x x x
Somnolence def postmarketing, 10% - 15% x x x x x x x x x x
Anorexia def postmarketing, 4% - 14% x x x x x x x x x x
Dizziness def postmarketing, 13% - 14% x x x x x x x x x x
Body temperature increased def postmarketing — 1% - 12% x x x x x x x x x
Cerebration impaired def postmarketing, 7% - 10% x x x x x x x x x x
Diarrhoea def postmarketing — 8% - 9% x x x x x x x x x x
Insomnia def postmarketing — 8% - 9% x x x x x x x x x x
Viral infection def 3% - 8% x x x x x x
Anxiety def postmarketing, 4% - 6% x x x x x x x x x
Asthenia def postmarketing, 0% - 6% x x x x x x x x
Rhinitis def 2% - 6% x x x x x x x x
Alopecia def postmarketing — 1% - 4% x x x x x x x x
Amenorrhoea def frequent x x x x x x x
Anaemia def frequent, 1% - 3% x x x x x x x x x
Arthralgia def postmarketing, frequent x x x x x x x x x
Bronchitis def frequent, 1% - 5% x x x x x x x
Conjunctivitis def frequent x x x x x x x x x
Convulsion def postmarketing, frequent x x x x x x x x x
Cough def frequent x x x x x x x x x
Libido decreased def frequent, 0% - 3% x x x x x x x
Dehydration def postmarketing — frequent x x x x x x x x x
Dysgeusia def postmarketing — 3% - 5% x x x x x x x
Dysuria def infrequent — 0% - 2% x x x x x x x x
Fatigue def postmarketing, frequent x x x x x x x x x
Flushing def postmarketing — 0% - 5% x x x x x x x x x
Hallucination def postmarketing, frequent x x x x x x x x
Haemorrhage def rare — 0% - 3% x x x x x x x x x
Haemorrhoids def infrequent, frequent x x x x x x x x x
Hypoaesthesia def postmarketing, 4% - 5% x x x x x x x x
Calculus of kidney def postmarketing — 0% - 3% x x x x x
Leukorrhea def frequent x x x x x x x
Menorrhagia def frequent x x x x x x x x
Metrorrhagia def frequent, 0% - 3% x x
Hypertonia def frequent, 0% - 3% x x x x x x x x
Osteoporosis def frequent x
Palpitations def frequent x x
Personality disorder def postmarketing — 0% - 3% x x x x x x x x x
Psychotic disorder def postmarketing, frequent x x x x x x x x x
Suicide def postmarketing — frequent x x x x x x x x x
Suicide attempt def postmarketing — frequent x x x x x x x x
Syncope def infrequent, frequent x x x x x x x x x
Tinnitus def frequent x x x x x x x x
Pollakiuria def frequent, 0% - 3% x x x x x x x
Urinary tract infection def frequent, 1% - 2% x x x x x x x
Urticaria def infrequent, frequent x x x x x x x
Vaginal inflammation def frequent x x
Vertigo def frequent, 0% - 3% x x x x x x x x
Vomiting def postmarketing, frequent x x x x x x x x x
Weight increased def frequent x x x x x
Stupor def frequent x x x x x x x
Hypokinesia def frequent x
Muscular weakness def frequent x x x x x x x x x
Malaise def frequent x
Euphoric mood def infrequent, frequent x x x x x x x x
Erectile dysfunction def frequent x x x x x x x x x
Acne def frequent, 2% - 3% x x x x x x x x
Weakness def frequent x x x x x x x x x
Ataxia def postmarketing, 3% - 4% x x x x x x x x x
Constipation def postmarketing, 1% - 4% x x x x x x x x
Epistaxis def 0% - 4% x x x x x x x x
Rash def postmarketing — 1% - 4% x x x x x x x x x
Pruritus def 1% - 4% x x x x x x x
Sinusitis def 1% - 4% x x x x x x x x
Confusional state def postmarketing, 0% - 3% x x x x x x x x x
Cystitis def 1% - 3% x x x x x x
Gastritis def infrequent, 0% - 3% x x x x x x x x x
Incontinence def infrequent, 1% - 3% x x x x x x x x x
Leg pain 2% - 3% x x x x x x x
Pain def postmarketing — 1% - 3% x x x x x x x x x
Urinary incontinence def 1% - 3% x x x x x
Dry mouth def 1% - 3% x x x x x x x
Muscle contractions involuntary 0% - 3% x x x x x x
Vaginal haemorrhage def 0% - 3% x x x
Chest pain def rare, 1% - 2% x x x x x x x
Dyspnoea def 1% - 2% x x x x x x x x
Gastrooesophageal reflux disease def infrequent, 1% - 2% x x x x x x x x
Acidosis def postmarketing, infrequent x x x x x x
Ageusia def infrequent x x x x x x x x x
Agranulocytosis def infrequent x x x x x x x x
Albuminuria def infrequent x x x x x x x x
Angina pectoris def infrequent x x x x x x x x
Apraxia def infrequent x x x x x x x x
Asthma def infrequent x x x
Atrioventricular block def infrequent x x x x x x x x
Bladder disorder def infrequent x
Bronchospasm def infrequent x
Carcinoma def infrequent x
Basal cell carcinoma def infrequent x
Delirium def infrequent x x x x x x x x
Delusion def postmarketing, infrequent x x x x x x x x
Dental caries def infrequent x
Dermatitis def infrequent x x x x x x x x
Diabetes mellitus def rare, infrequent x x x x x x x x
Dyskinesia def infrequent x x x x x x x x x
Eczema def infrequent x x x x x x x
Oedema def rare, infrequent x x x x x x x x x
Embolism def rare, infrequent x x x x x x x x
Eosinophilia def infrequent x x x x x x x x
Oesophagitis def infrequent x x x x x x x
Folliculitis def infrequent x
Gallbladder disorder def infrequent x
Gingival bleeding def infrequent x x x x x x x x
Gingival hyperplasia def infrequent x x x x
Goitre def infrequent x
Breath odour def infrequent x
Hiccups def infrequent x
Hyperaesthesia def infrequent x x x x x x x x
Hyperglycaemia def infrequent x x x x x x x x
Hyperlipidaemia def infrequent x x x x x x x
Hyperplasia def infrequent x x x x x x x
Hypertension def infrequent x x x x x x x
Hypocalcaemia def infrequent x x x x x x x x
Hypokalaemia def postmarketing, infrequent x x x x x
Hyponatraemia def rare, infrequent x x x x x x x x
Hypotension def infrequent x x x x x x x x
Orthostatic hypotension def infrequent x x x x x x x
Libido increased def rare, infrequent x x x x x x x
Arthropathy def infrequent x x x x x x x x
Lymphocytosis def rare, infrequent x x x x x x x x
Lymphopenia def infrequent x x x x x x x x
Melaena def infrequent x x x x x x x x
Mydriasis def rare, infrequent x x x x x x x x
Myopia def postmarketing, infrequent x x x x x x x
Nail disorder def infrequent x x
Nervous system disorder def postmarketing, infrequent x x x x x x x x
Neurosis def infrequent x x x x x x x
Nocturia def infrequent x x x x x x x
Oliguria def infrequent x x x x x x x x
Neuropathy peripheral def infrequent x x x x x x x x
Phlebitis def infrequent x x x x x x x x
Polyuria def infrequent x x x x x x x x
Ptosis def infrequent x x x x x x x x
Pulmonary embolism def rare, infrequent x x x x x x x x
Respiratory disorder def infrequent x x x x x x x
Scotoma def infrequent x x x x x x x x
Seborrhoeic dermatitis def infrequent x x x x x x x
Salivary hypersecretion def infrequent x x x x x x
Stomatitis def infrequent x x x x x x x x x
Strabismus def infrequent x x x x x x x x
Sweating def postmarketing, infrequent x x x x x x x x
Thirst def infrequent x x x x x x x x
Thrombosis def infrequent x x x x x x x x
Urinary tract disorder def postmarketing, infrequent x x x x x x x x x
Vasodilation def infrequent x x x x x x x x
Venous thrombosis def infrequent x x x x x x
Xerophthalmia def infrequent x x x x x x x x
Urinary retention def infrequent x x x x x x x
Encephalopathy def postmarketing, infrequent x x x x x x x x x
Photophobia def infrequent x x x x x x x x
Hyperchloraemia rare — infrequent x x x x x
Breast discharge def infrequent x x x x x x x
Deep vein thrombosis def infrequent x x x x x x
Creatinine increased def rare, infrequent x x x x x x x
Tongue oedema rare, infrequent x x x x x x x
Electroencephalogram abnormal rare, infrequent x x x x x x x x
Manic psychosis rare, infrequent x x x x x x
Paranoid reaction infrequent x x x x x x x x
Phosphatase alkaline increased infrequent x x x x
Aspartate aminotransferase increased def infrequent x x x x x x x
Alanine aminotransferase increased def infrequent x x x x x x x x
Skin discolouration def infrequent x x x x x
Dry skin def infrequent x
Photosensitivity reaction def infrequent x x x x x x x x
Cardiac fibrillation infrequent x
Hair texture abnormal infrequent x x x x x x x x
Upper motor neurone lesion rare, infrequent x x x x x x x
Ejaculation disorder def infrequent x x x x x x x
Colour blindness def infrequent x
Mania def rare, infrequent x x x x x x x x
Photosensitivity def infrequent x x x x x x x x
Enlargement abdomen def infrequent x x x x x x x
Dystonia def infrequent x x x x x x x x
Lacrimation def infrequent x x x x x x x
Hyperkinesia def postmarketing, infrequent x x x x x x x
Bradycardia def infrequent x x x x x x x
Neuropathy def infrequent x x x x x x x x x
Blindness def infrequent x
Lymphadenopathy def infrequent x x x x x x x x
Face oedema def infrequent x x x x x x x x
Sweating decreased postmarketing, infrequent x x x
Renal pain infrequent x x x x x x x
Thrombocytosis def infrequent x x x x x x x x
Paranoia def infrequent x x x x x x x x
Parosmia def infrequent x x x x x x x x
Dysphonia def infrequent x x x x x x x x
Abdominal pain def postmarketing x x x x x x
Renal tubular acidosis def postmarketing x x x x
Aggression def postmarketing x x x x x x x x x
Amblyopia def postmarketing
Amnesia def postmarketing
Arrhythmia def rare x
Mental disorder def postmarketing x x x x x x x x x
Blister def postmarketing x x x x x x x
Coagulopathy def rare x x x x x x x x x
Cerebellar syndrome def rare x x x x x x x
Connective tissue disorder def postmarketing x
Sudden death def rare x
Diplopia def postmarketing x x x x x x x x x
Ear pain def rare x x
Toxic epidermal necrolysis def postmarketing x x x x x x
Grand mal convulsion def postmarketing x x x x x
Eructation def rare x
Erythema multiforme def postmarketing x x x x x x
Eye disorder def postmarketing x
Gastrointestinal disorder def postmarketing x
Glaucoma def postmarketing
Angle closure glaucoma def postmarketing
Hepatitis def postmarketing x x x x x x x x
Hypernatraemia def rare x x x x x x x
Hypoglycaemia def rare x x x x x x x
Hypohidrosis def postmarketing x
Iritis def rare x x x x x x x x
Laryngospasm def rare x
Leukopenia def postmarketing x x x x x x x x
Chloasma rare x x x x x x x x
Musculoskeletal disorder def postmarketing x x x x x x x x
Musculoskeletal pain def postmarketing
Nausea def postmarketing x x x x x x x x x
Nervousness def postmarketing x x x x x x x x x
Neutropenia def postmarketing
Pancreatitis def postmarketing x x x x x x x
Pancytopenia def rare x x x x x x x x
Pemphigus def postmarketing x x x x x x x
Polycythaemia def rare x x x x x x x x
Hyperacusis def rare x
Speech disorder def postmarketing x x x x x x x x
Thrombocytopenia def postmarketing x x x x x x
Thyroid disorder def rare x
Erythema def postmarketing x x x x x x x
Visual impairment def postmarketing x x x x x x x x x
Hepatic failure def postmarketing x x x x x x x x
Vasospasm def rare x x x x x x x x
Agitation def postmarketing x x x x x x x x
Mood swings postmarketing x x x x x x
Hypophosphataemia def rare x x x x x
Cataract def rare x
Alcohol intolerance def rare x x x x x x x
Necrolysis epidermal postmarketing x x x x x x x
Hypocholesterolaemia def rare x x x x x x x x
Renal tubular disorder def postmarketing x x x x
Bone marrow depression def rare x x x x x x x
Retrosternal pain rare x
Eye pain def postmarketing x x x x x x x x
Drug withdrawal syndrome def postmarketing
Metabolic acidosis def postmarketing x
Hyperammonaemia def postmarketing x
Heat intolerance postmarketing x
Myalgia def postmarketing x x x x x x x x
Thinking abnormal postmarketing
Memory impairment def postmarketing
Convulsions aggravated postmarketing x x x x x x x x x
Tongue paralysis rare x x x x x x x
Hepatic enzyme increased postmarketing
Expressive language disorder def postmarketing
Vision blurred def postmarketing x x
Nephrolithiasis def postmarketing x
Suicidal ideation def postmarketing x
Paralysis def rare x x x x x x x x
Visual disturbance postmarketing
Sedation postmarketing
Hot flush def postmarketing x x x x x x
Drug interaction def postmarketing x
Gastrointestinal pain def postmarketing
Maculopathy postmarketing x x x x
Death rare x
Feeling abnormal postmarketing
Aggressive reaction postmarketing x x x x x x x x x
Hyperthermia def postmarketing x
Back pain def x x x x x x x
Bipolar disorder def x
Bundle branch block def x
Candidiasis def x x x x x x x
Cardiovascular disorder def x x x x x x x x
Collagen disorder def x
Coma def x
Dysphagia def x x x x x x
Depersonalisation def x x x x x x x x
Depression def
Dysmenorrhoea def x x x x x x x x x
Dyspepsia def x x x x x x x x
Endocrine disorder def x x
Epidermodysplasia verruciformis def x
Congenital eye disorder def x x x x
Faecal incontinence def x x x x x
Flatulence def x x x x x x x
Gastroenteritis def x x x x x x x x
Gingivitis def x x x x x x x
Glossitis def x x x x x x
Haematoma def x x x x x x x
Haematuria def x x x x x x x
Hypersensitivity def x x x x x x x
Hypertrichosis def x x x x x x
Body temperature decreased def
Influenza def x x x x x x x x
Cramps of lower extremities x x x x x
Mastitis def x
Breast pain def x x x x x x
Menstrual disorder def x x x x x x
Cramp muscle def x x x x x x x
Neoplasm def x x x x x x x x x
Nystagmus def x x x x x x x x
Obesity def x
Otitis def x x
Otitis media def x x
Pallor def x x x x x x
Pharyngitis def x x x x x x x
Pneumonia def x x x x x x x
Premature ejaculation def x x
Prostatic disorder def x x x x x
Purpura def x x x x x x x x
Skin disorder def x x x x
Ulcerative stomatitis x
Tachycardia def x
Testicular disorder def x
Tooth disorder def x x
Toothache def x
Tremor def x x x x x x x x
Ulcer def x
Unintended pregnancy def x
Angiopathy def x
Body odor def x x x x x
Apathy def x x x x x x x x
Oedema peripheral def x
Bone pain def x x x x
Prothrombin level increased x x x x x
Hyporeflexia x x x x x x x x
Hyperreflexia x
Sensory disturbance def x x
Reaction emotional
Increased appetite x x x x
Ache def x
Rash erythematous x x x x x
Urine abnormality x x x x
Depression aggravated x x
Migraine aggravated x x
Lacrimation abnormal NOS x x x x x
Auditory disorder NOS def
Osteoarthropathy def x x x x x
Found dead (cause undetermined)
Cognitive impairment def x
Genital candidiasis x x
Rash maculo-papular def x
Rigors x x x x x x x
Sudden death, cause unknown
Coordination abnormal x x x x x x x
Gait disturbance def x x x x x x
Breast disorder female
Sweating increased x x x x x x
Diabetic peripheral neuropathy x
Sleep disorder def x
Completed suicide x
Thromboembolic event x
Unspecified disorder of autonomic nervous system def x x x x x x
Hearing impaired def x x x x x
Suicidal behaviour
Indication Labels
Clonic convulsion def x x x x x x x
Cluster headache def x
Epilepsy def x x x x x x x x
Headache def x x
Langer-Giedion syndrome def x x
Lennox-Gastaut syndrome def x x x x x x x
Migraine def x x
Migraine prophylaxis x
Premenstrual syndrome def x
Seizures def x x x x x x x x x
Tonic-clonic seizures def x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N03AX11

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. TOPIRAMATE : 10 side effects (FDA XML label)
  2. TOPIRAMATE : 156 side effects (FDA XML label)
  3. TOPIRAMATE / PMS-TOPIRAMATE : 182 side effects (Health Canada)
  4. TOPIRAMATE : 212 side effects (FDA XML label)
  5. TOPIRAMATE : 212 side effects (FDA XML label)
  6. TOPIRAMATE / TOPAMAX SPRINKLE : 248 side effects (Drugs@FDA)
  7. topiramate / Topamax : 249 side effects (FDA CDER)
  8. TOPIRAMATE : 251 side effects (FDA XML label)
  9. TOPIRAMATE : 253 side effects (FDA XML label)
  10. topiramate : 265 side effects (FDA XML label)