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Topiramate

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N03AX11

Side effects

Options: Show MedDRA Preferred Terms,   display all 68 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Neuropathy peripheral 2% - 32% 15% x x x x x x x x x x x x x x x x x x
Headache postmarketing — 1% - 29% x
Upper respiratory tract infection 12% - 36.7% 12% x x x x x x x x x x x x x x x x x x
Nervousness 0% - 19.3% 2% - 7.4% x x x x x x x x x x x x x x x x x x
Vaginal inflammation 13% x
Fatigue postmarketing — 1% - 30.7% 4% - 13.4% x x x x x x x x x x x x x x x x x x x
Nystagmus 6.1% - 15% 6.8% - 9.3% x x x x x x x x x x x x x x x x x x x
Abnormal behaviour 0% - 11.2% 3.9% - 9% x x x x x x x x x x x x x x x x x x x
Irritability 2% - 14.6% 1% - 8.8% x
Anorexia postmarketing — 2% - 24.5% 1% - 15% x x x x x x x x x x x x x x x x x x x
Malnutrition postmarketing, 6% - 21% 3% - 4% x x x x x x x x x x x x x x x x x x x
Somnolence postmarketing — 0% - 30.1% 2% - 16% x x x x x x x x x x x x x x x x x x x
Purpura 4% - 8.2% 4% x x x x x x x x x x x x x x x x x x
Taste disorders 2% - 15% 0% x
Weight decreased postmarketing — 2.5% - 31% 0% - 4.2% x x x x x x x x x x x x x x x x x x x
Disturbance in attention 2.6% - 11.9% 1.8% - 2.3% x
Insomnia very rare — 0% - 14% 3% - 7% x x x x x x x x x x x x x x x x x x x
Depression rare, 0% - 13% 3.4% - 6% x x x x x x x x x x x x x x x x x x x
Dizziness postmarketing, 0% - 34.1% 2% - 15.3% x x x x x x x x x x x x x x x x x x x
Paraesthesia postmarketing — 0% - 51% 0% - 6% x x x x x x x x x x x x x x x x x x x
Cerebration impaired postmarketing, 0% - 15% 0% - 2% x x x x x x x x x x x x x x x x
Lethargy 1.2% - 13.5% 2.1% - 8.8% x
Abdominal pain very rare — 1.1% - 15% 0.8% - 5% x x x x x x x x x x x x x x x x x x x
Nausea postmarketing — 0% - 15.1% 5% - 8.4% x x x x x x x x x x x x x x x x x x x
Salivary hypersecretion 4% - 6.1% 4% x x x x x x x x x x x x x x x x x x x
Viral infection 1% - 15% 1% - 3% x x x x x x x x x x x x x x x x x x
Decreased appetite 1.3% - 19.2% 2% - 12.7% x
Anaemia frequent, 0.8% - 3% x x x x x x x x x x x x x x x x x x x x
Arthralgia postmarketing — 1% - 7% 2% x x x x x x x x x x x x x x x x x x x
Conjunctivitis frequent, 0% - 7% 1% x x x x x x x x x x x x x x x x x x
Diarrhoea very rare — 2% - 14% 1% - 5.2% x x x x x x x x x x x x x x x x x x x
Hallucination very rare — frequent x x x x x x x x x x x x x x x x x x x
Pain 2.9% - 6.2% 4.2% x x x x x x x x x x x x x x x x x x
Pharyngitis 2% - 21% 2% - 4% x x x x x x x x x x x x x x x x x x
Pneumonia 1% - 5.1% 1% x x x x x x x x x x x x x x x x x x
Psychotic disorder very rare — frequent x x x x x x x x x x x x x x x x x x x
Sinusitis 1% - 15% 4% - 6% x x x x x x x x x x x x x x x x x x
Suicide attempt postmarketing — frequent x x x x x x x x x x x x x x x x x x
Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x
Erectile dysfunction frequent, 1% - 2% x x x x x x x x x x x x x x x x x x x
Hyperkinesia postmarketing, 0% - 21% 4% x x x x x x x x x x x x x x x x x x
Vomiting very rare — 1% - 14% 2% x x x x x x x x x x x x x x x x x x x
Bradyphrenia 0% - 19.5% 1.4% - 3.1% x
Expressive language disorder postmarketing, 3.5% - 9.4% 1.4% - 1.6% x
Anxiety 0% - 10.4% 1.8% - 6% x x x x x x x x x x x x x x x x x x x
Asthenia very rare — 0% - 8% 1% - 1.8% x x x x x x x x x x x x x x x x x x x
Ataxia postmarketing, 1% - 21.2% 1% - 7% x x x x x x x x x x x x x x x x x x x
Confusional state very rare — 0% - 14% 0.8% - 5% x x x x x x x x x x x x x x x x x x x
Constipation 0% - 7% 0% - 4.9% x x x x x x x x x x x x x x x x x x x
Dysarthria 1.6% - 6.2% 1% x
Dyspepsia 0% - 8% 0% - 6.5% x x x x x x x x x x x x x x x x x x x
Breast pain 0% - 8.3% 1.7% - 2% x x x x x x x x x x x x x x x x x
Rhinitis 0% - 21% 0% - 6.9% x x x x x x x x x x x x x x x x x x
Speech disorder very rare — 1% - 16.8% 0.5% - 2.3% x x x x x x x x x x x x x x x x x x x
Coordination abnormal 3.6% - 11.4% 1.9% - 4.2% x x x x x x x x x x x x x x x x x x x
Action tremor 3.1% - 4.8% 2.9% x
Abdominal pain upper 3.7% - 3.9% 2.1% x
Balance disorder 0.4% - 5.8% 0% - 2.4% x
Amnesia very rare — 2.9% - 5.3% 0.5% - 1% x x
Dysmenorrhoea 0% - 8.3% 6.8% x x x x x x x x x x x x x x x x x
Upset stomach 1% - 3.2% 0.2% - 1.3% x
Convulsions aggravated 3% - 3.1% x x x x x x x x x x x x x x x x x x
Bronchitis 0% - 7% 2% x x x x x x x x x x x x x x x x x
Dysgeusia very rare — 0% - 15.4% 0% - 1% x x x x x x x x x x x x x x x x x x
Gastroenteritis 0% - 7% 1% - 2% x x x x x x x x x x x x x x x x x x
Skin disorder 1% - 3.1% 1% - 2% x x x x x x x x x x x x x x x x x x
Tremor 0% - 10.6% 1.4% - 6% x x x x x x x x x x x x x x x x x x x
Agitation postmarketing — 1% - 4.4% 1% - 2% x x x x x x x x x x x x x x x x x x x
Mood swings postmarketing, 0% - 5.1% 0.2% - 2% x x x x x x x x x x x x x x x x
Influenza-like symptoms 0% - 7% 1% - 3.2% x x x x x x x x x x x x x x x x x x
Gait disturbance 0% - 8% 1% - 5% x x x x x x x x x x x x x x x x x x x
Aggressive reaction 0% - 9.2% 0% - 4% x x x x x x x x x x x x x x x x x x x
Hypoaesthesia 1% - 8% 0% - 2% x x x x x x x x x x x x x x x x x x x
Disorientation 1.7% - 3.2% 1% x
Convulsion postmarketing — 1% - 2.3% 0% x x x x x x x x x x x x x x x x x x x
Muscle spasms 1.7% - 3.3% 0.8% x
Alopecia postmarketing — 0% - 6.3% 1% x x x x x x x x x x x x x x x x x x x
Amenorrhoea 2% 1% x x x x x x x x x x x x x x x x x
Aphasia 2% 0% x
Back pain 0% - 6.2% 0% - 4.2% x x x x x x x x x x x x x x x x x x
Chest pain 1% - 4.4% 1% - 3% x x x x x x x x x x x x x x x x x x
Infection postmarketing, 0% - 14% 1% - 13% x x x x x x x x x x x x x x x x x x x
Cough 0% - 7% 2% x x x x x x x x x x x x x x x x x x
Cystitis 0% - 3% 0% x x x x x x x x x x x x x x x x
Dermatitis 0% - 7% 0% x x x x x x x x x x x x x x x x x x
Diplopia 0% - 12.1% 0% - 5% x x x x x x x x x x x x x x x x x x x
Oedema postmarketing, 1% - 2% 1% x x x x x x x x x x x x x x x x x
Epistaxis 0% - 8% 0.5% - 1% x x x x x x x x x x x x x x x x x x x
Congenital eye disorder 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Body temperature increased very rare — 0% - 12% 1% x x x x x x x x x x x x x x x x x x x
Haematuria 0% - 2% 1% x x x x x x x x x x x x x x x x x x
Hypersensitivity 0% - 7% 1% x x x x x x x x x x x x x x
Hypertrichosis 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Cramps of lower extremities 0% - 2% 0% x x x x x x x x x x x x x x x x x
Leg pain 1% - 8% 2% - 2.3% x x x x x x x x x x x x x x x x x x x
Leukopenia postmarketing, 0% - 2.7% 0% - 1% x x x x x x x x x x x x x x x x x x
Leukorrhea 2% 0% x x x x x x x x x x x x x x x x x
Menorrhagia 1% - 2% 0% x x x x x x x x x x x x x x x x x x
Menstrual disorder 0.8% - 4.2% 0% - 2% x x x x x x x x x x x x x x x x x
Otitis media 0% - 8% 1% x x
Prostatic disorder 0% - 2.2% 1% - 0.6% x x x x x x x x x x x x x x x x x
Tachycardia 2% x
Thirst 1% - 2% 1% x x x x x x x x x x x x x x x x x x x
Tinnitus 0.4% - 2% 0% - 1% x x x x x x x x x x x x x x x x x x
Urinary incontinence 1% - 4.1% 1% - 2% x x x x x x x x x x x x x x x x x x
Urinary tract infection 0% - 5% 1% - 2% x x x x x x x x x x x x x x x x x x
Urinary tract disorder postmarketing, 0% - 4.1% 0% x x x x x x x x x x x x x x x x x x x
Disorder sight 0% - 13% x x x x x x x x x x x x x x x x x x
Dry mouth 0.4% - 5% 0% - 2.5% x x x x x x x x x x x x x x x x x x x
Stupor 1% - 2% 0% x x x x x x x x x x x x x x x x x x
Oedema peripheral 2% x
Hyporeflexia 0% - 2% 0% x x x x x x x x x x x x x x x x x x
Myalgia postmarketing, 2% - 2.5% 1% - 1.3% x x x x x x x x x x x x x x x x x x x
Rash erythematous 0% - 8% 0% - 1% x x x x x x x x x x x x x x x x x x
Muscle contractions involuntary 0% - 8% 1% x x x x x x x x x x x x x x x x x x
Vision blurred postmarketing — 2% - 8.9% 2% - 2.5% x x x
Depressed mood 0.4% - 2.9% 0.9% x
Psychomotor retardation 2% 0%
Hot flush postmarketing, 0.7% - 2.7% 1% - 1.9% x x x x x x x x x x x x x x x x x x x
Acne 0% - 3% x x x x x x x x x x x x x x x x
Hearing impaired 1% - 2% 1% x x x x x x x x x x x x x x x x x
Abnormal vision 0% - 14.2% 0% - 2% x x x x x x x x x x x x x x x x x x x
Anger 1.7% - 2.1% 0.5% x
Depersonalisation 1% - 2.2% 0.9% - 1% x x x x x x x x x x x x x x x x
Apathy 1% - 3.1% 0% - 1% x x x x x x x x x x x x x x x x x x x
Paraesthesia oral 1.2% - 3.3% 0.5% x
Learning disability 0% - 3.2% x
Coagulopathy 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Cardiovascular disorder 1% - 2% 0% x x x x x x x x x x x x x x x x x
Haemorrhage 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Red blood cell disorders 1% - 2% x x x x x x x x x x x x x x x x x x
Auditory disorder NOS 1% - 2% 1% x
Musculoskeletal chest pain 1.1% - 1.8% 0.3% x
Mental disability 0.4% - 5% 0.9% - 1.3% x
Personality disorder 0% - 11.2% 9% x x x x x x x x x x x x x x x x x x x
Muscle twitching 0.4% - 1.8% 0.7% x
Cognitive disorder 0.4% - 2% x
Memory impairment postmarketing, 1.2% - 10.8% 1% - 1.8% x
Hypoaesthesia facial 0.4% - 2% x
Candida infection 0% - 1% 0% - 1% x x x x x x x x x x x x x x x x
Libido decreased 0% - 3% 1% x x x x x x x x x x x x x x x x x x x
Dysphagia 1% 0% x x x x x x x x x x x x x x x x x
Dyspnoea 1% - 6% 0.9% - 2% x x x x x x x x x x x x x x x x x x
Eczema 0% - 1% 0% x x x x x x x x x x x x x x x x x
Grand mal convulsion 0% - 7% 0% x x x x x x x x x x x x x x
Rash very rare — 0.4% - 6.7% 1% - 5.9% x x x x x x x x x x x x x x x x x x x
Faecal incontinence 0% - 1% 0% x x x x x x x x x x x x x x x x x
Flatulence 1% 0% x x x x x x x x x x x x x x x x x x
Gastrooesophageal reflux disease 0.4% - 2% 0% - 0.5% x x x x x x x x x x x x x x x x x x x
Gingival hyperplasia 1% 0% x x x x x x x x x x x x x x x x
Gingivitis 1% 1% x x x x x x x x x x x x x x x x x
Glossitis 1% 0% x x x x x x x x x x x x x x x x x
Haematoma 0% - 2% 0% x x x x x x x x x x x x x x x x x
Hypertension 1% - 3% 0% - 1% x x x x x x x x x x x x x x x x
Hypoglycaemia 0% - 1% 0% x x x x x x x x x x x x x x x x x
Myopia very rare — 0% - 1% 0% x x x x x x x x x x x x x x x x x x
Neurosis infrequent, 1% 0% x x x x x x x x x x x x x x x x
Nocturia 0% - 1% 0% x x x x x x x x x x x x x x x x
Pallor 1% 0% x x x x x x x x x x x x x x x x
Pruritus 0% - 4% 2% x x x x x x x x x x x x x x x x x
Seborrhoeic dermatitis 0% - 1% 0% x x x x x x x x x x x x x x x x x
Thrombocytopenia postmarketing, 1% 0% x x x x x x x x x x x x x x x x x
Toothache 1% - 7% x
Pollakiuria 0% - 4% 1% x x x x x x x x x x x x x x x x x x x
Vertigo 0% - 3.2% 1% x x x x x x x x x x x x x x x x x x
Weight increased postmarketing, 0% - 1% 0% x x x x x x x x x x x x x x x x x
Body odor 0% - 1% 0% x x x x x x x x x x x x x x x x x
Migraine postmarketing, 0% - 2%
Gamma-glutamyltransferase increased infrequent, 1% - 3% x x x x x x x x x x x x x x x x
Muscular weakness frequent, 1% x x x x x x x x x x x x x x x x x x x
Bone pain 0% - 1% 0% x x x x x x x x x x x x x x x x
Prothrombin level increased 1% 0% x x x x x x x x x x x x x x x x x
Skin discolouration 0% - 1% 0% x x x x x x x x x x x x x x x x x
Increased appetite 1% 0% x x x x x x x x x x x x x x x x x x
Urine abnormality 0% - 1% 0% x x x x x x x x x x x x x x x x
Depression aggravated 1% - 3% 1% x x
Lacrimation abnormal NOS 0% - 1% 0% x x x x x x x x x x x x x x x x x
Rash maculo-papular 0% - 2% x
Rigors 1% 0% x x x x x x x x x x x x x x x x
Bradycardia 1% 0% x x x x x x x x x x x x x x x x
Sweating increased 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Psychomotor skills impaired 0% - 2% x
Dysphasia 1% 0% x
Ear pain 0% - 1.3% x x
Dry eye 0% - 1.3% x
Pruritus generalised 0% - 1.3% x
Rhinorrhoea 0% - 1.3% x
Agranulocytosis infrequent x x x x x x x x x x x x x x x x x
Albuminuria infrequent x x x x x x x x x x x x x x x x x
Angina pectoris infrequent x x x x x x x x x x x x x x x x x
Apraxia infrequent x x x x x x x x x x x x x x x x x x
Atrioventricular block infrequent x x x x x x x x x x x x x x x x x
Dehydration postmarketing — frequent x x x x x x x x x x x x x x x x x x
Delirium infrequent x x x x x x x x x x x x x x x x x
Delusion postmarketing, infrequent x x x x x x x x x x x x x x x x x x
Diabetes mellitus rare, infrequent x x x x x x x x x x x x x x x x x
Dyskinesia infrequent x x x x x x x x x x x x x x x x x x x
Eosinophilia infrequent x x x x x x x x x x x x x x x x x x
Oesophagitis infrequent x x x x x x x x x x x x x x x x x
Flushing postmarketing — 0% - 5% x x x x x x x x x x x x x x x x x x x
Gastritis infrequent, 0% - 3% x x x x x x x x x x x x x x x x x x x x
Gingival bleeding infrequent, 0% - 1.3% x x x x x x x x x x x x x x x x x x
Haemorrhoids infrequent, frequent x x x x x x x x x x x x x x x x x x
Hyperaesthesia infrequent x x x x x x x x x x x x x x x x x
Hyperglycaemia infrequent x x x x x x x x x x x x x x x x x
Hyperlipidaemia infrequent x x x x x x x x x x x x x x x x x
Hypocalcaemia infrequent x x x x x x x x x x x x x x x x x
Hypokalaemia postmarketing, infrequent x x x x x x
Hypotension infrequent x x x x x x x x x x x x x x x x x
Orthostatic hypotension infrequent x x x x x x x x x x x x x x x x x
Arthropathy infrequent x x x x x x x x x x x x x x x x x
Lymphopenia infrequent x x x x x x x x x x x x x x x x x
Melaena infrequent x x x x x x x x x x x x x x x x x
Oliguria infrequent x x x x x x x x x x x x x x x x x
Phlebitis infrequent x x x x x x x x x x x x x x x x x
Polyuria infrequent x x x x x x x x x x x x x x x x x
Pulmonary embolism rare, infrequent x x x x x x x x x x x x x x x x x
Scotoma infrequent, 0.4% - 1.3% x x x x x x x x x x x x x x x x x x
Stomatitis infrequent x x x x x x x x x x x x x x x x x
Urticaria infrequent, frequent x x x x x x x x x x x x x x x x x x
Vasodilation infrequent x x x x x x x x x x x x x x x x x
Xerophthalmia infrequent x x x x x x x x x x x x x x x x x
Urinary retention infrequent x x x x x x x x x x x x x x x x x
Encephalopathy postmarketing, infrequent x x x x x x x x x x x x x x x x x x
Photophobia infrequent x x x x x x x x x x x x x x x x x
Breast discharge infrequent x x x x x x x x x x x x x x x x x
Deep vein thrombosis infrequent x x x x x x x x x x x x x x x x x
Electroencephalogram abnormal infrequent x x x x x x x x x x x x x x x x x
Paranoid reaction infrequent x x x x x x x x x x x x x x x x x
Phosphatase alkaline increased infrequent x x x x x
Aspartate aminotransferase increased infrequent x x x x x x x x x x x x x x x x x
Alanine aminotransferase increased infrequent x x x x x x x x x x x x x x x x x
Accommodation disorder infrequent x x x x x x x x x x x x x x x x x x x
Photosensitivity reaction infrequent x x x x x x x x x x x x x x x x x
Euphoric mood infrequent, frequent x x x x x x x x x x x x x x x x x x
Hair texture abnormal infrequent x x x x x x x x x x x x x x x x x
Ejaculation disorder infrequent x x x x x x x x x x x x x x x x x
Enlargement abdomen infrequent x x x x x x x x x x x x x x x x x
Neuropathy infrequent x x x x x x x x x x x x x x x x x
Lymphadenopathy infrequent x x x x x x x x x x x x x x x x x x
Face oedema infrequent x x x x x x x x x x x x x x x x x
Renal pain infrequent x x x x x x x x x x x x x x x x x x
Thrombocytosis infrequent x x x x x x x x x x x x x x x x x
Paranoia infrequent x x x x x x x x x x x x x x x x x x
Parosmia infrequent x x x x x x x x x x x x x x x x x x
Dysphonia infrequent x x x