Apixaban
  
Side effects 
	
		
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			Show MedDRA Preferred Terms
		
	
	
| Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 
| Haemorrhage | common, 1.13% - 1.37% |  | x | x | 
| Anaemia | common, 2.58% - 3.01% |  | x | x | 
| Epistaxis | uncommon — 1.55% - 3.58% | 1.09% | x | x | 
| Haemorrhagic anaemia | 2.58% - 3.01% |  |  | x | 
| Gastrointestinal haemorrhage | uncommon, common |  | x | x | 
| Haematemesis | uncommon, common |  | x | x | 
| Melaena | uncommon, common |  | x | x | 
| Nausea | common, 2.58% - 2.69% |  | x | x | 
| Conjunctival haemorrhage | rare, common |  | x | x | 
| Eye haemorrhage | rare, common |  | x | x | 
| Contusion | common, 1.4% - 2.22% | 2.18% | x | x | 
| Haematuria | uncommon — 1.43% - 2.1% | 1.09% | x | x | 
| Haematoma | common, 1.13% - 1.97% | 1.21% | x | x | 
| Menorrhagia | 1.42% |  |  | x | 
| Urethral haemorrhage | common, 1.13% - 1.37% |  | x | x | 
| Gingival bleeding | rare — 0.972% - 1.43% | 0.363% | x | x | 
| Rectal haemorrhage | rare — 0.972% |  | x | x | 
| Wound haemorrhage | uncommon, 0.912% - 1.02% |  | x | x | 
| Catheter site haemorrhage | uncommon, 0.912% - 1.02% |  | x | x | 
| Post procedural haematoma | uncommon, 0.912% - 1.02% |  | x | x | 
| Vessel puncture site haematoma | uncommon, 0.912% - 1.02% |  | x | x | 
| Alanine aminotransferase increased | uncommon, 0.844% - 1.2% |  | x | x | 
| Transaminases increased | uncommon, 0.844% - 1.2% |  | x | x | 
| Alanine aminotransferase abnormal | uncommon, 0.844% - 1.2% |  | x | x | 
| Aspartate aminotransferase increased | uncommon, 0.793% - 1.17% |  | x | x | 
| Post procedural haemorrhage | uncommon, 0.912% - 1.02% |  | x | x | 
| Gamma-glutamyltransferase increased | uncommon, 0.641% - 1.1% |  | x | x | 
| Haemoptysis | rare, 1.2% |  | x | x | 
| Anaphylactic shock | uncommon |  | x | x | 
| Rash | uncommon |  | x | x | 
| Haematochezia | uncommon |  | x | x | 
| Subdural haematoma | uncommon |  | x |  | 
| Hypotension | uncommon |  | x | x | 
| Mouth haemorrhage | uncommon |  | x |  | 
| Subarachnoid haemorrhage | uncommon |  | x |  | 
| Thrombocytopenia | uncommon |  | x | x | 
| Traumatic haemorrhage | uncommon |  | x |  | 
| Intraoperative hemorrhage | uncommon |  | x | x | 
| Liver function test abnormal | uncommon |  | x | x | 
| Intra-abdominal haemorrhage | uncommon |  | x |  | 
| Haemorrhoidal haemorrhage | uncommon |  | x | x | 
| Blood bilirubin increased | uncommon |  | x | x | 
| Wound secretion | uncommon |  | x | x | 
| Allergic oedema | uncommon |  | x | x | 
| Blood alkaline phosphatase increased | uncommon |  | x | x | 
| Spinal haematoma | uncommon |  | x |  | 
| Occult blood positive | uncommon |  | x | x | 
| Application site haemorrhage | uncommon |  | x |  | 
| Urogenital haemorrhage | uncommon |  | x |  | 
| Incision site haemorrhage | uncommon |  | x | x | 
| Incision site haematoma | uncommon |  | x | x | 
| Procedural hypotension | uncommon |  | x | x | 
| Cerebral haemorrhage | uncommon |  | x |  | 
| Vaginal haemorrhage | uncommon |  | x | x | 
| Intraspinal bleeding | uncommon |  | x |  | 
| Hypersensitivity | rare, uncommon |  | x | x | 
| Muscle haemorrhage | rare |  | x | x | 
| Retroperitoneal haemorrhage | rare |  | x |  | 
| Respiratory tract haemorrhage | rare |  | x |  | 
| Pharyngeal haemorrhage | rare |  | x |  | 
| Pulmonary alveolar haemorrhage | rare |  | x |  | 
| Laryngeal haemorrhage | rare |  | x |  | 
| Breast disorder |  |  | x | x | 
| Compartment syndrome |  |  |  | x | 
| Connective tissue disorder |  |  | x | x | 
| Diabetes mellitus |  |  |  | x | 
| Drug hypersensitivity |  |  |  | x | 
| Ecchymosis |  |  |  | x | 
| Eye disorder |  |  | x | x | 
| Gastrointestinal disorder |  |  | x | x | 
| Immune system disorder |  |  | x |  | 
| Mediastinal disorder |  |  | x | x | 
| Metrorrhagia |  |  |  | x | 
| Nervous system disorder |  |  | x |  | 
| Petechiae |  |  |  | x | 
| Retinal haemorrhage |  |  |  | x | 
| Syncope |  |  |  | x | 
| Urinary tract disorder |  |  | x | x | 
| Angiopathy |  |  | x | x | 
| Haemorrhage intracranial |  |  |  | x | 
| Unspecified disorder of skin and subcutaneous tissue |  |  |  | x | 
| Blood urine |  |  |  | x | 
| Menometrorrhagia |  |  |  | x | 
| Hepatobiliary disease |  |  | x | x | 
| Anal haemorrhage |  |  |  | x | 
| Periorbital haematoma |  |  |  | x | 
| Injection site haematoma |  |  |  | x | 
| Traumatic haematoma |  |  |  | x | 
| Haemorrhagic stroke |  |  |  | x | 
| Blood and lymphatic system disorders |  |  | x | x | 
| Skin haemorrhage |  |  |  | x | 
| Genital haemorrhage |  |  |  | x | 
| Blood urine present |  |  |  | x | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 71 | 
|---|
		| Source: | EMA | 
|---|
		 
	  
	  
		| Side effects: | 76 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
  
 
  
	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |