Simvastatin

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 28)
1 2 3 4 5 6 7 8 9 10
Constipation def 1.3% - 29.1% 1.3% - 1.6% x x x x x x x x x
Flatulence def 0.7% - 14.5% 0.7% - 1.3% x x x x x x x x x
Nausea def 0.4% - 10.1% 0.6% - 1.9% x x x x x x x x x x
Abdominal pain def 0.9% - 8.9% 0.9% - 5.8% x x x x x x x x x x
Pain def 0.9% - 8.9% 0.9% - 5.8% x x x x x x x x x x
Diarrhoea def 0.3% - 7.8% 0.3% - 2.5% x x x x x x x x x
Bronchitis def 6.6% 6.3% x x x x x
Oedema def 2.7% - 5.9% 2.3% - 5.8% x x x x x
Swelling def 2.7% - 5.9% 2.3% - 5.8% x x x x x
Atrial fibrillation def 5.7% 5.1% x x x x
Cardiac fibrillation 5.7% 5.1% x x x x x
Headache def 2.5% - 5.1% 2.1% - 5.1% x x x x x x x x x x
Gastritis def 4.9% 3.9% x x x x x
Dyspepsia def 0.5% - 4.5% 0.5% x x x x x x x x x
Eczema def 0.8% - 4.5% 0.8% - 3% x x x x x
Vertigo def 4.5% 4.2% x x x x x x
Endocrine disorder def 4.2% 3.6% x x x x
Insomnia def 4% 3.8% x x x x x x
Musculoskeletal disorder def 3.7% 3.2% x x x x
Myalgia def postmarketing, 1.2% - 3.7% 1.3% - 3.2% x x x x x x x x x
Infection def 1.9% - 3.4% 1.9% - 3.1% x x x x x x x
Respiratory tract infection def 1.9% - 3.4% 1.9% x x x x x x x
Upper respiratory tract infection def 1.9% - 3.4% 1.9% x x x x x x x
Asthenia def postmarketing, 1.1% - 2.5% 2.5% x x x x x x x x x x
Sinusitis def 2.3% 1.8% x x x x x
Cataract def 0.5% - 0.8% 0.8% x
Rash def 0.6% 0.6% x x x x x x x x x
Pruritus def postmarketing, 0.4% - 0.5% 0.4% x x x x x x x x x
Alopecia def postmarketing x x x x x x x x x
Amnesia def postmarketing x
Anaphylactic shock def postmarketing x x x x x x
Anaemia def postmarketing x x x x x x x
Haemolytic anaemia def postmarketing x x x x x x
Angioedema def postmarketing x x x x x x x x
Arthralgia def postmarketing x x x x x x x x x
Arthritis def postmarketing x x x x x x x x
Confusional state def postmarketing x
Dermatomyositis def postmarketing x x x x x x x x
Dizziness def postmarketing x x x x x x x x
Dyspnoea def postmarketing x x x x x x x x
Eosinophilia def postmarketing x x x x x x x x
Toxic epidermal necrolysis def postmarketing x x x x x x
Erythema multiforme def postmarketing x x x x x x x x x
Body temperature increased def postmarketing x x x x x x x x
Flushing def postmarketing x x x x x x x x
Hepatitis def postmarketing x x x x x x x
Hypersensitivity def postmarketing x x x x x x x x x
Ichthyosis def postmarketing x x x x x x
Jaundice def postmarketing x x x x x x x
Leukopenia def postmarketing x x x x x x x
Lung disorder def postmarketing x x
Cramp muscle def postmarketing x x x x x x x x
Nodule def postmarketing x x x x x x
Pancreatitis def postmarketing x x x x x x x
Paraesthesia def postmarketing x x x x x x x x
Neuropathy peripheral def postmarketing x x x x x x x x
Polymyalgia rheumatica def postmarketing x x x x x x x x
Purpura def postmarketing x x x x x x x
Rhabdomyolysis def postmarketing x x x x x x x x x
Thrombocytopenia def postmarketing x x x x x x x x
Erythema def postmarketing x x x x x x x x x
Urticaria def postmarketing x x x x x x x x
Vasculitis def postmarketing x x x x x x x x
Vomiting def postmarketing x x x x x x x
Chills def postmarketing x x x x x x
Hepatic failure def postmarketing x x x x x x
Antinuclear antibody positive def postmarketing x x x x x x
Necrolysis epidermal postmarketing x x x x x x
Muscular weakness def postmarketing x x x
Phosphatase alkaline increased postmarketing x x x x x x
Sensory disturbance def postmarketing x x
Interstitial lung disease def postmarketing x x
Malaise def postmarketing x x x x x x x x
Memory impairment def postmarketing x x x x x
Erectile dysfunction def postmarketing x x x
Cognitive impairment def postmarketing x
Photosensitivity def postmarketing x x x x x x x x
Lupus erythematosus def postmarketing x x x x x x x x
Neuropathy def postmarketing x x x x x x x x
Polymyalgia postmarketing x x x x x x x x
Forgetfulness postmarketing x
Hypersensitive syndrome postmarketing x x x x x x x x x
Memory loss postmarketing x x
Weakness def postmarketing x x x
Anorexia def x
Anxiety def x
Mental disorder def x x x
Dysgeusia def x
Liver fatty def x
Gastrointestinal disorder def x x x x x x
Gynaecomastia def x
Jaundice cholestatic def x
Lens disorder def x
Hepatic cirrhosis def x
Myopathy def x x x x x x x x x x
Necrosis def x
Ophthalmoplegia def x
Paresis def x
Respiratory disorder def x x x
Tremor def x
Hepatic function abnormal x
Red blood cell sedimentation rate increased x x
Hepatic necrosis def x
Nerve paralysis x
Withdrawn x x x
Facial paresis def x
Transaminases increased x
Hepatitis chronic active def x
Paralysis def x
Drug interaction def x x x
Lenticular opacities x
Regurgitation def x x x
Liver carcinoma def x
Loss of libido x
Indication Labels
Angiopathy def x x x x x
Arterial disorder def x x x
Arterial occlusive disease def x x x
Arteriosclerosis coronary artery def x x x
Atherosclerosis def x x x x x x x x
Cardiac disorder def x x x x x x x x x
Cardiovascular disorder def x x x x x x
Cerebrovascular accident def x x x x x x x x
Cerebrovascular disorder def x x x x x x
Cholesterol serum elevated x x
Coronary heart disease def x x x x x x x x x
Diabetes mellitus def x x x x x x x x x
Disease progression def x x x
Dyslipidaemia def x x x x x x x
Heterozygous familial hypercholesterolemia x x x x x x
Homozygous familial hypercholesterolaemia x x x x x x x x x
Hypercholesterolaemia def x x x x x x x x x x
Hyperkinesia def x
Hyperlipidaemia def x x x x x x x x x x
Hypertriglyceridaemia def x x x x x x x
Hypothyroidism def x x x x
Infarction def x x x x x x x x
Ischaemic stroke x x
Lipid metabolism disorder def x x
Liver disorder def x x x x
Menarche def x x x x x x
Myocardial infarction def x x x x x x x x
Nephrotic syndrome def x x x x
Obstruction def x x x
Type II hyperlipidaemia def x x x x x x x x x
Type IIb hyperlipidaemia x
Type III hyperlipidaemia def x x x x x x x
Type IV hyperlipidaemia def x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: C10AA01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. SIMVASTATIN / PHL-SIMVASTATIN : 30 side effects (Health Canada)
  2. Simvastatin : 32 side effects (FDA XML label)
  3. SIMVASTATIN / APO-SIMVASTATIN : 37 side effects (Health Canada)
  4. SIMVASTATIN / ZOCOR : 56 side effects (Health Canada)
  5. SIMVASTATIN : 62 side effects (FDA XML label)
  6. SIMVASTATIN : 71 side effects (FDA XML label)
  7. SIMVASTATIN : 76 side effects (FDA XML label)
  8. SIMVASTATIN : 79 side effects (FDA XML label)
  9. SIMVASTATIN : 80 side effects (FDA XML label)
  10. simvastatin : 84 side effects (FDA XML label)