Type III hyperlipidaemia
Definition: An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.
Synonyms (terms occurring on more labels are shown first): dysbetalipoproteinemia, Type III hyperlipoproteinemia, dysbetalipoproteinaemia, type III hyperlipidaemia
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